Gender Differences in Highway Driving Performance After Administration of Sleep Medication: A Review of the Literature

REFERENCES

• Bianchetti , G , Dubruc , C Thiercelin , J F . 1988 . “ Clinical pharmacokinetics of zolpidem in various physiological and pathological conditions ” . In Imidazopyridines in Sleep Disorders , Edited by: Sauvanet , J P , Langer , S Z and Morselli , P L . 155 – 164 . New York, NY : Raven Press .
   Google Scholar
• Botiger , L E . 1973 . Adverse drug reactions: an analysis of 310 consecutive reports to the Swedish drug reaction committee . J Clin Pharmacol. , 13 : 373 – 382 .
   PubMed Web of Science ®Google Scholar
• Brookhuis , K A , Volkerts , E R and O’Hanlon , J F . 1986 . Repeated Dose Effects of Lormetazepam 1 and 2 mg (in Soft Gelatine Capsules) and Flurazepam 30 mg Upon Driving Performance , 86 – 18 . Groningen, The Netherlands : Traffic Research Centre, University of Groningen . VK
   Google Scholar
• Brookhuis , K A , Volkerts , E R and O’Hanlon , J F . 1990 . Repeated dose effects of lormetazepam and flurazepam upon driving performance . Eur J Clin Pharmacol. , 39 : 83 – 87 .
   PubMed Web of Science ®Google Scholar
• Darwish , M . 1999 . The effects of age and gender on the pharmacokinetics of zaleplon . Eur Neuropsychopharmacol. , 9 ( suppl 5 ) : S360
   Google Scholar
• Datz , F L , Christian , P E and Moore , J . 1987 . Gender-related differences in gastric emptying . Nucl Med. , 28 : 384 – 391 .
   Google Scholar
• Divoll , M , Greenblatt , D J , Harmatz , J S and Shader , R . 1981 . Effects of age and gender on disposition of temazepam . J Pharm Sci. , 70 : 1104 – 1107 .
   PubMed Web of Science ®Google Scholar
• Doghramji , K . 2000 . The need for flexibility in dosing of hypnotic agents . Sleep , 23 ( suppl 1 ) : S16 – S20 .
   PubMedGoogle Scholar
• Ellinwood , E H , Easler , M E , Linnoila , M , Molter , D W , Heatherley , D G and Bjorasson , T D . 1983 . Effects of oral contraceptives on diazepam-induced psychomotor impairment . Clin Pharmacol Ther. , 35 : 360 – 366 .
   Web of Science ®Google Scholar
• Fletcher , C V , Acosta , E P and Strykowski , J M . 1994 . Gender differences in human pharmacokinetics and pharmacodynamics . J Adolesc Health , 15 : 619 – 629 .
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration . 1993 . Guideline for the study and evaluation of gender difference in the clinical evaluation of drugs . Federal Register , 58 : 39406
   PubMedGoogle Scholar
• Franconi , F , Brunelleschi , S , Steardo , L and Cuomo , V . 2007 . Gender differences in drug responses . Pharmacol Res. , 55 : 81 – 95 .
   PubMed Web of Science ®Google Scholar
• Greenblatt , D J , Divoll , M , Harmatz , J S and Shader , R I . 1980 . Oxazepam kinetics: effects of age and sex . J Pharmacol Exp Ther. , 215 : 86 – 91 .
   PubMed Web of Science ®Google Scholar
• Greenblatt , D J , Harmatz , J S Von Moltke , L L . 2000 . Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences . J Pharmacol Exp Ther. , 293 : 435 – 443 .
   PubMed Web of Science ®Google Scholar
• Harris , R Z , Benet , L Z and Schwartz , J B . 1995 . Gender effects in pharmacokinetics and pharmacodynamics . Drugs , 50 : 222 – 239 .
   PubMed Web of Science ®Google Scholar
• Holazo , A A , Winkler , M B and Patel , I H . 1988 . Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics . J Clin Pharmacol. , 28 : 1040 – 1045 .
   PubMed Web of Science ®Google Scholar
• Jochemsen , R , van der Graaff , M , Boerjinga , J K and Breimer , D D . 1982 . Influence of sex, menstrual cycle and oral contraception on the disposition of nitrazepam . Br J Clin Pharmacol. , 13 : 319 – 324 .
   PubMed Web of Science ®Google Scholar
• Kando , J C , Yonkers , K A and Cole , J O . 1995 . Gender as a risk factor for adverse events to medications . Drugs. , 50 : 1 – 6 .
   PubMed Web of Science ®Google Scholar
• Kroboth , P D , Smith , R B , Stoehr , G P and Juhl , R P . 1985 . Pharmacodynamic evaluation of the benzodiazepine-oral contraceptive interaction . Clin Pharmacol Ther. , 38 : 525 – 532 .
   PubMed Web of Science ®Google Scholar
• Leufkens , T R , Lund , J S and Vermeeren , A . 2009 . Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem . J Sleep Res. , 18 : 387 – 396 .
   PubMed Web of Science ®Google Scholar
• Leufkens , T R and Vermeeren , A . 2009 . Highway driving in the elderly the morning after bedtime use of hypnotics: a comparison between temazepam 20 mg, zopiclone 7.5 mg, and placebo . J Clin Psychopharmacol. , 29 : 432 – 438 .
   PubMed Web of Science ®Google Scholar
• Leufkens , T R , Vermeeren , A , Smink , B E , van Ruitenbeek , P and Ramaekers , J G . 2007 . Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg . Psychopharmacology. , 191 : 951 – 959 .
   PubMed Web of Science ®Google Scholar
• Louwerens , J W , Gloerich , A BM , De Vries , G , Brookhuis , K A and O’Hanlon , J F . 1987 . The Relationship Between Drivers’ Blood Alcohol Concentration (BAC) and Actual Driving Performance During High Speed Travel., Amsterdam: Excerpfa Media; Edited by: Noordzij , P C and Roszbach , R . 183 – 192 .
   Google Scholar
• Martin , G and Gan , T J . 2000 . Gender differences: hype or fact? Seminars in anesthesia . Perioper Med Pain , 19 : 76 – 82 .
   Google Scholar
• Mets , M AJ , de Vries , J M , de Senerpont Domis , L M , Volkerts , E R , Olivier , B and Verster , J C . 2011 . Next-day effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on highway driving performance, memory functioning, psychomotor performance and mood in healthy adult subjects . Sleep , 34 : 1327 – 1334 .
   PubMed Web of Science ®Google Scholar
• O’ Hanlon , J F . 1984 . Driving performance under the influence of drugs: rationale for, and application of, a new test . Br J Clin Pharmacol. , 18 : 121S – 129S .
   PubMed Web of Science ®Google Scholar
• O’Hanlon , J F , Haak , T W , Blauw , G J and Riemersma , J B . 1982 . Diazepam impairs lateral position control in highway driving . Science. , 217 : 79 – 81 .
   PubMed Web of Science ®Google Scholar
• O’Hanlon , J F , Vermeeren , A , Uiterwijk , M M , Van Veggel , L MA and Swijgman , H F . 1995 . Anxiolytics’ effects on the actual driving performance of patients and healthy volunteers in a standardized test. An integration of three studies . Neuropsychobiology. , 31 : 81 – 88 .
   PubMed Web of Science ®Google Scholar
• O’Hanlon , J F and Volkerts , E R . 1986 . Hypnotics and actual driving ability . Acta Psychiatr Scand. , 74 ( suppl 332 ) : 95 – 104 .
   Google Scholar
• Ohayon , M M . 2010 . Nocturnal awakenings and difficulty resuming sleep: their burden in the European general population . J Psychosom Res. , 69 : 565 – 571 .
   PubMed Web of Science ®Google Scholar
• Phillips , B A , Collop , NA , Drake , C , Consens , F , Vgontzas , AN and Weaver , TE . 2008 . Sleep disorders and medical conditions in women. Proceedings of the women & sleep workshop, National Sleep Foundation, Washington, DC, March 5–6 2007 . Journal of Womens Health , 17 : 1191 – 1199 .
   PubMed Web of Science ®Google Scholar
• Ramaekers , J G , Conen , S de Kam , P J . 2011 . Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype . Psychopharmacology. , 215 : 321 – 332 .
   PubMed Web of Science ®Google Scholar
• Rosen , A S , Fournié , P , Darwish , M , Danjou , P and Troy , M . 1999 . Zaleplon pharmacokinetics and absolute bioavailability . Biopharm Drug Dispos. , 20 : 171 – 175 .
   PubMed Web of Science ®Google Scholar
• Scharf , M B . 2001 . Individualizing therapy for early, middle-of-the-night and late night insomnia . Int J Clin Pract. , 116 ( suppl ) : 20 – 24 .
   Google Scholar
• Schmucker , D L and Vesell , E S . 1993 . Underrepresentation of women in clinical drug trials . Clin Pharmacol Ther. , 54 : 11 – 15 .
   PubMed Web of Science ®Google Scholar
• Simpson , J M , Bateman , D N and Rawlins , M D . 1987 . Using the adverse reaction register to study the effects of age and sex on adverse drug reactions . Stat Med. , 6 : 270 – 278 .
   Web of Science ®Google Scholar
• van Laar , M W , Volkerts , E R and Van Willigenburg , A PP . 1992 . Therapeutic effects and effects on actual driving performance of chronically administered buspirone and diazepam in anxious outpatients . J Clin Psychopharmacol. , 12 : 86 – 95 .
   PubMed Web of Science ®Google Scholar
• van Laar , M W , Volkerts , E R and Verbaten , M N . 2001 . Subchronic effects of the GABA-agonist lorazepam and the 5-HT2a/2c antagonist ritanserin on driving performance, slow wave sleep and daytime sleepiness in healthy volunteers . Psychopharmacology , 154 : 189 – 197 .
   PubMed Web of Science ®Google Scholar
• Vermeeren , A , Danjou , P E and O’Hanlon , J F . 1998 . Residual effects of evening and middle-of-the-night administration of zaleplon 10 and 20 mg on memory and actual driving performance . Hum Psychopharmacol , 13 : S98 – S107 .
   Web of Science ®Google Scholar
• Vermeeren , A , O’Hanlon , J F , deClerck , A C and Kho , L . 1995 . Acute effects of zolpidem and flunitrazepam on sleep, memory and driving performance, compared to those of partial sleep deprivation and placebo . Acta Ther. , 21 : 47 – 64 .
   Google Scholar
• Vermeeren , A , Riedel , W J , van Boxtel , M P , Darwish , M , Paty , I and Patat , A . 2002 . Differential residual effects of zaleplon and zopiclone on actual driving: a comparison with a low dose of alcohol . Sleep. , 25 : 224 – 231 .
   PubMed Web of Science ®Google Scholar
• Verster , J C and Roth , T . 2011 . Standard Operation Procedures for conducting the on-the-road driving test, and measurement of the standard deviation of lateral position (SDLP) . Int J Gen Med. , 4 : 359 – 371 .
   PubMedGoogle Scholar
• Verster , J C , Spence , D W , Shahid , A , Pandi-Perumal , S R and Roth , T . 2011 . Zopiclone as positive control in clinical trials examining the residual effects of hypnotic drugs on driving ability . Curr Drug Saf. , 6 : 209 – 218 .
   PubMedGoogle Scholar
• Verster , J C , Veldhuijzen , D S , Patat , A , Olivier , B and Volkerts , E R . 2006 . Hypnotics and driving safety: meta-analyses of randomized controlled trials applying the on-the-road driving test . Curr Drug Saf. , 1 : 63 – 72 .
   PubMedGoogle Scholar
• Verster , J C , Veldhuijzen , D S and Volkerts , E R . 2004 . Residual effects of sleep medication on driving ability . Sleep Med Rev. , 8 : 309 – 325 .
   PubMed Web of Science ®Google Scholar
• Verster , J C , Volkerts , E R , Johnson , W and Liddicoat , L . 2007 . Zolpidem and traffic safety—the importance of treatment compliance . Curr Drg Saf , 2 : 220 – 226 .
   PubMedGoogle Scholar
• Verster , J C , Volkerts , E R Schreuder , A H . 2002 . Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions and psychomotor performance . J Clin Psychopharmacol , 22 : 576 – 583 .
   PubMed Web of Science ®Google Scholar
• Verster , J C , Volkerts , E R and Verbaten , M N . 2002 . Effects of alprazolam on driving ability, memory functioning and psychomotor performance: a randomized, placebo-controlled study . Neuropsychopharmacology. , 27 : 260 – 269 .
   PubMed Web of Science ®Google Scholar
• Volkerts , E R , Louwerens , J W , Gloerich , A BM , Brookhuis , K A and O’Hanlon , J F . 1984 . Zopiclone's Residual Effect Upon Actual Driving Performance Versus Those of Nitrazepam and Flunitrazepam , 84 – 10 . Groningen, The Netherlands : Traffic Research Centre . Technical Report VK
   Google Scholar
• Volkerts , E R , van Laar , M W , van Willigenburg , A PP and Maes , R AA . 1992 . A comparative study of on-the-road and simulated driving performance after nocturnal treatment with lormetazepam 1 mg and oxazepam 50 mg . Hum Psychopharmacol. , 7 : 297 – 309 .
   Web of Science ®Google Scholar