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Research Paper

Neohesperidin promotes the proliferation and osteogenic differentiation of BMSCs via BMP2-Wnt/β-catenin pathway

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Pages 187-201 | Received 16 Jan 2020, Accepted 26 Nov 2021, Published online: 17 Dec 2021

References

  • Wang XS, Zhuang QY, Weng XS, et al. Etiological and clinical analysis of osteonecrosis of the femoral head in Chinese patients. Chin Med J (Engl). 2013.Jan;126(2):290–295. PubMed PMID: 23324279.
  • Kubo T, Ueshima K, Saito M, et al. Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan. J Orthop Sci. 2016 Jul;21(4):407–413. PubMed PMID: 27062553.
  • Wei Q, Yang F, Chen X, et al. [Microarchitecture features and pathology of necrotic region in patients with steroid-induced and alcohol-induced osteonecrosis of femoral head]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Jul 15;32(7):866–872. PubMed PMID: 30129310.
  • Wang A, Ren M, Wang J. The pathogenesis of steroid-induced osteonecrosis of the femoral head: a systematic review of the literature. Gene. 2018 Sep 10;671:103–109. PubMed PMID: 29859289.
  • Pontikoglou C, Deschaseaux F, Sensebe L, et al. Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Rev Rep. 2011 Sep 7;7(3):569–589. PubMed PMID: 21249477.
  • Miao C, Lei M, Hu W, et al. A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction. Stem Cell Res Ther. 2017 Nov2;8(1):242. PubMed PMID: 29096705; PubMed Central PMCID: PMCPMC5667518.
  • Mohamed-Ahmed S, Fristad I, Lie SA, et al. Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res Ther. 2018 Jun 19;9(1):168. PubMed PMID: 29921311; PubMed Central PMCID: PMCPMC6008936.
  • Zhao P, Xiao L, Peng J, et al. Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway. Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3962–3970. PubMed PMID: 29949171.
  • Liu X, Li Q, Niu X, et al. Exosomes secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells prevent osteonecrosis of the femoral head by promoting angiogenesis. Int J Biol Sci. 2017;13(2):232–244. PubMed PMID: 28255275; PubMed Central PMCID: PMCPMC5332877.
  • Qiang H, Liu H, Ling M, et al. Early steroid-induced osteonecrosis of rabbit femoral head and panax notoginseng saponins: mechanism and protective effects. Evid Based Complement Alternat Med. 2015;2015:719370. PubMed PMID: 25866538; PubMed Central PMCID: PMCPMC4378605.
  • Wu H, Liu Y, Chen X, et al. Neohesperidin exerts lipid-regulating effects in vitro and in vivo via fibroblast growth factor 21 and AMP-activated protein kinase/sirtuin type 1/peroxisome proliferator-activated receptor gamma coactivator 1alpha signaling axis. Pharmacology. 2017;100(3–4):115–126. PubMed PMID: 28554169.
  • Han GE, Kang HT, Chung S, et al. Novel neohesperidin dihydrochalcone analogue inhibits adipogenic differentiation of human adipose-derived stem cells through the Nrf2 pathway. Int J Mol Sci. 2018 Jul 29;19(8):8. PubMed PMID: 30060630; PubMed Central PMCID: PMCPMC6121477.
  • Wen L, Jiang Y, Yang J, et al. Structure, bioactivity, and synthesis of methylated flavonoids. Ann N Y Acad Sci. 2017 Jun;1398(1):120–129. PubMed PMID: 28436044.
  • Tan Z, Cheng J, Liu Q, et al. Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice. Mol Cell Endocrinol. 2017 Jan 5;439:369–378. PubMed PMID: 27664516.
  • Xu J, Gong H, Lu S, et al. Animal models of steroid-induced osteonecrosis of the femoral head-a comprehensive research review up to 2018. Int Orthop. 2018 Jul;42(7):1729–1737. PubMed PMID: 29705870.
  • Boregowda SV, Krishnappa V, Phinney DG. Isolation of mouse bone marrow mesenchymal stem cells. Methods Mol Biol. 2016;1416:205–223. PubMed PMID: 27236673.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001Dec;25(4):402–408. PubMed PMID: 11846609; eng.
  • Lan F, Bayliss PE, Rinn JL, et al. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689–694. PubMed PMID: 17851529; eng.
  • Fang S, Li Y, Chen P. Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head. Drug Des Devel Ther. 2019;13:45–55. PubMed PMID: 30587927; PubMed Central PMCID: PMCPMC6305133.
  • Wang Q, Yang Q, Chen G, et al. LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation. Sci Rep. 2018 Jun 14;8(1):9127. PubMed PMID: 29904151; PubMed Central PMCID: PMCPMC6002551.
  • Yoon BH, Jones LC, Chen CH, et al. Etiologic classification criteria of ARCO on femoral head osteonecrosis part 1: glucocorticoid-associated osteonecrosis. J Arthroplasty. 2019 Jan;34(1):163–168e1. PubMed PMID: 30348552.
  • Yuan S, Zhang C, Zhu Y, et al. Neohesperidin ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting the histone modification of lncRNA HOTAIR. Drug Des Devel Ther. 2020;25:5419–5430. PubMed PMID: 33324039; PubMed Central PMCID: PMCPMC7733036. eng.
  • Chen YH, Luo R, Lei SS, et al. Anti-inflammatory effect of Ganluyin, a Chinese classic prescription, in chronic pharyngitis rat model. BMC Compl med Ther. 2020 Aug 28;20(1):265. PubMed PMID: 32859182; PubMed Central PMCID: PMCPMC7456022. eng.
  • Feng XLY. Clinical observation on the treatment of 78 cases of chronic pharyngitis with Ganluyin. Mongol J Tradit Chin Med. 2011;30(17):9–10.
  • Shi HL, Tan B, Ji G, et al. The ethanol extract isolated from Weiqi Decoction induces G₂/M arrest and apoptosis in AGS cells. Chin J Integr Med. 2014 Jun;20(6):430–437. PubMed PMID: 23943506; eng.
  • Jiang Y, Zhang Y, Chen W, et al. Achyranthes bidentata extract exerts osteoprotective effects on steroid-induced osteonecrosis of the femoral head in rats by regulating RANKL/RANK/OPG signaling. J Transl Med. 2014 Nov29;12(1):334. PubMed PMID: 25471933; PubMed Central PMCID: PMCPMC4256888.
  • Liu S, Huang Y, Wang C, et al. Epimedium protects steroid-induced avascular necrosis of femoral head in rats by inhibiting autophagy. Exp Ther Med. 2018 Dec;16(6):5047–5052. PubMed PMID: 30542458; PubMed Central PMCID: PMCPMC6257266.
  • Lee JH, Lee SH, Kim YS, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23(12):1748–1753. PubMed PMID: 19367677.
  • Mandalari G, Bennett RN, Bisignano G, et al. Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry. J Appl Microbiol. 2007 Dec;103(6):2056–2064. PubMed PMID: 18045389.
  • Wang A, Ren M, Song Y, et al. MicroRNA expression profiling of bone marrow mesenchymal stem cells in steroid-induced osteonecrosis of the femoral head associated with osteogenesis. Med Sci Monit. 2018 Mar 28;24:1813–1825. PubMed PMID: 29590087; PubMed Central PMCID: PMCPMC5887684.
  • Mildmay-White A, Khan W. Cell surface markers on adipose-derived stem cells: a systematic review. Curr Stem Cell Res Ther. 2017;12(6):484–492. PubMed PMID: 27133085.
  • Togarrati PP, Dinglasan N, Desai S, et al. CD29 is highly expressed on epithelial, myoepithelial, and mesenchymal stromal cells of human salivary glands. Oral Dis. 2018 May;24(4):561–572. PubMed PMID: 29197149; PubMed Central PMCID: PMCPMC5902634.
  • Sharma U, Pal D, Prasad R. Alkaline phosphatase: an overview. Indian J Clin Biochem. 2014Jul;29(3):269–278. PubMed PMID: 24966474; PubMed Central PMCID: PMCPMC4062654.
  • Komori T. Roles of Runx2 in Skeletal Development. Adv Exp Med Biol. 2017;962:83–93. PubMed PMID: 28299652.
  • Komori T. Runx2, an inducer of osteoblast and chondrocyte differentiation. Histochem Cell Biol. 2018Apr;149(4):313–323. PubMed PMID: 29356961.
  • Zhang P, Xu H, Wang P, et al. Yougui pills exert osteoprotective effects on rabbit steroid-related osteonecrosis of the femoral head by activating beta-catenin. Biomed Pharmacother. 2019 Oct 16;120:109520. PubMed PMID: 31629251.
  • Zhai JL, Weng XS, Wu ZH, et al. Effect of Resveratrol on Preventing Steroid-induced Osteonecrosis in a Rabbit Model. Chin Med J (Engl). 2016 Apr 5;129(7):824–830. PubMed PMID: 26996479; PubMed Central PMCID: PMCPMC4819304.
  • Chen XJ, Shen YS, He MC, et al. Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/beta-catenin signaling pathway. Biomed Pharmacother. 2019 Apr;112:108746. PubMed PMID: 30970530.
  • Zhang R, Oyajobi BO, Harris SE, et al. Wnt/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone. 2013 Jan;52(1):145–156. PubMed PMID: 23032104; PubMed Central PMCID: PMCPMC3712130.
  • Zhou Y, Lian H, Liu K, et al. Puerarin improves graft bone defect through microRNA-155-3p-mediated p53/TNF‑α/STAT1 signaling pathway. Int J Mol Med. 2020 Jul;46(1):239–251. PubMed PMID: 32377717; PubMed Central PMCID: PMCPMC7255454. eng.
  • Yang X, Yang Y, Zhou S, et al. Puerarin stimulates osteogenic differentiation and bone formation through the ERK1/2 and p38-MAPK signaling pathways. Curr Mol Med. 2018 Mar 9;17(7):488–496. PubMed PMID: 29256352; eng.
  • Yu H, Liu P, Zhu D, et al. Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol-induced osteonecrosis of the femoral head. Cell Prolif. 2020 Aug;53(8):e12871. PubMed PMID: 32597546; PubMed Central PMCID: PMCPMC7445404. eng.
  • Huang Z, Wei H, Wang X, et al. Icariin promotes osteogenic differentiation of BMSCs by upregulating BMAL1 expression via BMP signaling. Mol Med Rep. 2020 Mar;21(3):1590–1596. PubMed PMID: 32016461; PubMed Central PMCID: PMCPMC7002972. eng.
  • Ahmadzadeh A, Norozi F, Shahrabi S, et al. Wnt/beta-catenin signaling in bone marrow niche. Cell Tissue Res. 2016 Feb;363(2):321–335. PubMed PMID: 26475718.
  • Kim W, Kim M, Jho EH. Wnt/beta-catenin signalling: from plasma membrane to nucleus. Biochem J. 2013 Feb 15;450(1):9–21. PubMed PMID: 23343194.
  • Hwang JH, Cha PH, Han G, et al. Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation. Exp Mol Med. 2015 Mar 20;47(3):e152. PubMed PMID: 25792220; PubMed Central PMCID: PMCPMC4351407.
  • Bender S, Tang Y, Lindroth AM, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell. 2013 Nov11;24(5):660–672. PubMed PMID: 24183680; eng.
  • Ye L, Fan Z, Yu B, et al. Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs. Cell Stem Cell. 2012 Jul 6;11(1):50–61. PubMed PMID: 22770241; PubMed Central PMCID: PMCPMC3392612. eng.
  • Camilleri ET, Dudakovic A, Riester SM, et al. Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development. J Biol Chem. 2018 Dec 7;293(49):19001–19011. PubMed PMID: 30327434; PubMed Central PMCID: PMCPMC6295726. eng.

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