References
- Siddiqui Z, Acevedo-Jake AM, Griffith A, et al. Cells and material-based strategies for regenerative endodontics[J]. Bioactive Materials. 2022.
- Morsczeck C. Cellular senescence in dental pulp stem cells. Arch Oral Biol. 2019;99:150–155.
- Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011;192(4):547–556.
- Yi Q, Liu O, Yan F, et al. Analysis of senescence-related differentiation potentials and gene expression profiles in human dental pulp stem cells. Cells Tissues Organs. 2017;203(1):1–11. DOI:10.1159/000448026
- Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun. 1993;425(3):548–555. 2012: 10.1016/j.bbrc.2012.08.022.
- Garayoa M, Bodegas E, Cuttitta F, et al. Adrenomedullin in mammalian embryogenesis. Microsc Res Tech. 2002;57(1):40–54.
- Bełtowski J, Jamroz A. Adrenomedullin–what do we know 10 years since its discovery. Pol J Pharmacol. 2004;56(1):5–27.
- Martínez A, Elsasser TH, Muro-Cacho C, et al. Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument. Endocrinology. 1997;138(12):5597–5604. DOI:10.1210/endo.138.12.5622
- Zudaire E, Cuttitta F, Martínez A. Regulation of pancreatic physiology by adrenomedullin and its binding protein. Regul Pept. 2003;112(1–3):121–130.
- Zhu Q, Tian G, Tang Z, et al. Adrenomedullin promotes the proliferation and inhibits apoptosis of dental pulp stem cells involved in divergence pathways. J Endod. 2016;42(9):1347–1354.
- Shukla GC, Singh J, Barik S. MicroRnas: processing, Maturation, Target Recognition and Regulatory Functions. Mol Cell Pharmacol. 2011;3(3):83–92.
- Harries LW. MicroRnas as mediators of the ageing process. Genes (Basel). 2014;5(3):656–670.
- Chang YO, Park S, Jang HO, et al. FK866 protects human dental pulp cells against oxidative stress-induced cellular senescence. Antioxidants. 2021;10(2):271.
- Park S, Bak KJ, Chang YO, et al. Melatonin rescues human dental pulp cells from premature senescence induced by HO. 2017.
- Beck J, Horikawa I, Harris C. Cellular senescence: mechanisms, morphology, and mouse models. Vet Pathol. 2020;57(6):747–757.
- Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010;464(7288):520–528.
- Kumari R, Jat P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol. 2021;9:645593.
- Rossi M, Abdelmohsen K. The emergence of senescent surface biomarkers as senotherapeutic targets. Cells. 2021;10(7):1740.
- Zheng Y, Hu CJ, Zhuo RH, et al. Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term culture. Mol Med Rep. 2014;10(6):3003–3008.
- Kamal S, Junaid M, Ejaz A, et al. The secrets of telomerase: retrospective analysis and future prospects. Life Sci. 2020;257:118115.
- Liu X, Wan M. A tale of the good and bad: cell senescence in bone homeostasis and disease. Int Rev Cell Mol Biol. 2019;346:97–128.
- Rovillain E, Mansfield L, Lord CJ, et al. An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence. BMC Genomics. 2011;12(1):355.
- Jenkins NC, Liu T, Cassidy P, et al. The p16(ink4a) tumor suppressor regulates cellular oxidative stress. Oncogene. 2011;30(3):265–274. DOI:10.1038/onc.2010.419
- Magenta A, Cencioni C, Fasanaro P, et al. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ. 2011;18(10):1628–1639. DOI:10.1038/cdd.2011.42
- Chistiakov DA, Sobenin IA, Revin VV, et al. Mitochondrial aging and age-related dysfunction of mitochondria. Biomed Res Int. 2014;2014:238463.
- De Gaetano A, Gibellini L, Zanini G, et al. Mitophagy and oxidative stress: the role of aging. Antioxidants (Basel). 2021;10(5):794.
- Liguori I, Russo G, Curcio F, et al. Oxidative stress, aging, and diseases. Clin Interv Aging. 2018;13:757–772.
- Hu W, Shi L, Li MY, et al. Adrenomedullin protects Leydig cells against lipopolysaccharide-induced oxidative stress and inflammatory reaction via MAPK/NF-κB signalling pathways. Sci Rep. 2017;7(1):16479. DOI:10.1038/s41598-017-16008-x
- Huang J, Wang Y, Guo Y, et al. Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1. Hepatology. 2010;52(1):60–70.
- Mancini M, Saintigny G, Mahé C, et al. MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix. Aging (Albany NY). 2012;4(11):843–853.
- Gu S, Ran S, Liu B, et al. miR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression. FEBS Lett. 2016;590(8):1123–1131.
- Blanchard JM. Cyclin A2 transcriptional regulation: modulation of cell cycle control at the G1/S transition by peripheral cues. Biochem Pharmacol. 2000;60(8):1179–1184.
- Gopinathan L, Tan SL, Padmakumar VC, et al. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res. 2014;74(14):3870–3879.
- Xu S, Wu W, Huang H, et al. The p53/miRnas/Ccna2 pathway serves as a novel regulator of cellular senescence: complement of the canonical p53/p21 pathway. Aging Cell. 2019;18(3):e12918. DOI:10.1111/acel.12918