Advanced search
Publication Cover
Cell Cycle Volume 19, 2020 - Issue 17
Submit an article Journal homepage
625
Views
2
CrossRef citations to date
0
Altmetric
Research paper

Albumin promotes the progression of fibroblasts through late G1 into S-phase in the absence of growth factors

Sharmeen Uddina Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, USA;b Biology Program, Graduate Center of the City University of New York, New York, NY, USAView further author information
,
Nataliya Melnyka Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, USAView further author information
&
David A. Fostera Department of Biological Sciences, Hunter College of the City University of New York, New York, NY, USA;b Biology Program, Graduate Center of the City University of New York, New York, NY, USA;c Biochemistry Program, Graduate Center of the City University of New York, New York, NY, USA;d Department of Pharmacology, Weill Cornell Medicine, New York, NY, USACorrespondence[email protected]
View further author information
Pages 2158-2167 | Received 08 May 2020, Accepted 07 Jul 2020, Published online: 26 Jul 2020

References

  • Foster DA, Yellen P, Xu L, et al. Regulation of G1 cell cycle progression: distinguishing the restriction point from a nutrient-sensing cell growth checkpoint(s). Genes Cancer. 2010;1:1124–1131.
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674.
  • Pardee AB. A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A. 1974;71:1286–1290.
  • Zetterberg A, Larsson O, Wiman KG. What is the restriction point? Curr Opin Cell Biol. 1995;7:835–842.
  • Patel D, Salloum D, Saqcena M. A late G1 lipid checkpoint that is dysregulated in clear cell renal carcinoma cells. J Biol Chem. 2017;292:936–944.
  • Saqcena M, Menon D, Patel D, et al. Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. PLoS One. 2013;8:e74157.
  • Fingar DC, Richardson CJ, Tee AR, et al. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004;24:200–216.
  • Planas-Silva MD, Weinberg RA. The restriction point and control of cell proliferation. Curr Opin Cell Biol. 1997;9:768–772.
  • Chatterjee A, Mukhopadhyay S, Tung K, et al. Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways. Cancer Lett. 2015;360:134–140.
  • Zetterberg A, Larsson O. Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells. Proc Natl Acad Sci U S A. 1985;82:5365–5369.
  • Pledger WJ, Stiles CD, Antoniades HN, et al. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A. 1977;74:4481–4485.
  • Stiles CD, Capone GT, Scher CD, et al. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979;76:1279–1283.
  • Ibrahim B, Stange J, Dominik A, et al. Albumin promotes proliferation of G1 arrested serum starved hepatocellular carcinoma cells. PeerJ. 2020;8:e8568.
  • Commisso C, Davidson SM, Soydaner-Azeloglu RD, et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 2013;497:633–637.
  • Salloum D, Mukhopadhyay S, Tung K, et al. Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther. 2014;13:733–741.
  • Dibble CC, Manning BD. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat Cell Biol. 2013;15:555–564.
  • Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene. 2004;23:3151–3171.
  • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011;12:21–35.
  • Yoon MS. The role of mammalian target of rapamycin (mTOR) in insulin signaling. Nutrients. 2017;9:1176.
  • Avruch J, Long X, Ortiz-Vega S, et al. Amino acid regulation of TOR complex 1. Am J Phys Endocrin Metab. 2009;296:E592–602.
  • Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends Mol Med. 2012;18:524–533.
  • Wolfson RL, Sabatini DM. The dawn of the age of amino acid sensors for the mTORC1 pathway. Cell Metab. 2017;26:301–309.
  • Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature. 2015;517:302–310.
  • Frias MA, Mukhopadhyay S, Lehman E, et al. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. J Biol Chem. 2020;295:263–274.
  • Menon D, Salloum D, Bernfeld E, et al. Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. J Biol Chem. 2017;292:6303–6311.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.