287
Views
5
CrossRef citations to date
0
Altmetric
Perspective

Unfolded protein response in endothelial injury

Pages 2009-2012 | Received 29 Apr 2022, Accepted 13 May 2022, Published online: 26 May 2022

References

  • Huppert LA, Matthay MA, Ware LB. Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med. 2019;40(1):31–39.
  • Bos LDJ, Laffey JG, Ware LB, et al. Towards a biological definition of ARDS: are treatable traits the solution? Intensive Care Med Exp. 2022;10(1):8.
  • Landolf KM, Lemieux SM, Rose C, et al. Corticosteroid use in ARDS and its application to evolving therapeutics for coronavirus disease 2019 (COVID-19): a systematic review. Pharmacother. 2022;42(1):71–90.
  • Uddin MA, Barabutis N. P53 in the impaired lungs. DNA Repair (Amst). 2020;95:102952.
  • Kubra KT, Akhter MS, Uddin MA, et al. P53 versus inflammation: an update. Cell Cycle. 2020;19(2):160–162.
  • Barabutis N, Dimitropoulou C, Birmpas C, et al. p53 protects against LPS-induced lung endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015;308(8):L776–787.
  • Barabutis N, Dimitropoulou C, Gregory B, et al. Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition. J Cell Mol Med. 2018;22(3):1792–1804.
  • Uddin MA, Akhter MS, Kubra KT, et al., P53 deficiency potentiates LPS-Induced acute lung injury in vivo.Curr Res Physiol. 2020;3;30–33.
  • Akhter MS, Uddin MA, Barabutis N. P53 regulates the redox status of lung endothelial cells. Inflammation. 2020;43(2):686–691.
  • Uddin MA, Akhter MS, Siejka A, et al. P53 supports endothelial barrier function via APE1/Ref1 suppression. Immunobiology. 2019;224(4):532–538.
  • Uddin MA, Barabutis N. P53: the endothelium defender. J Cell Biochem. 2019;120(7):10952–10955.
  • Kubra KT, Uddin MA, Akhter MS, et al. Hsp90 inhibitors induce the unfolded protein response in bovine and mice lung cells. Cell Signal. 2020;67:109500.
  • Akhter MS, Uddin MA, Schally AV, et al. Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs. J Cell Commun Signal. 2021;15(1):125–129.
  • Uddin MA, Kubra KT, Sonju JJ, et al. Effects of heat shock protein 90 inhibition in the lungs. Med Drug Discov. 2020;6. doi:10.1016/j.medidd.2020.100046.
  • Kubra KT, Uddin MA, Akhter MS, et al. P53 mediates the protective effects of metformin in inflamed lung endothelial cells. Int Immunopharmacol. 2021;101(Pt B):108367.
  • Uddin MA, Akhter MS, Kubra KT, et al. Metformin in acute respiratory distress syndrome: an opinion. Exp Gerontol. 2021;145:111197.
  • Clerico EM, Gierasch LM. There are more Hsp90 chaperone mechanisms in heaven and earth, dear reader, than are dreamt of in your philosophy. Mol Cell. 2022;82(8):1403–1404.
  • Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, et al. Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med. 2007;176(7):667–675.
  • Barabutis N. P53 in acute respiratory distress syndrome. Cell Mol Life Sci. 2020;77(22):4725–4727.
  • Cai R, Zhang X, Wang H, et al. Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity. Peptides. 2022;150:170716.
  • Schally AV, Zhang X, Cai R, et al. Actions and potential therapeutic applications of growth hormone-releasing hormone agonists. Endocrinology. 2019;160(7):1600–1612.
  • Barabutis N. Growth hormone releasing hormone in endothelial barrier function. Trends Endocrinol Metab. 2021;32(6):338–340.
  • Barabutis N, Schally AV. Growth hormone-releasing hormone: extrapituitary effects in physiology and pathology. Cell Cycle. 2010;9(20):4110–4116.
  • Havt A, Schally AV, Halmos G, et al. The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues. Proc Natl Acad Sci USA. 2005;102(48):17424–17429.
  • Barabutis N, Schally AV, Siejka A. P53, GHRH, inflammation and cancer. EBioMedicine. 2018;37:557–562.
  • Zarandi M, Horvath JE, Halmos G, et al. Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone. Proc Natl Acad Sci USA. 1994;91(25):12298–12302.
  • Barabutis N. A glimpse at growth hormone-releasing hormone cosmos. Clin Exp Pharmacol Physiol. 2020;47(9):1632–1634.
  • Akhter MS, Kubra KT, Uddin MA, et al. An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration. Inflamm Res. 2022;71(2):183–185.
  • Antonov A, Snead C, Gorshkov B, et al. Heat shock protein 90 inhibitors protect and restore pulmonary endothelial barrier function. Am J Respir Cell Mol Biol. 2008;39(5):551–559.
  • Chatterjee A, Snead C, Yetik-Anacak G, et al. Heat shock protein 90 inhibitors attenuate LPS-induced endothelial hyperpermeability. Am J Physiol Lung Cell Mol Physiol. 2008;294(4):L755–763.
  • Akhter MS, Uddin MA, Kubra KT, et al. Elucidation of the molecular pathways involved in the protective effects of AUY-922 in LPS-induced inflammation in mouse lungs. Pharmaceuticals (Basel). 2021;14(6):522.
  • Hetz C, Zhang K, Kaufman RJ. Mechanisms, regulation and functions of the unfolded protein response. Nat Rev Mol Cell Biol. 2020;21(8):421–438.
  • Ren J, Bi Y, Sowers JR, et al. Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Nat Rev Cardiol. 2021;18(7):499–521.
  • Diaz-Hung ML, Martinez G, Hetz C. Emerging roles of the unfolded protein response (UPR) in the nervous system: a link with adaptive behavior to environmental stress? Int Rev Cell Mol Biol. 2020;350:29–61.
  • Barabutis N. Unfolded protein response in lung health and disease. Front Med (Lausanne). 2020;7:344.
  • Bartoszewska S, Collawn JF. Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia. Cell Mol Biol Lett. 2020;25:18.
  • Barabutis N. unfolded protein response supports endothelial barrier function. Biochimie. 2019;165:206–209.
  • Blackwood EA, Azizi K, Thuerauf DJ, et al. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun. 2019;10(1):187.
  • Zuehlke AD, Moses MA, Neckers L. Heat shock protein 90: its inhibition and function. Philos Trans R Soc Lond B Biol Sci. 2018;373(1738):20160527.
  • Akhter MS, Kubra KT, Uddin MA, et al. Kifunensine compromises lung endothelial barrier function. Microvasc Res. 2020;132:104051.
  • Kubra KT, Uddin MA, Akhter MS, et al., Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction.Curr Res Toxicol. 2020;1;111–115.
  • Barabutis N. Insights on supporting the aging brain microvascular endothelium. Aging Brain. 2021;1. doi:10.1016/j.nbas.2021.100009.
  • Kubra KT, Barabutis N. Brefeldin A and kifunensine modulate LPS-induced lung endothelial hyperpermeability in human and bovine cells. Am J Physiol Cell Physiol. 2021;321(2):C214–C220.
  • Kubra KT, Uddin MA, Barabutis N. Tunicamycin protects against LPS-induced lung injury. Pharmaceuticals (Basel). 2022;15(2):134.
  • Barabutis N, Akhter MS, Uddin MA, et al. GHRH antagonists protect against hydrogen peroxide-induced breakdown of brain microvascular endothelium integrity. Horm Metab Res. 2020;52(5):336–339.
  • Uddin MA, Akhter MS, Kubra KT, et al. Hsp90 inhibition protects brain endothelial cells against LPS-induced injury. Biofactors. 2022. 10.1002/biof.1833
  • Uddin MA, Akhter MS, Kubra KT, et al. Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress. Brain Disord. 2021;1. doi:10.1016/j.dscb.2020.100001.
  • Wood H. VEGFA mediates blood-brain barrier disruption in Parkinson disease. Nat Rev Neurol. 2022;18(1):1.
  • Akhter MS, Uddin MA, Barabutis N. Unfolded protein response regulates P53 expression in the pulmonary endothelium. J Biochem Mol Toxicol. 2019;33(10):e22380.
  • Barabutis N. Regulation of lung endothelial permeability by NEK kinases. IUBMB Life. 2020;72(4):801–804.
  • Fry AM, O’Regan L, Sabir SR, et al. Cell cycle regulation by the NEK family of protein kinases. J Cell Sci. 2012;125(Pt 19):4423–4433.
  • Moniz L, Dutt P, Haider N, et al. Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div. 2011;6(1):18.
  • Uddin MA, Akhter MS, Kubra KT, et al. Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis. Tissue Barriers. 2021;9(4):1929787.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.