Guilt by association, caspase-3 regulates microglia polarization

Xianli ShenDepartment of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, Sweden

Miguel A. BurguillosCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK

Bertrand JosephDepartment of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Institutet, Stockholm, SwedenCorrespondence[email protected]

References

Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science 2016; 353:777-83; PMID:27540165; http://dx.doi.org/10.1126/science.aag2590
PubMed Web of Science ®Google Scholar
Hambardzumyan D, Gutman DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nat Neurosci 2016; 19:20-7; PMID:26713745; http://dx.doi.org/10.1038/nn.4185
PubMed Web of Science ®Google Scholar
Shemer A, Erny D, Jung S, Prinz M. Microglia plasticity during health and disease: An immunological perspective. Trends Immunol 2015; 36:614-24; PMID:26431939; http://dx.doi.org/10.1016/j.it.2015.08.003
PubMed Web of Science ®Google Scholar
Venero JL, Burguillos MA, Brundin P, Joseph B. The executioners sing a new song: killer caspases activate microglia. Cell Death Differ 2011; 18:1679-91; PMID:21836616; http://dx.doi.org/10.1038/cdd.2011.107
PubMed Web of Science ®Google Scholar
Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, et al. Caspase signalling controls microglia activation and neurotoxicity. Nature 2011; 472:319-24; PMID:21389984; http://dx.doi.org/10.1038/nature09788
PubMed Web of Science ®Google Scholar
Kavanagh E, Rodhe J, Burguillos MA, Venero JL, Joseph B. Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. Cell Death Dis 2014; 5:e1565; PMID:25501826; http://dx.doi.org/10.1038/cddis.2014.514
PubMedGoogle Scholar
Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, et al. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype. Nat Immunol 2016; 17:1282-90; PMID:27618552; http://dx.doi.org/10.1038/ni.3545
PubMed Web of Science ®Google Scholar

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Guilt by association, caspase-3 regulates microglia polarization

References

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Guilt by association, caspase-3 regulates microglia polarization

References

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date