Inherited DNA lesions determine G1 duration in the next cell cycle

References

• Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660. doi:10.1038/ncomms10660. PMID:26876348
   PubMed Web of Science ®Google Scholar
• Akan P, Alexeyenko A, Costea PI, Hedberg L, Solnestam BW, Lundin S, Hallman J, Lundberg E, Uhlen M, Lundeberg J. Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines. Genome Med. 2012;4:86. doi:10.1186/gm387. PMID:23158748
   PubMed Web of Science ®Google Scholar
• Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO. Absence of poly(ADP-ribose) polymerase 1 delays the onset of salmonella enterica serovar typhimurium-induced gut inflammation. Infect Immun. 2010;78:3420-31. doi:10.1128/IAI.00211-10. PMID:20515923
   PubMed Web of Science ®Google Scholar
• Altmeyer M, Lukas J. Guarding against collateral damage during chromatin transactions. Cell. 2013;153:1431-4. doi:10.1016/j.cell.2013.05.044. PMID:23791174
   PubMed Web of Science ®Google Scholar
• Altmeyer M, Toledo L, Gudjonsson T, Grofte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J. The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling. Mol Cell. 2013;52:206-20. doi:10.1016/j.molcel.2013.08.025. PMID:24055346
   PubMed Web of Science ®Google Scholar
• Arora M, Moser J, Phadke H, Basha AA, Spencer SL. Endogenous replication stress in mother cells leads to quiescence of daughter cells. Cell Rep. 2017;19:1351-64. doi:10.1016/j.celrep.2017.04.055. PMID:28514656
   PubMed Web of Science ®Google Scholar
• Barr AR, Cooper S, Heldt FS, Butera F, Stoy H, Mansfeld J, Novak B, Bakal C. DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression. Nat Commun. 2017;8:14728. doi:10.1038/ncomms14728. PMID:28317845
   PubMed Web of Science ®Google Scholar
• Barr AR, Heldt FS, Zhang T, Bakal C, Novak B. A dynamical framework for the all-or-none G1/S transition. Cell Syst. 2016;2:27-37. doi:10.1016/j.cels.2016.01.001. PMID:27136687
   PubMed Web of Science ®Google Scholar
• Bartek J, Lukas J. Pathways governing G1/S transition and their response to DNA damage. Febs Lett. 2001;490:117-22. doi:10.1016/S0014-5793(01)02114-7. PMID:11223026
   PubMed Web of Science ®Google Scholar
• Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 2005;434:864-70. doi:10.1038/nature03482. PMID:15829956
   PubMed Web of Science ®Google Scholar
• Callen E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, et al. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell. 2007;130:63-75. doi:10.1016/j.cell.2007.06.016. PMID:17599403
   PubMed Web of Science ®Google Scholar
• Cescutti R, Negrini S, Kohzaki M, Halazonetis TD. TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. Embo J. 2010;29:3723-32. doi:10.1038/emboj.2010.238. PMID:20871591
   PubMed Web of Science ®Google Scholar
• Cuella-Martin R, Oliveira C, Lockstone HE, Snellenberg S, Grolmusova N, Chapman JR. 53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms. Mol Cell. 2016;64:51-64. doi:10.1016/j.molcel.2016.08.002. PMID:27546791
   PubMed Web of Science ®Google Scholar
• Dobbelstein M, Sorensen CS. Exploiting replicative stress to treat cancer. Nat Rev Drug Discov. 2015;14:405-23. doi:10.1038/nrd4553. PMID:25953507
   PubMed Web of Science ®Google Scholar
• Florenes VA, Maelandsmo GM, Forus A, Andreassen A, Myklebost O, Fodstad O. Mdm2 gene amplification and transcript levels in human sarcomas–relationship to Tp53 gene status. J Natl Cancer Inst. 1994;86:1297-302. doi:10.1093/jnci/86.17.1297. PMID:8064888
   PubMed Web of Science ®Google Scholar
• Gaillard H, Garcia-Muse T, Aguilera A. Replication stress and cancer. Nat Rev Cancer. 2015;15:276-89. doi:10.1038/nrc3916. PMID:25907220
   PubMed Web of Science ®Google Scholar
• Gorgoulis VG, Vassiliou LVF, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, DiTullio RA, Kastrinakis NG, Levy B, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 2005;434:907-13. doi:10.1038/nature03485. PMID:15829965
   PubMed Web of Science ®Google Scholar
• Gut G, Tadmor MD, Pe'er D, Pelkmans L, Liberali P. Trajectories of cell-cycle progression from fixed cell populations. Nat Methods. 2015;12:951–4. doi:10.1038/nmeth.3545. PMID:26301842
   PubMed Web of Science ®Google Scholar
• Halazonetis TD, Gorgoulis VG, Bartek J. An oncogene-induced DNA damage model for cancer development. Science. 2008;319:1352-5. doi:10.1126/science.1140735. PMID:18323444
   PubMed Web of Science ®Google Scholar
• Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, Jackson SP. Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol. 2011;193:97-108. doi:10.1083/jcb.201011083. PMID:21444690
   PubMed Web of Science ®Google Scholar
• Hoppe-Seyler F, Butz K. Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J Virol. 1993;67:3111-7. PMID:8388491
   PubMed Web of Science ®Google Scholar
• Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013;494:480-3. doi:10.1038/nature11897. PMID:23446419
   PubMed Web of Science ®Google Scholar
• Kleiblova P, Shaltiel IA, Benada J, Sevcik J, Pechackova S, Pohlreich P, Voest EE, Dundr P, Bartek J, Kleibl Z, et al. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol. 2013;201:511-21. doi:10.1083/jcb.201210031. PMID:23649806
   PubMed Web of Science ®Google Scholar
• Kochetkov DV, Il'inskaia GV, Komarov PG, Strom E, Agapova LS, Ivanov AV, Budanov AV, Frolova EI, Chumakov PM. [Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]. Mol Biol (Mosk). 2007;41:515-23. doi:10.1134/S0026893307030120. PMID:17685229
   PubMed Web of Science ®Google Scholar
• Liu YW, Heilman SA, Illanes D, Sluder G, Chen JJ. p53-independent abrogation of a postmitotic checkpoint contributes to human papillomavirus E6-induced polyploidy. Cancer Res. 2007;67:2603-10. doi:10.1158/0008-5472.CAN-06-3436. PMID:17363579
   PubMed Web of Science ®Google Scholar
• Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Pedersen RS, Grofte M, Chan KL, Hickson ID, Bartek J, et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat Cell Biol. 2011;13:243-53. doi:10.1038/ncb2201. PMID:21317883
   PubMed Web of Science ®Google Scholar
• Macheret M, Halazonetis TD. DNA replication stress as a hallmark of cancer. Annu Rev Pathol. 2015;10:425-48. doi:10.1146/annurev-pathol-012414-040424. PMID:25621662
   PubMed Web of Science ®Google Scholar
• Mankouri HW, Huttner D, Hickson ID. How unfinished business from S-phase affects mitosis and beyond. Embo J. 2013;32:2661-71. doi:10.1038/emboj.2013.211. PMID:24065128
   PubMed Web of Science ®Google Scholar
• Minocherhomji S, Ying SM, Bjerregaard VA, Bursomanno S, Aleliunaite A, Wu W, Mankouri HW, Shen HH, Liu Y, Hickson ID. Replication stress activates DNA repair synthesis in mitosis. Nature. 2015;528:286-+. doi:10.1038/nature16139. PMID:26633632
   PubMed Web of Science ®Google Scholar
• Moreno A, Carrington JT, Albergante L, Al Mamun M, Haagensen EJ, Komseli ES, Gorgoulis VG, Newman TJ, Blow JJ. Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells. Proc Natl Acad Sci U S A. 2016;113:E5757-64. doi:10.1073/pnas.1603252113. PMID:27516545
   PubMed Web of Science ®Google Scholar
• Muller PA, Vousden KH. p53 mutations in cancer. Nat Cell Biol. 2013;15:2-8. doi:10.1038/ncb2641. PMID:23263379
   PubMed Web of Science ®Google Scholar
• Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C. 53BP1 fosters fidelity of homology-directed DNA repair. Nat Struct Mol Biol. 2016;23:714-21. doi:10.1038/nsmb.3251. PMID:27348077
   PubMed Web of Science ®Google Scholar
• Overton KW, Spencer SL, Noderer WL, Meyer T, Wang CL. Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states. Proc Natl Acad Sci U S A. 2014;111:E4386-93. doi:10.1073/pnas.1409797111. PMID:25267623
   PubMed Web of Science ®Google Scholar
• Panier S, Durocher D. Push back to respond better: Regulatory inhibition of the DNA double-strand break response. Nat Rev Mol Cell Biol. 2013;14:661-72. doi:10.1038/nrm3659. PMID:24002223
   PubMed Web of Science ®Google Scholar
• Pedersen RS, Karemore G, Gudjonsson T, Rask MB, Neumann B, Heriche JK, Pepperkok R, Ellenberg J, Gerlich DW, Lukas J, et al. Profiling DNA damage response following mitotic perturbations. Nat Commun. 2016;7:13887. doi:10.1038/ncomms13887. PMID:27976684
   PubMed Web of Science ®Google Scholar
• Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M. Replication-coupled dilution of H4K20me2 guides 53BP1 to pre-replicative chromatin. Cell Rep. 2017;19:1819-31. doi:10.1016/j.celrep.2017.05.016. PMID:28564601
   PubMed Web of Science ®Google Scholar
• Reaper PM, Griffiths MR, Long JM, Charrier JD, MacCormick S, Charlton PA, Golec JMC, Pollard JR. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011;7:428-30. doi:10.1038/nchembio.573. PMID:21490603
   PubMed Web of Science ®Google Scholar
• Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H, Kashiwagi S, Fukami K, Miyata T, Miyoshi H, et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell. 2008;132:487-98. doi:10.1016/j.cell.2007.12.033. PMID:18267078
   PubMed Web of Science ®Google Scholar
• Schwertman P, Bekker-Jensen S, Mailand N. Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers. Nat Rev Mol Cell Biol. 2016;17:379-94. doi:10.1038/nrm.2016.58. PMID:27211488
   PubMed Web of Science ®Google Scholar
• Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013;155:369-83. doi:10.1016/j.cell.2013.08.062. PMID:24075009
   PubMed Web of Science ®Google Scholar
• Toledo L, Neelsen KJ, Lukas J. Replication catastrophe: When a checkpoint fails because of exhaustion. Mol Cell. 2017;66:735–49. doi:10.1016/j.molcel.2017.05.001. PMID:28622519
   PubMed Web of Science ®Google Scholar
• Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J. ATR prohibits replication catastrophe by preventing global exhaustion of RPA. Cell. 2013;155:1088-103. doi:10.1016/j.cell.2013.10.043. PMID:24267891
   PubMed Web of Science ®Google Scholar
• Zeman MK, Cimprich KA. Causes and consequences of replication stress. Nat Cell Biol. 2014;16:2-9. doi:10.1038/ncb2897. PMID:24366029
   PubMed Web of Science ®Google Scholar