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Ser289 phosphorylation activates both DAPK1 and DAPK2 but in response to different intracellular signaling pathways

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Pages 1169-1176 | Received 09 Jan 2019, Accepted 25 Mar 2019, Published online: 22 May 2019

References

  • Deiss LP, Feinstein E, Berissi H, et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995 Jan 1;9(1):15–30. PubMed PMID: 7828849; eng.
  • Inbal B, Shani G, Cohen O, et al. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol. 2000 Feb;20(3):1044–1054. PubMed PMID: 10629061; eng.
  • Kawai T, Nomura F, Hoshino K, et al. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene. 1999 Jun 10;18(23):3471–3480. PubMed PMID: 10376525; eng.
  • Shiloh R, Bialik S, Kimchi A. The DAPK family: a structure-function analysis. Apoptosis. 2014 Feb;19(2):286–297. PubMed PMID: 24220854; eng.
  • Bialik S, Kimchi A. The DAP-kinase interactome. Apoptosis. 2014 Feb;19(2):316–328. PubMed PMID: 24220855.
  • Gozuacik D, Kimchi A. DAPk protein family and cancer. Autophagy. 2006 Apr-Jun;2(2):74–79. PubMed PMID: 17139808; eng.
  • Esteller M, Corn PG, Baylin SB, et al. A gene hypermethylation profile of human cancer. Cancer Res. 2001 Apr 15;61(8):3225–3229. PubMed PMID: 11309270.
  • Collins Y, Dicioccio R, Keitz B, et al. Methylation of death-associated protein kinase in ovarian carcinomas. Int J Gynecol Cancer. 2006 Jan-Feb;16(Suppl 1):195–199. PubMed PMID: 16515590.
  • Mittag F, Kuester D, Vieth M, et al. DAPK promotor methylation is an early event in colorectal carcinogenesis. Cancer Lett. 2006 Aug 18;240(1):69–75. PubMed PMID: 16246486.
  • Qian J, Wang YL, Lin J, et al. Aberrant methylation of the death-associated protein kinase 1 (DAPK1) CpG island in chronic myeloid leukemia. Eur J Haematol. 2009 Feb;82(2):119–123. PubMed PMID: 19018866.
  • Kilinc D, Ozdemir O, Ozdemir S, et al. Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas. DNA Cell Biol. 2012 May;31(5):826–832. PubMed PMID: 22136354.
  • Kristensen LS, Asmar F, Dimopoulos K, et al. Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma. Oncotarget. 2014 Oct 30;5(20):9798–9810. PubMed PMID: 25229255; PubMed Central PMCID: PMCPMC4259438.
  • Zhang J, Yu XL, Zheng GF, et al. DAPK promoter methylation status correlates with tumor metastasis and poor prognosis in patients with non-small cell lung cancer. Cancer Biomark. 2015;15(5):609–617. PubMed PMID: 26406950.
  • Dai L, Ma C, Zhang Z, et al. DAPK promoter methylation and bladder cancer risk: a systematic review and meta-analysis. PLoS One. 2016;11(12):e0167228. PubMed PMID: 27907054; PubMed Central PMCID: PMCPMC5132202.
  • Yuan W, Chen J, Shu Y, et al. Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis. PLoS One. 2017;12(9):e0184959. PubMed PMID: 28934284; PubMed Central PMCID: PMCPMC5608298.
  • Cai F, Xiao X, Niu X, et al. Association between promoter methylation of DAPK gene and HNSCC: A meta-analysis. PLoS One. 2017;12(3):e0173194. PubMed PMID: 28249042; PubMed Central PMCID: PMCPMC5332095.
  • Geering B. Death-associated protein kinase 2: regulator of apoptosis, autophagy and inflammation. Int J Biochem Cell Biol. 2015 Aug;65:151–154. PubMed PMID: 26055515; eng.
  • Tur MK, Neef I, Jost E, et al. Targeted restoration of down-regulated DAPK2 tumor suppressor activity induces apoptosis in Hodgkin lymphoma cells. J Immunother. 2009 Jun;32(5):431–441. PubMed PMID: 19609235; eng.
  • Raveh T, Droguett G, Horwitz MS, et al. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol. 2001 Jan;3(1):1–7. PubMed PMID: 11146619; eng.
  • Jang CW, Chen CH, Chen CC, et al. TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol. 2002 Jan;4(1):51–58. PubMed PMID: 11740493.
  • Wang WJ, Kuo JC, Yao CC, et al. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol. 2002 Oct 14;159(1):169–179. PubMed PMID: 12370243; eng.
  • Llambi F, Lourenco FC, Gozuacik D, et al. The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. Embo J. 2005 Mar 23;24(6):1192–1201. PubMed PMID: 15729359; eng.
  • Guenebeaud C, Goldschneider D, Castets M, et al. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell. 2010 Dec 22;40(6):863–876. PubMed PMID: 21172653; eng.
  • Li H, Ray G, Yoo BH, et al. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. J Biol Chem. 2009 Jan 23;284(4):2012–2022. PubMed PMID: 18957423; eng.
  • Bialik S, Kimchi A. Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy. Curr Opin Cell Biol. 2010 Apr;22(2):199–205. PubMed PMID: 20005690.
  • Levin-Salomon V, Bialik S, Kimchi A. DAP-kinase and autophagy. Apoptosis. 2014 Feb;19(2):346–356. PubMed PMID: 24264886.
  • Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 2009 Apr;20(7):1992–2003. PubMed PMID: 19225151; PubMed Central PMCID: PMCPMC2663920.
  • Ganley IG, Lam Du H, Wang J, et al. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem. 2009 May 1;284(18):12297–12305. PubMed PMID: 19258318; PubMed Central PMCID: PMCPMC2673298.
  • Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011 Jan 28;331(6016):456–461. PubMed PMID: 21205641; PubMed Central PMCID: PMC3030664.
  • Kim J, Kundu M, Viollet B, et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 2011 Feb;13(2):132–141. PubMed PMID: 21258367; eng.
  • Itakura E, Kishi C, Inoue K, et al. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell. 2008 Dec;19(12):5360–5372. PubMed PMID: 18843052; eng.
  • Sun Q, Fan W, Chen K, et al. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211–19216. PubMed PMID: 19050071; eng.
  • He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol. 2010 Apr;22(2):140–149. PubMed PMID: 20097051; eng.
  • Feng Y, He D, Yao Z, et al. The machinery of macroautophagy. Cell Res. 2014 Jan;24(1):24–41. PubMed PMID: 24366339; eng.
  • Ohsumi Y. Historical landmarks of autophagy research. Cell Res. 2014 Jan;24(1):9–23. PubMed PMID: 24366340; PubMed Central PMCID: PMC3879711.
  • Mizushima N. A brief history of autophagy from cell biology to physiology and disease. Nat Cell Biol. 2018 May;20(5):521–527. PubMed PMID: 29686264.
  • Bialik S, Dasari SK, Kimchi A. Autophagy-dependent cell death - where, how and why a cell eats itself to death. J Cell Sci. 2018 Sep 20;131(18). PubMed PMID: 30237248. DOI:10.1242/jcs.215152
  • Inbal B, Bialik S, Sabanay I, et al. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol. 2002 Apr 29;157(3):455–468. PubMed PMID: 11980920; eng.
  • Gozuacik D, Bialik S, Raveh T, et al. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ. 2008 Dec;15(12):1875–1886. PubMed PMID: 18806755; eng.
  • Eisenberg-Lerner A, Kimchi A. PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk. Cell Death Differ. 2012 May;19(5):788–797. PubMed PMID: 22095288; PubMed Central PMCID: PMCPMC3321617.
  • Ber Y, Shiloh R, Gilad Y, et al. DAPK2 is a novel regulator of mTORC1 activity and autophagy. Cell Death Differ. 2015 Mar;22(3):465–475. PubMed PMID: 25361081; eng.
  • Soussi H, Reggio S, Alili R, et al. DAPK2 downregulation associates with attenuated adipocyte autophagic clearance in human obesity. Diabetes. 2015 Oct;64(10):3452–3463. PubMed PMID: 26038578; eng.
  • Zalckvar E, Berissi H, Eisenstein M, et al. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy. 2009 Jul;5(5):720–722. PubMed PMID: 19395874; eng.
  • Zalckvar E, Berissi H, Mizrachy L, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep. 2009 Mar;10(3):285–292. PubMed PMID: 19180116; PubMed Central PMCID: PMCPMC2658558.
  • Chi HC, Chen SL, Tsai CY, et al. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016 Sep 21;1–15. PubMed PMID: 27653365. DOI:10.1080/15548627.2016.1230583
  • Shiloh R, Gilad Y, Ber Y, et al. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nat Commun. 2018 May 1;9(1):1759. PubMed PMID: 29717115; PubMed Central PMCID: PMCPMC5931534.
  • Carlessi R, Levin-Salomon V, Ciprut S, et al. GTP binding to the ROC domain of DAP-kinase regulates its function through intramolecular signalling. EMBO Rep. 2011 Sep;12(9):917–923. PubMed PMID: 21738225; eng.
  • Gilad Y, Shiloh R, Ber Y, et al. Discovering protein-protein interactions within the programmed cell death network using a protein-fragment complementation screen. Cell Rep. 2014 Aug 7;8(3):909–921. PubMed PMID: 25066129; eng.
  • Shohat G, Spivak-Kroizman T, Cohen O, et al. The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. J Biol Chem. 2001 Dec 14;276(50):47460–47467. PubMed PMID: 11579085; eng.
  • Shani G, Henis-Korenblit S, Jona G, et al. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. Embo J. 2001 Mar 1;20(5):1099–1113. PubMed PMID: 11230133; eng.
  • Chen CH, Wang WJ, Kuo JC, et al. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. Embo J. 2005 Jan 26;24(2):294–304. PubMed PMID: 15616583; eng.
  • Yuasa K, Ota R, Matsuda S, et al. Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. Biochem Biophys Res Commun. 2015 Aug 14;464(1):70–75. PubMed PMID: 26047703; eng.
  • Anjum R, Roux PP, Ballif BA, et al. The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Curr Biol. 2005 Oct 11;15(19):1762–1767. PubMed PMID: 16213824; eng.

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