YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells

References

• Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sanchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015;21:1163–71. doi:10.1038/nm.3952. PMID:26390243
   PubMed Web of Science ®Google Scholar
• Roberts NJ, Norris AL, Petersen GM, Bondy ML, Brand R, Gallinger S, Kurtz RC, Olson SH, Rustgi AK, Schwartz AG, et al. Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov. 2016;6:166–75. doi:10.1158/2159-8290.CD-15-0402. PMID:26658419
   PubMed Web of Science ®Google Scholar
• Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Höfling S, Parsons M, Costa P, Soper R, et al. ADAM8 as a drug target in pancreatic cancer. Nat Commun. 2015;6:6175. doi:10.1038/ncomms7175. PMID:25629724
   PubMed Web of Science ®Google Scholar
• Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014;20:1193–8. doi:10.1038/nm.3686. PMID:25261994
   PubMed Web of Science ®Google Scholar
• Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, Fu Y, Parisien M, Dai Q, Jia G, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117–20. doi:10.1038/nature12730. PMID:24284625
   PubMed Web of Science ®Google Scholar
• Maity A, Das B. N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases. FEBS J. 2016;283:1607–30. doi:10.1111/febs.13614. PMID:26645578
   PubMed Web of Science ®Google Scholar
• Zhu T, Roundtree IA, Wang P, Wang X, Wang L, Sun C, Tian Y, Li J, He C, Xu Y. Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine. Cell Res. 2014;24:1493–6. doi:10.1038/cr.2014.152. PMID:25412661
   PubMed Web of Science ®Google Scholar
• Li F, Zhao D, Wu J, Shi Y. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Cell Res. 2014;24:1490–2. doi:10.1038/cr.2014.153. PMID:25412658
   PubMed Web of Science ®Google Scholar
• Zhang Z, Theler D, Kaminska KH, Hiller M, de la Grange P, Pudimat R, Rafalska I, Heinrich B, Bujnicki JM, Allain FH, et al. The YTH domain is a novel RNA binding domain. J Biol Chem. 2010;285:14701–10. doi:10.1074/jbc.M110.104711. PMID:20167602
   PubMed Web of Science ®Google Scholar
• Niu Y, Zhao X, Wu YS, Li MM, Wang XJ, Yang YG. N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function. Genomics Proteomics Bioinformatics. 2013;11:8–17. doi:10.1016/j.gpb.2012.12.002
   PubMedGoogle Scholar
• Medina M, Wandosell F. Deconstructing GSK-3: The Fine Regulation of Its Activity. Int J Alzheimers Dis. 2011;2011:479249. PMID:21629747
   PubMedGoogle Scholar
• Parvani JG, Gujrati MD, Mack MA, Schiemann WP, Lu ZR. Silencing beta3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2015;75:2316–25. doi:10.1158/0008-5472.CAN-14-3485. PMID:25858145
   PubMed Web of Science ®Google Scholar
• David CJ, Huang YH, Chen M, Su J, Zou Y, Bardeesy N, Iacobuzio-Donahue CA, Massagué J. TGF-beta Tumor Suppression through a Lethal EMT. Cell. 2016;164:1015–30. doi:10.1016/j.cell.2016.01.009. PMID:26898331
   PubMed Web of Science ®Google Scholar
• Jiang Y, Woosley AN, Sivalingam N, Natarajan S, Howe PH. Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-beta-induced autophagy. Nat Cell Biol. 2016;18:851–63. doi:10.1038/ncb3388. PMID:27398911
   PubMed Web of Science ®Google Scholar
• Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 2014;158:171–84. doi:10.1016/j.cell.2014.06.004. PMID:24954536
   PubMed Web of Science ®Google Scholar
• O'Leary B, Finn RS, Turner NC. Treating cancer with selective CDK4/6 inhibitors. Nat Rev Clin Oncol. 2016;13:417–30. doi:10.1038/nrclinonc.2016.26. PMID:27030077
   PubMed Web of Science ®Google Scholar
• Harney AS, Arwert EN, Entenberg D, Wang Y, Guo P, Qian BZ, Oktay MH, Pollard JW, Jones JG, Condeelis JS. Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA. Cancer Discov. 2015;5:932–43. doi:10.1158/2159-8290.CD-15-0012. PMID:26269515
   PubMed Web of Science ®Google Scholar
• Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, et al. A G i-GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate. Molecular Biology of the Cell. 2010;21:2338–54. doi:10.1091/mbc.E10-01-0028. PMID:20462955
   PubMed Web of Science ®Google Scholar
• Lopez-Sanchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P. Protein kinase C-theta (PKCtheta) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin. Proceedings of the National Academy of Sciences of the United States of America. 2013;110:5510–5. doi:10.1073/pnas.1303392110. PMID:23509302
   PubMed Web of Science ®Google Scholar
• Tomiyama L, Sezaki T, Matsuo M, Ueda K, Kioka N. Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation. Oncogene. 2014;34:1141–9. doi:10.1038/onc.2014.31. PMID:24662825
   PubMed Web of Science ®Google Scholar
• Hjelmeland AB, Dhruv HD, McDonough Winslow WS, Armstrong B, Tuncali S, Eschbacher J, et al. Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells. PLoS ONE. 2013;8:e72134. doi:10.1371/journal.pone.0072134. PMID:23967279
   PubMed Web of Science ®Google Scholar
• Tan X, Wang S, Yang B, Zhu L, Yin B, Chao T, Zhao J, Yuan J, Qiang B, Peng X. The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells. PLoS One. 2012;7:e49570. doi:10.1371/journal.pone.0049570. PMID:23185366
   PubMed Web of Science ®Google Scholar
• Kathagen-Buhmann A, Schulte A, Weller J, Holz M, Herold-Mende C, Glass R, Lamszus K. Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation. Neuro-Oncology. 2016;18:1219–29. doi:10.1093/neuonc/now024. PMID:26917237
   PubMed Web of Science ®Google Scholar
• Razidlo GL, Magnine C, Sletten AC, Hurley RM, Almada LL, Fernandez-Zapico ME, Ji B, McNiven MA. Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion. Cancer Res. 2015;75:2907–15. doi:10.1158/0008-5472.CAN-14-3103. PMID:25977335
   PubMed Web of Science ®Google Scholar
• von Karstedt S, Conti A, Nobis M, Montinaro A, Hartwig T, Lemke J, Legler K, Annewanter F, Campbell AD, Taraborrelli L, et al. Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis. Cancer cell. 2015;27:561–73. doi:10.1016/j.ccell.2015.02.014. PMID:25843002
   PubMed Web of Science ®Google Scholar
• Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B, et al. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat Commun. 2016;7:12630. doi:10.1038/ncomms12630. PMID:27600527
   PubMed Web of Science ®Google Scholar
• Tang B, Qi G, Tang F, Yuan S, Wang Z, Liang X, Li B, Yu S, Liu J, Huang Q, et al. Aberrant JMJD3 expression upregulates Slug to promote migration, invasion and stem cell-like behaviors in hepatocellular carcinoma. Cancer Res. 2016;76:6520–32. doi:10.1158/0008-5472.CAN-15-3029.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhu XD, Wang WQ, Shen Y, Qin Y, Ren ZG, Sun HC, Tang ZY. Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clinical cancer research: an official journal of the American Association for Cancer Research. 2010;16:2740–50. doi:10.1158/1078-0432.CCR-09-2610. PMID:20460486
   PubMed Web of Science ®Google Scholar
• Chen SC, Kung ML, Hu TH, Chen HY, Wu JC, Kuo HM, Tsai HE, Lin YW, Wen ZH, Liu JK, et al. Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial–mesenchymal transition. J Pathol. 2012;228:158–69. doi:10.1002/path.3988. PMID:22247069
   PubMed Web of Science ®Google Scholar
• Pei T, Li Y, Wang J, Wang H, Liang Y, Shi H, Sun B, Yin D, Sun J, Song R, et al. YAP is a critical oncogene in human cholangiocarcinoma. Oncotarget. 2015;6:17206–20. doi:10.18632/oncotarget.4043. PMID:26015398
   PubMed Web of Science ®Google Scholar
• Yu FX, Zhao B, Guan KL. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015;163:811–28. doi:10.1016/j.cell.2015.10.044. PMID:26544935
   PubMed Web of Science ®Google Scholar
• Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell. 2012;149:1635–46. doi:10.1016/j.cell.2012.05.003. PMID:22608085
   PubMed Web of Science ®Google Scholar