The role of FOXO1-mediated autophagy in the regulation of bone formation

References

• Suzuki A, Minamide M, Iwaya C, et al. Role of metabolism in bone development and homeostasis. Int J Mol Sci. 2020 Nov 26;21(23):8992. DOI:10.3390/ijms21238992
   PubMed Web of Science ®Google Scholar
• Datta HK, Ng WF, Walker JA, et al. The cell biology of bone metabolism. J Clin Pathol. 2008 May;61(5):577–587. DOI:10.1136/jcp.2007.048868
   PubMed Web of Science ®Google Scholar
• Yu L, Chen Y, Tooze SA. Autophagy pathway: cellular and molecular mechanisms. Autophagy. 2018;14(2):207–215.
   PubMed Web of Science ®Google Scholar
• Ravanan P, Srikumar IF, Talwar P. Autophagy: the spotlight for cellular stress responses. Life Sci. 2017 Nov 1;188:53–67. DOI:10.1016/j.lfs.2017.08.029
   PubMed Web of Science ®Google Scholar
• Zhang L, Guo YF, Liu YZ, et al. Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD. J Bone Miner Res. 2010 Jul;25(7):1572–1580. DOI:10.1002/jbmr.36
   PubMed Web of Science ®Google Scholar
• Nollet M, Santucci-Darmanin S, Breuil V, et al. Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy. 2014;10(11):1965–1977. DOI:10.4161/auto.36182
   PubMed Web of Science ®Google Scholar
• DeSelm CJ, Miller BC, Zou W, et al. Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev cell. 2011 Nov 15;21(5):966–974.
   PubMed Web of Science ®Google Scholar
• Chen D, Gong Y, Xu L, et al. Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of forkhead transcription factors in mammalian MSCs. Cell Proliferation. 2019 Mar;52(2):e12540.
   PubMed Web of Science ®Google Scholar
• Nakae J, Kitamura T, Kitamura Y, et al. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev cell. 2003 Jan;4(1):119–129.
   PubMed Web of Science ®Google Scholar
• Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29;423(6939):550–555. DOI:10.1038/nature01667
   PubMed Web of Science ®Google Scholar
• Peng S, Li W, Hou N, et al. A review of FoxO1-regulated metabolic diseases and related drug discoveries. Cells. 2020 Jan 10;9(1):184. DOI:10.3390/cells9010184
   PubMed Web of Science ®Google Scholar
• Xing YQ, Li A, Yang Y, et al. The regulation of FOXO1 and its role in disease progression. Life Sci. 2018 Jan 15;193:124–131. DOI:10.1016/j.lfs.2017.11.030
   PubMed Web of Science ®Google Scholar
• Teixeira CC, Liu Y, Thant LM, et al. Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem. 2010 Oct 1;285(40):31055–31065. DOI:10.1074/jbc.M109.079962
   PubMed Web of Science ®Google Scholar
• Ambrogini E, Almeida M, Martin-Millan M, et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 3;11(2):136–146.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xiong Y, Zhou J, et al. FoxO1 expression in osteoblasts modulates bone formation through resistance to oxidative stress in mice. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1401–1408. DOI:10.1016/j.bbrc.2018.07.055
   PubMed Web of Science ®Google Scholar
• Matsuzaki T, Alvarez-Garcia O, Mokuda S, et al. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Sci, trans med. 2018 Feb 14;10(428). DOI:10.1126/scitranslmed.aan0746
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhang Y, Xin N, et al. 1alpha,25-Dihydroxyvitamin D3 promotes bone formation by promoting nuclear exclusion of the FoxO1 transcription factor in diabetic mice. J Biol Chem. 2017 Dec 8;292(49):20270–20280. DOI:10.1074/jbc.M117.796367
   PubMed Web of Science ®Google Scholar
• Lin NY, Chen CW, Kagwiria R, et al. Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss. Ann Rheumatic Dis. 2016 Jun;75(6):1203–1210. DOI:10.1136/annrheumdis-2015-207240
   PubMed Web of Science ®Google Scholar
• Liu K, Guo C, Lao Y, et al. A fine-tuning mechanism underlying self-control for autophagy: deSumoylation of BECN1 by SENP3. Autophagy. 2020 Jun;16(6):975–990.
   PubMed Web of Science ®Google Scholar
• Levine B, Liu R, Dong X, et al. Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol. 2015 Sep;25(9):533–544.
   PubMed Web of Science ®Google Scholar
• Schaaf MB, Keulers TG, Vooijs MA, et al. LC3/GABARAP family proteins: autophagy-(un)related functions. FASEB J. 2016 Dec;30(12):3961–3978. DOI:10.1096/fj.201600698R
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010 Feb 5;140(3):313–326.
   PubMed Web of Science ®Google Scholar
• Komori T. Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell tissue res. 2010 Jan;339(1):189–195. DOI:10.1007/s00441-009-0832-8
   PubMed Web of Science ®Google Scholar
• Siqueira MF, Flowers S, Bhattacharya R, et al. FOXO1 modulates osteoblast differentiation. Bone. 2011 May 1;48(5):1043–1051. DOI:10.1016/j.bone.2011.01.019
   PubMed Web of Science ®Google Scholar
• Iyer S, Han L, Ambrogini E, et al. Deletion of FoxO1, 3, and 4 in osteoblast progenitors attenuates the loss of cancellous bone mass in a mouse model of type 1 diabetes. J Bone Miner Res. 2017 Jan;32(1):60–69. DOI:10.1002/jbmr.2934
   PubMed Web of Science ®Google Scholar
• Kim HN, Iyer S, Ring R, et al. The role of FoxOs in bone health and disease. Curr Top Dev Biol. 2018;127:149–163.
   PubMed Web of Science ®Google Scholar
• Wang S, Deng Z, Ma Y, et al. The role of autophagy and mitophagy in bone metabolic disorders. Int J Biol Sci. 2020;16(14):2675–2691.
   PubMed Web of Science ®Google Scholar
• Liu Z, Li T, Zhu F, et al. Regulatory roles of miR-22/redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury. Cell Death Amp Dis. 2019 Mar 7;10(3):227. DOI:10.1038/s41419-019-1373-z
   PubMedGoogle Scholar
• Ma Y, Qi M, An Y, et al. Autophagy controls mesenchymal stem cell properties and senescence during bone aging. Aging Cell. 2018 Feb;17(1). DOI:10.1111/acel.12709
   Web of Science ®Google Scholar
• Xiao L, Xiao Y. The autophagy in osteoimmonology: self-eating, maintenance, and beyond. Front Endocrinol (Lausanne). 2019;10:490.
   PubMed Web of Science ®Google Scholar
• Yun HR, Jo YH, Kim J, et al. Roles of autophagy in oxidative stress. Int J Mol Sci. 2020 May 6;21(9). DOI:10.3390/ijms21093289
   Web of Science ®Google Scholar
• Hariharan N, Maejima Y, Nakae J, et al. Deacetylation of FoxO by sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ Res. 2010 Dec 10;107(12):1470–1482. DOI:10.1161/circresaha.110.227371
   PubMed Web of Science ®Google Scholar
• Lin Q, Fan C, Gomez-Arroyo J, et al. HIMF (Hypoxia-induced mitogenic factor) signaling mediates the HMGB1 (high mobility group box 1)-dependent endothelial and smooth muscle cell crosstalk in pulmonary hypertension. Arteriosclerosis Thrombosis Vasc Biol. 2019 Dec;39(12):2505–2519. DOI:10.1161/atvbaha.119.312907
   PubMed Web of Science ®Google Scholar
• Cheng Z. The FoxO-autophagy axis in health and disease. Trends Endocrinol Metab. 2019 Sep;30(9):658–671. DOI:10.1016/j.tem.2019.07.009
   PubMed Web of Science ®Google Scholar
• Wang S, Xia P, Huang G, et al. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nat Commun. 2016 Mar 24;7:11023. DOI:10.1038/ncomms11023
   PubMed Web of Science ®Google Scholar
• Ohsumi Y, Mizushima N. Two ubiquitin-like conjugation systems essential for autophagy. Sem in Cell Develop Biolog. 2004 Apr;15(2):231–236. DOI:10.1016/j.semcdb.2003.12.004
   PubMed Web of Science ®Google Scholar
• Shen M, Cao Y, Jiang Y, et al. Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: implication of an antioxidation-independent mechanism. Redox Biol. 2018 Sep;18:138–157. DOI:10.1016/j.redox.2018.07.004
   PubMedGoogle Scholar