Molecular mechanisms for ABCA1-mediated cholesterol efflux

References

• Yu XH, Fu YC, Zhang DW, et al. Foam cells in atherosclerosis. Clin Chim Acta. 2013;424:245–252.
   PubMed Web of Science ®Google Scholar
• Collaborators GBDRF. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1659–1724.
   PubMed Web of Science ®Google Scholar
• Benn M, Nordestgaard BG, Frikke-Schmidt R, et al. Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: mendelian randomisation study. BMJ. 2017;357:j1648.
   PubMedGoogle Scholar
• Ebara S, Marumo M, Yamabata C, et al. Inverse associations of HDL cholesterol and oxidized HDL with d-dimer in patients with type 2 diabetes mellitus. Thromb Res. 2017;155:12–15.
   PubMed Web of Science ®Google Scholar
• Li G, Gu HM, Zhang DW. ATP-binding cassette transporters and cholesterol translocation. IUBMB Life. 2013;65(6):505–512.
   PubMedGoogle Scholar
• Gao JH, Zeng MY, Yu XH, et al. Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-kappaB/miR-33a pathway in THP-1 macropahge-derived foam cells. Biochem Biophys Res Commun. 2018;500(2):318–324.
   PubMed Web of Science ®Google Scholar
• Kuang HJ, Zhao GJ, Chen WJ, et al. Hsp27 promotes ABCA1 expression and cholesterol efflux through the PI3K/PKCzeta/Sp1 pathway in THP-1 macrophages. Eur J Pharmacol. 2017;810:57–62.
   PubMed Web of Science ®Google Scholar
• Li CH, Gong D, Chen LY, et al. Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. Eur J Pharmacol. 2017;811:74–86.
   PubMed Web of Science ®Google Scholar
• Zhang M, Li L, Xie W, et al. Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation. Atherosclerosis. 2016;248:149–159.
   PubMed Web of Science ®Google Scholar
• Wang H, Liu Y, Zhu L, et al. 17beta-estradiol promotes cholesterol efflux from vascular smooth muscle cells through a liver X receptor alpha-dependent pathway. Int J Mol Med. 2014;33(3):550–558.
   PubMed Web of Science ®Google Scholar
• Santamarina-Fojo S, Peterson K, Knapper C, et al. Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000;97(14):7987–7992.
   PubMed Web of Science ®Google Scholar
• Bungert S, Molday LL, Molday RS. Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites. J Biol Chem. 2001;276(26):23539–23546.
   PubMed Web of Science ®Google Scholar
• Kaminski WE, Piehler A, Wenzel JJ. ABC A-subfamily transporters: structure, function and disease. Biochim Biophys Acta. 2006;1762(5):510–524.
   PubMed Web of Science ®Google Scholar
• Hozoji M, Kimura Y, Kioka N, et al. Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1. J Biol Chem. 2009;284(17):11293–11300.
   PubMed Web of Science ®Google Scholar
• Dean M, Hamon Y, Chimini G. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res. 2001;42(7):1007–1017.
   PubMed Web of Science ®Google Scholar
• Hogue DL, Liu L, Ling V. Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. J Mol Biol. 1999;285(1):379–389.
   PubMed Web of Science ®Google Scholar
• Nagao K, Takahashi K, Azuma Y, et al. ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding. J Lipid Res. 2012;53(1):126–136.
   PubMed Web of Science ®Google Scholar
• Wang N, Chen W, Linsel-Nitschke P, et al. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J Clin Invest. 2003;111(1):99–107.
   PubMed Web of Science ®Google Scholar
• Qian H, Zhao X, Cao P, et al. Structure of the Human Lipid Exporter ABCA1. Cell. 2017;169(7):1228–1239 e1210.
   PubMed Web of Science ®Google Scholar
• van der Velde Ae. Reverse cholesterol transport: from classical view to new insights. World J Gastroenterol. 2010;16(47):5908–5915.
   PubMed Web of Science ®Google Scholar
• Rader DJ, Alexander ET, Weibel GL, et al. The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J Lipid Res. 2009;50:S189–194.
   PubMed Web of Science ®Google Scholar
• Phillips MC. Molecular mechanisms of cellular cholesterol efflux. J Biol Chem. 2014;289(35):24020–24029.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Van Berkel TJ, Van Eck M. Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions. Curr Opin Lipidol. 2010;21(5):441–453.
   PubMed Web of Science ®Google Scholar
• Yancey PG, de la Llera-moya M, Swarnakar S, et al. High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI. J Biol Chem. 2000;275(47):36596–36604.
   PubMed Web of Science ®Google Scholar
• Yu XH, Zhang DW, Zheng XL, et al. Cholesterol transport system: an integrated cholesterol transport model involved in atherosclerosis. Prog Lipid Res. 2019;73:65–91.
   PubMed Web of Science ®Google Scholar
• Adorni MP, Zimetti F, Billheimer JT, et al. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res. 2007;48(11):2453–2462.
   PubMed Web of Science ®Google Scholar
• Oram JF. Tangier disease and ABCA1. Biochim Biophys Acta. 2000;1529(1–3):321–330.
   PubMed Web of Science ®Google Scholar
• van Eck M, Bos IS, Kaminski WE, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A. 2002;99(9):6298–6303.
   PubMed Web of Science ®Google Scholar
• Wang MD, Franklin V, Marcel YL. In vivo reverse cholesterol transport from macrophages lacking ABCA1 expression is impaired. Arterioscler Thromb Vasc Biol. 2007;27(8):1837–1842.
   PubMed Web of Science ®Google Scholar
• Zhao ZW, Zhang M, Chen LY, et al. Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863(8):806–822.
   PubMed Web of Science ®Google Scholar
• Lv YC, Tang YY, Zhang P, et al. Histone methyltransferase enhancer of zeste homolog 2-Mediated ABCA1 promoter DNA methylation contributes to the progression of atherosclerosis. PLoS One. 2016;11(6):e0157265.
   PubMed Web of Science ®Google Scholar
• Lv YC, Tang YY, Peng J, et al. MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1. Atherosclerosis. 2014;236(1):215–226.
   PubMed Web of Science ®Google Scholar
• Tang SL, Zhao ZW, Liu SM, et al. Pregnancy-associated plasma protein-a accelerates atherosclerosis by regulating reverse cholesterol transport and inflammation. Circ J. 2019;83(3):515–523.
   PubMed Web of Science ®Google Scholar
• Van Eck M, Singaraja RR, Ye D, et al. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2006;26(4):929–934.
   PubMed Web of Science ®Google Scholar
• Singaraja RR, Fievet C, Castro G, et al. Increased ABCA1 activity protects against atherosclerosis. J Clin Invest. 2002;110(1):35–42.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhao GJ, Yao F, et al. AIBP reduces atherosclerosis by promoting reverse cholesterol transport and ameliorating inflammation in apoE(-/-) mice. Atherosclerosis. 2018;273:122–130.
   PubMed Web of Science ®Google Scholar
• Lv YC, Yang J, Yao F, et al. Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1. Atherosclerosis. 2015;240(1):80–89.
   PubMed Web of Science ®Google Scholar
• Yvan-Charvet L, Welch C, Pagler TA, et al. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation. 2008;118(18):1837–1847.
   PubMed Web of Science ®Google Scholar
• Stamatikos A, Dronadula N, Ng P, et al. ABCA1 overexpression in endothelial cells in vitro enhances apoai-Mediated cholesterol efflux and decreases inflammation. Hum Gene Ther. 2019;30(2):236–248.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhao GJ, Yin K, et al. Apolipoprotein A-1 binding protein inhibits inflammatory signaling pathways by binding to apolipoprotein a-1 in THP-1 macrophages. Circ J. 2018;82(5):1396–1404.
   PubMed Web of Science ®Google Scholar
• Yin K, Deng X, Mo ZC, et al. Tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I: role of ATP-binding membrane cassette transporter A1 and signal transducer and activator of transcription 3. J Biol Chem. 2011;286(16):13834–13845.
   PubMed Web of Science ®Google Scholar
• Li L, Xu L, Chen W, et al. Reduced annexin a1 secretion by ABCA1 causes retinal inflammation and ganglion cell apoptosis in a murine glaucoma model. Front Cell Neurosci. 2018;12:347.
   PubMed Web of Science ®Google Scholar
• Aguirre-Portoles C, Feliu J, Reglero G, et al. ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin-1-dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone. Mol Oncol. 2018;12(10):1735–1752.
   PubMed Web of Science ®Google Scholar
• Lhermusier T, Severin S, Van Rothem J, et al. ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1. J Thromb Haemost. 2016;14(3):585–595.
   PubMed Web of Science ®Google Scholar
• Lyu J, Imachi H, Fukunaga K, et al. Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells. J Lipid Res. 2018;59(10):1906–1915.
   PubMed Web of Science ®Google Scholar
• Oram JF, Heinecke JW. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol Rev. 2005;85(4):1343–1372.
   PubMed Web of Science ®Google Scholar
• Fielding PE, Nagao K, Hakamata H, et al. A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. Biochemistry. 2000;39(46):14113–14120.
   PubMed Web of Science ®Google Scholar
• Wang N, Silver DL, Thiele C, et al. ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem. 2001;276(26):23742–23747.
   PubMed Web of Science ®Google Scholar
• Chen J, Sharma S, Quiocho FA, et al. Trapping the transition state of an ATP-binding cassette transporter: evidence for a concerted mechanism of maltose transport. Proc Natl Acad Sci U S A. 2001;98(4):1525–1530.
   PubMed Web of Science ®Google Scholar
• Smith JD, Le Goff W, Settle M, et al. ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J Lipid Res. 2004;45(4):635–644.
   PubMed Web of Science ®Google Scholar
• Murata M, Peranen J, Schreiner R, et al. VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci U S A. 1995;92(22):10339–10343.
   PubMed Web of Science ®Google Scholar
• Fielding CJ, Bist A, Fielding PE. Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers. Proc Natl Acad Sci U S A. 1997;94(8):3753–3758.
   PubMed Web of Science ®Google Scholar
• Hailstones D, Sleer LS, Parton RG, et al. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J Lipid Res. 1998;39(2):369–379.
   PubMed Web of Science ®Google Scholar
• Truong TQ, Aubin D, Falstrault L, et al. CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells. Cell Biochem Funct. 2010;28(6):480–489.
   PubMed Web of Science ®Google Scholar
• Fu Y, Hoang A, Escher G, et al. Expression of caveolin-1 enhances cholesterol efflux in hepatic cells. J Biol Chem. 2004;279(14):14140–14146.
   PubMed Web of Science ®Google Scholar
• Hu Q, Zhang XJ, Liu CX, et al. PPARgamma1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice. J Vasc Res. 2010;47(1):69–79.
   PubMed Web of Science ®Google Scholar
• Lin YC, Ma C, Hsu WC, et al. Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cardiovasc Res. 2007;75(3):575–583.
   PubMed Web of Science ®Google Scholar
• Kuo CY, Lin YC, Yang JJ, et al. Interaction abolishment between mutant caveolin-1(Delta 62-100) and ABCA1 reduces HDL-mediated cellular cholesterol efflux. Biochem Biophys Res Commun. 2011;414(2):337–343.
   PubMed Web of Science ®Google Scholar
• Chroni A, Liu T, Fitzgerald ML, et al. Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004;43(7):2126–2139.
   PubMed Web of Science ®Google Scholar
• Fitzgerald ML, Morris AL, Chroni A, et al. ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux. J Lipid Res. 2004;45(2):287–294.
   PubMed Web of Science ®Google Scholar
• Yamauchi Y, Hayashi M, Abe-Dohmae S, et al. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. J Biol Chem. 2003;278(48):47890–47897.
   PubMed Web of Science ®Google Scholar
• Vedhachalam C, Ghering AB, Davidson WS, et al. ABCA1-induced cell surface binding sites for ApoA-I. Arterioscler Thromb Vasc Biol. 2007;27(7):1603–1609.
   PubMed Web of Science ®Google Scholar
• Vedhachalam C, Duong PT, Nickel M, et al. Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 2007;282(34):25123–25130.
   PubMed Web of Science ®Google Scholar
• Lin G, Oram JF. Apolipoprotein binding to protruding membrane domains during removal of excess cellular cholesterol. Atherosclerosis. 2000;149(2):359–370.
   PubMed Web of Science ®Google Scholar
• Iatan I, Bailey D, Ruel I, et al. Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. J Lipid Res. 2011;52(11):2043–2055.
   PubMed Web of Science ®Google Scholar
• Tanaka M, Dhanasekaran P, Nguyen D, et al. Contributions of the N- and C-terminal helical segments to the lipid-free structure and lipid interaction of apolipoprotein A-I. Biochemistry. 2006;45(34):10351–10358.
   PubMed Web of Science ®Google Scholar
• Duong PT, Collins HL, Nickel M, et al. Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. J Lipid Res. 2006;47(4):832–843.
   PubMed Web of Science ®Google Scholar
• Davidson WS, Hazlett T, Mantulin WW, et al. The role of apolipoprotein AI domains in lipid binding. Proc Natl Acad Sci U S A. 1996;93(24):13605–13610.
   PubMed Web of Science ®Google Scholar
• Silva RA, Hilliard GM, Li L, et al. A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins. Biochemistry. 2005;44(24):8600–8607.
   PubMed Web of Science ®Google Scholar
• Wang S, Gulshan K, Brubaker G, et al. ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein. Arterioscler Thromb Vasc Biol. 2013;33(6):1197–1205.
   PubMed Web of Science ®Google Scholar
• Mazhab-Jafari MT, Rohou A, Schmidt C, et al. Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase. Nature. 2016;539(7627):118–122.
   PubMed Web of Science ®Google Scholar
• McGuire C, Stransky L, Cotter K, et al. Regulation of V-ATPase activity. Front Biosci (Landmark Ed). 2017;22(4):609–622.
   PubMedGoogle Scholar
• Xia Y, Liu N, and Xie X, et al. The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion. Autophagy. 2019;15(6):960–975.
   PubMed Web of Science ®Google Scholar
• Rao VK, Zavala G, Deb Roy A, et al. A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells. J Cell Physiol. 2019;234(6):8683–8697.
   PubMed Web of Science ®Google Scholar
• Martins BX, Arruda RF, Costa GA, et al. Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma. Biochim Biophys Acta Gen Subj. 2019;1863:1–12.
   PubMed Web of Science ®Google Scholar
• Fukuda M, Nakano M, Miyazaki M, et al. Conformational change of apolipoprotein A-I and HDL formation from model membranes under intracellular acidic conditions. J Lipid Res. 2008;49(11):2419–2426.
   PubMed Web of Science ®Google Scholar
• Nguyen SD, Oorni K, Lee-Rueckert M, et al. Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells. J Lipid Res. 2012;53(10):2115–2125.
   PubMed Web of Science ®Google Scholar
• Lorkowski SW, Brubaker G, Gulshan K, et al. V-ATPase (vacuolar ATPase) activity required for ABCA1 (ATP-binding cassette protein A1)-Mediated cholesterol efflux. Arterioscler Thromb Vasc Biol. 2018;38(11):2615–2625.
   PubMed Web of Science ®Google Scholar
• Gursky O, Jones MK, Mei X, et al. Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I. J Lipid Res. 2013;54(12):3244–3257.
   PubMed Web of Science ®Google Scholar
• Takahashi Y, Smith JD. Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc Natl Acad Sci U S A. 1999;96(20):11358–11363.
   PubMed Web of Science ®Google Scholar
• Chen W, Sun Y, Welch C, et al. Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem. 2001;276(47):43564–43569.
   PubMed Web of Science ®Google Scholar
• Sorci-Thomas MG, Owen JS, Fulp B, et al. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res. 2012;53(9):1890–1909.
   PubMed Web of Science ®Google Scholar
• Pomorski T, Menon AK. Lipid flippases and their biological functions. Cell Mol Life Sci. 2006;63(24):2908–2921.
   PubMed Web of Science ®Google Scholar
• Mu L, Tu Z, Miao L, et al. A phosphatidylinositol 4,5-bisphosphate redistribution-based sensing mechanism initiates a phagocytosis programing. Nat Commun. 2018;9(1):4259.
   PubMedGoogle Scholar
• Walter AM, Muller R, and Tawfik B, et al. Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. Elife. 2017;6:e30203.
   PubMed Web of Science ®Google Scholar
• Egea-Jimenez AL, Gallardo R, Garcia-Pino A, et al. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Nat Commun. 2016;7(1):12101.
   PubMedGoogle Scholar
• Shi A, Grant BD. Interactions between Rab and Arf GTPases regulate endosomal phosphatidylinositol-4,5-bisphosphate during endocytic recycling. Small GTPases. 2013;4(2):106–109.
   PubMedGoogle Scholar
• Rohrbach TD, Shah N, Jackson WP, et al. The effector domain of marcks is a nuclear localization signal that regulates cellular PIP2 levels and nuclear PIP2 localization. PLoS One. 2015;10(10):e0140870.
   PubMed Web of Science ®Google Scholar
• Gerber PP, Cabrini M, Jancic C, et al. Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate. J Cell Biol. 2015;209(3):435–452.
   PubMed Web of Science ®Google Scholar
• Singaraja RR, Visscher H, James ER, et al. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ Res. 2006;99(4):389–397.
   PubMed Web of Science ®Google Scholar
• Nagao K, Zhao Y, Takahashi K, et al. Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation. J Lipid Res. 2009;50(6):1165–1172.
   PubMed Web of Science ®Google Scholar
• Gulshan K, Brubaker G, Wang S, et al. Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux. J Biol Chem. 2013;288(52):37166–37179.
   PubMed Web of Science ®Google Scholar
• Gulshan K, Brubaker G, Conger H, et al. PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly. Circ Res. 2016;119(7):827–838.
   PubMed Web of Science ®Google Scholar
• Denis M, Haidar B, Marcil M, et al. Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles. J Biol Chem. 2004;279(40):41529–41536.
   PubMed Web of Science ®Google Scholar
• Nagata KO, Nakada C, Kasai RS, et al. ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging. Proc Natl Acad Sci U S A. 2013;110(13):5034–5039.
   PubMed Web of Science ®Google Scholar
• Ishigami M, Ogasawara F, Nagao K, et al. Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation. Sci Rep. 2018;8(1):6170.
   PubMedGoogle Scholar
• Fitzgerald ML, Morris AL, Rhee JS, et al. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002;277(36):33178–33187.
   PubMed Web of Science ®Google Scholar
• Oram JF, Lawn RM, Garvin MR, et al. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages. J Biol Chem. 2000;275(44):34508–34511.
   PubMed Web of Science ®Google Scholar
• Mei X, Atkinson D. Crystal structure of C-terminal truncated apolipoprotein A-I reveals the assembly of high density lipoprotein (HDL) by dimerization. J Biol Chem. 2011;286(44):38570–38582.
   PubMed Web of Science ®Google Scholar
• Liu M, Mei X, Herscovitz H, et al. N-terminal mutation of apoA-I and interaction with ABCA1 reveal mechanisms of nascent HDL biogenesis. J Lipid Res. 2019;60(1):44–57.
   PubMed Web of Science ®Google Scholar
• Rached FH, Chapman MJ, Kontush A. HDL particle subpopulations: focus on biological function. Biofactors. 2015;41(2):67–77.
   PubMed Web of Science ®Google Scholar
• Mulya A, Lee JY, Gebre AK, et al. Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1. Arterioscler Thromb Vasc Biol. 2007;27(8):1828–1836.
   PubMed Web of Science ®Google Scholar
• Gordon DJ, Probstfield JL, Garrison RJ, et al. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation. 1989;79. 8–15.
   PubMed Web of Science ®Google Scholar
• Prospective Studies C, Lewington S, Whitlock G, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370:1829–1839.
   PubMed Web of Science ®Google Scholar
• Du XM, Kim MJ, Hou L, et al. HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export. Circ Res. 2015;116(7):1133–1142.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Zha X, Tabas I, et al. Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. Biophys J. 1998;75(4):1915–1925.
   PubMed Web of Science ®Google Scholar
• Neufeld EB, Remaley AT, Demosky SJ, et al. Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem. 2001;276(29):27584–27590.
   PubMed Web of Science ®Google Scholar
• Schmitz G, Robenek H, Lohmann U, et al. Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages. EMBO J. 1985;4(3):613–622.
   PubMed Web of Science ®Google Scholar
• Azuma Y, Takada M, Shin HW, et al. Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation. Genes Cells. 2009;14(2):191–204.
   PubMed Web of Science ®Google Scholar
• Chen W, Wang N, Tall AR. A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes. J Biol Chem. 2005;280(32):29277–29281.
   PubMed Web of Science ®Google Scholar
• Faulkner LE, Panagotopulos SE, Johnson JD, et al. An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages. J Lipid Res. 2008;49(6):1322–1332.
   PubMed Web of Science ®Google Scholar
• Denis M, Landry YD, Zha X. ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments. J Biol Chem. 2008;283(23):16178–16186.
   PubMed Web of Science ®Google Scholar
• Oram JF. The ins and outs of ABCA. J Lipid Res. 2008;49:1150–1151.
   PubMed Web of Science ®Google Scholar
• Lu R, Arakawa R, Ito-Osumi C, et al. ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation. Arterioscler Thromb Vasc Biol. 2008;28(10):1820–1824.
   PubMed Web of Science ®Google Scholar
• Mukhamedova N, Hoang A, Cui HL, et al. Small GTPase ARF6 regulates endocytic pathway leading to degradation of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2016;36(12):2292–2303.
   PubMed Web of Science ®Google Scholar
• Yu XH, Jiang N, Yao PB, et al. NPC1, intracellular cholesterol trafficking and atherosclerosis. Clin Chim Acta. 2014;429:69–75.
   PubMed Web of Science ®Google Scholar
• Linder MD, Uronen RL, Holtta-Vuori M, et al. Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. Mol Biol Cell. 2007;18(1):47–56.
   PubMed Web of Science ®Google Scholar
• Linder MD, Mayranpaa MI, Peranen J, et al. Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages. Arterioscler Thromb Vasc Biol. 2009;29(6):883–888.
   PubMed Web of Science ®Google Scholar
• Charollais J, Van Der Goot FG. Palmitoylation of membrane proteins (Review). Mol Membr Biol. 2009;26(1–2):55–66.
   PubMed Web of Science ®Google Scholar
• Singaraja RR, Kang MH, Vaid K, et al. Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function. Circ Res. 2009;105(2):138–147.
   PubMed Web of Science ®Google Scholar