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Research Paper

YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2

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Pages 2413-2427 | Received 20 Dec 2020, Accepted 23 Sep 2021, Published online: 28 Oct 2021

References

  • Siegel RL, Miller KD, and Jemal A. Cancer statistics, 2018. CA Cancer J Clin 2018;68(1):7–30.
  • Scelo G, Larose TL. Epidemiology and risk factors for kidney cancer. J Clin Oncol. 2018;JCO2018791905. DOI:10.1200/JCO.2018.79.1905
  • Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7(5):245–257.
  • Whelan P. The medical treatment of metastatic renal cell cancer. EAU Update Series. 2003;1(4):237–246.
  • Gupta K, Miller JD, Li JZ, et al. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev. 2008;34(3):193–205.
  • Prabhu L, Hartley, AV, Martin, M, et al. Role of post-translational modification of the Y box binding protein 1 in human cancers. Genes Dis. 2015;2(3)(:240–246
  • Eliseeva IA, Kim ER, Guryanov SG, et al. Y-box-binding protein 1 (YB-1) and its functions. Biochemistry (Mosc). 2011;76:1402–1433.
  • El-Naggar AM, Veinotte C, Cheng H, et al. Translational activation of HIF1alpha by YB-1 promotes sarcoma metastasis. Cancer Cell. 2015;27(5):682–697.
  • Kuwano M, Shibata T, Watari K, et al. Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer. Cancer Sci. 2019;110(5):1536–1543.
  • Dahl E, En-Nia A, Wiesmann F, et al. Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer. BMC Cancer. 2009;9(410). DOI:10.1186/1471-2407-9-410
  • Fujii T, Kawahara A, Basaki Y, et al. Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers. Cancer Res. 2008;68(1504–1512):1504–1512.
  • Shibahara K, Sugio, K, Osaki, T, et al. Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer. Clin Cancer Res. 2001;7:3151–3155.
  • Gessner C, Woischwill C, Schumacher A, et al. Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer. Eur Respir J. 2004;23(1):14–19.
  • Chatterjee M, Rancso C, Stühmer T, et al. The Y-box binding protein YB-1 is associated with progressive disease and mediates survival and drug resistance in multiple myeloma. Blood. 2008;111(7):3714–3722.
  • Oda Y, Sakamoto, A, Shinohara, N, et al. Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. Clin Cancer Res. 1998;4:2273–2277.
  • Oda Y, Ohishi Y, Saito T, et al. Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma. J Pathol. 2003;199(2):251–258.
  • Gimenez-Bonafe P, Fedoruk MN, Whitmore TG, et al. YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. Prostate. 2004;59(3):337–349.
  • Basaki Y, Hosoi F, Oda Y, et al. Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells. Oncogene. 2007;26(19):2736–2746.
  • Wang Y, Su, J, Wang, Y, et al. The interaction of YBX1 with G3BP1 promotes renal cell carcinoma cell metastasis via YBX1/G3BP1-SPP1- NF-kappaB signaling axis. Journal of experimental & clinical cancer research. 2019: 38: 386.
  • Calderwood DA, Campbell ID, Critchley DR. Talins and kindlins: partners in integrin-mediated adhesion. Nat Rev Mol Cell Biol. 2013;14(8):503–517.
  • Larjava H, Plow EF, Wu C. Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep. 2008;9(12):1203–1208.
  • Rognoni E, Ruppert R, Fassler R. The kindlin family: functions, signaling properties and implications for human disease. J Cell Sci. 2016;129(1):17–27.
  • Yu J, Hu Y, Gao Y, et al. Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis. Cell Death Discov. 2018;4(1). DOI:10.1038/s41420-018-0095-9
  • Tu Y, Wu S, Shi X, et al. Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation. Cell. 2003;113(1):37–47.
  • Burridge K. Focal adhesions: a personal perspective on a half century of progress. FEBS J. 2017;284(20):3355–3361.
  • Yu Y, Wu J, Wang Y, et al. Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling. EMBO Rep. 2012;13(8):750–758.
  • Yu Y, Wu J, Guan L, et al. Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family. Int J Cancer. 2013;133(6):1368–1379.
  • Zhang H-F, Zhang K, Liao L-D, et al. miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2. Carcinogenesis. 2014;35(2):292–301.
  • Zhan J, Song J, Wang P, et al. Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9. Cancer Lett. 2015;361(1):75–85.
  • An Z, Dobra K, Lock JG, et al. Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration. Int J Cancer. 2010;127(9):1999–2008.
  • Zhan J, Zhu X, Guo Y, et al. Opposite role of Kindlin-1 and Kindlin-2 in lung cancers. PloS One. 2012;7(11):e50313.
  • Talaat S, Somji S, Toni C, et al. Kindlin-2 expression in arsenite- and cadmium-transformed bladder cancer cell lines and in archival specimens of human bladder cancer. Urology. 2011;77(6):e1501–1507.
  • Ou Y, Zhao Z, Zhang W, et al. Kindlin-2 interacts with β-catenin and YB-1 to enhance EGFR transcription during glioma progression. Oncotarget. 2016;7(46):74872–74885.
  • Yan M, Zhang L, Wu Y, et al. Increased expression of kindlin‐2 is correlated with hematogenous metastasis and poor prognosis in patients with clear cell renal cell carcinoma. FEBS Open Bio. 2016;6(7):660–665.
  • Shen Z, Ye Y, KAUTTU T, et al. The novel focal adhesion gene kindlin-2 promotes the invasion of gastric cancer cells mediated by tumor-associated macrophages. Oncol Rep. 2013;29(2):791–797.
  • Shen Z, Ye Y, Dong L, et al. Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer. Am J Surg. 2012;203(2):222–229.
  • Sossey-Alaoui K, Pluskota E, Bialkowska K, et al. Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration. Cancer Res. 2017;77(18):5129–5141.
  • Guo L, Cui C, Zhang K, et al. Kindlin-2 links mechano-environment to proline synthesis and tumor growth. Nat Commun. 2019;10(1). 10.1038/s41467-019-08772-3
  • Hu S, Gao Y, Zhou H, et al. New insight into mitochondrial changes in vascular endothelial cells irradiated by gamma ray. Int J Radiat Biol. 2017;93(5):470–476.
  • Rodriguez-Fernandez IA, Rodríguez-Romo L, Hernandez-Barajas D, et al. Adjuvant radiation therapy after radical nephrectomy in patients with localized renal cell carcinoma: a systematic review and meta-analysis. European urology oncology. 2019; 2(4):448–455.
  • Bedke J, Gauler T, Grünwald V, et al. Systemic therapy in metastatic renal cell carcinoma. World J Urol. 2017;35(2):179–188.
  • Stein U, Jürchott K, Walther W, et al. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. J Biol Chem. 2001;276(30):28562–28569.
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674.
  • Lasham A, Print CG, Woolley AG, et al. YB-1: oncoprotein, prognostic marker and therapeutic target? Biochem J. 2013;449(1):11–23.
  • Kohno K, Izumi H, Uchiumi T, et al. The pleiotropic functions of the Y-box-binding protein, YB-1. Bioessays. 2003;25(7):691–698.
  • Kuwano M, Oda, Y, Izumi, H, et al. The role of nuclear Y-box binding protein 1 as a global marker in drug resistance. Mol Cancer Ther. 2004;3:1485–1492.
  • Zhao X, Zhao Z, Xu W, et al. Circ-SAR1A promotes renal cell carcinoma progression through miR-382/YBX1 axis. Cancer Manag Res. 2020;12:7353–7361.
  • D’Costa N, Lowerison MR, Raven PA, et al. Y-box binding protein-1 is crucial in acquired drug resistance development in metastatic clear-cell renal cell carcinoma. J Exp Clin Cancer Res. 2020;39(1):33.
  • Yue D, Wang Y, Sun Y et al. C1QBP Regulates YBX1 to Suppress the Androgen Receptor (AR)-Enhanced RCC Cell Invasion. Neoplasia. 2017;19:135–144.
  • Wang Y, Yue D, Xiao M, et al. C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis. J Proteome Res. 2015;14(2):804–813.
  • Wang Y, Chen Y, Geng H, et al. Overexpression of YB1 and EZH2 are associated with cancer metastasis and poor prognosis in renal cell carcinomas. Tumour Biol. 2015;36(9):7159–7166.
  • Wang Y, Su J, Fu D, et al. The role of YB1 in renal cell carcinoma cell adhesion. Int J Med Sci. 2018;15(12):1304–1311.
  • Liu Y, He, K, Hu, Y, et al. YAP modulates TGF-β1-induced simultaneous apoptosis and EMT through upregulation of the EGF receptor. Sci Rep-Uk. 2017;7(45523). DOI:10.1038/srep45523
  • Dowling J, Gibbs E, Russell M, et al. Kindlin-2 is an essential component of intercalated discs and is required for vertebrate cardiac structure and function. Circ Res. 2008;102(4):423–431.
  • Zhao T, Guan L, Yu Y, et al. Kindlin-2 promotes genome instability in breast cancer cells. Cancer Lett. 2013;330(2):208–216.
  • Yan M, Zhang L, Wu Y, et al. Increased expression of kindlin-2 is correlated with hematogenous metastasis and poor prognosis in patients with clear cell renal cell carcinoma. FEBS Open Bio. 2016;6(7):660–665.
  • Liu B, Tan X, Liang J, et al. A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells. Sci Rep. 2014;4(1). DOI:10.1038/srep07041
  • Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981–990.
  • Bratton SB, Cohen GM. Apoptotic death sensor: an organelle’s alter ego? Trends Pharmacol Sci. 2001;22(6):306–315.
  • Li C, Li X, Wu L, et al. Elevated AQP1 expression is associated with unfavorable oncologic outcome in patients with hilar cholangiocarcinoma. Technol Cancer Res Treat. 2017;16(4):421–427.
  • Shen A, Chen H, Chen Y, et al. Pien Tze huang overcomes multidrug resistance and epithelial-mesenchymal transition in human colorectal carcinoma cells via suppression of TGF- β pathway. Evid Based Complement Alternat Med. 2014;2014(679436):1–10.
  • Mallat Z, Tedgui A. Apoptosis in the vasculature: mechanisms and functional importance. Br J Pharmacol. 2000;130(5):947–962.

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