References
- Mol BWJ, Roberts CT, Thangaratinam S, et al. Pre-eclampsia. Lancet. 2016;387:999–1011.
- Sircar M, Thadhani R, Karumanchi SA. Pathogenesis of preeclampsia. Curr Opin Nephrol Hypertens. 2015;24:131–138.
- Esteve-Valverde E, Ferrer-Oliveras R, Gil-Aliberas N, et al. Pravastatin for preventing and treating preeclampsia: a systematic review. Obstet Gynecol Surv. 2018;73:40–55.
- Hutter D, Kingdom J, Jaeggi E. Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: a review. Int J Pediatr. 2010;2010:401323.
- Tal R. The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis. Biol Reprod. 2012;87:134.
- Soares MJ, Iqbal K, Kozai K. Hypoxia and placental development. Birth Defects Res. 2017;109:1309–1329.
- Macklin PS, McAuliffe J, Pugh CW, et al. Hypoxia and HIF pathway in cancer and the placenta. Placenta. 2017;56:8–13.
- Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol. 2006;70:1469–1480.
- Rajakumar A. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta. 2004;25:763–769.
- Saleh L, Verdonk K, Visser W, et al. The emerging role of endothelin-1 in the pathogenesis of pre-eclampsia. Ther Adv Cardiovasc Dis. 2016;10:282–293.
- Saleh L, Danser JA, van den Meiracker AH. Role of endothelin in preeclampsia and hypertension following antiangiogenesis treatment. Curr Opin Nephrol Hypertens. 2016;25:94–99.
- LeComte MD, Shimada IS, Sherwin C, et al. Notch1-STAT3-ETBR signaling axis controls reactive astrocyte proliferation after brain injury. Proc Natl Acad Sci U S A. 2015;112:8726–8731.
- Fang Y, Yu S, Ma Y, et al. Association of Dll4/notch and HIF-1a -VEGF signaling in the angiogenesis of missed abortion. PLoS One. 2013;8:e70667.
- Mazzuca MQ, Dang Y, Khalil RA. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca(2)(+)]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013;169:1335–1351.
- Mazzuca MQ, Li W, Reslan OM, et al. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension. 2014;64:632–643.
- Li J, LaMarca B, Reckelhoff JF. A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model. Am J Physiol Heart Circ Physiol. 2012;303:H1–8.
- Armaly Z, Jadaon JE, Jabbour A, et al. Preeclampsia: novel mechanisms and potential therapeutic approaches. Front Physiol. 2018;9:973.
- Caniggia I, Mostachfi H, Winter J, et al. Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3). J Clin Invest. 2000;105:577–587.
- Korkes HA, De Oliveira L, Sass N, et al. Relationship between hypoxia and downstream pathogenic pathways in preeclampsia. Hypertens Pregnancy. 2017;36:145–150.
- Lee SB, Wong AP, Kanasaki K, et al. Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. Am J Pathol. 2010;176:710–720.
- Nevo O, Soleymanlou N, Wu Y, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1085–1093.
- Chen DB, Zheng J. Regulation of placental angiogenesis. Microcirculation. 2014;21:15–25.
- Wu F, Tian FJ, Lin Y, et al. Oxidative stress: placenta function and dysfunction. Am J Reprod Immunol. 2016;76:258–271.
- Wu F, Tian FJ, Lin Y. Oxidative stress in placenta: health and diseases. Biomed Res Int. 2015;2015:293271.
- Granger JP, Spradley FT, Bakrania BA. The endothelin system: a critical player in the pathophysiology of preeclampsia. Curr Hypertens Rep. 2018;20:32.
- Garovic VD, August P. Preeclampsia and the future risk of hypertension: the pregnant evidence. Curr Hypertens Rep. 2013;15:114–121.
- Parikh NI, Gonzalez J. Preeclampsia and hypertension: courting a long while: time to make it official. JAMA Intern Med. 2017;177:917–918.
- Aggarwal PK, Chandel N, Jain V, et al. The relationship between circulating endothelin-1, soluble fms-like tyrosine kinase-1 and soluble endoglin in preeclampsia. J Hum Hypertens. 2012;26:236–241.
- Houde M, Desbiens L, D’Orleans-Juste P. Endothelin-1: biosynthesis, signaling and vasoreactivity. Adv Pharmacol. 2016;77:143–175.
- Jain A, Olovsson M, Burton GJ, et al. Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP(3) pathway: implications for placental pathophysiology in preeclampsia. Am J Pathol. 2012;180:2309–2320.