Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction

References

• Golledge J. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nature Reviews Cardiology. 2019;16(4):225–242.
   PubMed Web of Science ®Google Scholar
• Chang Z, Zhao G, Zhao Y, et al. Baf60a deficiency in vascular smooth muscle cells prevents abdominal aortic aneurysm by reducing inflammation and extracellular matrix degradation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020;40(10):2494–2507. DOI:10.1161/ATVBAHA.120.314955.
   PubMed Web of Science ®Google Scholar
• Nordon IM, Hinchliffe RJ, Loftus IM, et al. Pathophysiology and epidemiology of abdominal aortic aneurysms. Nature Reviews Cardiology. 2011;8(2):92–102.
   PubMed Web of Science ®Google Scholar
• Bernal S, Lopez-Sanz L, Jimenez-Castilla L, et al. Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm. British Journal of Pharmacology. 2021;178(3):564–581. DOI:10.1111/bph.15330.
   PubMed Web of Science ®Google Scholar
• Yang H, Zhou T, Sorenson CM, et al. Myeloid-derived TSP1 (Thrombospondin-1) contributes to abdominal aortic aneurysm through suppressing tissue inhibitor of metalloproteinases-1. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020;40(12):e350–e66.
   PubMed Web of Science ®Google Scholar
• Chiang MT, Chen IM, Hsu FF, et al. Gal-1 (Galectin-1) upregulation contributes to abdominal aortic aneurysm progression by enhancing vascular inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021;41(1):331–345. DOI:10.1161/ATVBAHA.120.315398.
   PubMed Web of Science ®Google Scholar
• Kokot M, Biolik G, Ziaja D, et al. Endothelium injury and inflammatory state during abdominal aortic aneurysm surgery: scrutinizing the very early and minute injurious effects using endothelial markers – a pilot study. Archives of Medical Science : AMS. 2013;3(3):479–486. DOI:10.5114/aoms.2013.34412.
   Google Scholar
• Peng H, Zhang K, Liu Z, et al. VPO1 modulates vascular smooth muscle cell phenotypic switch by activating extracellular signal-regulated kinase 1/2 (ERK 1/2) in abdominal aortic aneurysms. Journal of the American Heart Association. 2018;7(17):e010069. DOI:10.1161/JAHA.118.010069.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zou G, Chen X, et al. Knockdown of lncRNA PVT1 inhibits vascular smooth muscle cell apoptosis and extracellular matrix disruption in a murine abdominal aortic aneurysm model. Molecules and Cells. 2019;42(3):218–227. DOI:10.14348/molcells.2018.0162.
   PubMed Web of Science ®Google Scholar
• Li P, Zhu N, Yi B, et al. MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circulation Research. 2013;113(10):1117–1127. DOI:10.1161/CIRCRESAHA.113.301306.
   PubMed Web of Science ®Google Scholar
• Okabe T, Takeda S, Akada S, et al. Postoperative intensive care unit drug fever caused by dexmedetomidine. Anesthesia and Analgesia. 2009;108(5):1589–1591.
   PubMed Web of Science ®Google Scholar
• Wen W, Gong X, Cheung H, et al. Dexmedetomidine alleviates microglia-induced spinal inflammation and hyperalgesia in neonatal rats by systemic lipopolysaccharide exposure. Frontiers in Cellular Neuroscience. 2021;15:725267.
   PubMed Web of Science ®Google Scholar
• Wang X, Liu Q. Dexmedetomidine relieved neuropathic pain and inflammation response induced by CCI through HMGB1/TLR4/NF-κB signal pathway. Biological & Pharmaceutical Bulletin. 2021. DOI:10.1248/bpb.b21-00329
   Google Scholar
• Yang YF, Peng K, Liu H, et al. Dexmedetomidine preconditioning for myocardial protection in Ischaemia-reperfusion injury in rats by downregulation of the high mobility group box 1-toll-like receptor 4-nuclear factor κB signalling pathway. Clinical and Experimental Pharmacology & Physiology. 2017;44(3):353–361.
   PubMed Web of Science ®Google Scholar
• Lai CH, Wang KC, Lee FT, et al. Toll-like receptor 4 is essential in the development of abdominal aortic aneurysm. PloS One. 2016;11(1):e0146565. DOI:10.1371/journal.pone.0146565.
   PubMed Web of Science ®Google Scholar
• Renfeng Q, Shuxiao C, Peixian G, et al. ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model. Molecular Medicine Reports. 2021;24(5). DOI:10.3892/mmr.2021.12414.
   PubMed Web of Science ®Google Scholar
• Yu Q, Li Q, Yang X, et al. Dexmedetomidine suppresses the development of abdominal aortic aneurysm by downregulating the mircoRNA‑21/PDCD 4 axis. International Journal of Molecular Medicine. 2021;47(5). DOI:10.3892/ijmm.2021.4923.
   Web of Science ®Google Scholar
• Zhou XY, Liu J, Xu ZP, et al. Dexmedetomidine inhibits the lipopolysaccharide-stimulated inflammatory response in microglia through the pathway involving TLR4 and NF-κB. The Kaohsiung Journal of Medical Sciences. 2019;35(12):750–756.
   PubMed Web of Science ®Google Scholar
• Liu F, Zhu S, Ni L, et al. Dexmedetomidine alleviates insulin resistance in hepatocytes by reducing endoplasmic reticulum stress. Endocrine. 2020;67(1):87–94.
   PubMed Web of Science ®Google Scholar
• Chen G, Xu Y, Yao Y, et al. IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway. Experimental and Therapeutic Medicine. 2021;22(4):1051. DOI:10.3892/etm.2021.10485.
   PubMed Web of Science ®Google Scholar
• Wu G, Chen T, Shahsafaei A, et al. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010;121(11):1338–1346. DOI:10.1161/CIRCULATIONAHA.108.844589.
   PubMed Web of Science ®Google Scholar
• Tao L, Guo X, Xu M, et al. Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice. Pharmacology Research & Perspectives. 2021;9(1):e00700. DOI:10.1002/prp2.700.
   PubMed Web of Science ®Google Scholar
• Shi J, Yu T, Song K, et al. Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/ho-1 signaling pathway. Redox Biology. 2021;41:101954.
   PubMed Web of Science ®Google Scholar
• Fukuda D, Enomoto S, Nagai R, et al. Inhibition of renin-angiotensin system attenuates periadventitial inflammation and reduces atherosclerotic lesion formation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2009;63(10):754–761.
   PubMed Web of Science ®Google Scholar
• Bruemmer D, Daugherty A, Lu H, et al. Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms. Annals of the New York Academy of Sciences. 2011;1245:7–10.
   PubMed Web of Science ®Google Scholar
• Lu H, Rateri DL, Bruemmer D, et al. Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms. Clinical Science (London, England : 1979). 2012;123(9):531–543.
   PubMed Web of Science ®Google Scholar
• Lai CH, Shi GY, Lee FT, et al. Recombinant human thrombomodulin suppresses experimental abdominal aortic aneurysms induced by calcium chloride in mice. Annals of Surgery. 2013;258(6):1103–1110. DOI:10.1097/SLA.0b013e31827df7cb.
   PubMed Web of Science ®Google Scholar
• Wang KC, Li YH, Shi GY, et al. Membrane-bound thrombomodulin regulates macrophage inflammation in abdominal aortic aneurysm. Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35(11):2412–2422. DOI:10.1161/ATVBAHA.115.305529.
   PubMed Web of Science ®Google Scholar
• Guo B, Chen C, Yang L, et al. Effects of dexmedetomidine on postoperative cognitive function of sleep deprivation rats based on changes in inflammatory response. Bioengineered. 2021;12(1):7920–7928.
   PubMed Web of Science ®Google Scholar
• Marchesi C, Paradis P, Schiffrin EL. Role of the renin-angiotensin system in vascular inflammation. Trends in Pharmacological Sciences. 2008;29(7):367–374.
   PubMed Web of Science ®Google Scholar
• Chang Y, Wei W. Angiotensin II in inflammation, immunity and rheumatoid arthritis. Clinical and Experimental Immunology. 2015;179(2):137–145.
   PubMed Web of Science ®Google Scholar
• Qin X, He L, Tian M, et al. Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. Journal of Molecular and Cellular Cardiology. 2019;132:49–59.
   PubMed Web of Science ®Google Scholar
• Moxon JV, Parr A, Emeto TI, et al. Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects. Current Problems in Cardiology. 2010;35(10):512–548.
   PubMed Web of Science ®Google Scholar
• Schurgers LJ, Akbulut AC, Kaczor DM, et al. Initiation and propagation of vascular calcification is regulated by a concert of platelet- and smooth muscle cell-derived extracellular vesicles. Frontiers in Cardiovascular Medicine. 2018;5:36.
   PubMed Web of Science ®Google Scholar
• Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiological Reviews. 2004;84(3):767–801.
   PubMed Web of Science ®Google Scholar
• Qi S, Li C, Kong X, et al. Dexmedetomidine suppresses oxidative stress and inflammation of nucleus pulposus cells by activating the PI3K/Akt signaling pathway. Die Pharmazie. 2020;75(10):505–509.
   PubMed Web of Science ®Google Scholar
• Franck G, Dai J, Fifre A, et al. Reestablishment of the endothelial lining by endothelial cell therapy stabilizes experimental abdominal aortic aneurysms. Circulation. 2013;127(18):1877–1887. DOI:10.1161/CIRCULATIONAHA.113.001677.
   PubMed Web of Science ®Google Scholar
• Sun J, Deng H, Zhou Z, et al. Endothelium as a potential target for treatment of abdominal aortic aneurysm. Oxidative Medicine and Cellular Longevity. 2018;2018:6306542.
   PubMed Web of Science ®Google Scholar
• Godo S, Shimokawa H. Endothelial Functions. Arteriosclerosis, thrombosis, and vascular biology. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37(9):e108–e14.
   PubMed Web of Science ®Google Scholar
• Zhao G, Chang Z, Zhao Y, et al. KLF11 protects against abdominal aortic aneurysm through inhibition of endothelial cell dysfunction. JCI Insight. 2021;6(5). DOI:10.1172/jci.insight.141673.
   Web of Science ®Google Scholar
• Bao Y, Zhu Y, He G, et al. Dexmedetomidine attenuates neuroinflammation in LPS-stimulated BV2 microglia cells through upregulation of miR-340. Drug Design, Development and Therapy. 2019;13:3465–3475.
   PubMed Web of Science ®Google Scholar
• He Y, Yang Z, Li J, et al. Dexmedetomidine reduces the inflammation and apoptosis of doxorubicin-induced myocardial cells. Experimental and Molecular Pathology. 2020;113:104371.
   PubMed Web of Science ®Google Scholar
• Zhou S, Lu S, Guo S, et al. Protective effect of ginsenoside Rb1 nanoparticles against contrast-induced nephropathy by inhibiting high mobility group box 1 Gene/toll-like receptor 4/NF-κB signaling pathway. Journal of Biomedical Nanotechnology. 2021;17(10):2085–2098.
   PubMed Web of Science ®Google Scholar
• Lu JM, Jin GN, Lu YN, et al. Resveratrol modulates Toxoplasma gondii infection induced liver injury by intervening in the HMGB1/TLR4/NF-κB signaling pathway. European Journal of Pharmacology. 2021;910:174497.
   PubMed Web of Science ®Google Scholar
• Abdelmageed ME, Nader MA, Zaghloul MS. Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats. European Journal of Pharmacology. 2021;906:174279.
   PubMed Web of Science ®Google Scholar
• Ortiz-Espinosa S, Morales X, Senent Y, et al. Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis. Cancer Letters. 2022;529:70–84.
   PubMed Web of Science ®Google Scholar
• Xu T, Wang S, Li X, et al. Lithium chloride represses abdominal aortic aneurysm via regulating GSK3β/SIRT1/NF-κB signaling pathway. Free Radical Biology & Medicine. 2021;166:1–10.
   PubMed Web of Science ®Google Scholar
• Gendy AM, Elnagar MR, Allam MM, et al. Berberine-loaded nanostructured lipid carriers mitigate warm hepatic ischemia/reperfusion-induced lesion through modulation of HMGB1/TLR4/NF-κB signaling and autophagy. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2022;145:112122.
   PubMed Web of Science ®Google Scholar
• Zhai Y, Zhu Y, Liu J, et al. Dexmedetomidine post-conditioning alleviates cerebral Ischemia-reperfusion injury in rats by inhibiting high mobility group protein B1 Group (Hmgb1)/toll-like receptor 4 (Tlr4)/nuclear factor kappa B (NF-κB) signaling pathway. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 2020;26:e918617.
   PubMed Web of Science ®Google Scholar
• Liu J, Zhang S, Fan X, et al. Dexmedetomidine preconditioning ameliorates inflammation and blood-spinal cord barrier damage after spinal cord Ischemia-reperfusion injury by down-regulation high mobility group box 1-toll-like receptor 4-nuclear factor κB signaling pathway. Spine. 2019;44(2):E74–e81.
   PubMed Web of Science ®Google Scholar