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Original Articles

The Anatomy and Biomechanics of Acute and Chronic Whiplash Injury

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Pages 101-112 | Received 12 Oct 2008, Accepted 02 Nov 2008, Published online: 07 Apr 2009

REFERENCES

  • Aldman , B . . An Analytical Approach to the Impact Biomechanics of Head and Neck Injury . Proc. 30th Annual AAAM . pp. 446 – 454 .
  • Anderson , J S , Hsu , A W and Vasavada , A N . 2005 . Morphology, Architecture and Biomechanics of Human Cervical Multifidus Muscles . Spine , Vol. 30 : E86 – E91 .
  • Aprill , C and Bogduk , N . 1992 . The Prevalence of Cervical Zygapophyseal Joint Pain: A First Approximation . Spine , Vol. 17 : 744 – 747 .
  • Banic , B , Petersen-Felix , S , Andersen , O , Radanov , B , Villiger , P , Arendt-Nielsen , L and Curatolo , M . 2004 . Evidence for Spinal Cord Hypersensitivity in Chronic Pain after Whiplash Injury and in Fibromyalgia . Pain , Vol. 107 : 7 – 15 .
  • Barnsley , L , Lord , S and Bogduk , N . 1993 . Comparative Local Anaesthetic Blocks in the Diagnosis of Cervical Zygapophyseal Joint Pain . Pain , Vol. 55 : 99 – 106 .
  • Barnsley , L , Lord , S and Bogduk , N . 1994 . Whiplash Injury . Pain , Vol. 58 : 283 – 307 .
  • Barton , J W and Margolis , M T . 1975 . Rotational Obstructions of the Vertebral Artery at the Atlantoaxial Joint . Neuroradiology , Vol. 9 : 117 – 120 .
  • Binder , A . 2007 . The Diagnosis and Treatment of Nonspecific Neck Pain and Whiplash . Eura Medicophys. , Vol. 43 : 79 – 89 .
  • Bogduk , N and Marsland , A . 1988 . The Cervical Zygapophyseal Joints as a Source of Neck Pain . Spine , Vol. 13 : 610 – 617 .
  • Boström , O , Fredriksson , R , Håland , Y , Jakobsson , L , Krafft , M , Lövsund , P , Muser , M H and Svensson , M Y . 2000 . Comparison of Car Seats in Low Speed Rear-end Impacts Using the BioRID Dummy and the New Neck Injury Criterion (NIC) . Accid. Anal. Prev. , Vol. 32 : 321 – 328 .
  • Boyd-Clark , L C , Briggs , C A and Galea , M P . 2002 . Muscle Spindle Distribution, Morphology, and Density in Longus Colli and Multifidus Muscles of the Cervical Spine . Spine , Vol. 27 : 694 – 701 .
  • Brault , J R , Siegmund , G P and Wheeler , J B . 2000 . Cervical Muscle Response during Whiplash: Evidence of a Lengthening Muscle Contraction . Clin. Biomech. , Vol. 15 : 426 – 435 .
  • Carlson , E J , Tominaga , Y , Ivancic , P C and Panjabi , M M . 2007 . Dynamic Vertebral Artery Elongation during Frontal and Side Impacts . Spine J. , Vol. 7 : 222 – 228 .
  • Carter , J W , Mirza , S K , Tencer , A F and Ching , R P . 2000 . Canal Geometry Changes Associated with Axial Compressive Cervical Spine Fracture . Spine , Vol. 25 : 46 – 54 .
  • Cassidy , J D , Carroll , L J , Côté , P , Lemstra , M , Berglund , A and Nygren , A . 2000 . Effect of Eliminating Compensation for Pain and Suffering on the Outcome of Insurance Claims for Whiplash Injury . N. Engl. J. Med. , Vol. 342 : 1179 – 1186 .
  • Cavanaugh , J M . 2000 . “ Neurophysiology and Neuroanatomy of Neck Pain ” . In Frontiers in Whiplash Trauma: Clinical and Biomechanical , Edited by: Yoganandan , N. and Pintar , F. A. 79 – 96 . Amsterdam : IOS Press .
  • Cavanaugh , J M , el-Bohy , A A , Hardy , W N , Getchell , T V , Getchell , M L and King , A I . 1989 . Sensory Innervation of Soft Tissues of the Lumbar Spine in the Rat . J. Orthop. Res. , Vol. 7 : 278 – 288 .
  • Chopard , R P , de Miranda Neto , M H , Lucas , G A and Chopard , M R . 1992 . The Vertebral Artery: Its Relationship with Adjoining Tissues in its Course Intra and Inter Transverse Processes in Man . Rev. Paul Med. , Vol. 110 : 245 – 250 .
  • Chung , Y S and Han , D H . 2002 . Vertebrobasilar Dissection: A Possible Role of Whiplash Injury in its Pathogenesis . Neurol. Res. , Vol. 24 : 129 – 138 .
  • Curatolo , M , Petersen-Felix , S , Arendt-Nielsen , L , Giana , C , Zbinden , A M and Radanov , B P . 2001 . Central Hypersensitivity in Chronic Pain after Whiplash Injury . Clin. J. Pain , Vol. 17 : 306 – 315 .
  • Cusick , J F , Pintar , F A and Yoganandan , N . 2001 . Whiplash Syndrome: Kinematic Factors Influencing Pain Patterns . Spine , Vol. 26 : 1252 – 1258 .
  • Davis , J M and Zimmerman , R A . 1983 . Injury of the Carotid and Vertebral Arteries . Neuroradiology , Vol. 25 : 55 – 69 .
  • DeLeo , J A and Yezierski , R P . 2001 . The Role of Neuroinflammation and Neuroimmune Activation in Persistent Pain . Pain , Vol. 90 : 1 – 6 .
  • Dobrin , P B . 1978 . Mechanical Properties of Arteries . Physiol. Rev. , Vol. 58 : 397 – 460 .
  • Dong , L , Odeleye , A , Akay , C , Jordan-Sciutto , K and Winkelstein , B A . 2008 . Painful Facet Joint Injury Induces Neuronal Stress Activation in the DRG: Implications for Cellular Mechanisms of Pain . Neurosci. Lett. , Vol. 443 : 90 – 94 .
  • Dvorak , J , Schneider , E , Saldinger , P and Rahn , B . 1988 . Biomechanics of the Craniocervical Region: The Alar and Transverse Ligaments . J. Orthop. Res. , Vol. 6 : 452 – 461 .
  • Eichberger , A , Darok , M , Steffan , H , Leinzinger , P E , Boström , O and Svensson , M Y . 2000 . Pressure Measurements in the Spinal Canal of Post-mortem Human Subjects During Rear-end Impact and Correlation of Results to the Neck Injury Criterion . Accid. Anal. Prev. , Vol. 32 : 251 – 260 .
  • Elert , J E , Rantepaa-Dahlqvist , S B , Henriksson-Larsen , K , Lorentzon , R and Gerdle , B UC . 1992 . Muscle Performance, Electromyography and Fibre Type Composition in Fibromyalgia and Work-Related Myalgia . Scand. J. Rheumatol. , Vol. 21 : 28 – 34 .
  • Evans , R W . 1992 . Some Observations on Whiplash Injuries . Neurol. Clin. , Vol. 10 : 975 – 997 .
  • Evans , W J , Meredith , C N , Cannon , J G , Dinarello , C A , Frontera , W R , Hughes , V A , Jones , B H and Knuttgen , H G . 1986 . Metabolic Changes Following Eccentric Exercise in Trained and Untrained Men . J. Appl. Physiol. , Vol. 61 : 1864 – 1868 .
  • Falla , D , Bilenkij , G and Jull , G . 2004 . Patients with Chronic Neck Pain Demonstrate Altered Patterns of Muscle Activation during Performance of a Functional Upper Limb Task . Spine , Vol. 29 : 1436 – 1440 .
  • Farmer , C M , Wells , J K and Lund , A K . 2003 . Effects of Head Restraint and Seat Redesign on Neck Injury Risk in Rear-end Crashes . Traffic Inj. Prev. , Vol. 4 : 83 – 90 .
  • Ferrari , R and Schrader , H . 2001 . The late whiplash syndrome: a biopsychosocial approach . J. Neurol. Neurosurg. Psychiatry , Vol. 70 : 722 – 726 .
  • Freund , B J and Schwartz , M . 2002 . Use of Botulinum Toxin in Chronic Whiplash-Associated disorder . Clin. J. Pain , Vol. 18 : S163 – S168 .
  • Giles , L GF and Harvey , A R . 1987 . Immunohistochemical Demonstration of Nociceptors in the Capsule and Synovial Folds of Human Zygapophyseal Joints . Br. J. Rheumatol. , Vol. 26 : 362 – 364 .
  • Gray , H. 1977 . Gray's Anatomy , New York : Gramercy Books .
  • Greening , J , Dilley , A L and Lynn , B . 2005 . In vivo Study of Nerve Movement and Mechanosensitivity of the Median Nerve in Whiplash and Non-specific Arm Pain Patients . Pain , Vol. 115 : 248 – 253 .
  • Hartwig , E , Kettler , A , Schultheiss , M , Kinzl , L , Claes , L and Wilke , H J . 2004 . In vitro Low-Speed Side Collisions Cause Injury to the Lower Cervical Spine but Do Not Damage Alar Ligaments . Eur. Spine J. , Vol. 13 : 590 – 597 .
  • Howe , J F , Loeser , J D and Calvin , W H . 1977 . Mechanosensitivity of Dorsal Root Ganglia and Chronically Injured Axons: A Physiological Basis for the Radicular Pain of Nerve Root Compression . Pain , Vol. 3 : 25 – 41 .
  • Hubbard , R and Winkelstein , B . 2005 . Transient Cervical Nerve Root Compression in the Rat Induces Bilateral Forepaw Allodynia and Spinal Glial Activation: Mechanical Factors in Painful Neck Injuries . Spine , Vol. 30 : 1924 – 1932 .
  • Hubbard , R D , Chen , Z and Winkelstein , B A . 2008 . Transient Cervical Nerve Root Compression Modulates Pain: Load Thresholds for Allodynia and Sustained Changes in Spinal Neuropeptide Expression . J. Biomech. , Vol. 41 : 677 – 685 .
  • Hubbard , R D and Winkelstein , B A . 2008 . Nerve Root Compression Produces Axonal Degeneration Dependent on Biomechanical Thresholds for Mechanical Allodynia . Exp. Neurol. , Vol. 212 : 482 – 489 .
  • Inami , S , Shiga , T , Tsujino , A , Yabuki , T , Okado , N and Ochiai , N . 2001 . Immunohistochemical Demonstration of Nerve Fibers in the Synovial Fold of the Human Cervical Facet Joint . J. Orthop. Res. , Vol. 19 : 593 – 596 .
  • Ito , S , Ivancic , P C , Panjabi , M M and Cunningham , B W . 2004 . Soft Tissue Injury Threshold during Simulated Whiplash: A Biomechanical Investigation . Spine , Vol. 29 : 979 – 987 .
  • Ito , S , Ivancic , P C , Pearson , A M , Tominaga , Y , Gimenez , S E , Rubin , W and Panjabi , M M . 2005 . Cervical Intervertebral Disc Injury during Simulated Frontal Impact . Eur. Spine J. , Vol. 14 : 356 – 365 .
  • Ivancic , P C , Ito , S , Tominaga , Y , Carlson , E J , Rubin , W and Panjabi , M M . 2006 . Effect of Rotated Head Posture on Dynamic Vertebral Artery Elongation during Simulated Rear Impact . Clin. Biomech. , Vol. 21 : 213 – 220 .
  • Ivancic , P C , Panjabi , M M , Ito , S , Cripton , P A and Wang , J L . 2005 . Biofidelic Whole Cervical Spine Model with Muscle Force Replication for Whiplash Simulation . Eur. Spine J. , Vol. 14 : 346 – 355 .
  • Ivancic , P C , Pearson , A M , Panjabi , M M and Ito , S . 2004 . Injury of the Anterior Longitudinal Ligament during Whiplash Simulation . Eur. Spine J. , Vol. 13 : 61 – 68 .
  • Jakobsson , L and Norin , H . . AIS1 Neck Injury Reducing Effect of WHIPS (Whiplash Protection System) . Proc. IRCOBI Conference on Biomechanics of Impacts . pp. 297 – 305 .
  • Johansson , H and Sojka , P . 1991 . Pathophysiological Mechanisms Involved in Genesis and Spread of Muscular Tension in Occupational Muscle Pain and in Chronic Musculoskeletal Pain Syndromes: A Hypothesis . Med. Hypotheses , Vol. 35 : 196 – 203 .
  • Jonsson , H , Bring , G , Rauschning , W and Sahlstedt , B . 1991 . Hidden Cervical Spine Injuries in Traffic Accident Victims with Skull Fractures . J. Spinal Disord. , Vol. 4 : 251 – 263 .
  • Kaale , B R , Krakenes , J , Albrektsen , G and Wester , K . 2005a . Head Position and Impact Direction in Whiplash Injuries: Associations with MRI-Verified Lesions of Ligaments and Membranes in the Upper Cervical Spine . J. Neurotrauma , Vol. 22 : 1294 – 1302 .
  • Kaale , B R , Krakenes , J , Albrektsen , G and Wester , K . 2005b . Whiplash-Associated Disorders Impairment Rating: Neck Disability Index Score According to Severity of MRI Findings of Ligaments and Membranes in the Upper Cervical Spine . J. Neurotrauma , Vol. 22 : 466 – 475 .
  • Kallakuri , S , Singh , A , Chen , C and Cavanaugh , J M . 2004 . Demonstration of Substance P, Calcitonin-Gene-Related Peptide, and Protein Gene Product 9.5 Containing Nerve Fibers in Human Cervical Facet Joint Capsules . Spine , Vol. 29 : 1182 – 1186 .
  • Kamibayashi , L K and Richmond , F JR . 1998 . Morphometry of Human Neck Muscles . Spine , Vol. 23 : 1314 – 1323 .
  • Kaneoka , K , Ono , K , Inami , S and Hayashi , K . 1999 . Motion Analysis of Cervical Vertebrae during Simulated Whiplash Loading . Spine , Vol. 24 : 763 – 770 .
  • Kasch , H , Stengaard-Pedersen , K , Arendt-Nielsen , L and Staehelin Jensen , T . 2001a . Pain Thresholds and Tenderness in Neck and Head Following Acute Whiplash Injury: A Prospective Study . Cephalgia , Vol. 21 : 189 – 197 .
  • Kasch , H , Stengaard-Pederson , K , Arendt-Nielsen , L and Staehelin Jensen , T . 2001b . Headache, Neck Pain, and Neck Mobility after Acute Whiplash Injury: A Prospective Study . Spine , Vol. 26 : 1246 – 1251 .
  • Koelbaek Johansen , M , Graven-Nielsen , T , Schou Olesen , A and Arendt-Nielsen , L . 1999 . Generalised Muscular Hyperalgesia in Chronic Whiplash Syndrome . Pain , Vol. 83 : 229 – 234 .
  • Krafft , M , Kullgren , A , Lie , A and Tingvall , C . 2003 . Utvärdering av Whiplashskydd vid Påkörning Bakifrån—Verkliga Olyckor och Krockprov [Evaluation of Whiplash Protection Systems in Rearend Collisions—Real-life Crashes and Crash Tests] , Stockholm, , Sweden : Folksam and SRA . Folksam Research, SE-10660
  • Krakenes , J and Kaale , B R . 2006 . Magnetic Resonance Imaging Assessment of Craniovertebral Ligaments and Membranes after Whiplash Trauma . Spine , Vol. 31 : 2820 – 2826 .
  • Krivickas , L S and Wilbourn , A J . 2000 . Peripheral Nerve Injuries in Athletes: A Case Series of over 200 Injuries . Semin. Neurol. , Vol. 20 : 225 – 232 .
  • Lang , J . 1993 . Clinical Anatomy of the Cervical Spine , New York : Thieme Medical Publishers .
  • Lee , K , Thinnes , J , Gokhin , D and Winkelstein , B . 2004 . A Novel Rodent Neck Pain Model of Facet-Mediated Behavioral Hypersensitivity: Implications for Persistent Pain and Whiplash Injury . J. Neurosci. Meth. , Vol. 137 : 151 – 159 .
  • Lee , K E , Davis , M B , Mejilla , R M and Winkelstein , B A . 2004 . In vivo Cervical Facet Capsule Distraction: Mechanical Implications for Whiplash and Neck Pain . Stapp Car Crash J. , Vol. 48 : 373 – 393 .
  • Lee , K E , Davis , M B and Winkelstein , B A . 2008 . Capsular Ligament Involvement in the Development of Mechanical Allodynia Following Facet Joint Distraction: Behavioral & Inflammatory Outcomes in a Rodent Model of Pain . J. Neurotrauma , Vol. 25 : 1383 – 1393 .
  • Lord , S M , Barnsley , L , Wallis , B J and Bogduk , N . 1996a . Chronic Cervical Zygapophysial Joint Pain after Whiplash. A Placebo-Controlled Prevalence Study . Spine , Vol. 21 : 1737 – 1744 .
  • Lord , S M , Barnsley , L , Wallis , B J , McDonald , G J and Bogduk , N . 1996b . Percutaneous Radio-Frequency Neurotomy for Chronic Cervical Zygapophyseal-Joint Pain . N. Engl. J. Med. , Vol. 335 : 1721 – 1726 .
  • Lu , Y , Chen , C , Kallakuri , S , Patwardhan , A and Cavanaugh , J M . 2005a . Neural Response of Cervical Facet Joint Capsule to Stretch: A Potential Whiplash Pain Mechanism . Stapp Car Crash J. , Vol. 49 : 49 – 65 .
  • Lu , Y , Chen , C , Kallakuri , S , Patwardhan , A and Cavanaugh , J M . 2005b . Neurophysiological and Biomechanical Characterization of Goal Cervical Facet Joint Capsules . J. Orthop. Res. , Vol. 23 : 779 – 787 .
  • Luan , F , Yang , K H , Deng , B , Begeman , P C , Tashman , S and King , A I . 2000 . Qualitative Analysis of Neck Kinematics during Low-speed Rear-end Impact . Clin. Biomech. , Vol. 15 : 649 – 657 .
  • Lund , J P , Donga , R , Widmer , C G and Stohler , C S . 1991 . The Pain-Adaptation Model: A Discussion of the Relationship between Chronic Musculoskeletal Pain and Motor Activity . Can. J. Physiol. Pharmacol. , Vol. 69 : 683 – 694 .
  • Ma , W and Eisenach , J C . 2003 . Intraplantar Injection of a Cyclooxyenase Inhibitor Ketorolac Reduces Immunoreactivities of Substance P, Calcitonin Gene-Related Peptide, and Dynorphin in the Dorsal Horn of Rats with Nerve Injury or Inflammation . Neuroscience , Vol. 121 : 681 – 690 .
  • Maak , T G , Tominaga , Y , Panjabi , M M and Ivancic , P C . 2006 . Alar, Transverse, and Apical Ligament Strain Due to Head-Turned Rear Impact . Spine , Vol. 31 : 632 – 638 .
  • Macpherson , P CK , Schork , M A and Faulkner , J A . 1996 . Contraction-Induced Injury in Single Fiber Segments from Fast and Slow Muscles of Rats by Single Stretches . Am. J. Physiol. , Vol. 271 : C1438 – C1446 .
  • McCully , K K and Faulkner , J A . 1985 . Injury to Skeletal Muscle Fibers of Mice Following Lengthening Contractions . J. Appl. Physiol. , Vol. 59 : 119 – 126 .
  • McLain , R F . 1994 . Mechanoreceptor Endings in Human Cervical Facet Joints . Spine , Vol. 19 : 495 – 501 .
  • Munglani , R , Harrison , S M , Smith , G D , Bountra , C , Birch , P J , Elliot , P J and Hunt , S P . 1996 . Neuropeptide Changes Persist in Spinal Cord Despite Resolving Hyperalgesia in a Rat Model of Mononeuropathy . Brain Res. , Vol. 743 : 102 – 108 .
  • Nederhand , M J , Hermans , J HI , Jzerman , M J , Turk , D C and Zilvold , G . 2002 . Cervical Muscle Dysfunction in Chronic Whiplash-Associated Disorder Grade 2: The Relevance of the Trauma . Spine , Vol. 27 : 1056 – 1061 .
  • Nederhand , M J , Hermens , J HI , Jzerman , M J , Turk , D C and Zilvold , G . 2003 . Chronic Neck Pain Disability Due to an Acute Whiplash Injury . Pain , Vol. 102 : 63 – 71 .
  • Nederhand , M JI , Jzerman , M J , Hermens , H J , Baten , C T and Zilvold , G . 2000 . Cervical Muscle Dysfunction in the Chronic Whiplash Associated Disorder Grade II (WAD-II) . Spine , Vol. 25 : 1938 – 1943 .
  • Norris , S H and Watt , I . 1983 . The Prognoisis of Neck Injuries Resulting from Rear-end Vehicle Collisions . J. Bone Joint Surg. , Vol. 65 : 608 – 611 .
  • Nuckley , D J , Konodi , M A , Raynak , G C , Ching , R P , Chapman , J R and Mirza , S K . 2004 . Neural Space Integrity of the Lower Cervical Spine: Effect of Anterior Lesions . Spine , Vol. 29 : 642 – 649 .
  • Ohtori , S , Takahashi , K and Moriya , H . 2003 . Calcitonin Gene-Related Peptide Immunoreactive DRG Neurons Innervating the Cervical Facet Joints Show Phenotypic Switch in Cervical Facet Injury in Rats . Eur. Spine J. , Vol. 12 : 211 – 215 .
  • Ono , K , Kaneoka , K , Wittek , A and Kajzer , J . . Cervical Injury Mechanism Based on the Analysis of Human Cervical Vertebral Motion and Head-Neck-Torso Kinematics during Low-speed Rear Impacts . Proc. 41st Stapp Car Crash Conference . pp. 339 – 356 .
  • Örtengren , T , Hansson , H A , Lövsund , P , Svensson , M Y , Suneson , A and Saljo , A . 1996 . Membrane Leakage in Spinal Ganglion Nerve Cells Induced by Experimental Whiplash Extension Motion: A Study in Pigs . J. Neurotrauma , Vol. 13 : 171 – 180 .
  • Otremski , I , Marsh , J L , Wilde , B R , McLardy Smith , P D and Newman , R J . 1989 . Soft Tissue Cervical Spinal Injuries in Motor Vehicle Accidents . Injury , Vol. 20 : 349 – 351 .
  • Panjabi , M M . 2006 . A Hypothesis of Chronic Back Pain: Ligament Subfailure Injuries Lead to Muscle Control Dysfunction . Eur. Spine J. , Vol. 15 : 668 – 676 .
  • Panjabi , M M , Cholewicki , J , Nibu , K , Grauer , J and Vahldiek , M . 1998a . Capsular Ligament Stretches during In vitro Whiplash Simulations . J. Spinal Disord. , Vol. 11 : 227 – 232 .
  • Panjabi , M M , Crisco , J J , Lydon , C and Dvorak , J . 1998b . The Mechanical Properties of Human Alar and Transverse Ligaments at Slow and Fast Extension Rates . Clin. Biomech. , Vol. 13 : 112 – 120 .
  • Panjabi , M M , Ito , S , Pearson , A M and Ivancic , P C . 2004a . Injury Mechanisms of the Cervical Intervertebral Disc during Simulated Whiplash . Spine , Vol. 29 : 1217 – 1225 .
  • Panjabi , M M , Maak , T G , Ivancic , P C and Ito , S . 2006 . Dynamic Intervertebral Foramen Narrowing during Simulated Rear Impact . Spine , Vol. 31 : E128 – E134 .
  • Panjabi , M M , Pearson , A M , Ito , S , Ivancic , P C , Gimenez , S E and Tominaga , Y . 2004b . Cervical Spine Ligament Injury during Simulated Frontal Impact . Spine , Vol. 29 : 2395 – 2403 .
  • Pearson , A M , Ivancic , P C , Ito , S and Panjabi , M M . 2004 . Facet Joint Kinematics and Injury Mechanisms during Simulated Whiplash . Spine , Vol. 29 : 390 – 397 .
  • Pettersson , K , Hildingsson , C , Toolanen , G , Fagerlund , M and Bjornebrink , J . 1997 . Disc Pathology after Whiplash Injury. A Prospective Magnetic Resonance Imaging and Clinical Investigation . Spine , Vol. 22 : 283 – 287 .
  • Pollanen , M S , Deck , J H and Blenkinsop , B . 1996 . Injury of the Tunica Media in Fatal Rupture of the Vertebral Artery . Am. J. Forensic Med. Pathol. , Vol. 17 : 197 – 201 .
  • Quinlan , K P , Annest , J L , Myers , B , Ryan , G and Hill , H . 2004 . Neck Strains and Sprains among Motor Vehicle Occupants—United States, 2000 . Accid. Anal. Prev. , Vol. 36 : 21 – 27 .
  • Quinn , K P , Lee , K E , Ahaghotu , C and Winkelstein , B A . 2007 . Structural Changes in the Cervical Facet Capsular Ligament: Potential Contributions to Pain Following Subfailure Loading . Stapp Car Crash J. , Vol. 51 : 169 – 187 .
  • Quinn , K P and Winkelstein , B A . 2007 . Cervical Facet Capsular Ligament Yield Defines the Threshold for Injury and Persistent Joint-Mediated Neck Pain . J. Biomech. , Vol. 40 : 2299 – 2306 .
  • Radanov , B P , Sturzenegger , M and Di Stefano , G . 1995 . Long-Term Outcome after Whiplash Injury. A 2-Year Follow-up Considering Features of Injury Mechanism and Somatic, Radiologic, and Psychosocial Findings . Medicine , Vol. 74 : 281 – 297 .
  • Reddy , M , Reddy , B , Schoggl , A , Saringer , W and Matula , C . 2002 . The Complexity of Trauma to the Cranio-Cervical Junction: Correlation of Clinical Presentation with Doppler Flow Velocities in the V3-Segment of the Vertebral Arteries . Acta Neurochir. (Wien) , Vol. 144 : 575 – 580 .
  • Rohen , J W and Yokochi , C . 1993 . Colour Atlas of Anatomy, A Photographic Study of the Human Body, , 3rd ed. , Tokyo, , Japan : Igaku-Shoin Ltd .
  • Rothman , S M , Kreider , R A and Winkelstein , B A . 2005 . Spinal Neuropeptide Responses in Persistent and Transient Pain Following Cervical Nerve Root Injury . Spine , Vol. 30 : 2491 – 2496 .
  • Schmitt , K U , Muser , M , Niederer , P and Walz , F . 2003 . Pressure Aberrations Inside the Spinal Canal during Rear-end Impact . Pain Res. Manag. , Vol. 8 : 86 – 92 .
  • Scholten-Peeters , G G , Verhagen , A P , Bekkering , G E , van der Windt , D A , Barnsley , L , Oostendorp , R A and Hendriks , E J . 2003 . Prognostic Factors of Whiplash-Associated Disorders: A Systematic Review of Prospective Cohort Studies . Pain , Vol. 104 : 303 – 322 .
  • Schrader , H , Obelieniene , D , Bovim , G , Surkiene , D , Mickeviciene , D , Miseviciene , I and Sand , T . 1996 . Natural Evolution of Late Whiplash Syndrome Outside the Medicolegal Context . Lancet , Vol. 347 : 1207 – 1211 .
  • Scott , D , Jull , G and Sterling , M . 2005 . Widespread Sensory Hypersensitivity Is a Feature of Chronic Whiplash-Associated Disorder but Not Chronic Idiopathic Neck Pain . Clin. J. Pain , Vol. 21 : 175 – 181 .
  • Scott , S and Sanderson , P L . 2002 . Whiplash: A Biochemical Study of Muscle Injury . Eur. Spine J. , Vol. 11 : 389 – 392 .
  • Seric , V , Blazic-Cop , N and Demarin , V . 2000 . Haemodynamic Changes in Patients with Whiplash Injury Measured by Transcranial Doppler Sonography (TCD) . Coll. Antropol. , Vol. 24 : 197 – 204 .
  • Sherman , D G , Hart , R G and Easton , J D . 1981 . Abrupt Change in Head Position and Cerebral Infarction . Stroke , Vol. 12 : 2 – 6 .
  • Siegmund , G P , Blouin , J S , Carpenter , M G , Brault , J R and Inglis , J T . 2008a . Are Cervical Multifidus Muscles Active during Whiplash and Startle? An Initial Experimental Study . BMC Musculoskel. Disord. , Vol. 9 : 80
  • Siegmund , G P , Davis , M B , Quinn , K P , Hines , E , Myers , B S , Ejima , S , Ono , K , Kamiji , K , Yasuki , T and Winkelstein , B A . 2008b . Head-Turned Postures Increase the Risk of Cervical Facet Capsule Injury during Whiplash . Spine , Vol. 33 : 1643 – 1649 .
  • Siegmund , G P , Myers , B S , Davis , M B , Bohnet , H F and Winkelstein , B A . 2001 . Mechanical Evidence of Cervical Facet Capsule Injury during Whiplash: A Cadaveric Study Using Combined Shear, Compression and Extension Loading . Spine , Vol. 26 : 2095 – 2101 .
  • Siegmund , G P , Sanderson , D J , Myers , B S and Inglis , J T . 2003 . Rapid Neck Muscle Adaptation Alters the Head Kinematics of Aware and Unaware Subjects Undergoing Multiple Whiplash-like Perturbations . J. Biomech. , Vol. 36 : 473 – 482 .
  • Stahmer , S A , Raps , E C and Mines , D I . 1997 . Carotid and Vertebral Artery Dissections . Emerg. Med. Clin. North Am. , Vol. 15 : 677 – 698 .
  • Sterling , M . 2006 . Balancing the ‘Bio’ with the Psychosocial in Whiplash Associated Disorders . Manual Therapy , Vol. 11 : 180 – 181 .
  • Sterling , M , Jull , G and Kenardy , J . 2006 . Physical and Psychological Factors Maintain Long-term Predictive Capacity Post-whiplash Injury . Pain , Vol. 122 : 102 – 108 .
  • Sterling , M , Jull , G , Vicenzino , B and Kenardy , J . 2003 . Sensory Hypersensitivity Occurs Soon after Whiplash Injury and Is Associated with Poor Recovery . Pain , Vol. 104 : 509 – 517 .
  • Sterner , Y and Gerdle , B . 2004 . Acute and Chronic Whiplash Disorders—A Review . J. Rehabil. Med. , Vol. 36 : 193 – 209 .
  • Sterner , Y , Toolanen , G , Knibestol , M , Gerdle , B and Hidingsson , C . 2001 . Prospective Study of Trigeminal Sensibility after Whiplash Trauma . J. Spinal Disord. , Vol. 14 : 479 – 486 .
  • Suissa , S , Harder , S and Veilleux , M . 2001 . The relation between initial symptoms and signs and the prognosis of whiplash . Eur. Spine J. , Vol. 10 : 44 – 49 .
  • Sundararajan , S , Prasad , P , Demetropolous , C K , Tashman , S , Begeman , P C , Yang , K H and King , A I . 2004 . Effect of Head-Neck Position on Cervical Facet Stretch of Post Mortem Human Subjects during Low Speed Rear End Impacts . Stapp Car Crash J. , Vol. 48 : 331 – 372 .
  • Svensson , M Y , Boström , O , Davidsson , J , Hansson , H-A , Håland , Y , Lövsund , P , Suneson , A and Säljö , A . 2000 . Neck Injuries in Car Collisions—A Review Covering a Possible Injury Mechanism and the Development of a New Rear-Impact Dummy . Accid. Anal. Prev. , Vol. 32 : 167 – 175 .
  • Taneichi , H , Suda , K , Kajino , T and Kaneda , K . 2005 . Traumatically Induced Vertebral Artery Occlusion Associated with Cervical Spine Injuries: Prospective Study Using Magnetic Resonance Angiography . Spine , Vol. 30 : 1955 – 1962 .
  • Taylor , J R , Twomey , L T and Kakulas , B A . 1998 . Dorsal root ganglion injuries in 109 blunt trauma fatalities . Injury , Vol. 29 : 335 – 339 .
  • Tominaga , Y , Maak , T G , Ivancic , P C , Panjabi , M M and Cunningham , B W . 2006 . Head-Turned Rear Impact Causing Dynamic Cervical Intervertebral Foramen Narrowing: Implications for Ganglion and Nerve Root Injury . J. Neurosurg. Spine , Vol. 4 : 380 – 387 .
  • Vasavada , A N , Brault , J R and Siegmund , G P . 2007 . Musculotendon and Fascicle Strains in Anterior and Posterior Muscles during Whiplash Injury . Spine , Vol. 32 : 756 – 765 .
  • Viano , D C . 2003 . Role of the Seat in Rear Crash Safety , Warrendale, PA : Society of Automotive Engineers .
  • Viano , D C and Olsen , S . 2001 . The Effectiveness of Active Head Restraint in Preventing Whiplash . J. Trauma , Vol. 51 : 959 – 969 .
  • Westgaard , R H , Jensen , C and Nilsen , K . 1993 . Muscle Coordination and Choice-Reaction Time Tests as Indicators of Occupational Muscle Load and Shoulder-Neck Complaints . Eur. J. Appl. Physiol. , Vol. 67 : 106 – 114 .
  • White , A A and Panjabi , M M . 1990 . Clinical Biomechanics of the Spine , Philadelphia : J. B. Lippincott Co. .
  • Williams , M , Williamson , E , Gates , S , Lamb , S and Cooke , M . 2007 . A Systematic Literature Review of Physical Prognostic Factors for the Development of Late Whiplash Syndrome . Spine , Vol. 32 : E764 – E780 .
  • Winkelstein , B , McLendon , R , Barbir , A and Myers , B S . 2001 . An Anatomical Investigation of the Human Cervical Facet Capsule, Quantifying Muscle Insertion Area . J. Anat. , Vol. 198 : 455 – 461 .
  • Winkelstein , B A , Nightingale , R W , Richardson , W J and Myers , B S . 2000 . The Cervical Facet Capsule and Its Role in Whiplash Injury: A Biomechanical Investigation . Spine , Vol. 25 : 1238 – 1246 .
  • Yahia , L H , Garzon , S , Strykowski , H and Rivard , C H . 1990 . Ultrastructure of the Human Interspinous Ligament and Ligamentum Flavum. A Preliminary Study . Spine , Vol. 15 : 262 – 268 .
  • Yang , K H and King , A I . 2003 . Neck Kinematics in Rear-end Impacts . Pain Res. Manag. , Vol. 8 : 79 – 85 .
  • Yoganandan , N , Pintar , F A and Cusick , J F . 2002 . Biomechanical Analyses of Whiplash Injuries Using an Experimental Mode . Accid. Anal. Prev. , Vol. 34 : 663 – 671 .
  • Yoo , J U , Zou , D , Edwards , W T , Bayley , J and Yuan , H A . 1992 . Effect of Cervical Spine Motion on the Neuroforaminal Dimensions of Human Cervical Spine . Spine , Vol. 17 : 1131 – 1136 .

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