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Cell Cycle Volume 20, 2021 - Issue 23
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Research Paper

Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer

Qi Gaoa Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China;c Department of General Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Yunhua Wuc Department of General Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Chaoxiang Lua Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Wang Kaic Department of General Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Weike Xiea Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Qi Wanga Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Lei Wanga Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
,
Shiqi Liua Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaView further author information
&
Yongkang Pana Department of General Surgery, Xi’an Children’s Hospital, Xi‘an, Shaanxi, China;b Department of General Surgery, The Affiliated Children Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaCorrespondence[email protected]
View further author information
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Pages 2465-2475 | Received 31 Jul 2020, Accepted 27 Sep 2021, Published online: 19 Oct 2021

References

  • Wang FH, Shen L, Li J, et al. The Chinese Society of Clinical Oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer. Cancer Commun (Lond). 2019;39(1):10.
  • Banks M, Graham D, Jansen M, et al. British society of gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. Gut. 2019;68(9):1545–1575.
  • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
  • Huang Y, Wei J, Liu BR. [Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer]. Zhonghua Zhong Liu Za Zhi. 2016;38(2):81–85.
  • Oxford G, Smith SC, Hampton G, et al. Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector. Oncogene. 2007;26(50):7143–7152.
  • Thiagalingam A, De Bustros A, Borges M, et al. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Mol Cell Biol. 1996;16(10):5335–5345.
  • Zhang S, Qian X, Redman C, et al. p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB. Oncogene. 2003;22(15):2285–2295.
  • Kent OA, Fox-Talbot K, Halushka MK, et al. RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets. Oncogene. 2013;32(20):2576–2585.
  • Hui B, Ji H, Xu Y, et al. RREB1-induced upregulation of the lncRNA AGAP2-AS1 regulates the proliferation and migration of pancreatic cancer partly through suppressing ANKRD1 and ANGPTL4. Cell Death Dis. 2019;10(3):207.
  • Su J, Morgani SM, David CJ, et al. TGF-β orchestrates fibrogenic and developmental EMTs via the Ras effector RREB1. Nature. 2020;577(7791):566–571.
  • Kent OA, Saha M, Coyaud E, et al. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nat Commun. 2020;11(1):4673.
  • Deng YN, Xia Z, Zhang P, et al. Transcription factor RREB1: from target genes towards biological functions. Int J Biol Sci. 2020;16(8):1463–1473.
  • Yu JH, Zheng JB, Qi J, et al. Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR/NF-κB signalling pathway. Int J Oncol. 2019;54(3):879–892.
  • Nitz MD, Harding MA, Smith SC, et al. RREB1 transcription factor splice variants in urologic cancer. Am J Pathol. 2011;179(1):477–486.
  • Zou J, Milon BC, Desouki MM, et al. hZIP1 zinc transporter down-regulation in prostate cancer involves the overexpression of ras responsive element binding protein-1 (RREB-1). Prostate. 2011;71(14):1518–1524.
  • Ju, M , Wang, SC, and Syed, C et al Multidisciplinary teams improve gastric cancer treatment efficiency at a large safety net hospital[J]. Ann Surg Onco. 2020;27(3):645–650.
  • Ramos, M , Pereira, M, and Oliveira, Y S et al Surgical results of remnant gastric cancer treatment[J]. Rev Col Bras Cir. 2020;47(1):e20202703.
  • Franklin RB, Feng P, Milon B, et al. hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer. Mol Cancer. 2005;4(1):32.
  • Date S, Nibu Y, Yanai K, et al. Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene. Int J Mol Med. 2004;13(5):637–642.
  • Liu H, Hew HC, Lu ZG, et al. DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. Biochem J. 2009;422(3):543–551.
  • Rahrmann EP, Wolf NK, Otto GM, et al. Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma. Mol Cancer Res. 2019;17(2):567–582.
  • Sen M, Akeno N, Reece A, et al. p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis. 2017;6(4):e320.
  • Liu Q, Song LJ, Xu WQ, et al. Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma. Mol Med Rep. 2009;2(2):169–174.
  • Xu WQ, Song LJ, Liu Q, et al. Expression of anion exchanger 1 is associated with tumor progress in human gastric cancer. J Cancer Res Clin Oncol. 2009;135(10):1323–1330.
  • Guo T, Chai X, Liu Q, et al. Downregulation of P16 promotes cigarette smoke extract-induced vascular smooth muscle cell proliferation via preventing G1/S phase transition. Exp Ther Med. 2017;14(1):214–220.

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