LncRNA NBR2 aggravates hepatoblastoma cell malignancy and promotes cell proliferation under glucose starvation through the miR-22/TCF7 axis

References

• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
   PubMed Web of Science ®Google Scholar
• Koppenol WH, Bounds PL, Dang CV. Otto Warburg’s contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325–337.
   PubMed Web of Science ®Google Scholar
• Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 1989;49(23):6449–6465.
   PubMed Web of Science ®Google Scholar
• Yun J, Rago C, Cheong I, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science. 2009;325(5947):1555–1559.
   PubMed Web of Science ®Google Scholar
• Roberts HR, Smartt HJ, Greenhough A, et al. Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. Carcinogenesis. 2011;32(11):1741–1747.
   PubMed Web of Science ®Google Scholar
• Cairo S, Armengol C, De Reyniès A, et al. Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer. Cancer Cell. 2008;14(6):471–484.
   PubMed Web of Science ®Google Scholar
• Koch A, Denkhaus D, Albrecht S, et al. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. Cancer Res. 1999;59(2):269–273.
   PubMed Web of Science ®Google Scholar
• Lopez-Terrada D, Gunaratne PH, Adesina AM, et al. Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors. Hum Pathol. 2009;40(6):783–794.
   PubMed Web of Science ®Google Scholar
• Eichenmuller M, Trippel F, Kreuder M, et al. The genomic landscape of hepatoblastoma and their progenies with HCC-like features. J Hepatol. 2014;61(6):1312–1320.
   PubMed Web of Science ®Google Scholar
• Gebhardt R, Hovhannisyan A. Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond. Dev Dyn. 2010;239(1):45–55.
   PubMed Web of Science ®Google Scholar
• Yoshimura H, Matsuda Y, Yamamoto M, et al. Expression and role of long non-coding RNA H19 in carcinogenesis. Front Biosci (Landmark Ed). 2018;23:614–625.
   PubMed Web of Science ®Google Scholar
• Aird J, Baird A-M, Lim MCJ, et al. Carcinogenesis in prostate cancer: the role of long non-coding RNAs. Noncoding RNA Res. 2018;3(1):29–38.
   PubMedGoogle Scholar
• Gupta RA, Shah N, Wang KC, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464(7291):1071–1076.
   PubMed Web of Science ®Google Scholar
• Prensner JR, Iyer MK, Sahu A, et al. The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet. 2013;45(11):1392–1398.
   PubMed Web of Science ®Google Scholar
• Trimarchi T, Bilal E, Ntziachristos P, et al. Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell. 2014;158(3):593–606.
   PubMed Web of Science ®Google Scholar
• Xing Z, Lin A, Li C, et al. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014;159(5):1110–1125.
   PubMed Web of Science ®Google Scholar
• Yang L, Lin C, Jin C, et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature. 2013;500(7464):598–602.
   PubMed Web of Science ®Google Scholar
• Engreitz JM, Pandya-Jones A, McDonel P, et al. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. Science. 2013;341(6147):1237973.
   PubMed Web of Science ®Google Scholar
• Huarte M, Guttman M, Feldser D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010;142(3):409–419.
   PubMed Web of Science ®Google Scholar
• Simon MD, Pinter SF, Fang R, et al. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 2013;504(7480):465–469.
   PubMed Web of Science ®Google Scholar
• Abdollahzadeh R, Daraei A, Mansoori Y, et al. Competing endogenous RNA (ceRNA) cross talk and language in ceRNA regulatory networks: a new look at hallmarks of breast cancer. J Cell Physiol. 2019;234(7):10080–10100.
   PubMed Web of Science ®Google Scholar
• Chan JJ, Tay Y. Noncoding RNA:RNA regulatory networks in cancer. Int J Mol Sci. 2018;19(5):1310.
   Web of Science ®Google Scholar
• Qu J, Li M, Zhong W, et al. Competing endogenous RNA in cancer: a new pattern of gene expression regulation. Int J Clin Exp Med. 2015;8(10):17110–17116.
   PubMed Web of Science ®Google Scholar
• Wei S, Fan Q, Yang L, et al. Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTOR signaling. Oncol Rep. 2017;38(3):1902– 1908.
   PubMed Web of Science ®Google Scholar
• Chen X, Wang L, Wang H. LINC01638 lncRNA promotes cancer cell proliferation in hepatocellular carcinoma by increasing cancer cell glucose uptake. Oncol Lett. 2019;18(4):3811–3816.
   PubMed Web of Science ®Google Scholar
• Malakar P, Stein I, Saragovi A, et al. Long noncoding RNA MALAT1 regulates cancer glucose metabolism by enhancing mTOR-mediated translation of TCF7L2. Cancer Res. 2019;79(10):2480–2493.
   PubMed Web of Science ®Google Scholar
• Liu X, Xiao Z-D, Han L, et al. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol. 2016;18(4):431–442.
   PubMed Web of Science ®Google Scholar
• Chen Z, Liu H, Jin W, et al. Tissue microRNA-21 expression predicted recurrence and poor survival in patients with colorectal cancer - a meta-analysis. Onco Targets Ther. 2016;9:2615–2624.
   PubMed Web of Science ®Google Scholar
• Liu X, Gan B. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle. 2016;15(24):3471–3481.
   PubMed Web of Science ®Google Scholar
• Zhang X, Lin HK. NBR2-GLUT1 axis regulates cancer cell sensitivity to biguanides. Cell Cycle. 2017;16(3):249–250.
   PubMed Web of Science ®Google Scholar
• Ge S, Xiong Y, Wu X, et al. Role of growth factor receptor-bound 2 in CCl4-induced hepatic fibrosis. Biomed Pharmacother. 2017;92:942–951.
   PubMed Web of Science ®Google Scholar
• Ge S, Zhang L, Xie J, et al. MicroRNA-146b regulates hepatic stellate cell activation via targeting of KLF4. Ann Hepatol. 2016;15(6):918–928.
   PubMed Web of Science ®Google Scholar
• Yang -J-J, Liu L-P, Tao H, et al. MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R. Toxicology. 2016;359–360:39–46.
   PubMed Web of Science ®Google Scholar
• Zhao T, Xu Y, Ren S, et al. The siRNA silencing of DcR3 expression induces Fas ligand-mediated apoptosis in HepG2 cells. Exp Ther Med. 2018;15(5):4370–4378.
   PubMed Web of Science ®Google Scholar
• Norton L, Chen X, Fourcaudot M, et al. The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Res. 2014;42(22):13646–13661.
   PubMed Web of Science ®Google Scholar
• Kartha RV, Subramanian S. Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation. Front Genet. 2014;5:8.
   PubMed Web of Science ®Google Scholar
• Iyer VV, Yang H, Ierapetritou MG, et al. Effects of glucose and insulin on HepG2-C3A cell metabolism. Biotechnol Bioeng. 2010;107(2):347–356.
   PubMed Web of Science ®Google Scholar
• Yang X, Sun D, Dong C, et al. Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis. Oncotarget. 2016;7(26):39694–39704.
   PubMedGoogle Scholar
• Huang D, Li T, Wang L, et al. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress. Cell Res. 2016;26(10):1112–1130.
   PubMed Web of Science ®Google Scholar
• Ferretti AC, Tonucci FM, Hidalgo F, et al. AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation. Oncotarget. 2016;7(14):17815–17828.
   PubMedGoogle Scholar
• Ferretti AC, Hidalgo F, Tonucci FM, et al. Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration. Sci Rep. 2019;9(1):2815.
   PubMedGoogle Scholar
• Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27–47.
   PubMed Web of Science ®Google Scholar
• Liu X, Xiao ZD, Gan B. An lncRNA switch for AMPK activation. Cell Cycle. 2016;15(15):1948–1949.
   PubMed Web of Science ®Google Scholar
• Nejak-Bowen KN, Monga SP. Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol. 2011;21(1):44–58.
   PubMed Web of Science ®Google Scholar
• Schepers A, Clevers H. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol. 2012;4(4):a007989.
   PubMed Web of Science ®Google Scholar
• Clevers H, Nusse R. Wnt/beta-catenin signaling and disease. Cell. 2012;149(6):1192–1205.
   PubMed Web of Science ®Google Scholar
• Liu Z, Sun R, Zhang X, et al. Transcription factor 7 promotes the progression of perihilar cholangiocarcinoma by inducing the transcription of c-Myc and FOS-like antigen 1. EBioMedicine. 2019;45:181–191.
   PubMed Web of Science ®Google Scholar
• Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10(10):704–714.
   PubMed Web of Science ®Google Scholar
• Yang Q, JIANG W, ZHUANG C, et al. microRNA-22 downregulation of galectin-9 influences lymphocyte apoptosis and tumor cell proliferation in liver cancer. Oncol Rep. 2015;34(4):1771–1778.
   PubMed Web of Science ®Google Scholar
• Qian X, Xu W, Xu J, et al. Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer. Oncotarget. 2017;8(29):47691–47708.
   PubMedGoogle Scholar