AKAP95 interacts with nucleoporin TPR in mitosis and is important for the spindle assembly checkpoint

References

• Sacristan C, Kops GJPL. Joined at the hip: Kinetochores, microtubules, and spindle assembly checkpoint signaling. Trends Cell Biol 2015; 25:21-8; PMID:25220181; http://dx.doi.org/10.1016/j.tcb.2014.08.006
   PubMed Web of Science ®Google Scholar
• Santaguida S, Amon A. Short- and long-term effects of chromosome mis-segregation and aneuploidy. Nat Rev Mol Cell Biol 2015; 16:473-85; PMID:26204159; http://dx.doi.org/10.1038/nrm4025
   PubMed Web of Science ®Google Scholar
• Musacchio A. The molecular biology of spindle assembly checkpoint signaling dynamics. Curr Biol 2015; 25:R1002-18; PMID:26485365; http://dx.doi.org/10.1016/j.cub.2015.08.051
   PubMed Web of Science ®Google Scholar
• Sironi L, Mapelli M, Knapp S, DeAntoni A, Jeang K-T, Musacchio A. Crystal structure of the tetrameric Mad1-Mad2 core complex: Implications of a “safety belt” binding mechanism for the spindle checkpoint. EMBO J 2002; 21:2496-506; PMID:12006501; http://dx.doi.org/10.1093/emboj/21.10.2496
   PubMed Web of Science ®Google Scholar
• Lee SH, Sterling H, Burlingame A, McCormick F. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev 2008; 22:2926-31; PMID:18981471; http://dx.doi.org/10.1101/gad.1677208
   PubMed Web of Science ®Google Scholar
• Byrd DA, Sweet DJ, Panté N, Konstantinov KN, Guan T, Saphire AC, Mitchell PJ, Cooper CS, Aebi U, Gerace L. Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 1994; 127:1515-26; PMID:7798308; http://dx.doi.org/10.1083/jcb.127.6.1515
   PubMed Web of Science ®Google Scholar
• Cordes VC, Reidenbach S, Rackwitz HR, Franke WW. Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J Cell Biol 1997; 136:515-29; PMID:9024684; http://dx.doi.org/10.1083/jcb.136.3.515
   PubMed Web of Science ®Google Scholar
• Schweizer N, Ferrás C, Kern DM, Logarinho E, Cheeseman IM, Maiato H. Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis. J Cell Biol 2013; 203:883-93; PMID:24344181; http://dx.doi.org/10.1083/jcb.201309076
   PubMed Web of Science ®Google Scholar
• De Souza CP, Hashmi SB, Nayak T, Oakley B, Osmani SA. Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans. Mol Biol Cell 2009; 20:2146-2159.
   Google Scholar
• Lince-Faria M, Maffini S, Orr B, Ding Y, Florindo C, Sunkel CE, Tavares A, Johansen J, Johansen KM, Maiato H. Spatiotemporal control of mitosis by the conserved spindle matrix protein megator. J Cell Biol 2009; 184:647-57; PMID:19273613; http://dx.doi.org/10.1083/jcb.200811012
   PubMed Web of Science ®Google Scholar
• Nakano H, Funasaka T, Hashizume C, Wong RW. Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis. J Biol Chem 2010; 285:10841-9; PMID:20133940; http://dx.doi.org/10.1074/jbc.M110.105890
   PubMed Web of Science ®Google Scholar
• Collas P, Le Guellec K, Taskén K. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. J Cell Biol 1999; 147:1167-80; PMID:10601332; http://dx.doi.org/10.1083/jcb.147.6.1167
   PubMed Web of Science ®Google Scholar
• Akileswaran L, Taraska JW, Sayer Ja, Gettemy JM, Coghlan VM. A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. J Biol Chem 2001; 276:17448-54; PMID:11279182; http://dx.doi.org/10.1074/jbc.M101171200
   PubMed Web of Science ®Google Scholar
• Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG. Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95. Nat Struct Mol Biol 2013; 4:1156-1163.
   Google Scholar
• Wall EA, Zavzavadjian JR, Chang MS, Randhawa B, Zhu X, Hsueh RC, Liu J, Driver A, Bao XR, Sternweis PC, et al. Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Sci Signal 2009; 2:ra28; PMID:19531803; http://dx.doi.org/10.1126/scisignal.2000202
   PubMed Web of Science ®Google Scholar
• Gao X, Chaturvedi D, Patel TB. Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: Implications for its function. Mol Biol Cell 2012; 23:503-515.
   PubMed Web of Science ®Google Scholar
• Eide T, Taskén Ka, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P. Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication. J Biol Chem 2003; 278:26750-6; PMID:12740381; http://dx.doi.org/10.1074/jbc.M300765200
   PubMed Web of Science ®Google Scholar
• Arsenijevic T, Degraef C, Dumont JE, Roger PP, Pirson I. A novel partner for D-type cyclins: Protein kinase A-anchoring protein AKAP95. Biochem J 2004; 378:673-9; PMID:14641107; http://dx.doi.org/10.1042/bj20031765
   PubMed Web of Science ®Google Scholar
• Arsenijevic T, Degraef C, Dumont JE, Pirson I. G1/S Cyclins interact with regulatory subunit of PKA via A-Kinase anchoring protein, AKAP95. Cell Cycle 2006; 5:1217-22; PMID:16721056; http://dx.doi.org/10.4161/cc.5.11.2802
   PubMed Web of Science ®Google Scholar
• Steen RL, Cubizolles F, Le Guellec K, Collas P. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. J Cell Biol 2000; 149:531-6; PMID:10791967; http://dx.doi.org/10.1083/jcb.149.3.531
   PubMed Web of Science ®Google Scholar
• Eide T, Carlson C, Taskén Ka, Hirano T, Taskén K, Collas P. Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. EMBO Rep 2002; 3:426-32; PMID:11964380; http://dx.doi.org/10.1093/embo-reports/kvf089
   PubMed Web of Science ®Google Scholar
• Li Y, Kao GD, Garcia Ba, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar Ma. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 2006; 20:2566-79; PMID:16980585; http://dx.doi.org/10.1101/gad.1455006
   PubMed Web of Science ®Google Scholar
• Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, et al. Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp Cell Res 1998; 238:305-16; PMID:9473338; http://dx.doi.org/10.1006/excr.1997.3855
   PubMed Web of Science ®Google Scholar
• Landsverk HB, Carlson CR, Steen RL, Vossebein L, Herberg FW, Taskén K, Collas P. Regulation of anchoring of the RII α regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RII α : Implications for chromosome dynamics at mitosis. J Cell Sci 2001; 114:3255-64; PMID:11591814.
   PubMed Web of Science ®Google Scholar
• Ivanov A, Pawlikowski J, Manoharan I, Van Tuyn J, Nelson DM, Singh Rai T, Shah PP, Hewitt G, Korolchuk VI, Passos JF, et al. Lysosome-mediated processing of chromatin in senescence. J Cell Biol 2013; 202:129-43; PMID:23816621; http://dx.doi.org/10.1083/jcb.201212110
   PubMed Web of Science ®Google Scholar
• Roux KJ, Kim DI, Raida M, Burke B. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. J Cell Biol 2012; 196:801-10; PMID:22412018; http://dx.doi.org/10.1083/jcb.201112098
   PubMed Web of Science ®Google Scholar
• Coghlan VM, Langeberg K, Fernandez A, Scott JD. Cloning and characterization of AKAP95, a nuclear protein that associates with the regulatory subunuit of type II cAMP-dependent protein kinase. J Biol Chem 1994; 269:7658-65; PMID:8125992.
   PubMed Web of Science ®Google Scholar
• Ishihama Y, Oda Y, Tabata T, Sato T, Nagasu T, Rappsilber J, Mann M. Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics 2005; 4:1265-72; PMID:15958392; http://dx.doi.org/10.1074/mcp.M500061-MCP200
   PubMed Web of Science ®Google Scholar
• Kirkeby S, Moe D, Bøg-Hansen TC, van Noorden CJ. Biotin carboxylases in mitochondria and the cytosol from skeletal and cardiac muscle as detected by avidin binding. Histochemistry 1993; 100:415-21; PMID:8163385; http://dx.doi.org/10.1007/BF00267821
   PubMedGoogle Scholar
• Roux KJ, Kim DI, Burke B. BioID: A screen for protein-protein interactions. Curr Protoc Protein Sci 2013; 74:1-14.
   Google Scholar
• Snow CJ, Paschal BM. Roles of the nucleoporin Tpr in cancer and aging. Cancer Biol Nucl Env 2014; 773:309-322
   Google Scholar
• Rajanala K, Sarkar A, Jhingan GD, Priyadarshini R, Jalan M, Sengupta S, Nandicoori VK. Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function. J Cell Sci 2014; 127:3505-20; PMID:24938596; http://dx.doi.org/10.1242/jcs.149112
   PubMed Web of Science ®Google Scholar
• Soderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius K-J, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson L-G, et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods 2006; 3:995-1000.
   Google Scholar
• Ono T, Fang Y, Spector DL, Hirano T. Spatial and temporal regulation of condensins I and II in mitotic chromosome assembly in human cells. Mol Biol Cell 2004; 16:1-13; PMID:15509653; http://dx.doi.org/10.1091/mbc.E04-07-0565
   PubMed Web of Science ®Google Scholar
• Hudson DF, Vagnarelli P, Gassmann R, Earnshaw WC. Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes. Dev Cell 2003; 5:323-36; PMID:12919682; http://dx.doi.org/10.1016/S1534-5807(03)00199-0
   PubMed Web of Science ®Google Scholar
• Hirota T, Gerlich D, Koch B, Ellenberg J, Peters J-M. Distinct functions of condensin I and II in mitotic chromosome assembly. J Cell Sci 2004; 117:6435-45; PMID:15572404; 10.1242/jcs.01604
   PubMed Web of Science ®Google Scholar
• Watrin E, Legagneux V. Contribution of hCAP-D2, a non-SMC subunit of condensin I, to chromosome and chromosomal protein dynamics during mitosis. Mol Cell Biol 2005; 25:740-50; PMID:15632074; http://dx.doi.org/10.1128/MCB.25.2.740-750.2005
   PubMed Web of Science ®Google Scholar
• Nebel RA, Kirschen J, Cai J, Woo YJ, Cherian K, Abrahams BS. Reciprocal relationship between head size, an autism endophenotype, and gene dosage at 19p13.12 points to AKAP8 and AKAP8L. PLoS One 2015; 10:1-14; PMID:26076356; http://dx.doi.org/10.1371/journal.pone.0129270
   PubMed Web of Science ®Google Scholar
• Ostergaard P, Simpson MA, Mendola A, Vasudevan P, Connell FC, Van Impel A, Moore AT, Loeys BL, Ghalamkarpour A, Onoufriadis A, et al. Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. Am J Hum Genet 2012; 90:356-62; PMID:22284827; http://dx.doi.org/10.1016/j.ajhg.2011.12.018
   PubMed Web of Science ®Google Scholar
• Rogne M, Stokka AJ, Taskèn K, Collas P, Küntziger T. Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network. Hum Mol Genet 2009; 18:978-87.
   Google Scholar