1,123
Views
7
CrossRef citations to date
0
Altmetric
Extra View

Maf1 limits RNA polymerase III-directed transcription to preserve genomic integrity and extend lifespan

, , , , & ORCID Icon
Pages 247-255 | Received 02 Dec 2020, Accepted 05 Jan 2021, Published online: 21 Jan 2021

References

  • Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature. 2013;493:338–345.
  • Eltschinger S, Loewith R. TOR complexes and the maintenance of cellular homeostasis. Trends Cell Biol. 2016;26:148–159.
  • Shetty M, Noguchi C, Wilson S, et al. Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan. Aging Cell. 2020;19:e13068.
  • Zhang S, Li X, Wang HY, et al. Beyond regulation of pol III: role of MAF1 in growth, metabolism, aging and cancer. Biochim Biophys Acta. 2018;1861:338-343.
  • Liu GY, Sabatini DM. mTOR at the nexus of nutrition, growth, ageing and disease. Nat Rev Mol Cell Biol. 2020;21:183–203.
  • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol. 2011;12:21–35.
  • Hannan KM, Brandenburger Y, Jenkins A, et al. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol. 2003;23:8862–8877.
  • Michels AA, Robitaille AM, Buczynski-Ruchonnet D, et al. mTORC1 directly phosphorylates and regulates human MAF1. Mol Cell Biol. 2010;30:3749–3757.
  • Khanna A, Pradhan A, Curran SP. Emerging Roles for Maf1 beyond the regulation of RNA polymerase III activity. J Mol Biol. 2015;427:2577–2585.
  • Filer D, Thompson MA, Takhaveev V, et al. RNA polymerase III limits longevity downstream of TORC1. Nature. 2017;552:263–267.
  • Bonhoure N, Byrnes A, Moir RD, et al. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev. 2015;29:934–947.
  • Oler AJ, Cairns BR. PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. Embo J. 2012;31:1440–1452.
  • Keogh MC, Kim JA, Downey M, et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006;439:497–501.
  • O’Neill BM, Szyjka SJ, Lis ET, et al. Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage. Proc Natl Acad Sci U S A. 2007;104:9290–9295.
  • Chowdhury D, Xu X, Zhong X, et al. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell. 2008;31:33–46.
  • Heideker J, Lis ET, Romesberg FE. Phosphatases, DNA damage checkpoints and checkpoint deactivation. Cell Cycle. 2007;6:3058–3064.
  • Duch A, de Nadal E, Posas F. Dealing with transcriptional outbursts during S phase to protect genomic integrity. J Mol Biol. 2013;425:4745–4755.
  • Rudolph CJ, Upton AL, Stockum A, et al. Avoiding chromosome pathology when replication forks collide. Nature. 2013;500:608–611.
  • Callegari AJ. Does transcription-associated DNA damage limit lifespan? DNA Repair (Amst). 2016;41:1–7.
  • Ogawa Y, Takahashi T, Masukata H. Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins. Mol Cell Biol. 1999;19:7228–7236.
  • Noguchi E, Noguchi C, Du LL, et al. Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1. Mol Cell Biol. 2003;23:7861–7874.
  • Noguchi E, Noguchi C, McDonald WH, et al. Swi1 and Swi3 are components of a replication fork protection complex in fission yeast. Mol Cell Biol. 2004;24:8342–8355.
  • Nyberg KA, Michelson RJ, Putnam CW, et al. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet. 2002;36:617–656.
  • Cai Y, Wei YH. Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9. Aging (Albany NY). 2015;7:133–143.
  • Cai Y, Wei YH. Stress resistance and lifespan are increased in C. elegans but decreased in S. cerevisiae by mafr-1/maf1 deletion. Oncotarget. 2016;7:10812-10826.
  • Khanna A, Johnson DL, Curran SP. Physiological roles for mafr-1 in reproduction and lipid homeostasis. Cell Rep. 2014;9:2180–2191.
  • Palian BM, Rohira AD, Johnson SA, et al. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014;10:e1004789.
  • Rideout EJ, Marshall L, Grewal SS. Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling. Proc Natl Acad Sci U S A. 2012;109:1139–1144.
  • Tanaka A, Tanizawa H, Sriswasdi S, et al. Epigenetic regulation of condensin-mediated genome organization during the cell cycle and upon DNA damage through histone H3 lysine 56 acetylation. Mol Cell. 2012;48:532–546.
  • Zaratiegui M, Vaughn MW, Irvine DV, et al. CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR. Nature. 2011;469:112–115.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.