1,431
Views
19
CrossRef citations to date
0
Altmetric
Reports

Toxoplasma gondii induces autophagy and apoptosis in human umbilical cord mesenchymal stem cells via downregulation of Mcl−1

, , , , , , , , , , , , & show all
Pages 477-486 | Received 07 Nov 2016, Accepted 05 Jan 2017, Published online: 06 Feb 2017

References

  • Tanaka N, Ashour D, Dratz E, Halonen S. Use of human induced pluripotent stem cell-derived neurons as a model for cerebral Toxoplasmosis. Microbes Infect 2016; 18:496-504; PMID:27083472; http://dx.doi.org/10.1016/j.micinf.2016.03.012
  • Quan JH, Cha GH, Zhou W, Chu JQ, Nishikawa Y, Lee YH. Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp Parasitol 2013; 133:462-71; PMID:23333591; http://dx.doi.org/10.1016/j.exppara.2013.01.005
  • Hampton MM. Congenital toxoplasmosis: a review. Neonatal Netw 2015; 34:274-8; PMID:26802827; http://dx.doi.org/10.1891/0730-0832.34.5.274
  • Chen JL, Ge YY, Zhang J, Qiu XY, Qiu JF, Wu JP, Wang Y. The dysfunction of CD4(+)CD25(+) regulatory T cells contributes to the abortion of mice caused by Toxoplasma gondii excreted-secreted antigens in early pregnancy. PLoS One 2013; 8:e69012; PMID:23874852; http://dx.doi.org/10.1371/journal.pone.0069012
  • Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36:568-84; PMID:15010324; http://dx.doi.org/10.1016/j.biocel.2003.11.001
  • Jorgensen C, Gordeladze J, Noel D. Tissue engineering through autologous mesenchymal stem cells. Curr Opin Biotechnol 2004; 15:406-10; PMID:15464369; http://dx.doi.org/10.1016/j.copbio.2004.08.003
  • Li X, Xu Z, Bai J, Yang S, Zhao S, Zhang Y, Chen X, Wang Y. Umbilical cord tissue-derived mesenchymal stem cells induce T lymphocyte apoptosis and cell cycle arrest by expression of indoleamine 2, 3-dioxygenase. Stem Cells Int 2016; 2016:7495135; Article ID 7495135; PMID:27418932; http://dx.doi.org/10.1155/2016/7495135
  • Liang L, Han ZC. Umbilical cord mesenchymal stem cells: biology and clinical application. In: Stoltz JF, ed. Regenerative Medicine and Cell Therapy. Amsterdam (Netherlands): IOS Press; 2012. p. 62-70
  • Martino R, Maertens J, Bretagne S, Rovira M, Deconinck E, Ullmann AJ, Held T, Cordonnier C. Toxoplasmosis after hematopoietic stem cell transplantation. Clin Infect Dis 2000; 31:1188-95; PMID:11073751; http://dx.doi.org/10.1086/317471
  • Kerl K, Ehlert K, Brentrup A, Schiborr M, Keyvani K, Becker K, Rossig C, Groll AH. Cerebral toxoplasmosis in an adolescent post allogeneic hematopoietic stem cell transplantation: successful outcome by antiprotozoal chemotherapy and CD4+ T-lymphocyte recovery. Transpl Infect Dis 2015; 17:119-24; PMID:25581774; http://dx.doi.org/10.1111/tid.12344
  • Gao D, Zhang J, Zhao J, Wen H, Pan J, Zhang S, Fang Y, Li X, Cai Y, Wang X, et al. Autophagy activated by Toxoplasma gondii infection in turn facilitates Toxoplasma gondii proliferation. Parasitol Res 2014; 113:2053-8; PMID:24696274; http://dx.doi.org/10.1016/j.micinf.2016.03.012
  • Sinha K, Das J, Pal PB, Sil PC. Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol 2013; 87:1157-80; PMID:23543009; http://dx.doi.org/10.1007/s00204-013-1034-4
  • Wang Y, Weiss LM, Orlofsky A. Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J Biol Chem 2009; 284:1694-701; PMID:19028680; http://dx.doi.org/10.1074/jbc.M807890200
  • Zhou J, Gan X, Wang Y, Zhang X, Ding X, Chen L, Du J, Luo Q, Wang T, Shen J, et al. Toxoplasma gondii prevalent in China induce weaker apoptosis of neural stem cells C17.2 via endoplasmic reticulum stress (ERS) signaling pathways. Parasit Vectors 2015; 8:73; PMID:25649541; http://dx.doi.org/10.1186/s13071-015-0670-3
  • Weissman IL. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000; 100:157-68; PMID:10647940; http://dx.doi.org/10.1016/S0092-8674(00)81692-X
  • Zhang Y, Hao H, Liu J, Fu X, Han W. Repair and regeneration of skin injury by transplanting microparticles mixed with Wharton's jelly and MSCs from the human umbilical cord. Int J Low Extrem Wounds 2012; 11:264-70; PMID:23089966; http://dx.doi.org/10.1177/1534734612463577
  • Shi W, Nie D, Jin G, Chen W, Xia L, Wu X, Su X, Xu X, Ni L, Zhang X, et al. BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy. Biomaterials 2012; 33:3119-26; PMID:22264526; http://dx.doi.org/10.1016/j.biomaterials.2012.01.009
  • Melamed J, Dornelles F, Eckert GU. [Cerebral CT scan alterations in children with ocular lesions caused by congenital toxoplasmosis]. J Pediatr (Rio J) 2001; 77:475-80; PMID:14647827
  • Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39; PMID:16179260; http://dx.doi.org/10.1016/j.cell.2005.07.002
  • Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26:2527-39; PMID:17446862; http://dx.doi.org/10.1038/sj.emboj.7601689
  • Zhou F, Yang Y, Xing D. Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 2011; 278:403-13; PMID:21182587; http://dx.doi.org/10.1111/j.1742-4658.2010.07965.x
  • Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010; 40:280-93; PMID:20965422; http://dx.doi.org/10.1016/j.molcel.2010.09.023
  • Ghosh D, Walton JL, Roepe PD, Sinai AP. Autophagy is a cell death mechanism in Toxoplasma gondii. Cell Microbiol 2012; 14:589-607; PMID:22212386; http://dx.doi.org/10.1111/j.1462-5822.2011.01745.x
  • Contreras-Ochoa CO, Lagunas-Martínez A, Belkind-Gerson J, Díaz-Chávez J, Correa D. Toxoplasma gondii invasion and replication within neonate mouse astrocytes and changes in apoptosis related molecules. Exp Parasitol 2013; 134:256-65; PMID:23538030; http://dx.doi.org/10.1016/j.exppara.2013.03.010
  • Germain M, Nguyen AP, Le Grand JN, Arbour N, Vanderluit JL, Park DS, Opferman JT, Slack RS. MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner. EMBO J 2011; 30:395-407; PMID:21139567; http://dx.doi.org/10.1038/emboj.2010.327
  • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741-52; PMID:17717517; http://dx.doi.org/10.1038/nrm2239
  • Djavaheri-Mergny M, Maiuri MC, Kroemer G. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 2010; 29:1717-9; PMID:20101204; http://dx.doi.org/10.1038/onc.2009.519
  • Tai WT, Shiau CW, Chen HL, Liu CY, Lin CS, Cheng AL, Chen PJ, Chen KF. Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis 2013; 4:e485; PMID:23392173; http://dx.doi.org/10.1038/cddis.2013.18
  • Sarkar S. Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers. Biochem Soc Trans 2013; 41:1103-30; PMID:24059496; http://dx.doi.org/10.1042/BST20130134
  • Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 2008; 13:1-9; PMID:17990121; http://dx.doi.org/10.1007/s10495-007-0154-9
  • Qiao C, Xu W, Zhu W, Hu J, Qian H, Yin Q, Jiang R, Yan Y, Mao F, Yang H, et al. Human mesenchymal stem cells isolated from the umbilical cord. Cell Biol Int 2008; 32:8-15; PMID:17904875; http://dx.doi.org/10.1016/j.cellbi.2007.08.002
  • Zhang L, Li L, Leavesley HW, Zhang X, Borowitz JL, Isom GE. Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. J Pharmacol Exp Ther 2010; 332:97-105; PMID:19841471; http://dx.doi.org/10.1124/jpet.109.159103

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.