HRD1 prevents atherosclerosis-mediated endothelial cell apoptosis by promoting LOX-1 degradation

References

• Mäkinen PI, Ylä-Herttuala S. Therapeutic gene targeting approaches for the treatment of dyslipidemias and atherosclerosis. Curr Opin Lipidol. 2013;24:116–122.
   PubMed Web of Science ®Google Scholar
• Hopkins PN. Molecular biology of atherosclerosis. Physiol Rev. 2013;93:1317–1542.
   PubMed Web of Science ®Google Scholar
• Meyers MR, Gokce N. Endothelial dysfunction in obesity: etiological role in atherosclerosis. Curr Opin Endocrinol Diabetes Obes. 2007;14:365–369.
   PubMedGoogle Scholar
• Cahill PA, Redmond EM. Vascular endothelium - Gatekeeper of vessel health. Atherosclerosis. 2016;248:97–109.
   PubMed Web of Science ®Google Scholar
• Valente AJ, Irimpen AM, Siebenlist U, et al. OxLDL induces endothelial dysfunction and death via TRAF3IP2: inhibition by HDL3 and AMPK activators. Free Radic Biol Med. 2014;70:117–128.
   PubMed Web of Science ®Google Scholar
• Donato L, Bramanti P, Scimone C, et al. miRNA expression profile of retinal pigment epithelial cells under oxidative stress conditions. FEBS Open Bio. 2018;8:219–233.
   PubMed Web of Science ®Google Scholar
• Al-Banna N, Lehmann C. Oxidized LDL and LOX-1 in experimental sepsis. Mediators Inflamm. 2013;2013:761789.
   PubMed Web of Science ®Google Scholar
• Mitra S, Goyal T, Mehta JL. Oxidized LDL, LOX-1 and atherosclerosis. Cardiovasc Drugs Ther. 2011;25:419–429.
   PubMed Web of Science ®Google Scholar
• Hermonat PL, Zhu H, Cao M, et al. LOX-1 transcription. Cardiovasc Drugs Ther. 2011;25:393–400.
   PubMed Web of Science ®Google Scholar
• Rinaldi C, Bramanti P, Famà A, et al. GLYOXALASE I A111E, PARAOXONASE 1 Q192R AND L55M POLYMORPHISMS IN ITALIAN PATIENTS WITH SPORADIC CEREBRAL CAVERNOUS MALFORMATIONS: A PILOT STUDY. Scimone C, Donato L, Antognelli C, Alafaci C, Tomasello F, D’Angelo R, Sidoti A. J Biol Regul Homeost Agents. 2015;29:493–500.
   PubMed Web of Science ®Google Scholar
• Donato L, Scimone C, Nicocia G, et al. GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population. Mol Biol Rep. 2018;45:1349–1355.
   PubMed Web of Science ®Google Scholar
• Akhmedov A, Rozenberg I, Paneni F, et al. Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo. Eur Heart J. 2014;35:2839–2848.
   PubMed Web of Science ®Google Scholar
• Hu C, Dandapat A, Sun L, et al. LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet. Cardiovasc Res. 2008;79:287–293.
   PubMed Web of Science ®Google Scholar
• Mehta JL, Sanada N, Hu CP, et al. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesteroldiet. Circ Res. 2007;100:1634–1642.
   PubMed Web of Science ®Google Scholar
• Chistiakov DA, Orekhov AN, Bobryshev YV. LOX-1-mediated effects on vascular cells in atherosclerosis. Cell Physiol Biochem. 2016;38:1851–1859.
   PubMed Web of Science ®Google Scholar
• Novodvorsky P, Chico TJ. The role of the transcription factor KLF2 in vascular development and disease. Prog Mol Biol Transl Sci. 2014;124:155–188.
   PubMed Web of Science ®Google Scholar
• Atkins GB, Jain MK. Role of Krüppel-like transcription factors in endothelial biology. Circ Res. 2007;100:1686–1695.
   PubMed Web of Science ®Google Scholar
• Yang L, Zhou X, Guo R, et al. Role of Krüppel-like factor 2 and protease-activated receptor-1 in vulnerable plaques ofApoE(-/-) mice and intervention with statin. Can J Cardiol. 2013;29:997–1005.
   PubMed Web of Science ®Google Scholar
• Lin Z, Kumar A, SenBanerjee S, et al. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. Circ Res. 2005;96:e48–57.
   PubMed Web of Science ®Google Scholar
• Parmar KM, Nambudiri V, Dai G, et al. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. J Biol Chem. 2005;280:26714–26719.
   PubMed Web of Science ®Google Scholar
• Yagishita N, Yamasaki S, Nishioka K, et al. Synoviolin, protein folding and the maintenance of joint homeostasis. Nat Clin Pract Rheumatol. 2008;4:91–97.
   PubMedGoogle Scholar
• Yamasaki S, Yagishita N, Sasaki T, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’. Embo J. 2007;26:113–122.
   PubMed Web of Science ®Google Scholar
• Wu T, Zhao F, Gao B, et al. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 2014;28:708–722.
   PubMed Web of Science ®Google Scholar
• Xu YM, Wang HJ, Chen F, et al. HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation. Oncotarget. 2015;6:42854–42867.
   PubMedGoogle Scholar
• Doroudgar S, Völkers M, Thuerauf DJ, et al. Hrd1 and ER-associated protein degradation, ERAD, are critical elements of the adaptive ER stress response in cardiac myocytes. Circ Res. 2015;117:536–546.
   PubMed Web of Science ®Google Scholar
• Tang Y, Zhang YC, Chen Y, et al. The role of miR-19b in the inhibition of endothelial cell apoptosis and its relationship with coronary artery disease. Sci Rep. 2015;5:15132.
   PubMed Web of Science ®Google Scholar
• Jia L, Xing J, Ding Y, et al. Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway. PLoS One. 2013;8:e78284.
   PubMed Web of Science ®Google Scholar
• Maier JA. Endothelial cells and magnesium: implications in atherosclerosis. Clin Sci (Lond). 2012;122:397–407.
   PubMed Web of Science ®Google Scholar
• Lubrano V, Balzan S. Roles of LOX-1 in microvascular dysfunction. Microvasc Res. 2016;105:132–140.
   PubMed Web of Science ®Google Scholar
• Doddaballapur A, Michalik KM, Manavski Y, et al. Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. Arterioscler Thromb Vasc Biol. 2015;35:137–145.
   PubMed Web of Science ®Google Scholar
• Ali F, Hamdulay SS, Kinderlerer AR, et al. Statin-mediated cytoprotection of human vascular endothelial cells: a role for Kruppel-like factor 2-dependent induction of heme oxygenase-1. J Thromb Haemost. 2007;5:2537–2546.
   PubMed Web of Science ®Google Scholar
• Panigrahi S, Freeman ML, Funderburg NT, et al. SIV/SHIV infection triggers vascular inflammation, diminished expression of krüppel-like factor 2 and endothelial dysfunction. J Infect Dis. 2016;213:1419–1427.
   PubMed Web of Science ®Google Scholar
• Li M, Wang X, Fu W, et al. CD4+CD25+Foxp3+ regulatory T cells protect endothelial function impaired by oxidized low density lipoprotein via the KLF-2 transcription factor. Cell Physiol Biochem. 2011;28:639–648.
   PubMedGoogle Scholar