miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells

References

• Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115-32. doi:10.3322/caac.21338
   PubMed Web of Science ®Google Scholar
• Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893-917. doi:10.1002/ijc.25516. PMID:21351269
   PubMed Web of Science ®Google Scholar
• Pignon JP, Arriagada R, Ihde DC, Johnson DH, Perry MC, Souhami RL, Brodin O, Joss RA, Kies MS, Lebeau B, et al. A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med. 1992;327:1618-24. doi:10.1056/NEJM199212033272302. PMID:1331787
   PubMed Web of Science ®Google Scholar
• Czochor JR, Glazer PM. microRNAs in cancer cell response to ionizing radiation. Antioxid Redox Signal. 2014;21:293-312. doi:10.1089/ars.2013.5718. PMID:24206455
   PubMed Web of Science ®Google Scholar
• Metheetrairut C, Slack FJ. MicroRNAs in the ionizing radiation response and in radiotherapy. Curr Opin Genet Dev. 2013;23:12-9. doi:10.1016/j.gde.2013.01.002. PMID:23453900
   PubMed Web of Science ®Google Scholar
• Garofalo M, Croce CM. MicroRNAs as therapeutic targets in chemoresistance. Drug Resist Updat. 2013;16:47-59. doi:10.1016/j.drup.2013.05.001. PMID:23757365
   PubMed Web of Science ®Google Scholar
• Hong L, Yang Z, Ma J, Fan D. Function of miRNA in controlling drug resistance of human cancers. Curr Drug Targets. 2013;14:1118-27. doi:10.2174/13894501113149990183. PMID:23834156
   PubMed Web of Science ®Google Scholar
• Li Y, Kowdley KV. MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics. 2012;10:246-53. doi:10.1016/j.gpb.2012.07.005. PMID:23200134
   PubMedGoogle Scholar
• Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 2010;10:389-402. doi:10.1038/nrc2867. PMID:20495573
   PubMed Web of Science ®Google Scholar
• Wan G, Mathur R, Hu X, Zhang X, Lu X. miRNA response to DNA damage. Trends Biochem Sci. 2011;36:478-84. doi:10.1016/j.tibs.2011.06.002. PMID:21741842
   PubMed Web of Science ®Google Scholar
• He M, Zhou W, Li C, Guo M. MicroRNAs, DNA damage response, and cancer treatment. Int J Mol Sci. 2016;17:E2087. doi:10.3390/ijms17122087. PMID:27973455
   PubMed Web of Science ®Google Scholar
• Wu CW, Dong YJ, Liang QY, He XQ, Ng SS, Chan FK, Sung JJ, Yu J. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS One. 2013;8:e57036. doi:10.1371/journal.pone.0057036. PMID:23437304
   PubMed Web of Science ®Google Scholar
• Song L, Lin C, Wu Z, Gong H, Zeng Y, Wu J, Li M, Li J. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PLoS One. 2011;6:e25454. doi:10.1371/journal.pone.0025454. PMID:21980462
   PubMed Web of Science ®Google Scholar
• Wang J, He J, Su F, Ding N, Hu W, Yao B, Wang W, Zhou G. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death Dis. 2013;4:e699. doi:10.1038/cddis.2013.227. PMID:23807228
   PubMed Web of Science ®Google Scholar
• He J, Hua J, Ding N, Xu S, Sun R, Zhou G, Xie X, Wang J. Modulation of microRNAs by ionizing radiation in human gastric cancer. Oncol Rep. 2014;32:787-93. PMID:24919435
   PubMed Web of Science ®Google Scholar
• Kumar S, Kumar A, Shah PP, Rai SN, Panguluri SK, Kakar SS. MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines. J Ovarian Res. 2011;4:17. doi:10.1186/1757-2215-4-17. PMID:21939554
   PubMed Web of Science ®Google Scholar
• Oren M. Decision making by p53: life, death and cancer. Cell Death Differ. 2003;10:431-42. doi:10.1038/sj.cdd.4401183. PMID:12719720
   PubMed Web of Science ®Google Scholar
• Leroy B, Anderson M, Soussi T. TP53 mutations in human cancer: database reassessment and prospects for the next decade. Hum Mutat. 2014;35:672-88. doi:10.1002/humu.22552. PMID:24665023
   PubMed Web of Science ®Google Scholar
• El-Deiry WS. The role of p53 in chemosensitivity and radiosensitivity. Oncogene. 2003;22:7486-95. doi:10.1038/sj.onc.1206949. PMID:14576853
   PubMed Web of Science ®Google Scholar
• Sengupta S, Harris CC. p53: traffic cop at the crossroads of DNA repair and recombination. Nat Rev Mol Cell Biol. 2005;6:44-55. doi:10.1038/nrm1546. PMID:15688066
   PubMed Web of Science ®Google Scholar
• Le MT, Teh C, Shyh-Chang N, Xie H, Zhou B, Korzh V, Lodish HF, Lim B. MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 2009;23:862-76. doi:10.1101/gad.1767609. PMID:19293287
   PubMed Web of Science ®Google Scholar
• Liu Y, Xing R, Zhang X, Dong W, Zhang J, Yan Z, Li W, Cui J, Lu Y. miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair (Amst). 2013;12:741-50. doi:10.1016/j.dnarep.2013.06.002. PMID:23835407
   PubMed Web of Science ®Google Scholar
• Hartwell LH, Weinert TA. Checkpoints: controls that ensure the order of cell cycle events. Science. 1989;246:629-34. doi:10.1126/science.2683079. PMID:2683079
   PubMed Web of Science ®Google Scholar
• Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 53BP1, a mediator of the DNA damage checkpoint. Science. 2002;298:1435-8. doi:10.1126/science.1076182. PMID:12364621
   PubMed Web of Science ®Google Scholar
• Iwabuchi K, Basu BP, Kysela B, Kurihara T, Shibata M, Guan D, Cao Y, Hamada T, Imamura K, Jeggo PA, et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem. 2003;278:36487-95. doi:10.1074/jbc.M304066200. PMID:12824158
   PubMed Web of Science ®Google Scholar
• Panier S, Boulton SJ. Double-strand break repair: 53BP1 comes into focus. Nat Rev Mol Cell Biol. 2014;15:7-18. doi:10.1038/nrm3719. PMID:24326623
   PubMed Web of Science ®Google Scholar
• Helton ES, Chen X. p53 modulation of the DNA damage response. J Cell Biochem. 2007;100:883-96. doi:10.1002/jcb.21091. PMID:17031865
   PubMed Web of Science ®Google Scholar
• Zermati Y, Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL, Rosselli F, D'Amelio M, Amendola R, et al. Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell. 2007;28:624-37. doi:10.1016/j.molcel.2007.09.030. PMID:18042457
   PubMed Web of Science ®Google Scholar
• O'Connor PM, Jackman J, Bae I, Myers TG, Fan S, Mutoh M, Scudiero DA, Monks A, Sausville EA, Weinstein JN, et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 1997;57:4285-300. PMID:9331090
   PubMed Web of Science ®Google Scholar
• Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A, Teague J, Futreal PA, Stratton MR, et al. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website. Br J Cancer. 2004;91:355-8. PMID:15188009
   PubMed Web of Science ®Google Scholar
• Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D'Amico D, Bodner S, Oie HK, Linnoila RI, Mulshine JL, Minna JD, et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. 1992;7:171-80. PMID:1311061
   PubMed Web of Science ®Google Scholar
• Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science. 1998;282:1497-501. doi:10.1126/science.282.5393.1497. PMID:9822382
   PubMed Web of Science ®Google Scholar
• Moroni MC, Hickman ES, Lazzerini Denchi E, Caprara G, Colli E, Cecconi F, Muller H, Helin K. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol. 2001;3:552-8. doi:10.1038/35078527. PMID:11389439
   PubMed Web of Science ®Google Scholar
• Robles AI, Bemmels NA, Foraker AB, Harris CC. APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. Cancer Res. 2001;61:6660-4. PMID:11559530
   PubMed Web of Science ®Google Scholar
• He J, Li J, Ye C, Zhou L, Zhu J, Wang J, Mizota A, Furusawa Y, Zhou G. Cell cycle suspension: a novel process lurking in G(2) arrest. Cell Cycle. 2011;10:1468-76. doi:10.4161/cc.10.9.15510. PMID:21455017
   PubMed Web of Science ®Google Scholar
• Zhang X, Ye C, Sun F, Wei W, Hu B, Wang J. Both Complexity and location of DNA damage contribute to cellular senescence induced by ionizing radiation. PLoS One. 2016;11:e0155725. doi:10.1371/journal.pone.0155725. PMID:27187621
   PubMed Web of Science ®Google Scholar
• Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A. 1995;92:9363-7. doi:10.1073/pnas.92.20.9363. PMID:7568133
   PubMed Web of Science ®Google Scholar
• Bassaneze V, Miyakawa AA, Krieger JE. A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures. Anal Biochem. 2008;372:198-203. doi:10.1016/j.ab.2007.08.016. PMID:17920029
   PubMed Web of Science ®Google Scholar
• Wang Y, Huang JW, Li M, Cavenee WK, Mitchell PS, Zhou X, Tewari M, Furnari FB, Taniguchi T. MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. Mol Cancer Res. 2011;9:1100-11. doi:10.1158/1541-7786.MCR-11-0007. PMID:21693595
   PubMed Web of Science ®Google Scholar
• Zhang D, Yang G, Chen X, Li C, Wang L, Liu Y, Han D, Liu H, Hou X, Zhang W, et al. mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells. J Mol Neurosci. 2014;53:637-44. doi:10.1007/s12031-014-0230-x. PMID:24464870
   PubMed Web of Science ®Google Scholar
• Xue Z, Zhao J, Niu L, An G, Guo Y, Ni L. Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7. PLoS One. 2015;10:e0127682. doi:10.1371/journal.pone.0127682. PMID:26010572
   PubMed Web of Science ®Google Scholar
• Yu J, Xie F, Bao X, Chen W, Xu Q. miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer. Mol Cancer. 2014;13:121. doi:10.1186/1476-4598-13-121. PMID:24885626
   PubMed Web of Science ®Google Scholar
• Zhou F, Li Y, Hao Z, Liu X, Chen L, Cao Y, Liang Z, Yuan F, Liu J, Wang J, et al. MicroRNA-300 inhibited glioblastoma progression through ROCK1. Oncotarget. 2016;7(24):36529-36538. doi:10.18632/oncotarget.9068. PMID:27145462
   PubMed Web of Science ®Google Scholar
• Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol. 2007;17:1298-307. doi:10.1016/j.cub.2007.06.068. PMID:17656095
   PubMed Web of Science ®Google Scholar
• Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 2011;208:875-83. doi:10.1084/jem.20110235. PMID:21518799
   PubMed Web of Science ®Google Scholar
• Sachdeva M, Zhu S, Wu F, Wu H, Walia V, Kumar S, Elble R, Watabe K, Mo YY. p53 represses c-Myc through induction of the tumor suppressor miR-145. Proc Natl Acad Sci U S A. 2009;106:3207-12. doi:10.1073/pnas.0808042106. PMID:19202062
   PubMed Web of Science ®Google Scholar
• Cao B, Wang K, Liao JM, Zhou X, Liao P, Zeng SX, He M, Chen L, He Y, Li W, et al. Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation. Elife. 2016;5:e15978. doi:10.7554/eLife.15978. PMID:27383270
   PubMed Web of Science ®Google Scholar
• Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS, Tang LH, Levine AJ, Feng Z. Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010;38:689-99. doi:10.1016/j.molcel.2010.05.027. PMID:20542001
   PubMed Web of Science ®Google Scholar
• Liang HQ, Wang RJ, Diao CF, Li JW, Su JL, Zhang S. The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop. Oncotarget. 2015;6:29413-27. doi:10.18632/oncotarget.5003. PMID:26320179
   PubMed Web of Science ®Google Scholar
• Wiebusch L, Hagemeier C. p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress. Oncogene. 2010;29:3477-89. doi:10.1038/onc.2010.99. PMID:20383190
   PubMed Web of Science ®Google Scholar
• Ye C, Zhang X, Wan J, Chang L, Hu W, Bing Z, Zhang S, Li J, He J, Wang J, et al. Radiation-induced cellular senescence results from a slippage of long-term G2 arrested cells into G1 phase. Cell Cycle. 2013;12:1424-32. doi:10.4161/cc.24528. PMID:23574719
   PubMed Web of Science ®Google Scholar
• Zhang XR, Liu YA, Sun F, Li H, Lei SW, Wang JF. p21 is Responsible for Ionizing Radiation-induced Bypass of Mitosis. Biomed Environ Sci. 2016;29:484-93. PMID:27554118
   PubMed Web of Science ®Google Scholar
• Cruz FM, Tome M, Bernal JA, Bernad A. miR-300 mediates Bmi1 function and regulates differentiation in primitive cardiac progenitors. Cell Death Dis. 2015;6:e1953. doi:10.1038/cddis.2015.255. PMID:26512961
   PubMed Web of Science ®Google Scholar
• Gump JM, Thorburn A. Autophagy and apoptosis: what is the connection? Trends Cell Biol. 2011;21:387-92. doi:10.1016/j.tcb.2011.03.007. PMID:21561772
   PubMed Web of Science ®Google Scholar
• Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol. 2007;17:118-26. doi:10.1016/j.tcb.2006.12.007. PMID:17197185
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402-8. doi:10.1006/meth.2001.1262. PMID:11846609
   PubMed Web of Science ®Google Scholar