CYP27A1 inhibits bladder cancer cells proliferation by regulating cholesterol homeostasis

References

• Nicholas Munro F, Peter Whelan F. Bladder cancer. Surgery. 2000;24:1349–1358.
   Google Scholar
• Hemelt M, Yamamoto H, Cheng KK, et al. The effect of smoking on the male excess of bladder cancer: a meta-analysis and geographical analyses. Int J Cancer. 2009;124:412–419. PMID:18792102
   PubMed Web of Science ®Google Scholar
• Chung LW, Zhau HE, Ro JY. Morphologic and biochemical alterations in rat prostatic tumors induced by fetal urogenital sinus mesenchyme. Prostate. 1990;17:165–174. PMID:2399192
   PubMed Web of Science ®Google Scholar
• Miyamoto H, Yang Z, Chen YT, et al. Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. 2007;99:558–568. PMID:17406000
   PubMed Web of Science ®Google Scholar
• Lombard AP, Mudryj M. The emerging role of the androgen receptor in bladder cancer. Endocr Relat Cancer. 2015;22:R265–R77. PMID:26229034
   PubMed Web of Science ®Google Scholar
• Hamm R, Chen YR, Seo EJ, et al. Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells. Biochem Pharmacol. 2014;91:18–30. PMID:24976507
   PubMed Web of Science ®Google Scholar
• Hu J, La Vecchia C, de Groh M, et al. Dietary cholesterol intake and cancer. Ann Oncol. 2012;23:491–500. PMID:21543628
   PubMed Web of Science ®Google Scholar
• Shah RR, Bono P, Oudard S, et al. Outcomes in patients with metastatic renal cell carcinoma who develop everolimus-related hyperglycemia and hypercholesterolemia: combined subgroup analyses of the RECORD-1 and REACT trials. Clin Genitourin Cancer. 2016;15:e53–e54. 2017. PMID:27524511
   PubMedGoogle Scholar
• Magura L, Blanchard R, Hope B, et al. Hypercholesterolemia and prostate cancer: a hospital-based case-control study. Cancer Causes Control. 2008;19:1259–1266. PMID:18704722
   PubMed Web of Science ®Google Scholar
• Nelson ER, Wardell SE, Jasper JS, et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science. 2013;342:1094–1098. PMID:24288332
   PubMed Web of Science ®Google Scholar
• Goodwin B, Gauthier KC, Umetani M, et al. Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A. 2003;100:223–228. PMID:12509506
   PubMed Web of Science ®Google Scholar
• Gottfried E, Rehli M, Hahn J, et al. Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite. Biochem Biophys Res Commun. 2006;349:209–213. PMID:16930540
   PubMed Web of Science ®Google Scholar
• Sawada N, Sakaki T, Ohta M, et al. Metabolism of vitamin D(3) by human CYP27A1. Biochem Biophys Res Commun. 2000;273:977–984. PMID:10891358
   PubMed Web of Science ®Google Scholar
• Alfaqih MA, Nelson ER, Liu W, et al. CYP27A1 loss dysregulates cholesterol homeostasis in prostate’ cancer. Cancer Res. 2017;77:1662–1673. PMID:28130224
   PubMed Web of Science ®Google Scholar
• Kimbung S, Chang CY, Bendahl PO, et al. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. Endocr Relat Cancer. 2017;24:339–349. PMID:28442559
   PubMed Web of Science ®Google Scholar
• Ji YC, Liu C, Zhang X, et al. Intestinal bacterium-derived cyp27a1 prevents colon cancer cell apoptosis. Am J Transl Res. 2016;8:4434–4439. PMID:27830027
   PubMed Web of Science ®Google Scholar
• Marwarha G, Raza S, Hammer K, et al. 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. Chem Phys Lipids. 2017;207:108–126. PMID:28583434
   PubMed Web of Science ®Google Scholar
• Cruz P, Torres C, Ramirez ME, et al. Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol. Exp Ther Med. 2010;1:531–536. PMID:22993572
   PubMed Web of Science ®Google Scholar
• Raza S, Meyer M, Schommer J, et al. 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. Med Oncol. 2016;33:12. PMID:26732475
   PubMed Web of Science ®Google Scholar
• Endo-Umeda K, Uno S, Fujimori K, et al. Differential expression and function of alternative splicing variants of human liver X receptor alpha. Mol Pharmacol. 2012;81:800–810. PMID:22399489
   PubMed Web of Science ®Google Scholar
• Jitao W, Jinchen H, Qingzuo L, et al. Androgen receptor inducing bladder cancer progression by promoting an epithelial-mesenchymal transition. Andrologia. 2014;46:1128–1133. PMID:24329492
   PubMed Web of Science ®Google Scholar
• Zheng Y, Izumi K, Yao JL, et al. Dihydrotestosterone upregulates the expression of epidermal growth factor receptor and ERBB2 in androgen receptor-positive bladder cancer cells. Endocr Relat Cancer. 2011;18:451–464. PMID:21613411
   PubMed Web of Science ®Google Scholar
• Huber MD, Vesely PW, Datta K, et al. Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J Cell Biol. 2013;203:427–436. PMID:24217618
   PubMed Web of Science ®Google Scholar
• Ouvrier A, Cadet R, Vernet P, et al. LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner. J Lipid Res. 2009;50:1766–1775. PMID:19395734
   PubMed Web of Science ®Google Scholar
• Tamehiro N, Shigemoto-Mogami Y, Kakeya T, et al. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. J Biol Chem. 2007;282:21090–21099. PMID:17526932
   PubMed Web of Science ®Google Scholar
• Tarling EJ, Edwards PA. Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochim Biophys Acta. 2012;1821:386–395. PMID:21824529
   PubMed Web of Science ®Google Scholar
• Mir C, Shariat SF, van der Kwast TH, et al. Loss of androgen receptor expression is not associated with pathological stage, grade, gender or outcome in bladder cancer: a large multi-institutional study. BJU Int. 2011;108:24–30. PMID:21070579
   PubMed Web of Science ®Google Scholar
• Wu JT, Han BM, Yu SQ, et al. Androgen receptor is a potential therapeutic target for bladder cancer. Urology. 2010;75:820–827. PMID:WOS:000276258300011
   PubMed Web of Science ®Google Scholar
• Di Vizio D, Solomon KR, Freeman MR. Cholesterol and cholesterol-rich membranes in prostate cancer: an update. Tumori. 2008;94:633–639. PMID:WOS:000261045000001
   PubMed Web of Science ®Google Scholar
• Baruthio F, Quadroni M, Ruegg C, et al. Proteomic analysis of membrane rafts of melanoma cells identifies protein patterns characteristic of the tumor progression stage. Proteomics. 2008;(8):4733–4747. DOI:10.1002/pmic.200800169 PMID:18942674
   PubMedGoogle Scholar
• Llaverias G, Danilo C, Mercier I, et al. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011;178:402–412. PMID:21224077
   PubMed Web of Science ®Google Scholar
• Adlakha YK, Khanna S, Singh R, et al. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRalpha expression and cholesterol homeostasis. Cell Death Dis. 2013;4:e780. PMID:23990020
   PubMed Web of Science ®Google Scholar
• Fukuchi J, Kokontis JM, Hiipakka RA, et al. Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells. Cancer Res. 2004;64:7686–7689. PMID:15520170
   PubMed Web of Science ®Google Scholar
• Vedin LL, Lewandowski SA, Parini P, et al. The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis. 2009;30:575–579. PMID:19168586
   PubMed Web of Science ®Google Scholar