MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice

References

• Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–378.
   PubMed Web of Science ®Google Scholar
• León-Carrión J, Del Rosario Domínguez-Morales M,Y, Martín JMB, et al. Epidemiology of traumatic brain injury and subarachnoid hemorrhage. Pituitary. 2005;8:197–202.
   PubMedGoogle Scholar
• Daneshvar DH, Nowinski CJ, McKee AC, et al. The epidemiology of sport-related concussion. Clin Sports Med. 2011;30: 1–17. vii.
   PubMed Web of Science ®Google Scholar
• Taylor CA, Bell JM, Breiding MJ, et al. Traumatic brain injury-related emergency department visits, hospitalizations, and deaths - United States, 2007 and 2013. Morbidity and mortality weekly report Surveillance summaries 2017; 66:1–16.
   Google Scholar
• Liang J, Wu S, Xie W, et al. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathway. Drug Des Devel Ther. 2018;12:845–853.
   PubMed Web of Science ®Google Scholar
• Jassam YN, Izzy S, Whalen M, et al. Neuroimmunology of traumatic brain injury: time for a paradigm shift. Neuron. 2017;95:1246–1265.
   PubMed Web of Science ®Google Scholar
• Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10:704–714.
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–233.
   PubMed Web of Science ®Google Scholar
• Lei P, Li Y, Chen X, et al. Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury. Brain Res. 2009;1284:191–201.
   PubMed Web of Science ®Google Scholar
• Redell JB, Liu Y, Dash PK. Traumatic brain injury alters expression of hippocampal microRNAs: potential regulators of multiple pathophysiological processes. J Neurosci Res. 2009;87:1435–1448.
   PubMed Web of Science ®Google Scholar
• Ge XT, Lei P, Wang HC, et al. miR-21 improves the neurological outcome after traumatic brain injury in rats. Sci Rep. 2014;4:6718.
   PubMed Web of Science ®Google Scholar
• Henry RJ, Doran SJ, Barrett JP, et al. Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice. Neurotherapeutics. 2019;16:216–230.
   PubMed Web of Science ®Google Scholar
• Sullivan PG, Thompson MB, Scheff SW. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury. Exp Neurol. 1999;160:226–234.
   PubMed Web of Science ®Google Scholar
• Hu JZ, Huang JH, Zeng L, et al. Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats. J Neurotrauma. 2013;30:1349–1360.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Cuello-Carrion FD, Ciocca DR. Improved detection of apoptotic cells using a modified in situ TUNEL technique. J Histochem Cytochem. 1999;47:837–839.
   PubMed Web of Science ®Google Scholar
• Yan EB, Hellewell SC, Bellander BM, et al. Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury. J Neuroinflammation. 2011;8:147.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhang Y, Mahmood A, et al. Neuroprotective and neurorestorative effects of thymosin beta4 treatment initiated 6 hours after traumatic brain injury in rats. J Neurosurg. 2012;116:1081–1092.
   PubMed Web of Science ®Google Scholar
• Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke. 2001;32:2682–2688.
   PubMed Web of Science ®Google Scholar
• Chen X, Lin YP, Wang D, et al. Dexamethasone exacerbates spatial acquisition deficits after traumatic brain injury in rats. Neurol Res. 2010;32:1097–1102.
   PubMed Web of Science ®Google Scholar
• Di Giovanni S, Movsesyan V, Ahmed F, et al. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U.S.A 2005; 102:8333–8338.
   PubMed Web of Science ®Google Scholar
• Yakovlev AG, Di X, Movsesyan V, et al. Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injury. Mol Med. 2001;7:205–216.
   PubMed Web of Science ®Google Scholar
• Han Z, Zhou X, Li S, et al. Inhibition of miR-23a increases the sensitivity of lung cancer stem cells to erlotinib through PTEN/PI3K/Akt pathway. Oncol Rep. 2017;38:3064–3070.
   PubMed Web of Science ®Google Scholar
• Sabirzhanov B, Zhao Z, Stoica BA, et al. Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins. J Neurosci. 2014;34:10055–10071.
   PubMed Web of Science ®Google Scholar
• Chen Q, Xu J, Li L, et al. MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis. 2014;5:e1132.
   PubMed Web of Science ®Google Scholar
• Lin H, Qian J, Castillo AC, et al. Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2011;52:6308–6314.
   PubMed Web of Science ®Google Scholar
• Kou Y, Zheng WT, Zhang YR. Inhibition of miR-23 protects myocardial function from ischemia-reperfusion injury through restoration of glutamine metabolism. Eur Rev Med Pharmacol Sci. 2016;20:4286–4293.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang B, Kan Z, et al. Progesterone increases circulating endothelial progenitor cells and induces neural regeneration after traumatic brain injury in aged rats. J Neurotrauma. 2012;29:343–353.
   PubMed Web of Science ®Google Scholar
• Wei HL, Ma SQ, Li CX. Deficiency of unc-51 like kinase 1 (Ulk1) protects against mice traumatic brain injury (TBI) by suppression of p38 and JNK pathway. Biochem Biophys Res Commun. 2018;503:467–473.
   PubMed Web of Science ®Google Scholar
• Eme R. Neurobehavioral outcomes of mild traumatic brain injury: a mini review. Brain Sci. 2017. 7.
   Web of Science ®Google Scholar
• Brogan RJ, Kontojannis V, Garara B, et al. Near-infrared spectroscopy (NIRS) to detect traumatic intracranial haematoma: A systematic review and meta-analysis. Brain Inj. 2017;31:581–588.
   PubMed Web of Science ®Google Scholar
• Zhao H, Tao Z, Wang R, et al. MicroRNA-23a-3p attenuates oxidative stress injury in a mouse model of focal cerebral ischemia-reperfusion. Brain Res. 2014;1592:65–72.
   PubMed Web of Science ®Google Scholar
• Ma Y, Liu W, Wang Y, et al. VEGF protects rat cortical neurons from mechanical trauma injury induced apoptosis via the MEK/ERK pathway. Brain Res Bull. 2011;86:441–446.
   PubMed Web of Science ®Google Scholar
• Chen A, Xiong LJ, Tong Y, et al. Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep. 2013;8:1011–1016.
   PubMed Web of Science ®Google Scholar
• Zhu X, Park J, Golinski J, et al. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. J Cereb Blood Flow and Metab. 2014;34:1531–1539.
   PubMed Web of Science ®Google Scholar
• Park J, Zhang J, Qiu J, et al. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow and Metab. 2012;32:330–340.
   PubMed Web of Science ®Google Scholar
• Blanco-Aparicio C, Renner O, Leal JF, et al. PTEN, more than the AKT pathway. Carcinogenesis. 2007;28:1379–1386.
   PubMed Web of Science ®Google Scholar
• Hill R, Wu H. PTEN, stem cells, and cancer stem cells. J Biol Chem. 2009;284:11755–11759.
   PubMed Web of Science ®Google Scholar
• Fiore R, Siegel G, Schratt G. MicroRNA function in neuronal development, plasticity and disease. Biochim Biophys Acta. 2008;1779:471–478.
   PubMed Web of Science ®Google Scholar
• Wang WX, Rajeev BW, Stromberg AJ, et al. The expression of microRNA miR-107 decreases early in Alzheimer’s disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 2008;28:1213–1223.
   PubMed Web of Science ®Google Scholar
• Wang WX, Visavadiya NP, Pandya JD, et al. Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury. Exp Neurol. 2015;265:84–93.
   PubMed Web of Science ®Google Scholar
• Pan YB, Sun ZL, Feng DF. The role of MicroRNA in traumatic brain injury. Neuroscience. 2017;367:189–199.
   PubMed Web of Science ®Google Scholar
• Redell JB, Zhao J, Dash PK. Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res. 2011;89:212–221.
   PubMed Web of Science ®Google Scholar
• Ji W, Jiao J, Cheng C, et al. MicroRNA-21 in the pathogenesis of traumatic brain injury. Neurochem Res. 2018;43:1863–1868.
   PubMed Web of Science ®Google Scholar
• Chen W, Zhao L, Zhang J, et al. Elevated expression of miR-302 cluster improves traumatic brain injury by inhibiting phosphorylation of connexin43 via ERK signaling. J Chem Neuroanat. 2019;99:1–8.
   PubMed Web of Science ®Google Scholar
• Sabirzhanov B, Stoica BA, Zhao Z, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654–668.
   PubMed Web of Science ®Google Scholar
• Sun L, Zhao M, Zhang J, et al. MiR-144 promotes beta-amyloid accumulation-induced cognitive impairments by targeting ADAM10 following traumatic brain injury. Oncotarget. 2017;8:59181–59203.
   PubMedGoogle Scholar
• Ziebell JM, Morganti-Kossmann MC. Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics. 2010;7:22–30.
   PubMed Web of Science ®Google Scholar
• Chen X, Zhang KL, Yang SY, et al. Glucocorticoids aggravate retrograde memory deficiency associated with traumatic brain injury in rats. J Neurotrauma. 2009;26:253–260.
   PubMed Web of Science ®Google Scholar
• Blennow K, Hardy J, Zetterberg H. The neuropathology and neurobiology of traumatic brain injury. Neuron. 2012;76:886–899.
   PubMed Web of Science ®Google Scholar
• Backman SA, Stambolic V, Suzuki A, et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet. 2001;29:396–403.
   PubMed Web of Science ®Google Scholar
• Park KK, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008;322:963–966.
   PubMed Web of Science ®Google Scholar
• Wang G, Shi Y, Jiang X, et al. HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3beta/PTEN/Akt axis. Proc Natl Acad Sci U.S.A 2015; 112:2853–2858.
   PubMed Web of Science ®Google Scholar
• Ding J, Guo J, Yuan Q, et al. Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. PloS One. 2013;8:e80429.
   PubMed Web of Science ®Google Scholar
• Liu R, Liao XY, Tang JC, et al. BpV(pic) confers neuroprotection by inhibiting M1 microglial polarization and MCP-1 expression in rat traumatic brain injury. Mol Immunol. 2019;112:30–39.
   PubMed Web of Science ®Google Scholar
• Tian K, Di R, Wang L. MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma. Cancer Gene Ther. 2015;22:351–359.
   PubMed Web of Science ®Google Scholar
• Park KK, Liu K, Hu Y, et al. PTEN/mTOR and axon regeneration. Exp Neurol. 2010;223:45–50.
   PubMed Web of Science ®Google Scholar
• Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 2009;10:307–318.
   PubMed Web of Science ®Google Scholar
• Xu K, Wu F, Xu K, et al. NaHS restores mitochondrial function and inhibits autophagy by activating the PI3K/Akt/mTOR signalling pathway to improve functional recovery after traumatic brain injury. Chem Biol Interact. 2018;286:96–105.
   PubMed Web of Science ®Google Scholar
• Ma J, Shui S, Han X, et al. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. Am J Transl Res. 2016;8:1895–1902.
   PubMed Web of Science ®Google Scholar
• Xu L, Xing Q, Huang T, et al. HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway. Front Cell Neurosci. 2018;12:498.
   PubMed Web of Science ®Google Scholar
• Zhang M, Wu Y, Xie L, et al. Isoliquiritigenin protects against bloodbrain barrier damage and inhibits the secretion of pro-inflammatory cytokines in mice after traumatic brain injury. Int Immunopharmacol. 2018;65:64–75.
   PubMed Web of Science ®Google Scholar
• Dong Z, Li S, Wang X, et al. lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. Am J Physiol Gastrointest Liver Physiol. 2019;316:G539–G50.
   PubMed Web of Science ®Google Scholar