A cell based screening approach for identifying protein degradation regulators

References

• Teixeira LK and Reed SI. Ubiquitin ligases and cell cycle control. Annu Rev Biochem 2013; 82:387-414; PMID:23495935; http://dx.doi.org/10.1146/annurev-biochem-060410-105307
   PubMed Web of Science ®Google Scholar
• Penas C, Ramachandran V, and Ayad NG. The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol 2011; 1:60; PMID:22655255
   PubMedGoogle Scholar
• Emanuele, MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, et al. Global identification of modular cullin-RING ligase substrates. Cell 2011; 147(2):459-74; PMID:21963094; http://dx.doi.org/10.1016/j.cell.2011.09.019
   PubMed Web of Science ®Google Scholar
• Yen, HC and SJ Elledge Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science 2008; 322(5903):923-9; PMID:18988848; http://dx.doi.org/10.1126/science.1160462
   PubMed Web of Science ®Google Scholar
• Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, et al. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science 2004; 306(5693):117-20; PMID:15459393; http://dx.doi.org/10.1126/science.1100946
   PubMed Web of Science ®Google Scholar
• Penas C, Govek EE, Fang Y, Ramachandran V, Daniel M, Wang W, Maloof ME, Rahaim RJ, Bibian M, Kawauchi D, et al. Casein kinase 1delta is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell Rep 2015; 11(2):249-60; PMID:25843713; http://dx.doi.org/10.1016/j.celrep.2015.03.016
   PubMed Web of Science ®Google Scholar
• Penas C, Mishra JK, Wood SD, Schürer SC, Roush WR, Ayad NG. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Cell Cycle 2015; 14(3):417-24; PMID:25616418; http://dx.doi.org/10.4161/15384101.2014.974439
   PubMed Web of Science ®Google Scholar
• Trojanowsky M. Vidovic D, Simanski S, Penas C, Schurer S, Ayad NG. Screening of cell cycle fusion proteins to identify kinase signaling networks. Cell Cycle 2015; 14(8):1274-81; PMID:25606665; http://dx.doi.org/10.1080/15384101.2015.1006987
   PubMed Web of Science ®Google Scholar
• Chanda SK, White S, Orth AP, Reisdorph R, Miraglia L, Thomas RS, DeJesus P, Mason DE, Huang Q, Vega R, et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A 2003; 100(21):12153-8; PMID:14514886; http://dx.doi.org/10.1073/pnas.1934839100
   PubMed Web of Science ®Google Scholar
• Smith A, Simanski S, Fallahi M, Ayad NG. Redundant ubiquitin ligase activities regulate wee1 degradation and mitotic entry. Cell Cycle 2007; 6(22):2795-9; PMID:18032919; http://dx.doi.org/10.4161/cc.6.22.4919
   PubMed Web of Science ®Google Scholar
• Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW. Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol 2005; 399:404-14; PMID:16338372
   PubMed Web of Science ®Google Scholar
• Bashir T. Dorrello NV, Amador V, Guardavaccaro D, Pagano M. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 2004; 428(6979):190-3; PMID:15014502; http://dx.doi.org/10.1038/nature02330
   PubMed Web of Science ®Google Scholar
• Harmey D, Smith A, Simanski S, Moussa CZ, Ayad NG. The anaphase promoting complex induces substrate degradation during neuronal differentiation. J Biol Chem 2009; 284(7):4317-23; PMID:19047054; http://dx.doi.org/10.1074/jbc.M804944200
   PubMed Web of Science ®Google Scholar
• Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK. Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Cell 2001; 105(5):645-55; PMID:11389834; http://dx.doi.org/10.1016/S0092-8674(01)00361-0
   PubMed Web of Science ®Google Scholar
• Fang G, Yu H, Kirschner MW Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell 1998; 2(2):163-71.
   PubMed Web of Science ®Google Scholar
• Koh, K, X Zheng, and A Sehgal JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 2006. 312(5781):1809-12; PMID:PMID:16794082; http://dx.doi.org/10.1126/science.1124951
   PubMed Web of Science ®Google Scholar
• Jin, J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 2004; 18(21):2573-80; PMID:15520277; http://dx.doi.org/10.1101/gad.1255304
   PubMed Web of Science ®Google Scholar
• Cui, Y, He S, Xing C, Lu K, Wang J, Xing G, Meng A, Jia S, He F, Zhang L. SCFFBXL(1)(5) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. EMBO J 2011; 30(13):2675-89; PMID:21572392; http://dx.doi.org/10.1038/emboj.2011.155
   PubMed Web of Science ®Google Scholar
• Li, D, Xie P, Zhao F, Shu J, Li L, Zhan Y, Zhang L. F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation. Biochem Biophys Res Commun 2015. 458(4):941-5; PMID:25721664; http://dx.doi.org/10.1016/j.bbrc.2015.02.089
   PubMed Web of Science ®Google Scholar
• Kalinovsky, A, Boukhtouche F, Blazeski R, Bornmann C, Suzuki N, Mason CA, Scheiffele P. Development of Axon-Target Specificity of Ponto-Cerebellar Afferents. PLOS Biology 2011. 9(2):e1001013; PMID:21346800; http://dx.doi.org/10.1371/journal.pbio.1001013
   PubMed Web of Science ®Google Scholar
• Patzke, H, Reissmann E, Stanke M, Bixby JL, Ernsberger U. BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development. Mech Dev 2001. 108(1–2):149-159; PMID:11578868; http://dx.doi.org/10.1016/S0925-4773(01)00503-2
   PubMed Web of Science ®Google Scholar
• Su, H-L, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, Sasai Y. Generation of cerebellar neuron precursors from embryonic stem cells. Dev Biol 2006. 290(2):287-96; PMID:16406324; http://dx.doi.org/10.1016/j.ydbio.2005.11.010
   PubMed Web of Science ®Google Scholar