Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells

References

• Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: neoadjuvant chemotherapy, surgical resection first or palliation alone? World J Gastroenterol 2014; 20:12391-406; PMID:25253940; http://dx.doi.org/10.3748/wjg.v20.i35.12391
   PubMed Web of Science ®Google Scholar
• Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin 2014; 64:104-17; PMID:24639052; http://dx.doi.org/10.3322/caac.21220
   PubMed Web of Science ®Google Scholar
• Jia Y, Xu G, Zhou W, Wang Z, Meng L, Zhou S, Xu X, Yuan H, Tian K. Diabetes promotes DMH-induced colorectal cancer by increasing the activity of glycolytic enzymes in rats. PLoS One 2014; 9:e110455; PMID:25329503; http://dx.doi.org/10.1371/journal.pone.0110455
   PubMedGoogle Scholar
• Li T, Leong MH, Harms B, Kennedy G, Chen L. MicroRNA-21 as a potential colon and rectal cancer biomarker. World J Gastroenterol 2013; 19:5615-21; PMID:24039353; http://dx.doi.org/10.3748/wjg.v19.i34.5615
   PubMed Web of Science ®Google Scholar
• Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol 2012; 23:352-61; PMID:22406683; http://dx.doi.org/10.1016/j.semcdb.2012.02.003
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
   PubMed Web of Science ®Google Scholar
• Ko H, Son S, Jeon J, Thambi T, Kwon S, Chae YS, Kang YM, Park JH. Tumor microenvironment-specific nanoparticles activatable by stepwise transformation. J Control Release 2016; 234:68-78; PMID:27164544; http://dx.doi.org/10.1016/j.jconrel.2016.05.009
   PubMed Web of Science ®Google Scholar
• Sung SY, Chung LW. Prostate tumor-stroma interaction: molecular mechanisms and opportunities for therapeutic targeting. Differentiation 2002; 70:506-21; PMID:12492493; http://dx.doi.org/10.1046/j.1432-0436.2002.700905.x
   PubMed Web of Science ®Google Scholar
• Xue T, Liu P, Zhou Y, Liu K, Yang L, Moritz RL, Yan W, Xu LX. Interleukin-6 induced “Acute” phenotypic microenvironment promotes Th1 anti-tumor immunity in Cryo-thermal therapy revealed by shotgun and parallel reaction monitoring proteomics. Theranostics 2016; 6:773-94; PMID:27162549; http://dx.doi.org/10.7150/thno.14394
   PubMed Web of Science ®Google Scholar
• Gascard P, Tlsty TD. Carcinoma-associated fibroblasts: orchestrating the composition of malignancy. Genes Dev 2016; 30:1002-19; PMID:27151975; http://dx.doi.org/10.1101/gad.279737.116
   PubMed Web of Science ®Google Scholar
• Shaker H, Bundred NJ, Albadry H, Nicholson S, Castle J, Lumsden LJ, Pritchard S, Landberg G, Kirwan CC. PO-21 - Stromal fibroblasts in preinvasive breast cancer (ductal carcinoma in situ, DCIS) demonstrate a cancer-like procoagulant phenotypic switch that may facilitate invasion. Thromb Res 2016; 140 Suppl 1:S184; PMID:27161710; http://dx.doi.org/10.1016/S0049-3848(16)30154-2
   PubMedGoogle Scholar
• Verghese ET, Drury R, Green CA, Holliday DL, Lu X, Nash C, Speirs V, Thorne JL, Thygesen HH, Zougman A, et al. MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion. J Pathol 2013; 231:388-99; PMID:23939832; http://dx.doi.org/10.1002/path.4248
   PubMed Web of Science ®Google Scholar
• Lisanti MP, Martinez-Outschoorn UE, Sotgia F. Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 2013; 12:2723-32; PMID:23860382; http://dx.doi.org/10.4161/cc.25695
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Pavlides S, Whitaker-Menezes D, Daumer KM, Milliman JN, Chiavarina B, Migneco G, Witkiewicz AK, Martinez-Cantarin MP, Flomenberg N, et al. Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle 2010; 9:2423-33; PMID:20562526; http://dx.doi.org/10.4161/cc.9.12.12048
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. Cell Cycle 2010; 9:3515-33; PMID:20855962; http://dx.doi.org/10.4161/cc.9.17.12928
   PubMed Web of Science ®Google Scholar
• Sanchez-Alvarez R, Martinez-Outschoorn UE, Lin Z, Lamb R, Hulit J, Howell A, Sotgia F, Rubin E, Lisanti MP. Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention. Cell Cycle 2013; 12:289-301; PMID:23257780; http://dx.doi.org/10.4161/cc.23109
   PubMed Web of Science ®Google Scholar
• Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005; 121:335-48; PMID:15882617; http://dx.doi.org/10.1016/j.cell.2005.02.034
   PubMed Web of Science ®Google Scholar
• Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 1999; 98:137-46; PMID:10428026; http://dx.doi.org/10.1016/S0092-8674(00)81009-0
   PubMed Web of Science ®Google Scholar
• Fujii N, Shomori K, Shiomi T, Nakabayashi M, Takeda C, Ryoke K, Ito H. Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance. J Oral Pathol Med 2012; 41:444-51; PMID:22296275; http://dx.doi.org/10.1111/j.1600-0714.2012.01127.x
   PubMed Web of Science ®Google Scholar
• Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci U S A 2002; 99:12877-82; PMID:12297622; http://dx.doi.org/10.1073/pnas.162488599
   PubMed Web of Science ®Google Scholar
• Hayward SW, Wang Y, Cao M, Hom YK, Zhang B, Grossfeld GD, Sudilovsky D, Cunha GR. Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res 2001; 61:8135-42; PMID:11719442
   PubMed Web of Science ®Google Scholar
• Pena C, Cespedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, et al. STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Cancer Res 2013; 73:1287-97; PMID:23243022; http://dx.doi.org/10.1158/0008-5472.CAN-12-1875
   PubMed Web of Science ®Google Scholar
• Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, And∫ S, Martinez-Outschoorn U, et al. Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: connecting TGF-beta signaling with “Warburg-like” cancer metabolism and L-lactate production. Cell Cycle 2012; 11:3019-35; PMID:22874531; http://dx.doi.org/10.4161/cc.21384
   PubMed Web of Science ®Google Scholar
• Sotgia F, Martinez-Outschoorn UE, Pavlides S, Howell A, Pestell RG, Lisanti MP. Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res 2011; 13:213; PMID:21867571; http://dx.doi.org/10.1186/bcr2892
   PubMed Web of Science ®Google Scholar
• Liu L, Zhang LI, Lin YE, Bian Y, Gao X, Qu BO, Li Q. 14-3-3gamma regulates cell viability and milk fat synthesis in lipopolysaccharide-induced dairy cow mammary epithelial cells. Exp Ther Med 2016; 11:1279-87; PMID:27073437
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn U, Sotgia F, Lisanti MP. Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. Semin Oncol 2014; 41:195-216; PMID:24787293; http://dx.doi.org/10.1053/j.seminoncol.2014.03.002
   PubMed Web of Science ®Google Scholar
• Jia CC, Wang TT, Liu W, Fu BS, Hua X, Wang GY, Li TJ, Li X, Wu XY, Tai Y, et al. Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion. PLoS One 2013; 8:e63243; PMID:23667593; http://dx.doi.org/10.1371/journal.pone.0063243
   PubMed Web of Science ®Google Scholar
• Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 1999; 59:5002-11; PMID:10519415
   PubMed Web of Science ®Google Scholar
• Xing F, Saidou J, Watabe K. Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed) 2010; 15:166-79; PMID:20036813; http://dx.doi.org/10.2741/3613
   PubMed Web of Science ®Google Scholar
• Li X, Xu Q, Wu Y, Li J, Tang D, Han L, Fan Q. A CCL2/ROS autoregulation loop is critical for cancer-associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma. Carcinogenesis 2014; 35:1362-70; PMID:24531940; http://dx.doi.org/10.1093/carcin/bgu046
   PubMed Web of Science ®Google Scholar
• Warburg O. On respiratory impairment in cancer cells. Science 1956; 124:269-70; PMID:13351639
   PubMed Web of Science ®Google Scholar
• Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009; 92:329-33; PMID:19604589; http://dx.doi.org/10.1016/j.radonc.2009.06.025
   PubMed Web of Science ®Google Scholar
• Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008; 134:703-7; PMID:18775299; http://dx.doi.org/10.1016/j.cell.2008.08.021
   PubMed Web of Science ®Google Scholar
• Casey TM, Eneman J, Crocker A, White J, Tessitore J, Stanley M, Harlow S, Bunn JY, Weaver D, Muss H, et al. Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study. Breast Cancer Res Treat 2008; 110:39-49; PMID:17674196; http://dx.doi.org/10.1007/s10549-007-9684-7
   PubMed Web of Science ®Google Scholar
• Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK, et al. Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol Cancer Res 2013; 11:579-92; PMID:23475953; http://dx.doi.org/10.1158/1541-7786.MCR-12-0437-T
   PubMed Web of Science ®Google Scholar
• Shi Y, Tan SH, Ng S, Zhou J, Yang ND, Koo GB, McMahon KA, Parton RG, Hill MM, Del Pozo MA, et al. Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy 2015; 11:769-84; PMID:25945613; http://dx.doi.org/10.1080/15548627.2015.1034411
   PubMed Web of Science ®Google Scholar
• Lampiasi N, Azzolina A, Umezawa K, Montalto G, McCubrey JA, Cervello M. The novel NF-kappaB inhibitor DHMEQ synergizes with celecoxib to exert antitumor effects on human liver cancer cells by a ROS-dependent mechanism. Cancer Lett 2012; 322:35-44; PMID:22343223; http://dx.doi.org/10.1016/j.canlet.2012.02.008
   PubMed Web of Science ®Google Scholar
• Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer KM, Lin Z, Witkiewicz AK, et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010; 9:3256-76; PMID:20814239
   PubMed Web of Science ®Google Scholar
• Montero AJ, Jassem J. Cellular redox pathways as a therapeutic target in the treatment of cancer. Drugs 2011; 71:1385-96; PMID:21812504; http://dx.doi.org/10.2165/11592590-000000000-00000
   PubMed Web of Science ®Google Scholar
• Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, et al. A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts. Aging (Albany NY) 2016; 8:1608-35; PMID:27385366; http://dx.doi.org/10.18632/aging.100987
   PubMedGoogle Scholar
• Mercier I, Camacho J, Titchen K, Gonzales DM, Quann K, Bryant KG, Molchansky A, Milliman JN, Whitaker-Menezes D, Sotgia F, et al. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol 2012; 181:278-93; PMID:22698676; http://dx.doi.org/10.1016/j.ajpath.2012.03.017
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV. Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) 2011; 3:1078-91; PMID:22156391; http://dx.doi.org/10.18632/aging.100402
   PubMedGoogle Scholar
• Lisanti MP, Martinez-Outschoorn UE, Sotgia F. Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 2013; 12:2723-32; PMID:23860382; http://dx.doi.org/10.4161/cc.25695
   PubMed Web of Science ®Google Scholar
• Peiris-Pages M, Smith DL, Gyorffy B, Sotgia F, Lisanti MP. Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts. Aging (Albany NY) 2015; 7:816-38; PMID:26539730
   PubMedGoogle Scholar