NPSR1-AS1 activates the MAPK pathway to facilitate thyroid cancer cell malignant behaviors via recruiting ELAVL1 to stabilize NPSR1 mRNA

References

• Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016;388(10061):2783–2795.
   PubMed Web of Science ®Google Scholar
• Carling T, Udelsman R. Thyroid cancer. Annu Rev Med. 2014;65(1):125–137.
   PubMed Web of Science ®Google Scholar
• Pemayun TG. Current Diagnosis and Management of Thyroid Nodules. Acta Med Indones. 2016;48:247–257.
   PubMed Web of Science ®Google Scholar
• Ferrari SM, Fallahi P, Politti U, et al. Molecular Targeted Therapies of Aggressive Thyroid Cancer. Front Endocrinol (Lausanne). 2015;6:176.
   PubMed Web of Science ®Google Scholar
• Renganathan A, Long Noncoding F-BE. RNAs in Cancer and Therapeutic Potential. Adv Exp Med Biol. 2017;1008:199–222.
   PubMed Web of Science ®Google Scholar
• Peng WX, Koirala P, Mo YY. LncRNA-mediated regulation of cell signaling in cancer. Oncogene. 2017;36(41):5661–5667.
   PubMed Web of Science ®Google Scholar
• Luo Y, Hao T, Zhang J, et al. MicroRNA-592 suppresses the malignant phenotypes of thyroid cancer by regulating lncRNA NEAT1 and downregulating NOVA1. Int J Mol Med. 2019;44:1172–1182.
   PubMed Web of Science ®Google Scholar
• Liu H, Deng H, Zhao Y, et al. LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 2018;37(1):279.
   PubMedGoogle Scholar
• Ji L, Fan X, Zhou F, et al. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer. J Cell Physiol. 2020;235(4):3669–3678.
   PubMed Web of Science ®Google Scholar
• Huang ZL, Li W, Chen QF, et al. Eight key long non-coding RNAs predict hepatitis virus positive hepatocellular carcinoma as prognostic targets. World J Gastrointest Oncol. 2019;11(11):983–997.
   PubMed Web of Science ®Google Scholar
• Pereira B, Billaud M, Almeida R. RNA-Binding Proteins in Cancer: old Players and New Actors. Trends Cancer. 2017;3(7):506–528.
   PubMed Web of Science ®Google Scholar
• Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 2010;79(1):351–379.
   PubMed Web of Science ®Google Scholar
• Chen X, Li A, Sun BF, et al. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nat Cell Biol. 2019;21(8):978–990.
   PubMed Web of Science ®Google Scholar
• Abdelmohsen K, Gorospe M. Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA. 2010;1(2):214–229.
   PubMed Web of Science ®Google Scholar
• Zhang YX, Yuan J, Gao ZM, et al. LncRNA TUC338 promotes invasion of lung cancer by activating MAPK pathway. Eur Rev Med Pharmacol Sci. 2018;22:443–449.
   PubMed Web of Science ®Google Scholar
• Xiang Y, Zhang Y, Xia Y, et al. LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke. Aging (Albany NY). 2020;12(4):3156–3174.
   PubMedGoogle Scholar
• He H, Chen T, Mo H, et al. Hypoxia-inducible long noncoding RNA NPSR1-AS1 promotes the proliferation and glycolysis of hepatocellular carcinoma cells by regulating the MAPK/ERK pathway. Biochem Biophys Res Commun. 2020;533(4):886–892.
   PubMed Web of Science ®Google Scholar
• Barber RD, Harmer DW, Coleman RA, et al. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol Genomics. 2005;21(3):389–395.
   PubMed Web of Science ®Google Scholar
• Wu X, Xiao Y, Zhou Y, et al. LncRNA FOXP4-AS1 is activated by PAX5 and promotes the growth of prostate cancer by sequestering miR-3184-5p to upregulate FOXP4. Cell Death Dis. 2019;10(7):472.
   PubMedGoogle Scholar
• Pulkkinen V, Ezer S, Sundman L, et al. Neuropeptide S receptor 1 (NPSR1) activates cancer-related pathways and is widely expressed in neuroendocrine tumors. Virchows Arch. 2014;465(2):173–183.
   PubMed Web of Science ®Google Scholar
• Mahmoudian-Sani MR, Jalali A, Jamshidi M, et al. Long Non-Coding RNAs in Thyroid Cancer: implications for Pathogenesis, Diagnosis, and Therapy. Oncol Res Treat. 2019;42(3):136–142.
   PubMed Web of Science ®Google Scholar
• Zhou H, Sun Z, Li S, et al. LncRNA SPRY4-IT was concerned with the poor prognosis and contributed to the progression of thyroid cancer. Cancer Gene Ther. 2018;25(1–2):39–46.
   PubMed Web of Science ®Google Scholar
• Luzón-Toro B, Fernández RM, Martos-Martínez JM, et al. LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer. Sci Rep. 2019;9(1):14374.
   PubMedGoogle Scholar
• Diepenbruck M, Christofori G. Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe? Curr Opin Cell Biol. 2016;43:7–13.
   PubMed Web of Science ®Google Scholar
• Li S, Cong X, Gao H, et al. Tumor-associated neutrophils induce EMT by IL-17a to promote migration and invasion in gastric cancer cells. J Exp Clin Cancer Res. 2019;38(1):6.
   PubMedGoogle Scholar
• Lei H, Gao Y, Xu X. LncRNA TUG1 influences papillary thyroid cancer cell proliferation, migration and EMT formation through targeting miR-145. Acta Biochim Biophys Sin (Shanghai). 2017;49(7):588–597.
   PubMed Web of Science ®Google Scholar
• Ferrè F, Colantoni A, Helmer-Citterich M. Revealing protein-lncRNA interaction. Brief Bioinform. 2016;17(1):106–116.
   PubMed Web of Science ®Google Scholar
• Lan Y, Xiao X, He Z, et al. Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer. Nucleic Acids Res. 2018;46(11):5809–5821.
   PubMed Web of Science ®Google Scholar
• Guo X, Connick MC, Vanderhoof J, et al. MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. Int J Mol Sci. 2015;16(12):7112–7132.
   PubMedGoogle Scholar
• Trojanowicz B, Sekulla C, Dralle H, et al. Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. Neoplasma. 2016;63(3):371–377.
   PubMed Web of Science ®Google Scholar
• Win S, Than TA, Kaplowitz N. The Regulation of JNK Signaling Pathways in Cell Death through the Interplay with Mitochondrial SAB and Upstream Post-Translational Effects. Int J Mol Sci. 2018;19(11):3657.
   PubMedGoogle Scholar
• Wang N, Li Y, Wei J, et al. TBX1 Functions as a Tumor Suppressor in Thyroid Cancer Through Inhibiting the Activities of the PI3K/AKT and MAPK/ERK Pathways. Thyroid. 2019;29(3):378–394.
   PubMed Web of Science ®Google Scholar