IL-8, MSPa, MIF, FGF-9, ANG-2 and AgRP collection were identified for the diagnosis of colorectal cancer based on the support vector machine model

References

• Brenner H, Kloor M, Pox CP. Colorectal cancer. Lancet. 2014;383(9927):1490–1502.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. Ca A Cancer J Clinicians. 2017;67:104–117.
   Web of Science ®Google Scholar
• Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. Ca Cancer J Clin. 2012;62:10–29.
   PubMed Web of Science ®Google Scholar
• Fang YJ, Wu XJ, Zhao Q, et al. Hospital-based colorectal cancer survival trend of different tumor locations from 1960s to 2000s. PloS One. 2013;8:e73528.
   PubMed Web of Science ®Google Scholar
• Nakajima J, Iida T, Okumura S, et al. Recent improvement of survival prognosis after pulmonary metastasectomy and advanced chemotherapy for patients with colorectal cancer. Eur J Cardio-thorac Surg. 2017;51:869–873.
   PubMed Web of Science ®Google Scholar
• Gonzalez PM, Cruz CM. Colorectal cancer biomarkers: where are we now? Biomed Res Int. 2015;2015:149014.
   PubMed Web of Science ®Google Scholar
• Zhang L, Xie F, Tang C, et al. miR-340 suppresses tumor growth and enhances chemosensitivity of colorectal cancer by targeting RLIP76. Eur Rev Med Pharmacol Sci. 2017;21:2875–2886.
   PubMed Web of Science ®Google Scholar
• Wulfkuhle J, Liotta L, Petricoin E. Proteomic applications for the early detection of cancer. Nat Rev Cancer. 2003;3(4):267–275.
   PubMed Web of Science ®Google Scholar
• Safari-Alighiarloo N, Taghizadeh M, Rezaei-Tavirani M, et al. Protein-protein interaction networks (PPI) and complex diseases. Gastroenterol Hepatol Bed Bench. 2014;7(1):17–31.
   PubMedGoogle Scholar
• Hara M, Sato M, Takahashi H, et al. Does serum carcinoembryonic antigen elevation in patients with postoperative stage II colorectal cancer indicate recurrence? Comparison with stage III. J Surg Oncol. 2010;102(2):154–157.
   PubMed Web of Science ®Google Scholar
• Byström P, Berglund Å, Nygren P, et al. Evaluation of predictive markers for patients with advanced colorectal cancer. Acta Oncol. 2012;51(7):849–859. .
   PubMed Web of Science ®Google Scholar
• Smyth G.K. (2005) limma: Linear Models for Microarray Data. In: Gentleman R., Carey V.J., Huber W., Irizarry R.A., Dudoit S. (eds) Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Statistics for Biology and Health. Springer, New York, NY.
   Google Scholar
• Kanehisa M, Goto S. KEGG: kyoto encyclopaedia of genes and genomes. Nucleic Acids Res. 2000;28:27–30(4).
   Web of Science ®Google Scholar
• Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. Nat Genet. 2000;25(1):25–29. .
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Franceschini A, Kuhn M, et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 2011;39(Database issue):D561-8. https://pubmed.ncbi.nlm.nih.gov/21045058/.
   Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–2504.
   PubMed Web of Science ®Google Scholar
• Wang Q, Liu X. Screening of feature genes in distinguishing different types of breast cancer using support vector machine. Onco Targets Ther. 2015;8:2311–2317.
   PubMed Web of Science ®Google Scholar
• Zou G, Wang R, Wang M. Clinical response and prognostic significance of serum miR-497 expression in colorectal cancer. Cancer Biomarkers. 2019;25(1):11–18.
   Google Scholar
• Wu X, Wang Y, Wang L, et al. Id-1 expression in colorectal adenocarcinoma tissues and its clinical significance. Rev Assoc Med Bras. 2019;65:404–409.
   PubMed Web of Science ®Google Scholar
• Bae S, Park W, Jeong W, et al. Prognostic impact of telomeric repeat-containing RNA expression on long-term oncologic outcomes in colorectal cancer. Medicine (Baltimore). 2019;98(14):e14932.
   PubMed Web of Science ®Google Scholar
• Qi Y, Qi H, Liu Z, et al. Bioinformatics analysis of key genes and pathways in colorectal cancer. J Comput Biol. 2019;26:364–375.
   PubMed Web of Science ®Google Scholar
• Yu C, Hong H, Zhang S, et al. Identification of key genes and pathways involved in microsatellite instability in colorectal cancer. Mol Med Rep. 2019;19:2065–2076.
   PubMed Web of Science ®Google Scholar
• Cabrero-de LHS, Martínez-Balibrea E. CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer. World J Gastroenterol. 2018;24:4738–4749.
   PubMed Web of Science ®Google Scholar
• Coelho M, De Carné Trécesson S, Zecchin D, et al. Oncogenic RAS signaling promotes tumor immunoresistance by stabilizing PD-L1 mRNA. Immunity. 2017;47(1083–99.e6). DOI:10.1016/j.immuni.2017.11.016.
   PubMedGoogle Scholar
• Carné TS, Souazé F, Basseville A, et al. BCL-X directly modulates RAS signalling to favour cancer cell stemness. Nat Commun. 2017;8:1123.
   PubMed Web of Science ®Google Scholar
• Zhang X, Liu G, Ding L, et al. HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway. J Cell Biochem. 2018;119:2864–2874.
   PubMed Web of Science ®Google Scholar
• Huang B, Tsilidis K, Smith M, et al. Polymorphisms in genes related to inflammation and obesity and colorectal adenoma risk. Mol Carcinog. 2018;57(10):1278–1288. .
   PubMed Web of Science ®Google Scholar
• Shimizu M, Tanaka N. IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells. Oncogene. 2019;38(9):1520–1533.
   PubMed Web of Science ®Google Scholar
• Wang H, Wang Y, Pan J, et al. Evaluation of specific fecal protein biochips for the diagnosis of colorectal cancer. World J Gastroenterol. 2014;20:1332–1339.
   PubMed Web of Science ®Google Scholar
• Huang J, Song Q, Wang H, et al. Poor prognostic impact of FGF4 amplification in patients with esophageal squamous cell carcinoma. Hum Pathol. 2018;80:210–218.
   PubMed Web of Science ®Google Scholar
• Fabišíková K, Behulová RL, Repiska V. Molecular biomarkers in the diagnostic of patients with colorectal cancer. Neuro Endocrinol Lett. 2019;40:215–221.
   PubMed Web of Science ®Google Scholar
• Haupts A, Roth W, Hartmann N. [Liquid biopsy in colorectal cancer: an overview of ctDNA analysis in tumour diagnostics]. Pathologe. 2019;40:244–251.
   PubMed Web of Science ®Google Scholar
• Osumi H, Shinozaki E, Yamaguchi K, et al. Clinical utility of circulating tumor DNA for colorectal cancer. Cancer Sci. 2019;110:1148–1155.
   PubMed Web of Science ®Google Scholar
• Alizadehsani R, Abdar M, Roshanzamir M, et al. Machine learning-based coronary artery disease diagnosis: a comprehensive review. Comput Biol Med. 2019;111:103346.
   PubMed Web of Science ®Google Scholar
• Wang H, Huang G. Application of support vector machine in cancer diagnosis. Med Oncol. 2011;28(Suppl 1):S613–8.
   PubMedGoogle Scholar
• Zhi J, Sun J, Wang Z, et al. Support vector machine classifier for prediction of the metastasis of colorectal cancer. Int J Mol Med. 2018;41:1419–1426.
   PubMed Web of Science ®Google Scholar