LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis

References

• Dekker E, Tanis PJ, Vleugels JLA, et al. Colorectal cancer. Lancet. 2019;394(10207):1467–1480.
   PubMed Web of Science ®Google Scholar
• Bian Z, Zhang J, Li M, et al. LncRNA-FEZF1-AS1 promotes tumor proliferation and metastasis in colorectal cancer by regulating PKM2 signaling. Clin Cancer Res off J Am Assoc Cancer Res. 2018;24(19):4808–4819.
   PubMed Web of Science ®Google Scholar
• Dai G, Ding K, Cao Q, et al. Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2. Eur J Pharmacol. 2019;859:172525.
   PubMed Web of Science ®Google Scholar
• Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89–103.
   PubMed Web of Science ®Google Scholar
• Miller KD, Siegel RL, Lin CC, et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J Clin. 2016;66(4):271–289.
   PubMed Web of Science ®Google Scholar
• Woo IS, Jung YH. Metronomic chemotherapy in metastatic colorectal cancer. Cancer Lett. 2017;400:319–324.
   PubMed Web of Science ®Google Scholar
• Munro MJ, Wickremesekera SK, Peng L, et al. Cancer stem cells in colorectal cancer: a review. J Clin Pathol. 2018;71(2):110–116.
   PubMed Web of Science ®Google Scholar
• Renganathan A, Felley-Bosco E. Long noncoding RNAs in cancer and therapeutic potential. Adv Exp Med Biol. 2017;1008:199–222.
   PubMed Web of Science ®Google Scholar
• Wang L, Cho KB, and Li Y, et al. Long noncoding RNA (lncRNA)-mediated competing endogenous RNA networks provide novel potential biomarkers and therapeutic targets for colorectal cancer. Int J Mol Sci. 2019;20:5758.
   PubMed Web of Science ®Google Scholar
• Han P, Li JW, Zhang BM, et al. The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. Mol Cancer. 2017;16(1):9.
   PubMed Web of Science ®Google Scholar
• Xu Y, Zhang X, Hu X, et al. The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9. Mol Med (Cambridge, MA). 2018;24(1):52.
   PubMedGoogle Scholar
• Xu M, Xu X, Pan B, et al. LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2. Mol Cancer. 2019;18(1):135.
   PubMed Web of Science ®Google Scholar
• Naorem LD, Prakash VS, Muthaiyan M, et al. Comprehensive analysis of dysregulated lncRNAs and their competing endogenous RNA network in triple-negative breast cancer. Int J Biol Macromol. 2020;145:429–436.
   PubMed Web of Science ®Google Scholar
• Balacescu O, Sur D, Cainap C, et al. The impact of miRNA in colorectal cancer progression and its liver metastases. Int J Mol Sci. 2018;19(12):3711.
   Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207.
   PubMed Web of Science ®Google Scholar
• Baltruskeviciene E, Schveigert D, Stankevicius V, et al. Down-regulation of miRNA-148a and miRNA-625-3p in colorectal cancer is associated with tumor budding. BMC Cancer. 2017;17(1):607.
   PubMedGoogle Scholar
• Xiao R, Li C, Chai B. miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1. Biomed Pharmacothe. 2015;74:138–144.
   PubMed Web of Science ®Google Scholar
• Li X, Guo S, Xiong X-K, et al. Combination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-kappa B pathway. J Cancer. 2019;10(19):4509–4521.
   PubMed Web of Science ®Google Scholar
• Wang M, Zheng S, Li X, et al. Integrated analysis of lncRNA-miRNA-mRNA ceRNA network identified lncRNA EPB41L4A-AS1 as a potential biomarker in non-small cell lung cancer. Front Genet. 2020;11:511676.
   PubMed Web of Science ®Google Scholar
• Min SJ, Lim JY, Kim HR, et al. Sasa quelpaertensis leaf extract inhibits colon cancer by regulating cancer cell stemness in vitro and in vivo. Int J Mol Sci. 2015;16(12):9976–9997.
   PubMedGoogle Scholar
• Grassi ES, Jeannot P, Pantazopoulou V, et al. Niche-derived soluble DLK1 promotes glioma growth. Neoplasia. 2020;22(12):689–701.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Wang C, Becker SA, et al. Camp ER. miR-145 antagonizes SNAI1-mediated stemness and radiation resistance in colorectal cancer. Mol Ther. 2018;26(3):744–754.
   PubMed Web of Science ®Google Scholar
• Lu G, Li Y, Ma Y, et al. Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/Nanog axis. J Exp Clin Cancer Res. 2018;37(1):289.
   PubMedGoogle Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods (San Diego Calif). 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Fu Z, Chen C, Zhou Q, et al. LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9. Cancer Lett. 2017;410:68–81.
   PubMed Web of Science ®Google Scholar
• Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007;104(24):10158–10163.
   PubMed Web of Science ®Google Scholar
• Yu SS, Cirillo N. The molecular markers of cancer stem cells in head and neck tumors. J Cell Physiol. 2020;235(1):65–73.
   PubMed Web of Science ®Google Scholar
• Xia T, Jiang H, Li C, et al. Molecular imaging in tracking tumor stem-like cells. J Biomed Biotechnol. 2012;2012:420364.
   PubMedGoogle Scholar
• Hou L, Li Q, Yu Y, et al. SET8 induces epithelial‑mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1. Mol Med Rep. 2016;13(2):1681–1688.
   PubMed Web of Science ®Google Scholar
• Jia XX, Zhu TT, Huang Y, et al. Wnt/β-catenin signaling pathway regulates asthma airway remodeling by influencing the expression of c-Myc and cyclin D1 via the p38 MAPK-dependent pathway. Exp Ther Med. 2019;18(5):3431–3438.
   PubMed Web of Science ®Google Scholar
• Liu L, Zhu H, Liao Y, et al. Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4(+)/Nanog(+) NSCLC cells. Biomed Pharmacothe. 2020;127:110225.
   PubMed Web of Science ®Google Scholar
• Katona BW, Weiss JM. Chemoprevention of Colorectal Cancer. Gastroenterology. 2020;158(2):368–388.
   PubMed Web of Science ®Google Scholar
• Pan Y, Ma S, Cao K, et al. Therapeutic approaches targeting cancer stem cells. J Cancer Res Ther. 2018;14(7):1469–1475.
   PubMed Web of Science ®Google Scholar
• Fanali C, Lucchetti D, Farina M, et al. Cancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectives. World J Gastroenterol. 2014;20(4):923–942.
   PubMed Web of Science ®Google Scholar
• Shin KH, Kim RH. An updated review of oral cancer stem cells and their stemness regulation. Crit Rev Oncog. 2018;23(3–4):189–200.
   PubMedGoogle Scholar
• Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature. 2007;445(7123):111–115.
   PubMed Web of Science ®Google Scholar
• Gangemi R, Paleari L, Orengo AM, et al. Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance. Curr Med Chem. 2009;16(14):1688–1703.
   PubMed Web of Science ®Google Scholar
• Feitelson MA, Arzumanyan A, Kulathinal RJ, et al. Sustained proliferation in cancer: mechanisms and novel therapeutic targets. Semin Cancer Biol. 2015;35(Suppl):S25–S54.
   PubMed Web of Science ®Google Scholar
• Tahtamouni L, Ahram M, Koblinski J, et al. Molecular regulation of cancer cell migration, invasion, and metastasis. Anal Cell Pathol (Amst). 2019;2019:1356508.
   PubMedGoogle Scholar
• Cao L, Zhou Y, Zhai B, et al. Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines. BMC Gastroenterol. 2011;11(1):71.
   PubMedGoogle Scholar
• Fujimoto K, Beauchamp RD, Whitehead RH. Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology. 2002;123(6):1941–1948.
   PubMed Web of Science ®Google Scholar
• Sagiv E, Memeo L, Karin A, et al. CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis. Gastroenterology. 2006;131(2):630–639.
   PubMed Web of Science ®Google Scholar
• Li W, Ma H, Zhang J, et al. Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis. Sci Rep. 2017;7(1):13856.
   PubMedGoogle Scholar
• Thapa R, Wilson GD. The importance of CD44 as a stem cell biomarker and therapeutic target in cancer. Stem Cells Int. 2016;2016:2087204.
   PubMed Web of Science ®Google Scholar
• Di Bonito M, Collina F, Cantile M, et al. Aberrant expression of cancer stem cells marker prominin-1 in low-grade tubulolobular breast carcinoma: a correlative study between qRT-PCR, flow-cytometric and immunohistochemistry analysis [corrected]. J Breast Cancer. 2012;15(1):15–23.
   PubMed Web of Science ®Google Scholar
• Sneath RJ, Mangham DC. The normal structure and function of CD44 and its role in neoplasia. Molecular Pathology: MP. 1998;51(4):191–200.
   PubMedGoogle Scholar
• Takeda K, Mizushima T, Yokoyama Y, et al. Sox2 is associated with cancer stem-like properties in colorectal cancer. Sci Rep. 2018;8(1):17639.
   PubMedGoogle Scholar
• Zhang P, Sun Y, Ma L. ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance. Cell Cycle (Georgetown, Tex). 2015;14(4):481–487.
   PubMed Web of Science ®Google Scholar
• Drápela S, Bouchal J, Jolly MK, et al. ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance. Front Mol Biosci. 2020;7:36.
   PubMed Web of Science ®Google Scholar
• Pal M, Bhattacharya S, Kalyan G, et al. Cadherin profiling for therapeutic interventions in Epithelial Mesenchymal Transition (EMT) and tumorigenesis. Exp Cell Res. 2018;368(2):137–146.
   PubMed Web of Science ®Google Scholar
• Wei H, Yu Y, Wang Y, et al. Vimentin-targeting AIEgen-peptide conjugates: wash-free fluorescence detection of EMT-type cancer cells and tissues. Sens Actuators B Chem. 2020;321:128536.
   Web of Science ®Google Scholar
• Liu J, Li H, Zheng B, et al. Competitive endogenous RNA (ceRNA) regulation network of lncRNA-miRNA-mRNA in colorectal carcinogenesis. Dig Dis Sci. 2019;64(7):1868–1877.
   PubMed Web of Science ®Google Scholar
• Gomes LG, Cunha-Silva M, Crespo RP, et al. DLK1 is a novel link between reproduction and metabolism. J Clin Endocrinol Metab. 2019;104(6):2112–2120.
   PubMed Web of Science ®Google Scholar
• Yanai H, Nakamura K, Hijioka S, et al. Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency. J Biochem. 2010;148(1):85–92.
   PubMed Web of Science ®Google Scholar
• Zhang RM, Tang T, Yu HM, et al. LncRNA DLX6-AS1/miR-129-5p/DLK1 axis aggravates stemness of osteosarcoma through Wnt signaling. Biochem Biophys Res Commun. 2018;507(1–4):260–266.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wang X, Zhang L, et al. Wnt/beta-catenin signaling pathway in trophoblasts and abnormal activation in preeclampsia (Review). Mol Med Rep. 2017;16(2):1007–1013.
   PubMed Web of Science ®Google Scholar
• Chinison J, Aguilar JS, Avalos A, et al. Triptonide Effectively Inhibits Wnt/beta-Catenin Signaling via C-terminal transactivation domain of beta-catenin. Sci Rep. 2016;6(1):32779.
   PubMedGoogle Scholar
• Wang Q, Zhou Y, Rychahou P, et al. Deptor is a novel target of Wnt/β-Catenin/c-Myc and contributes to colorectal cancer cell growth. Cancer Res. 2018;78(12):3163–3175.
   PubMed Web of Science ®Google Scholar
• Yong X, Tang B, Xiao YF, et al. Helicobacter pylori upregulates Nanog and Oct4 via Wnt/β-catenin signaling pathway to promote cancer stem cell-like properties in human gastric cancer. Cancer Lett. 2016;374(2):292–303.
   PubMed Web of Science ®Google Scholar