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Research Paper

Human pulmonary artery smooth muscle cell dysfunction is regulated by miR-509-5p in hypoxic environment

, , & ORCID Icon
Pages 1212-1221 | Received 15 Apr 2021, Accepted 15 Feb 2022, Published online: 04 Mar 2022

References

  • Zhao M, Chen N, Li X, et al. MiR-19a modulates hypoxia-mediated cell proliferation and migration via repressing PTEN in human pulmonary arterial smooth muscle life. Sci. 2019 Dec 15;239:116928.
  • Deng L, Blanco FJ, Stevens H, et al. MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circ Res. 2015 Oct 23;117(10):870–883.
  • Orriols M, Gomez-Puerto MC, Ten Dijke P. BMP type II receptor as a therapeutic target in pulmonary arterial hypertension. Cell Mol Life Sci. 2017 Aug;74(16):2979–2995.
  • Liu G, Hao P, Xu J, et al. Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN. Respir Res. 2018 Oct 10;19(1):200.
  • Caruso P, Dunmore BJ, Schlosser K, et al. Identification of MicroRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2. Circulation. 2017 Dec 19;136(25):2451–2467.
  • Zhu TT, Zhang WF, Yin YL, et al. MicroRNA-140-5p targeting tumor necrosis factor-α prevents pulmonary arterial hypertension. J Cell Physiol. 2019 Jun;234(6):9535–9550.
  • Guo J, Wu Q, Peng X, et al. miR-509-5p inhibits the proliferation and invasion of osteosarcoma by targeting TRIB2. Biomed Res Int. 2019 Dec 16;2019:2523032.
  • Li X, Li Y, Wan L, et al. miR-509-5p inhibits cellular proliferation and migration via targeting MDM2 in pancreatic cancer cells. Onco Targets Ther. 2017 Sep 11;10:4455–4464.
  • Wang P, Deng Y, Fu X. MiR-509-5p suppresses the proliferation, migration, and invasion of non-small cell lung cancer by targeting YWHAG. Biochem Biophys Res Commun. 2017 Jan 22;482(4):935–941.
  • Ma N, Zhang W, Qiao C, et al. The tumor suppressive role of MiRNA-509-5p by targeting FOXM1 in non-small cell lung cancer. Cell Physiol Biochem. 2016;38(4):1435–1446.
  • Shen H, Zhang J, Wang C, et al. MDM2-mediated ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension. Circulation. 2020 Sep 22;142(12):1190–1204.
  • Gopisetty G, Ramachandran K, Singal R. DNA methylation and apoptosis. Mol Immunol. 2006 Apr;43(11):1729–1740.
  • Hong L, Sun G, Peng L, et al. The interaction between miR-148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer. Oncol Rep. 2018 Nov;40(5):2916–2925.
  • Dakhlallah D, Batte K, Wang Y, et al. Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Feb 15;187(4):397–405.
  • Zhang Y, Xu J. MiR-140-5p regulates hypoxia-mediated human pulmonary artery smooth muscle cell proliferation, apoptosis and differentiation by targeting Dnmt1 and promoting SOD2 expression. Biochem Biophys Res Commun. 2016 Apr 22;473(1):342–348.
  • Ou M, Zhang C, Chen J, et al. Overexpression of MicroRNA-340-5p inhibits pulmonary arterial hypertension induced by APE by downregulating IL-1β and IL-6. Mol Ther Nucleic Acids. 2020 May 22;21:542–554.
  • Le Ribeuz H, Courboulin A, Ghigna MR, et al. In vivo miR-138-5p inhibition alleviates monocrotaline-induced pulmonary hypertension and normalizes pulmonary KCNK3 and SLC45A3 expression. Respir Res. 2020 Jul 16;21(1):186.
  • Sun L, Lin P, Chen Y, et al. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism. Theranostics. 2020 Apr 25;10(12):5581–5599.
  • Li H, Yang Z, Gao F, et al. MicroRNA-17 as a potential diagnostic biomarker in pulmonary arterial hypertension. J Int Med Res. 2020 Jun;48(6):300060520920430.
  • Yang C, Wang Y, Yang W, et al. MiR-509-5p improves the proliferative and invasive abilities of papillary thyroid carcinoma cells by inhibiting SFRP1. Arch Med Sci. 2019 Jul;15(4):968–978.
  • Zhang J, Yang C, Wu C, et al. DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy. Cancers (Basel). 2020 Jul 31;12(8):E2123.
  • Yang L, Luo P, Song Q, et al. DNMT1/miR-200a/GOLM1 signaling pathway regulates lung adenocarcinoma cells proliferation. Biomed Pharmacother. 2018 Mar;99:839–847.
  • Li Y, Li L, Qian Z, et al. Phosphatidylinositol 3-Kinase-DNA methyltransferase 1-miR-1281-histone deacetylase 4 regulatory axis mediates platelet-derived growth factor-induced proliferation and migration of pulmonary artery smooth muscle cells. J Am Heart Assoc. 2018 Mar 7;7(6):e007572.
  • Kim GH, Ryan JJ, Marsboom G, et al. Epigenetic mechanisms of pulmonary hypertension. Pulm Circ. 2011 Jul-Sep;1(3):347–356.

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