65
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

PSMC2 knockdown exerts an anti-tumor role in nasopharyngeal carcinoma through regulating AKT signaling pathway

, , &
Pages 2381-2391 | Received 13 Jun 2022, Accepted 05 Dec 2023, Published online: 20 Dec 2023

References

  • Brennan B. Nasopharyngeal carcinoma. Orphanet J Rare Dis. 2006 Jun 26;1(1):23. doi: 10.1186/1750-1172-1-23
  • Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005 Jun 11-17;365(9476):2041–2054. doi: 10.1016/S0140-6736(05)66698-6
  • Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1765–1777. doi: 10.1158/1055-9965.EPI-06-0353
  • Cai LM, Lyu XM, Luo WR, et al. EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN. Oncogene. 2015 Apr 23;34(17):2156–2166. doi: 10.1038/onc.2014.341
  • Chua MLK, Wee JTS, Hui EP, et al. Nasopharyngeal carcinoma. Lancet. 2016 Mar 5;387(10022):1012–1024. doi: 10.1016/S0140-6736(15)00055-0
  • Wang X, Dong C, Sun L, et al. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep. 2016 Nov 18;6(1):37443. doi: 10.1038/srep37443
  • Nijhawan D, Zack TI, Ren Y, et al. Cancer vulnerabilities unveiled by genomic loss. Cell. 2012 Aug 17;150(4):842–854. doi: 10.1016/j.cell.2012.07.023
  • He J, Xing J, Yang X, et al. Silencing of proteasome 26S subunit ATPase 2 regulates colorectal cancer cell proliferation, apoptosis, and migration. Chemotherapy. 2019;64(3):146–154. doi: 10.1159/000502224
  • Song M, Wang Y, Zhang Z, et al. PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration. Oncotarget. 2017 Jan 3;8(1):933–953. doi: 10.18632/oncotarget.13511
  • Qin J, Wang W, An F, et al. PSMC2 is up-regulated in pancreatic cancer and promotes cancer cell proliferation and inhibits apoptosis. J Cancer. 2019;10(20):4939–4946. doi: 10.7150/jca.27616
  • Cui F, Wang Y, Wang J. et al. The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice. Proteomics. 2006 Jan;6(2):498–504.
  • Retraction: microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1. Biosci Rep. 2021 Sep 30;41(9). 10.1042/BSR-20182196_RET
  • Fan X, Xie X, Yang M, et al. YBX3 mediates the metastasis of nasopharyngeal carcinoma via PI3K/AKT signaling. Front Oncol. 2021;11:617621. doi: 10.3389/fonc.2021.617621
  • Lin X, Bi Z, Hu Q, et al. TSPAN8 serves as a prognostic marker involving Akt/MAPK pathway in nasopharyngeal carcinoma. Ann Transl Med. 2019 Sep;7(18):470.
  • Yang Y, Qi F, Wei C, et al. PSMC2 knockdown suppressed tumor progression of skin cutaneous melanoma. Cell Death Discov. 2021 Oct 29;7(1):323. doi: 10.1038/s41420-021-00727-2
  • Duan X, Li H, Wang M, et al. PSMC2/ITGA6 axis plays critical role in the development and progression of hepatocellular carcinoma. Cell Death Discov. 2021 Aug 19;7(1):217. doi: 10.1038/s41420-021-00585-y
  • Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020 Jul;17(7):395–417. doi: 10.1038/s41571-020-0341-y
  • Xue Y, Morris JL, Yang K, et al. SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca(2+) flux to mitochondria. Nat Commun. 2021 Sep 13;12(1):5404. doi: 10.1038/s41467-021-25260-9
  • Korsmeyer SJ. BCL-2 gene family and the regulation of programmed cell death. Cancer Res. 1999 Apr 1;59(7 Suppl):1693s–1700s
  • Kim EM, Jung CH, Song JY, et al. Pro-apoptotic Bax promotes mesenchymal-epithelial transition by binding to respiratory complex-I and antagonizing the malignant actions of pro-survival Bcl-2 proteins. Cancer Lett. 2018 Jun 28;424:127–135. doi: 10.1016/j.canlet.2018.03.033
  • Kim EM, Jung CH, Kim J, et al. The p53/p21 complex regulates cancer cell invasion and apoptosis by Targeting Bcl-2 family proteins. Cancer Res. 2017 Jun 1;77(11):3092–3100. doi: 10.1158/0008-5472.CAN-16-2098
  • Wu LZ, Huang ML, Qi CL, et al. Overexpression of Notch2 enhances radiosensitivity via inhibition of the AKT/mTOR signaling pathway in nasopharyngeal carcinoma. Bioengineered. 2021 Dec;12(1):3398–3409.
  • Qi CL, Huang ML, Zou Y, et al. The IRF2/CENP-N/AKT signaling axis promotes proliferation, cell cycling and apoptosis resistance in nasopharyngeal carcinoma cells by increasing aerobic glycolysis. J Exp Clin Cancer Res. 2021 Dec 10;40(1):390. doi: 10.1186/s13046-021-02191-3
  • Xie Z, Li W, Ai J, et al. C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway. J Transl Med. 2022 Jun 8;20(1):264. doi: 10.1186/s12967-022-03446-z
  • Wang Y, Sun J, Yao N. Correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognosis of nasopharyngeal carcinoma. Eur J Histochem. 2021 Nov 16;65(4). doi: 10.4081/ejh.2021.3304
  • Zou Y, Yang R, Huang ML, et al. NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2019 Nov 7;38(1):456. doi: 10.1186/s13046-019-1463-x
  • Xie H, Wang Y, Ding Y, et al. Global ubiquitome profiling revealed the roles of Ubiquitinated proteins in metabolic pathways of tea leaves in responding to drought stress. Sci Rep. 2019 Mar 12;9(1):4286. doi: 10.1038/s41598-019-41041-3

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.