Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

References

• Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. Jama. 2007;298:2038–2047.
   PubMed Web of Science ®Google Scholar
• Zhang L, Wang F, Wang L, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet. 2012;379:815–822.
   PubMed Web of Science ®Google Scholar
• Minutolo R, Borrelli S, De Nicola L. CKD in the elderly: kidney senescence or blood pressure-related nephropathy? Am J Kidney Dis. 2015;66:184–186.
   PubMed Web of Science ®Google Scholar
• Coresh J, Astor BC, Greene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: third national health and nutrition examination survey. Am J Kidney Dis. 2003;41:1–12.
   PubMed Web of Science ®Google Scholar
• Latcha S, Jaimes EA, Patil S, et al. Long-term renal outcomes after cisplatin treatment. Clin J Am Soc Nephrol. 2016;11:1173–1179.
   PubMed Web of Science ®Google Scholar
• Mccay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. Nutrition. 1989;5:63–79.
   Web of Science ®Google Scholar
• Orentreich N, Matias JR, DeFelice A, et al. Low methionine ingestion by rats extends life span. J Nutr. 1993;123:269–274.
   PubMed Web of Science ®Google Scholar
• Sun L, Sadighi Akha AA, Miller RA, et al. Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci. 2009;64:711–722.
   PubMed Web of Science ®Google Scholar
• Sanz A, Caro P, Ayala V, et al. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. Faseb J. 2006;20:1064–1073.
   PubMed Web of Science ®Google Scholar
• Liu H, Zhang W, Wang K, et al. Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy. Toxicol Lett. 2015;232:349–355.
   PubMed Web of Science ®Google Scholar
• Kozieł R, Ruckenstuhl C, Albertini E, et al. Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell. 2015;13:1038–1048.
   Web of Science ®Google Scholar
• Stone KP, Wanders D, Orgeron M, et al. Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes. 2014;63:3721–3733.
   PubMed Web of Science ®Google Scholar
• Hine C, Harputlugil E, Zhang Y, et al. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015;160:132–144.
   PubMed Web of Science ®Google Scholar
• Yang G, Wu L, Jiang B, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (New York, NY). 2008;322:587–590.
   Google Scholar
• Paul BD, Snyder SH. H(2)S signalling through protein sulfhydration and beyond. Nat Rev Mol Cell Biol. 2012;13:499–507.
   PubMed Web of Science ®Google Scholar
• Miller DL, Roth MB. Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:20618–20622.
   PubMed Web of Science ®Google Scholar
• Blackstone E, Morrison M, Roth MB. H2S induces a suspended animation-like state in mice. Science (New York, NY). 2005;308:518.
   Google Scholar
• Buemi M, Nostro L, Aloisi C, et al. Kidney aging: from phenotype to genetics. Rejuvenation Res. 2005;8:101–109.
   PubMed Web of Science ®Google Scholar
• Melk A, Schmidt BM, Takeuchi O, et al. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int. 2004;65:510–520.
   PubMed Web of Science ®Google Scholar
• Shimizu H, Bolati D, Adijiang A, et al. NF-kappaB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. Am J Physiol Cell Physiol. 2011;301:C1201–12.
   PubMed Web of Science ®Google Scholar
• Han WK, Bailly V, Abichandani R, et al. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002;62::237–244.
   PubMed Web of Science ®Google Scholar
• Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365:1231–1238.
   PubMed Web of Science ®Google Scholar
• Nickolas TL, O’Rourke MJ, Yang J, et al. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008;148:810–819.
   PubMed Web of Science ®Google Scholar
• Srisawat N, Murugan R, Lee M, et al. Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int. 2011;80:545–552.
   PubMed Web of Science ®Google Scholar
• Carlsson AC, Larsson A, Helmersson‐Karlqvist J, et al. Urinary kidney injury molecule 1 and incidence of heart failure in elderly men. Eur J Heart Fail. 2013;15::441–446.
   PubMed Web of Science ®Google Scholar
• Humphreys BD, Xu F, Sabbisetti V, et al. Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest. 2013;123:4023–4035.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Mariappan MM, Feliers D, et al. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem. 2012;287:4451–4461.
   PubMed Web of Science ®Google Scholar
• Niwa T, Ise M. Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J Lab Clin Med. 1994;124:96–104.
   PubMed Web of Science ®Google Scholar
• Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011;192:547–556.
   PubMed Web of Science ®Google Scholar
• Laberge RM, Sun Y, Orjalo AV, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049–1061.
   PubMed Web of Science ®Google Scholar
• Herranz N, Gallage S, Mellone M, et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol. 2015;17:1205–1217.
   PubMed Web of Science ®Google Scholar
• Xu XM, Cai GY, Bu R, et al. Beneficial effects of caloric restriction on chronic kidney disease in rodent models: a meta-analysis and systematic review. PloS One. 2015;10:e0144442.
   PubMedGoogle Scholar
• Ning YC, Cai GY, Zhuo L, et al. Beneficial effects of short-term calorie restriction against cisplatin-induced acute renal injury in aged rats. Nephron Exp Nephrol. 2013;124:19–27.
   PubMedGoogle Scholar
• Shimokawa I, Higami Y, Yu BP, et al. Influence of dietary components on occurrence of and mortality due to neoplasms in male F344 rats. Aging. 1996;8:254–262.
   PubMedGoogle Scholar
• Sanchez-Roman I, Barja G. Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction. Exp Gerontol. 2013;48:1030–1042.
   PubMed Web of Science ®Google Scholar
• Ying Y, Yun J, Guoyao W, et al. Dietary L-methionine restriction decreases oxidative stress in porcine liver mitochondria. Exp Gerontol. 2015;65:35–41.
   PubMed Web of Science ®Google Scholar
• Hasek BE, Boudreau A, Shin J, et al. Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats. Diabetes. 2013;62:3362–3372.
   PubMed Web of Science ®Google Scholar
• Lees EK, Krol E, Grant L, et al. Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21. Aging Cell. 2014;13:817–827.
   PubMed Web of Science ®Google Scholar
• Ruckenstuhl C, Netzberger C, Entfellner I, et al. Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. PLoS Genet. 2014;10:e1004347.
   PubMed Web of Science ®Google Scholar
• Dowling RJ, Zakikhani M, Fantus IG, et al. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res. 2007;67:10804–10812.
   PubMed Web of Science ®Google Scholar
• Morrison ML, Blackwood JE, Lockett SL, et al. Surviving blood loss using hydrogen sulfide. J Trauma. 2008;65:183–188.
   PubMedGoogle Scholar
• Xue R, Hao DD, Sun JP, et al. Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. Antioxid Redox Signal. 2013;19:5–23.
   PubMed Web of Science ®Google Scholar
• Lee ZW, Teo XY, Tay EY, et al. Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance. Br J Pharmacol. 2014;171:4322–4336.
   PubMed Web of Science ®Google Scholar
• Wen YD, Wang H, Kho SH, et al. Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress. PloS One. 2013;8:e53147.
   PubMed Web of Science ®Google Scholar
• Wang WJ, Cai GY, Ning YC, et al. Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats. Sci Rep. 2016;6:30292.
   PubMed Web of Science ®Google Scholar
• Niwa T, Ise M, Miyazaki T. Progression of glomerular sclerosis in experimental uremic rats by administration of indole, a precursor of indoxyl sulfate. Am J Nephrol. 1994;14:207–212.
   PubMed Web of Science ®Google Scholar
• Enomoto A, Takeda M, Tojo A, et al. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol. 2002;13:1711–1720.
   PubMed Web of Science ®Google Scholar
• Motojima M, Hosokawa A, Yamato H, et al. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells. Kidney Int. 2003;63:1671–1680.
   PubMed Web of Science ®Google Scholar
• Shimizu H, Bolati D, Adijiang A, et al. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. Am J Physiol Cell Physiol. 2010;299:C1110–7.
   PubMed Web of Science ®Google Scholar
• Shimizu H, Bolati D, Higashiyama Y, et al. Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-kappaB, p53, ERK, and JNK in proximal tubular cells. Life Sci. 2012;90:525–530.
   PubMed Web of Science ®Google Scholar
• Shimizu H, Bolati D, Adijiang A, et al. Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-kB. Am J Nephrol. 2011;33:319–324.
   PubMed Web of Science ®Google Scholar
• Ikushima M, Rakugi H, Ishikawa K, et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339:827–832.
   PubMed Web of Science ®Google Scholar
• Sun Z. Current understanding of klotho. Ageing Res Rev. 2009;8:43–51.
   PubMed Web of Science ®Google Scholar
• Yoon HE, Ghee JY, Piao S, et al. Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dialysis Trans. 2011;26:800–813.
   PubMed Web of Science ®Google Scholar
• Lu M, Liu YH, Goh HS, et al. Hydrogen sulfide inhibits plasma renin activity. J Am Soc Nephrol. 2010;21:993–1002.
   PubMed Web of Science ®Google Scholar
• Campisi J, d’Adda Di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007;8:729–740.
   PubMed Web of Science ®Google Scholar
• Kuilman T, Michaloglou C, Mooi WJ, et al. The essence of senescence. Genes Dev. 2010;24:2463–2479.
   PubMed Web of Science ®Google Scholar
• Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal. 2012;24:835–845.
   PubMed Web of Science ®Google Scholar
• Tomimatsu K, Narita M. Translating the effects of mTOR on secretory senescence. Nat Cell Biol. 2015;17:1230–1232.
   PubMed Web of Science ®Google Scholar
• Wang M, Tang W, Zhu YZ. An update on AMPK in hydrogen sulfide pharmacology. Front Pharmacol. 2017;8:810.
   PubMed Web of Science ®Google Scholar
• Sun L, Zhang S, Yu C, et al. Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway. Am J Physiol Endocrinol Metab. 2015;309:E925–35.
   PubMed Web of Science ®Google Scholar