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Research Paper

Long non-coding RNA FABP5P3/miR-22 axis improves TGFβ1-induced fatty acid oxidation deregulation and fibrotic changes in proximal tubular epithelial cells of renal fibrosis

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References

  • Woodward M, Frank D. Postnatal management of antenatal hydronephrosis. BJU Int. 2002;89:149–156.
  • Ismaili K, Avni FE, Wissing KM, et al. Long-Term clinical outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal ultrasound as a screening tool to detect significant nephrouropathies. J Pediatr. 2004;144:759–765.
  • Shapiro E. Antenatal hydronephrosis: here today, gone tomorrow-one way or another: nYU Case of the Month, May 2017. Rev Urol. 2017;19:138–141.
  • Seseke F, Thelen P, Ringert RH. Characterization of an animal model of spontaneous congenital unilateral obstructive uropathy by cDNA microarray analysis. Eur Urol. 2004;45:374–381.
  • Vielhauer V, Anders HJ, Mack M, et al. Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes. J Am Soc Nephrol. 2001;12:1173–1187.
  • Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382:260–272.
  • Kaissling B, Lehir M, Kriz W. Renal epithelial injury and fibrosis. Biochim Biophys Acta. 2013;1832:931–939.
  • Singh SP, Tao S, Fields TA, et al. Glycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice. Dis Model Mech. 2015;8:931–940.
  • Ito K, Chen J, El Chaar M, et al. Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats. Am J Physiol Renal Physiol. 2004;287:F1283–93.
  • Brosius FC 3rd, Alpers CE, Bottinger EP, et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2009;20:2503–2512.
  • Hodgkins KS, Schnaper HW. Tubulointerstitial injury and the progression of chronic kidney disease. Pediatr Nephrol. 2012;27:901–909.
  • Kapitsinou PP, Haase VH. Molecular mechanisms of ischemic preconditioning in the kidney. Am J Physiol Renal Physiol. 2015;309:F821–34.
  • Bielesz B, Sirin Y, Si H, et al. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest. 2010;120:4040–4054.
  • Bottinger EP, Bitzer M. TGF-Beta signaling in renal disease. J Am Soc Nephrol. 2002;13:2600–2610.
  • DeBerardinis RJ, Thompson CB. Cellular metabolism and disease: what do metabolic outliers teach us? Cell. 2012;148:1132–1144.
  • Susztak K, Ciccone E, McCue P, et al. Multiple metabolic hits converge on CD36 as novel mediator of tubular epithelial apoptosis in diabetic nephropathy. PLoS Med. 2005;2:e45.
  • Schug TT, Li X. Sirtuin 1 in lipid metabolism and obesity. Ann Med. 2011;43:198–211.
  • Tran M, Tam D, Bardia A, et al. PGC-1alpha promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011;121:4003–4014.
  • Bouchard-Mercier A, Rudkowska I, Lemieux S, et al. Polymorphisms in genes involved in fatty acid beta-oxidation interact with dietary fat intakes to modulate the plasma TG response to a fish oil supplementation. Nutrients. 2014;6:1145–1163.
  • Lim D, Chai HH, Lee SH, et al. Gene expression patterns associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the Longissimus dorsi of Hanwoo (Korean Cattle). Asian-Australas J Anim Sci. 2015;28:1075–1083.
  • Hostetler HA, Huang H, Kier AB, et al. Glucose directly links to lipid metabolism through high affinity interaction with peroxisome proliferator-activated receptor alpha. J Biol Chem. 2008;283:2246–2254.
  • Rost TH, Haugan Moi LL, Berge K, et al. A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation. Biochim Biophys Acta. 2009;1791:1076–1083.
  • Mendell JT, Olson EN. MicroRnas in stress signaling and human disease. Cell. 2012;148:1172–1187.
  • Trionfini P, Benigni A, Remuzzi G. MicroRnas in kidney physiology and disease. Nat Rev Nephrol. 2015;11:23–33.
  • Yamamura S, Imai-Sumida M, Tanaka Y, et al. Interaction and cross-talk between non-coding RNAs. Cell Mol Life Sci. 2018;75:467–484.
  • Du Y, Liu P, Chen Z, et al. PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway. J Cell Biochem. 2019;120:17887–17897.
  • Xi Y, Nakajima G, Gavin E, et al. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. Rna. 2007;13:1668–1674.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408.
  • Hills CE, Willars GB, Brunskill NJ. Proinsulin C-peptide antagonizes the pro-fibrotic effects of TGF-beta1 via up-regulation of retinoic acid and HGF-related signaling pathways. Mol Endocrinol. 2010;24:822–831.
  • Casals N, Zammit V, Herrero L, et al. Carnitine palmitoyltransferase 1C: from cognition to cancer. Prog Lipid Res. 2016;61:134–148.
  • Brandt JM, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem. 1998;273:23786–23792.
  • Yu GS, Lu YC, Gulick T. Co-Regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate. J Biol Chem. 1998;273:32901–32909.
  • Westin S, Kurokawa R, Nolte RT, et al. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. Nature. 1998;395:199–202.
  • Smolle E, Haybaeck J. Non-Coding RNAs and lipid metabolism. Int J Mol Sci. 2014;15:13494–13513.
  • Trevisan R, Dodesini AR, Lepore G. Lipids and renal disease. J Am Soc Nephrol. 2006;17:S145–7.
  • Bobulescu IA. Renal lipid metabolism and lipotoxicity. Curr Opin Nephrol Hypertens. 2010;19:393–402.
  • van Herpen NA, Schrauwen-Hinderling VB. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav. 2008;94:231–241.
  • Herman-Edelstein M, Scherzer P, Tobar A, et al. Altered renal lipid metabolism and renal lipid accumulation in human diabetic nephropathy. J Lipid Res. 2014;55:561–572.
  • Kang HM, Ahn SH, Choi P, et al. Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Nat Med. 2015;21:37–46.
  • Kume S, Uzu T, Araki S, et al. Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. J Am Soc Nephrol. 2007;18:2715–2723.
  • Chung KW, Lee EK, Lee MK, et al. Impairment of PPARalpha and the fatty acid oxidation pathway aggravates renal fibrosis during aging. J Am Soc Nephrol. 2018;29:1223–1237.
  • van Solingen C, Scacalossi KR, Moore KJ. Long non-coding RNAs in lipid metabolism. Curr Opin Lipidol. 2018;29:224–232.
  • Yan C, Chen J, Chen N. Long non-coding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci Rep. 2016;6:22640.
  • Liu C, Yang Z, Wu J, et al. Long non-coding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis. Hepatology. 2018;67:1768–1783.
  • Halley P, Kadakkuzha BM, Faghihi MA, et al. Regulation of the apolipoprotein gene cluster by a long non-coding RNA. Cell Rep. 2014;6:222–230.
  • Cui M, Xiao Z, Wang Y, et al. Long non-coding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res. 2015;75:846–857.
  • Sallam T, Jones M, Thomas BJ, et al. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long non-coding RNA. Nat Med. 2018;24:304–312.
  • Ulitsky I, Bartel DP. lincRnas: genomics, evolution, and mechanisms. Cell. 2013;154:26–46.
  • Koufaris C, Valbuena GN, Pomyen Y, et al. Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells. Oncogene. 2016;35:2766–2776.
  • Pant K, Yadav AK, Gupta P, et al. Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. Redox Biol. 2017;12:340–349.

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