References
- Kronenberg HM. Developmental regulation of the growth plate. Nature. 2003;423:332–336.
- Kozhemyakina E, Lassar AB, Zelzer E. A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation. Development. 2015;142:817–831.
- Xie Y, Zhou S, Chen H, et al. Recent research on the growth plate: advances in fibroblast growth factor signaling in growth plate development and disorders. J Mol Endocrinol. 2014;53:T11–34.
- Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature. 2002;418:935–941.
- Reinke H, Asher G. Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol. 2019;20:227–241.
- Stevenson S, Hunziker EB, Herrmann W, et al. Is longitudinal bone growth influenced by diurnal variation in the mitotic activity of chondrocytes of the growth plate? J Orthop Res. 1990;8:132–135.
- Simmons DJ, Arsenis C, Whitson SW, et al. Mineralization of rat epiphyseal cartilage: a circadian rhythm. Miner Electrolyte Metab. 1983;9:28–37.
- Takarada T, Kodama A, Hotta S, et al. Clock genes influence gene expression in growth plate and endochondral ossification in mice. J Biol Chem. 2012;287:36081–36095.
- Ma Z, Jin X, Qian Z, et al. Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1alpha-VEGF signaling pathway. Cell Cycle. 2019;18:1473–1489.
- Chang C, Loo CS, Zhao X, et al. The nuclear receptor REV-ERBalpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A. 2019;116:18528–18536.
- Pariollaud M, Gibbs JE, Hopwood TW, et al. Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation. J Clin Invest. 2018;128:2281–2296.
- Hunter AL, Pelekanou CE, and Barron NJ, et al. Adipocyte NR1D1 dictates adipose tissue expansion during obesity. eLife. 2021;10:e63324.
- Hunter AL, Pelekanou CE, Adamson A, et al. Nuclear receptor REVERBalpha is a state-dependent regulator of liver energy metabolism. Proc Natl Acad Sci U S A. 2020;117:25869–25879.
- Woldt E, Sebti Y, Solt LA, et al. Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nat Med. 2013;19:1039–1046.
- Gerhart-Hines Z, Feng D, Emmett MJ, et al. The nuclear receptor Rev-erbalpha controls circadian thermogenic plasticity. Nature. 2013;503:410–413.
- Sulli G, Rommel A, Wang X, et al. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018;553:351–355.
- Akagi R, Akatsu Y, Fisch KM, et al. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-beta signaling in chondrocytes. Osteoarthritis Cartilage. 2017;25:943–951.
- Krishnan Y, Grodzinsky AJ. Cartilage diseases. Matrix Biol. 2018;71-72:51–69.
- Song W, Fhu CW, Ang KH, et al. The fetal mouse metatarsal bone explant as a model of angiogenesis. Nat Protoc. 2015;10:1459–1473.
- Kang X, Yang W, Wang R, et al. Sirtuin-1 (SIRT1) stimulates growth-plate chondrogenesis by attenuating the PERK-eIF-2alpha-CHOP pathway in the unfolded protein response. J Biol Chem. 2018;293:8614–8625.
- Gosset M, Berenbaum F, Thirion S, et al. Primary culture and phenotyping of murine chondrocytes. Nat Protoc. 2008;3:1253–1260.
- Atsuta Y, Tomizawa RR, Levin M, et al. L-type voltage-gated Ca(2+) channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592–21601.
- Sinturel F, Petrenko V, Dibner C. Circadian clocks make metabolism run. J Mol Biol. 2020;432:3680–3699.
- Das V, Kc R, Li X, et al. Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain. Gene. 2018;655:1–12.
- Liu H, Zhu Y, Gao Y, et al. NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis. Cell Death Dis. 2020;11:129.
- He Y, Lin F, Chen Y, et al. Overexpression of the circadian clock gene rev-erbalpha affects murine bone mesenchymal stem cell proliferation and osteogenesis. Stem Cells Dev. 2015;24:1194–1204.
- Song C, Tan P, Zhang Z, et al. REV-ERB agonism suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss partially via FABP4 upregulation. FASEB J. 2018;32:3215–3228.
- Murakami S, Balmes G, McKinney S, et al. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev. 2004;18:290–305.
- Matsushita T, Chan YY, Kawanami A, et al. Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol. 2009;29:5843–5857.
- Sebastian A, Matsushita T, Kawanami A, et al. Genetic inactivation of ERK1 and ERK2 in chondrocytes promotes bone growth and enlarges the spinal canal. J Orthop Res. 2011;29:375–379.
- Chen Z, Yue SX, Zhou G, et al. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2015;30:765–774.