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Research Paper

Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells

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Pages 84-96 | Received 08 May 2019, Accepted 07 Nov 2019, Published online: 25 Nov 2019

References

  • Nurse P. Universal control mechanism regulating onset of M-phase. Nature. 1990;344:503–508.
  • Kornberg RD, Lorch Y. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell. 1999;98:285–294.
  • King RW, Deshaies RJ, Peters JM, et al. How proteolysis drives the cell cycle. Science. 1996;274:1652–1659.
  • Den EN, Pines J. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase. J Cell Biol. 2001;153:121–135.
  • Morgan DO. Principles of CDK regulation. Nature. 1995;374:131–134.
  • Harper JW, Elledge SJ, Keyomarsi K, et al. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell. 1995;6:387–400.
  • Polyak K, Lee MH, Erdjument-Bromage H, et al. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994;78:59–66.
  • Pagano M, Pepperkok R, Verde F, et al. Cyclin A is required at two points in the human cell cycle. Embo J. 1992;11:961–971.
  • Resnitzky D, Hengst L, Reed SI. Cyclin A-associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G1 by p27Kip1. Mol Cell Biol. 2015;15:4347–4352.
  • Kabeche L, Compton DA. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature. 2013;502:110–113.
  • Chung JH, Bunz F. Cdk2 is required for p53-independent G2/M checkpoint control. PLoS Genet. 2010;6:e1000863.
  • Chibazakura T, McGrew SG, Cooper JA, et al. Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome stability by p21, p27, and p107. Proc Natl Acad Sci. 2004;101:4465–4470.
  • Turner DL, Weintraub H. Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 1994;8:1434–1447.
  • Marraccino RL, Firpo EJ, Roberts JM. Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle. Mol Biol Cell. 1992;3:389–401.
  • Clurman BE, Sheaff RJ, Thress K, et al. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev. 1996;10:1979–1990.
  • Ghiara JB, Richardson HE, Sugimoto K, et al. A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell. 1991;65:163–174.
  • Surana U, Amon A, Dowzer C, et al. Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. Embo J. 2018;12:1969–1978.
  • Geley S, Kramer E, Gieffers C, et al. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol. 2001;153:137–148.
  • Chibazakura T, Kamachi K, Ohara M, et al. Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7. Mol Cell Biol. 2011;31:248–255.
  • Kobayashi H, Stewart E, Poon R, et al. Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits. Mol Biol Cell. 1992;3:1279–1294.
  • Turnell AS. Regulation of the 26S proteasome by adenovirus E1A. Embo J. 2002;19:4759–4773.
  • Uto K, Inoue D, Shimuta K, et al. Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism. Embo J. 2004;23:3386–3396.
  • Bačević K, Lossaint G, Achour TN, et al. Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage. Sci Rep. 2017;7:13429.

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