Telomere dynamics in human pluripotent stem cells

References

• Chan SW, Blackburn EH. New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene. 2002;21(4):553–563. PubMed PMID: 11850780. doi: 10.1038/sj.onc.1205082
   PubMed Web of Science ®Google Scholar
• de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005;19(18):2100–2110. PubMed PMID: 16166375. doi: 10.1101/gad.1346005
   PubMed Web of Science ®Google Scholar
• Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science. 1995;269(5230):1533–1534. PubMed PMID: 7545310. doi: 10.1126/science.7545310
   PubMed Web of Science ®Google Scholar
• Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985;43(2 Pt 1):405–413. PubMed PMID: 3907856. doi: 10.1016/0092-8674(85)90170-9
   PubMed Web of Science ®Google Scholar
• Dunham MA, Neumann AA, Fasching CL, et al. Telomere maintenance by recombination in human cells. Nat Genet. 2000;26(4):447–450. PubMed PMID: 11101843. doi: 10.1038/82586
   PubMed Web of Science ®Google Scholar
• Blasco MA. Telomere length, stem cells and aging. Nat Chem Biol. 2007;3(10):640–649. PubMed PMID: 17876321. doi: 10.1038/nchembio.2007.38
   PubMed Web of Science ®Google Scholar
• Armanios M, Greider CW. Telomerase and cancer stem cells. Cold Spring Harb Symp Quant Biol. 2005;70:205–208. PubMed PMID: 16869755. doi: 10.1101/sqb.2005.70.030
   PubMedGoogle Scholar
• Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature. 1990;345(6274):458–460. PubMed PMID: 2342578. doi: 10.1038/345458a0
   PubMed Web of Science ®Google Scholar
• Fumagalli M, Rossiello F, Clerici M, et al. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol. 2012;14(4):355–365. PubMed PMID: 22426077; PubMed Central PMCID: PMCPMC3717580. doi: 10.1038/ncb2466
   PubMed Web of Science ®Google Scholar
• Martinez P, Blasco MA. Telomere-driven diseases and telomere-targeting therapies. J Cell Bio. 2017;216(4):875–887. PubMed PMID: 28254828; PubMed Central PMCID: PMCPMC5379954. doi: 10.1083/jcb.201610111
   PubMed Web of Science ®Google Scholar
• Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012;13(10):693–704. PubMed PMID: 22965356; PubMed Central PMCID: PMCPMC3548426. doi: 10.1038/nrg3246
   PubMed Web of Science ®Google Scholar
• Wong JM, Collins K. Telomere maintenance and disease. Lancet. 2003;362(9388):983–988. PubMed PMID: 14511933. doi: 10.1016/S0140-6736(03)14369-3
   PubMed Web of Science ®Google Scholar
• Tomas-Loba A, Flores I, Fernandez-Marcos PJ, et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell. 2008;135(4):609–622. PubMed PMID: 19013273. doi: 10.1016/j.cell.2008.09.034
   PubMed Web of Science ®Google Scholar
• Bernardes de Jesus B, Vera E, Schneeberger K, et al. Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med. 2012;4(8):691–704. PubMed PMID: 22585399; PubMed Central PMCID: PMCPMC3494070. doi: 10.1002/emmm.201200245
   PubMed Web of Science ®Google Scholar
• Garcia-Cao M, O’Sullivan R, Peters AH, et al. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet. 2004;36(1):94–99. PubMed PMID: 14702045. doi: 10.1038/ng1278
   PubMed Web of Science ®Google Scholar
• Benetti R, Gonzalo S, Jaco I, et al. Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Bio. 2007;178(6):925–936. PubMed PMID: 17846168; PubMed Central PMCID: PMCPMC2064618. doi: 10.1083/jcb.200703081
   PubMed Web of Science ®Google Scholar
• Blasco MA. The epigenetic regulation of mammalian telomeres. Nat Rev Genet. 2007;8(4):299–309. PubMed PMID: 17363977. doi: 10.1038/nrg2047
   PubMed Web of Science ®Google Scholar
• Gonzalo S, Jaco I, Fraga MF, et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol. 2006;8(4):416–424. PubMed PMID: 16565708. doi: 10.1038/ncb1386
   PubMed Web of Science ®Google Scholar
• Schoeftner S, Blasco MA. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat Cell Biol. 2008;10(2):228–236. PubMed PMID: 18157120. doi: 10.1038/ncb1685
   PubMed Web of Science ®Google Scholar
• Azzalin CM, Reichenbach P, Khoriauli L, et al. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science. 2007;318(5851):798–801. PubMed PMID: 17916692. doi: 10.1126/science.1147182
   PubMed Web of Science ®Google Scholar
• Montero JJ, Lopez-Silanes I, Megias D, et al. TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin. Nat Commun. 2018;9(1):1548. PubMed PMID: 29670078; PubMed Central PMCID: PMCPMC5906467. doi: 10.1038/s41467-018-03916-3
   PubMedGoogle Scholar
• Liu L, Bailey SM, Okuka M, et al. Telomere lengthening early in development. Nat Cell Biol. 2007;9(12):1436–1441. PubMed PMID: 17982445. doi: 10.1038/ncb1664
   PubMed Web of Science ®Google Scholar
• Schaetzlein S, Lucas-Hahn A, Lemme E, et al. Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A. 2004;101(21):8034–8038. PubMed PMID: 15148368; PubMed Central PMCID: PMCPMC419552. doi: 10.1073/pnas.0402400101
   PubMed Web of Science ®Google Scholar
• Varela E, Schneider RP, Ortega S, et al. Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells. Proc Natl Acad Sci U S A. 2011;108(37):15207–15212. PubMed PMID: 21873233; PubMed Central PMCID: PMCPMC3174656. doi: 10.1073/pnas.1105414108
   PubMed Web of Science ®Google Scholar
• Varela E, Munoz-Lorente MA, Tejera AM, et al. Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations. Nat Commun. 2016;7:11739. PubMed PMID: 27252083; PubMed Central PMCID: PMCPMC4895768. doi: 10.1038/ncomms11739
   PubMed Web of Science ®Google Scholar
• Marion RM, Strati K, Li H, et al. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell. 2009;4(2):141–154. PubMed PMID: 19200803. doi: 10.1016/j.stem.2008.12.010
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663–676. PubMed PMID: 16904174. doi: 10.1016/j.cell.2006.07.024
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861–872. PubMed PMID: 18035408. doi: 10.1016/j.cell.2007.11.019
   PubMed Web of Science ®Google Scholar
• Marion RM, Strati K, Li H, et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature. 2009;460(7259):1149–1153. PubMed PMID: 19668189; PubMed Central PMCID: PMCPMC3624089. doi: 10.1038/nature08287
   PubMed Web of Science ®Google Scholar
• Huang J, Wang F, Okuka M, et al. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res. 2011;21(5):779–792. PubMed PMID: 21283131; PubMed Central PMCID: PMCPMC3203670. doi: 10.1038/cr.2011.16
   PubMed Web of Science ®Google Scholar
• Munoz-Lorente MA, Cano-Martin AC, Blasco MA. Mice with hyper-long telomeres show less metabolic aging and longer lifespans. Nat Commun. 2019;10(1):4723. PubMed PMID: 31624261; PubMed Central PMCID: PMCPMC6797762. doi: 10.1038/s41467-019-12664-x
   PubMedGoogle Scholar
• Yehezkel S, Rebibo-Sabbah A, Segev Y, et al. Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives. Epigenetics. 2011;6(1):63–75. PubMed PMID: 20861676; PubMed Central PMCID: PMCPMC3052915. doi: 10.4161/epi.6.1.13390
   PubMed Web of Science ®Google Scholar
• Liu L. Linking Telomere Regulation to Stem Cell Pluripotency. Trends Genet. 2017;33(1):16–33. PubMed PMID: 27889084. doi: 10.1016/j.tig.2016.10.007
   PubMed Web of Science ®Google Scholar
• Schneider RP, Garrobo I, Foronda M, et al. TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells. Nat Commun. 2013;4:1946. doi: 10.1038/ncomms2946. PubMed PMID: 23735977.
   Google Scholar
• Marion RM, Montero JJ, Lopez de Silanes I, et al. TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2. Elife. 2019;8. PubMed PMID: 31426913; PubMed Central PMCID: PMCPMC6701927. doi: 10.7554/eLife.44656
   Web of Science ®Google Scholar
• Zeng S, Liu L, Sun Y, et al. Telomerase-mediated telomere elongation from human blastocysts to embryonic stem cells. J Cell Sci. 2014;127(Pt 4):752–762. PubMed PMID: 24338368. doi: 10.1242/jcs.131433
   PubMed Web of Science ®Google Scholar
• Draper JS, Smith K, Gokhale P, et al. Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol. 2004;22(1):53–54. PubMed PMID: 14661028. doi: 10.1038/nbt922
   PubMed Web of Science ®Google Scholar
• I AK, Andrews PW, Anyfantis G, et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011;29(12):1132–1144. PubMed PMID: 22119741; PubMed Central PMCID: PMCPMC3454460. doi:10.1038/nbt.2051
   PubMed Web of Science ®Google Scholar
• Mender I, Gryaznov S, Dikmen ZG, et al. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2’-deoxyguanosine. Cancer Discov. 2015;5(1):82–95. PubMed PMID: 25516420; PubMed Central PMCID: PMCPMC4293221. doi: 10.1158/2159-8290.CD-14-0609
   PubMed Web of Science ®Google Scholar
• Winkler T, Hong SG, Decker JE, et al. Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPscs. J Clin Invest. 2013;123(5):1952–1963. PubMed PMID: 23585473; PubMed Central PMCID: PMCPMC3635755. doi: 10.1172/JCI67146
   PubMed Web of Science ®Google Scholar
• Batista LF, Pech MF, Zhong FL, et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 2011;474(7351):399–402. PubMed PMID: 21602826; PubMed Central PMCID: PMCPMC3155806. doi: 10.1038/nature10084
   PubMed Web of Science ®Google Scholar
• Wang H, Zhang K, Liu Y, et al. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017;15(1):114. PubMed PMID: 29216888; PubMed Central PMCID: PMCPMC5721592. doi: 10.1186/s12915-017-0453-8
   PubMedGoogle Scholar
• Liu CC, Ma DL, Yan TD, et al. Distinct responses of stem cells to telomere uncapping-A potential strategy to improve the safety of cell therapy. Stem Cells. 2016;34(10):2471–2484. PubMed PMID: 27299710. doi: 10.1002/stem.2431
   PubMed Web of Science ®Google Scholar
• Li H, Collado M, Villasante A, et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature. 2009;460(7259):1136–1139. PubMed PMID: 19668188; PubMed Central PMCID: PMCPMC3578184. doi: 10.1038/nature08290
   PubMed Web of Science ®Google Scholar
• Blasco MA, Lee HW, Hande MP, et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997;91(1):25–34. PubMed PMID: 9335332. doi: 10.1016/s0092-8674(01)80006-4
   PubMed Web of Science ®Google Scholar