Discovery of a novel splice variant of Fcar (CD89) unravels sequence segments necessary for efficient secretion: A story of bad signal peptides and good ones that nevertheless do not make it

References

• Herr A, White C, Milburn C, Wu C, Bjorkman P. Bivalent binding of IgA1 to FcαRI suggests mechanism for cytokine activation of IgA phagocytosis. J Mol Biol 2003; 327:645-57; PMID:12634059; http://dx.doi.org/10.1016/S0022-2836(03)00149-9
   PubMed Web of Science ®Google Scholar
• Maliszewski C, Vanden Bos T, Shen L, Schoenborn M, Kubagawa H, Beckmann M, Monteiro R. Recombinant soluble IgA Fc receptor: generation, biochemical characterization, and functional analysis of the recombinant protein. J Leukoc Biol 1993; 53:223-32; PMID:8454945
   PubMed Web of Science ®Google Scholar
• Maliszewski C, March C, Schoenborn M, Gimpel S, Shen L. Expression cloning of a human Fc receptor for IgA. J Exp Med 1990; 172:1665-72; PMID:2258698; http://dx.doi.org/10.1084/jem.172.6.1665
   PubMed Web of Science ®Google Scholar
• Van Dijk T, Bracke M, Caldenhoven E, Raaijmakers J, Cammers J, Koenderman L, de Groot R. Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils. Blood 1996; 88:4229-38; PMID:8943858
   PubMed Web of Science ®Google Scholar
• Reterink T, Verweij C, van Es L, Daha M. Alternative splicing of IgA receptor (CD78) transcripts. Gene 1996; 175:279-80; PMID:8917112; http://dx.doi.org/10.1016/0378-1119(96)00152-7
   PubMed Web of Science ®Google Scholar
• Pleass R, Andrews P, Kerr M, Woof J. Alternative splicing of the human IgA receptor CD89 in neutrophils and eosinophils. Biochem J 1996; 318:771-7; PMID:8836118; http://dx.doi.org/10.1042/bj3180771
   PubMed Web of Science ®Google Scholar
• Patry C, Sibille Y, Lehuen A, Monteiro R. Indentification of Fcα Receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. J Immunol 1996; 156:4442-8; PMID:8666819
   PubMed Web of Science ®Google Scholar
• Morton H, Schiel A, Janssen S, van de Winkel J. Alternatively spliced forms of the human myeloid Fcα receptor (CD89) in neutrophils. Immunogenetics 1996; 43:246-7; PMID:8575829; http://dx.doi.org/10.1007/s002510050057
   PubMed Web of Science ®Google Scholar
• Yang M, Yao M, Gao G, Wang L, Zhang W, Rao Z. Crystal structure of the ectodomain of human FcαRI. J Biol Chem 2003; 278:27966-70; PMID:12783876; http://dx.doi.org/10.1074/jbc.C300223200
   PubMed Web of Science ®Google Scholar
• Yang M, Xu G, Li S, Sun L, Shi N, Zeng W, Pang H, Zhang W, Rao Z. Crystallization and preliminary crystallographic analysis of the extracellular fragment of FcαRI/CD89. Acta Crystallog Section D 2003; 59:2251-3; ; http://dx.doi.org/10.1107/S0907444903020602
   PubMedGoogle Scholar
• Wenig K, Sendermann P. Purification, crystallization and X-ray diffraction analysis of the extracellular part of the human Fc receptor for IgA, FcαRI (CD89). Acta Crystallog Section D 2003; 59:2247-50; ; http://dx.doi.org/10.1107/S0907444903016421
   PubMedGoogle Scholar
• Herr A, Ballister E, Bjorkman P. Insights into IgA-mediated immune responses from the crystal structures of human FcαRI and its complex with IgA1-Fc. Nature 2003; 423:614-20; PMID:12768205; http://dx.doi.org/10.1038/nature01685
   PubMed Web of Science ®Google Scholar
• Wines B, Hulett M, Jawieson G, Trist H, Spratt J, Hogarth P. Identification of residues in the first domain of the human Fcα receptor essential for interaction with IgA. J Immunol 1999; 162:2146-53; PMID:9973489
   PubMed Web of Science ®Google Scholar
• Monteiro R, van de Winkel J. IgA Fc receptors. Annu Rev Immunol 2003; 21:177-204; PMID:12524384; http://dx.doi.org/10.1146/annurev.immunol.21.120601.141011
   PubMed Web of Science ®Google Scholar
• Van Vuuren A, van Egmond M, Coenen M, Morton H, van de Winkel J. Characterization of the human myeloid IgA Fc receptor I (CD89) gene in a cosmid clone. Immunogenetics 1999; 49:586-9; PMID:10380711; http://dx.doi.org/10.1007/s002510050544
   PubMed Web of Science ®Google Scholar
• Toyabe S, Kuwano Y, Takeda K, Uchiyama M, Abo T. IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. Clin Exp Immunol 1997; 110:226-32; PMID:9367406; http://dx.doi.org/10.1111/j.1365-2249.1997.tb08321.x
   PubMed Web of Science ®Google Scholar
• Ooi H, Kwo C, Wildpaner M, Sirota F, Eisenhaber B, S M-S, Wong W, Scheleiffer A, Eisenhaber F, Schneider G. ANNIE: integrated de novo protein sequence annotation. Nucleic Acids Res 2009; 37:W435-W40; PMID:19389726; http://dx.doi.org/10.1093/nar/gkp254
   PubMedGoogle Scholar
• Petersen T, Brunak S, Helijne G, Nielsen H. SignalP 4.0: discriminating signal peptides from transmembrance regions. Nat Methods 2011; 8:785-6; PMID:21959131; http://dx.doi.org/10.1038/nmeth.1701
   PubMed Web of Science ®Google Scholar
• Guo K, Li J, Tang J, Tan C, Wang H, Zeng Q. Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice. Cancer Biol Ther 2008; 7:750-7; PMID:18364570; http://dx.doi.org/10.4161/cbt.7.5.5764
   PubMed Web of Science ®Google Scholar
• Hegde R, Bernstein H. The surprising complexity of signal sequences. Trends Biochem Sci 2006; 31:563-70; PMID:16919958; http://dx.doi.org/10.1016/j.tibs.2006.08.004
   PubMed Web of Science ®Google Scholar
• Eisenhaber F, Argos P. Hydrophobic regions on protein surfaces: definition based on hydration shell structure and a quick method for their computation. Protein Eng 1996; 9:1121-33; PMID:9010925; http://dx.doi.org/10.1093/protein/9.12.1121
   PubMedGoogle Scholar
• Eisenhaber F. Hydrophobic regions on protein surfaces. Derivation of the solvation energy from their area distribution in crystallographic protein structures. Protein Sci 1996; 5:1676-86.
   PubMed Web of Science ®Google Scholar
• Skjaerven L, Yao X, Scarabelli G, Grant BJ. Integrating protein structural dynamics and evolutionary analysis with Bio3D. BMC Bioinformatics 2015; 15:399; ; http://dx.doi.org/10.1186/s12859-014-0399-6
   Web of Science ®Google Scholar
• Grant BJ, Rodrigues APC, ElSawy KM, McCammon JA, Caves LSD. Bio3d: an R package for the comparative analysis of protein structures. Bioinformatics 2006; 22:2695-6; PMID:16940322; http://dx.doi.org/10.1093/bioinformatics/btl461
   PubMed Web of Science ®Google Scholar
• Karagiannis P, Singer J, Hunt J, Gan S, Rudman S, Mechtcheriakova D, Knittelfelder R, Daniels T, Hobson P, Beavil A, et al. Charaterization of an engineered Trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu positive tumor cells. Cancer Immunol Immunother 2009; 58:915-30; PMID:18941743; http://dx.doi.org/10.1007/s00262-008-0607-1
   PubMed Web of Science ®Google Scholar
• Poh J, Gan S. The determination factors involved in column-based nucleic acid extraction and purification. J Bioprocess Biotech 2014; 4:157.
   Google Scholar
• Nguyen P-V, Verma CS, Gan SK-E. DNAApp: a mobile application for sequencing data analysis. Bioinformatics 2014; 30:3270; PMID:25095882; http://dx.doi.org/10.1093/bioinformatics/btu525
   PubMed Web of Science ®Google Scholar
• Katoh K, Standley D. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol 2013; 30:772-80; PMID:23329690; http://dx.doi.org/10.1093/molbev/mst010
   PubMed Web of Science ®Google Scholar
• Durocher Y, Perret S, Kamen A. High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res 2002; 30:E9; PMID:11788735; http://dx.doi.org/10.1093/nar/30.2.e9
   PubMed Web of Science ®Google Scholar
• Sim JZ, Nguyen PV, Lee HK, Gan S. GelApp: mobile gel electrophoresis analyser. Nat Methods Application Notes 2015.
   Google Scholar