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Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention

Kei KawaguchiAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA;Dept. of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan

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Qinghong HanAntiCancer, Inc., San Diego, CA, USA

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Shukuan LiAntiCancer, Inc., San Diego, CA, USA

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Yuying TanAntiCancer, Inc., San Diego, CA, USA

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Kentaro IgarashiAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA

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Tasuku KiyunaAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA

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Kentaro MiyakeAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA

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Masuyo MiyakeAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA

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Bartosz ChmielowskiDiv. of Hematology-Oncology, University of California, Los Angeles, CA, USA

https://orcid.org/0000-0002-2374-3320

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Scott D. NelsonDept. of Pathology, University of California, Los Angeles, CA, USA

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Tara A. RussellDiv. of Surgical Oncology, University of California, Los Angeles, CA, USA

https://orcid.org/0000-0002-3912-3601

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Sarah M. DryDept. of Pathology, University of California, Los Angeles, CA, USA

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Yunfeng LiDept. of Pathology, University of California, Los Angeles, CA, USA

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Arun S. SinghDiv. of Hematology-Oncology, University of California, Los Angeles, CA, USA

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Mark A. EckardtDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA

https://orcid.org/0000-0002-9528-8419

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Michiaki UnnoDept. of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan

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Fritz C. EilberDiv. of Surgical Oncology, University of California, Los Angeles, CA, USACorrespondence[email protected]

https://orcid.org/0000-0003-3336-9333

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Robert M. HoffmanAntiCancer, Inc., San Diego, CA, USA;Dept. of Surgery, University of California, San Diego, CA, USA;Department of Surgery, Yale School of Medicine, New Haven, CT, USACorrespondence[email protected]