1,097
Views
9
CrossRef citations to date
0
Altmetric
Research Paper

miR-106b-5p induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura through NR4A3/Foxp3 pathway

, , , , , , & show all
Pages 1265-1274 | Received 11 Jul 2019, Accepted 19 Mar 2020, Published online: 23 Apr 2020

References

  • Audia S, Mahévas M, Samson M, et al. Pathogenesis of immune thrombocytopenia. Autoimmun Rev. 2017;16:620–632.
  • Mariotte E, Azoulay E, Galicier L, et al. Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy. Lancet Haematol. 2016;3:e237–245.
  • Scully M, Cataland SR, Peyvandi F, et al. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019;380:335–346.
  • Jestin M, Benhamou Y, Schelpe A-S, et al. Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura. Blood. 2018;132:2143.
  • Song I, Kim J, Kwon K, et al. Expression of CD154 (CD40L) on stimulated T lymphocytes in patients with idopathic thrombocytopenic purpura. Hematology. 2016;21:187–192.
  • Pabbisetty SK, Rabacal W, Volanakis EJ, et al. Peripheral tolerance can be modified by altering KLF2-regulated Treg migration. Proc Natl Acad Sci U S A. 2016;113:E4662–E4670.
  • Li F, Ji L, Wang W, et al. Insufficient secretion of IL-10 by Tregs compromised its control on over-activated CD4+ T effector cells in newly diagnosed adult immune thrombocytopenia patients1. Immunol Res. 2015;61:269–280.
  • Xu Z-S, Zhang H-X, Li -W-W, et al. FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis. Proc Nat Acad Sci. 2019;116:10447.
  • Qiao J, Li X, Wu Y, et al. An increased expression profile of Th9/IL-9 correlated with Th17/IL-17 in patients with immune thrombocytopenia. Platelets. 2017;28:287–294.
  • Yu S, Liu C, Li L, et al. Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia. Lab Invest. 2014;95:157.
  • Hu Y, Wang X, Yu S, et al. Neutralizations of IL-17A and IL-21 regulate regulatory T cell/T-helper 17 imbalance via T-helper 17-associated signaling pathway in immune thrombocytopenia. Expert Opin Ther Targets. 2015;19:723–732.
  • Michlewski G, Cáceres JF. Post-transcriptional control of miRNA biogenesis. RNA. 2019;25:1–16.
  • Jernås M, Nookaew I, Wadenvik H, et al. MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP). Blood. 2013;121:2095–2098.
  • Qian BH, Ye X, Zhang L, et al. Increased miR-155 expression in peripheral blood mononuclear cells of primary immune thrombocytopenia patients was correlated with serum cytokine profiles. Acta Haematol. 2015;133:257–263.
  • Nishida N, Nagahara M, Sato T, et al. Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters. Clin Cancer Res. 2012;18:3054.
  • Dong P, Kaneuchi M, Watari H, et al. MicroRNA-106b modulates epithelial–mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines. Mol Carcinog. 2014;53:349–359.
  • Qian C, Yan W, Li T, et al. Differential expression of miR-106b-5p and miR-200c-3p in newly diagnosed versus chronic primary immune thrombocytopenia patients based on systematic analysis. Cell Physiol Biochem. 2018;45:301–318.
  • Sekiya T, Kashiwagi I, Yoshida R, et al. Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. Nat Immunol. 2013;14:230.
  • Xie M, Wang J, Gong W, et al. NF-κB-driven miR-34a impairs Treg/Th17 balance via targeting Foxp3. J Autoimmun. 2019;102:96–113.
  • Fan M, Li Y, Yao C, et al. Dihydroartemisinin derivative DC32 attenuates collagen-induced arthritis in mice by restoring the Treg/Th17 balance and inhibiting synovitis through down-regulation of IL-6. Int Immunopharmacol. 2018;65:233–243.
  • Ryba-Stanisławowska M, Sakowska J, Zieliński M, et al. Regulatory T cells: the future of autoimmune disease treatment. Expert Rev Clin Immunol. 2019;15:777–789.
  • Rai G, Das S, Ansari MA, et al. Phenotypic and functional profile of Th17 and Treg cells in allergic fungal sinusitis. Int Immunopharmacol. 2018;57:55–61.
  • Bao W, Bussel JB, Heck S, et al. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood. 2010;116:4639–4645.
  • Poissonnier A, Guégan J-P, Nguyen HT, et al. Disrupting the CD95–PLCγ1 interaction prevents Th17-driven inflammation. Nat Chem Biol. 2018;14:1079–1089.
  • Korn T, Bettelli E, Oukka M, et al. IL-17 and Th17 Cells. Annu Rev Immunol. 2009;27:485–517.
  • Lee A, Lim HX, Kim MS, et al. Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability. Int J Mol Med. 2018;41:531–540.
  • Hirano T, Nagasaki-Maeoka E, Ishizuka Y, et al. Forced expression of NR4A3 induced the differentiation of human neuroblastoma-derived NB1 cells. Med Oncol. 2019;36:66.
  • Close AF, Dadheech N, Villela BS, et al. The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of β-cell mass. J Biol Chem. 2019;294:4889–4897.
  • Policardo L, Seghieri G, Anichini R, et al. Effect of diabetes on hospitalization for ischemic stroke and related in-hospital mortality: a study in Tuscany, Italy, over years 2004–2011. Diabetes Metab Res Rev. 2015;31:280–286.
  • Wang Y, Huang R, Song C, et al. Some viral microRNAs were up-regulated in megakaryocytes incubated with immune thrombocytopenia plasma. Eur J Haematol. 2013;90:220–227.
  • Li JQ, Hu SY, Wang ZY, et al. Long non-coding RNA MEG3 inhibits microRNA-125a-5p expression and induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura. Biomed Pharmacother. 2016;83:905–911.
  • Gu H, Gu S, Zhang X, et al. miR-106b-5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3. Cancer Med. 2019;8:6756–6767.
  • Wei K, Pan C, Yao G, et al. MiR-106b-5p promotes proliferation and inhibits apoptosis by regulating BTG3 in non-small cell lung cancer. Cell Physiol Biochem. 2017;44:1545–1558.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.