Neuroprotective investigation of tanshinone in the cerebral infarction model in the Keap1-Nrf2/ARE pathway

References

• Regenhardt RW, Das AS, Lo EH, et al. Advances in understanding the pathophysiology of lacunar stroke: a review. JAMA Neurol. 2018 Oct 1;75(10):1273–1281. DOI:10.1001/jamaneurol.2018.1073
   PubMed Web of Science ®Google Scholar
• Barantsevich YR, Emanuel YV. Vosstano vlenieposleishemicheskogoinsul’ta v molodomvozraste [Recovery from ischemic stroke at a young age]. ZhNevrolpsikhiatrim S Skorsakova. 2020 Russian;120(2):49–55.
   Google Scholar
• Khaku AS, Tadi P. Cerebrovascular Disease. 2021 Jan 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021Jan. PMID: 28613677.
   Google Scholar
• Diener HC, Hankey GJ. Primary and secondary prevention of ischemic stroke and cerebral hemorrhage: jACC focus seminar. J Am Coll Cardiol. 2020 Apr 21;75(15):1804–1818. DOI:10.1016/j.jacc.2019.12.072
   PubMed Web of Science ®Google Scholar
• Paul S, Candelario-Jalil E. Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies. Exp Neurol. 2021 Jan;335:113518.
   PubMed Web of Science ®Google Scholar
• Hurford R, Sekhar A, Hughes TAT, et al. Diagnosis and management of acute ischaemic stroke. Pract Neurol. 2020 Aug;20(4):304–316.
   PubMedGoogle Scholar
• Dovinova I, Kvandová M, Balis P, et al. The role of Nrf2 and PPARgamma in the improvement of oxidative stress in hypertension and cardiovascular diseases. Physiol Res. 2020 Dec 31;69(Suppl 4):S541–S553. DOI:10.33549/physiolres.934612
   PubMedGoogle Scholar
• Kopacz A, Kloska D, Forman HJ, et al. Beyond repression of Nrf2: an update on Keap1. Free Radic Biol Med. 2020 Sep;157:63–74.
   PubMed Web of Science ®Google Scholar
• Liu J, Xu F, Mohammadtursun N, et al. The analysis of constitutions of traditional ChineSe medicine in relation to cerebral infarction in a Chinese sample. J Altern Complement Med. 2018 May;24(5):458–462.
   PubMed Web of Science ®Google Scholar
• He J, Kwon Y, Li C, et al. Several considerations in using traditional Chinese patent medicine for cerebral infarction. Chin J Integr Med. 2012 Aug;18(8):571–574.
   PubMed Web of Science ®Google Scholar
• Meim XD, Cao YF, Che YY, et al. Danshen: a phytochemical and pharmacological overview. Chin J Nat Med. 2019 Jan;17(1):59–80.
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhang J, Wang C, et al. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model. Int J Immunopathol Pharmacol. 2017 Jun;30(2):123–129.
   PubMed Web of Science ®Google Scholar
• Liu S, Wang K, Duan X, et al. EfficaCy of danshen class injection in the treatment of acute cerebral infarction: a bayesian network meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med. 2019 Feb 3;2019:5814749.
   Google Scholar
• Tang Q, Han R, Xiao H, et al. Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion. Exp Ther Med. 2014 Nov;8(5):1616–1622.
   PubMed Web of Science ®Google Scholar
• Yang G, Wang F, Wang Y, et al. Protective effect of tanshinone IIA on H2O2-induced oxidative stress injury in rat cardiomyocytes by activating Nrf2 pathway. J Recept Signal Transduct Res. 2020 Jun;40(3):264–272.
   PubMed Web of Science ®Google Scholar
• Zhang P, Huang Z, Yan HQ, et al. Improvement of the suture-occluded method in rat models of focal cerebral ischemia-reperfusion. Exp Ther Med. 2014 Mar;7(3):657–662.
   PubMed Web of Science ®Google Scholar
• Liu QS, Zhang WW, Yin XY, et al. [Neuro-Protective effects and mechanism of Terminalia chebula extract HZ4 on cerebral infarction models]. Zhongguo Zhong Yao Za Zhi. 2016 May;41(10):1910–1915. Chinese10.4268/cjcmm20161025
   PubMedGoogle Scholar
• Barth TM, Stanfield BB. The recovery of forelimb-placing behavior in rats with neonatal unilateral cortical damage involves the remaining hemisphere. J Neurosci. 1990 Oct;10(10):3449–3459.
   PubMed Web of Science ®Google Scholar
• van Veluw SJ, Shih AY, Smith EE, et al. Detection, risk factors, and functional consequences of cerebral microinfarcts. Lancet Neurol. 2017 Sep;16(9):730–740. DOI:10.1016/S1474-4422(17)30196-5.
   PubMed Web of Science ®Google Scholar
• Sveinsson OA, Kjartansson O, Em V. Heilablóðþurrð/heiladrep: faraldsfræði, orsakirogeinkenni [Cerebral ischemia/infarction - epidemiology, causes and symptoms]. Laeknabladid. 2014 May;100(5):271–279. Icelandic10.17992/lbl.2014.05.543
   PubMed Web of Science ®Google Scholar
• Zhang Y, Hu Y, Li M, et al. ThE traditional Chinese medicine compound, GRS, alleviates blood-brain barrier dysfunction. Drug Des Devel Ther. 2020 Feb 28;14:933–947.
   PubMed Web of Science ®Google Scholar
• Fei YX, Wang SQ, Yang LJ, et al. Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats. J Ethnopharmacol. 2017 Jul 31;207:57–66. DOI:10.1016/j.jep.2017.06.023.
   PubMed Web of Science ®Google Scholar
• Wang K, Zhang D, Wu J, et al. A comparative study of Danhong injection and Salvia miltiorrhiza injection in the treatment of cerebral infarction: a systematic review and meta-analysis. Medicine (Baltimore). 2017 Jun;96(22):e7079.
   PubMed Web of Science ®Google Scholar
• Gong Z, Pan J, Shen Q, et al. Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury. J Neuroinflammation. 2018 Aug 28;15(1):242. DOI:10.1186/s12974-018-1282-6
   PubMedGoogle Scholar
• Pan G, Zhang H, Zhu A, et al. Treadmill exercise attenuates cerebral ischaemic injury in rats by protecting mitochondrial function via enhancement of caveolin-1. Life Sci. 2021 Jan 1;264:118634. DOI:10.1016/j.lfs.2020.118634.
   PubMed Web of Science ®Google Scholar
• Wang H, Chen S, Zhang Y, et al. Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion. Nitric Oxide. 2019 Oct 1;91:23–34. DOI:10.1016/j.niox.2019.07.004.
   PubMed Web of Science ®Google Scholar
• Huang T, Chen B, Zeng ZM. VEGF-Transfected hBmsCs aggravate early brain edema in cerebral hemorrhage rats. Sichuan Da XueXue Bao Yi Xue Ban. 2020 Sep;51(5):622–629.
   PubMedGoogle Scholar
• Gholamzadeh R, Ramezani F, Tehrani PM, et al. Apelin-13 attenuates injury following ischemic stroke by targeting matrix metalloproteinases (MMP), endothelin- B receptor, occludin/claudin-5 and oxidative stress. J Chem Neuroanat. 2021 Dec;118:102015.
   PubMed Web of Science ®Google Scholar
• Huang Y, Long X, Tang J, et al. The attenuation of traumatic brain injury via inhibition of oxidative stress and apoptosis by tanshinone IIA. Oxid Med Cell Longev. 2020 May 1;2020:4170156.
   Google Scholar
• Wang L, Xiong X, Zhang X, et al. Sodium tanshinone IIA sulfonate protects against cerebral ischemia-reperfusion injury by inhibiting autophagy and inflammation. Neuroscience. 2020 Aug 10;441:46–57. DOI:10.1016/j.neuroscience.2020.05.054.
   PubMed Web of Science ®Google Scholar
• Bellezza I, Giambanco I, Minelli A, et al. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721–733.
   PubMed Web of Science ®Google Scholar
• Baird L, Yamamoto M. ThE molecular mechanisms regulating the KEAP1-NRF2 pathway. Mol Cell Biol. 2020 Jun 15;40(13):20–e00099. DOI:10.1128/MCB.00099-20
   Web of Science ®Google Scholar
• Tu W, Wang H, Li S, et al. The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging Dis. 2019 Jun 1;10(3):637–651. DOI:10.14336/AD.2018.0513
   PubMed Web of Science ®Google Scholar