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Acute impairing effects of morphine related to driving: A systematic review of experimental studies to define blood morphine concentrations related to impairment in opioid-naïve subjects

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Pages 788-794 | Received 27 Mar 2017, Accepted 01 May 2017, Published online: 19 Jul 2017

References

  • Ahmedzai S, Brooks D. Transdermal fentanyl versus sustained-release oral morphine in cancer pain: preference, efficacy, and quality of life. The TTS-Fentanyl Comparative Trial Group. J Pain Symptom Manage. 1997;13:254–261.
  • Bachs L, Hoiseth G, Skurtveit S, Morland J. Heroin-using drivers: importance of morphine and morphine-6-glucuronide on late clinical impairment. Eur J Clin Pharmacol. 2006;62:905–912.
  • Baillie SP, Bateman DN, Coates PE, Woodhouse KW. Age and the pharmacokinetics of morphine. Age Ageing. 1989;18:258–262.
  • Bauer RO, Pearson RG. The effects of morphine–nalorphine mixtures on psychomotor performance. J Pharmacol.Exp Ther. 1956;117:258–264.
  • Bourke DL, Rosenberg M, Allen PD. Physostigmine: effectiveness as an antagonist of respiratory depression and psychomotor effects caused by morphine or diazepam. Anesthesiology. 1984;61:523–528.
  • Coda BA, Hill HF, Hunt EB, et al. Cognitive and motor function impairments during continuous opioid analgesic infusions. Hum Psychopharm Clin. 1993;8:383–400.
  • Conley KM, Toledano AY, Apfelbaum JL, Zacny JP. Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology. 1997;131:313–320.
  • Dahan A, vanDorp E, Smith T, Yassen A. Morphine-6-glucuronide (M6G) for postoperative pain relief. Eur J Pain. 2008;12:403–411.
  • Dershwitz M, Walsh JL, Morishige RJ, et al. Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers. Anesthesiology. 2000;93:619–628.
  • Drake J, Kirkpatrick CT, Aliyar CA, et al. Effect of food on the comparative pharmacokinetics of modified-release morphine tablet formulations: Oramorph SR and MST Continus. Br J Clin Pharmacol. 1996;41:417–420.
  • DRUID-project. 2009. Available at: http://www.druid-project.eu/Druid/EN/Home/home_node.html. Accessed June 28, 2017.
  • Drummer OH, Gerostamoulos J, Batziris H, et al. The involvement of drugs in drivers of motor vehicles killed in Australian road traffic crashes. Accid Anal Prev. 2004;36:239–248.
  • Engeland A, Skurtveit S, Morland J. Risk of road traffic accidents associated with the prescription of drugs: a registry-based cohort study. Ann Epidemiol. 2007;17:597–602.
  • Fishbain DA, Cutler RB, Rosomoff HL, Rosomoff RS. Are opioid-dependent/tolerant patients impaired in driving-related skills? A structured evidence-based review. J Pain Symptom Manage. 2003;25:559–577.
  • Glynn C, Dawson D, Sanders R. A double-blind comparison between epidural morphine and epidural clonidine in patients with chronic non-cancer pain. Pain. 1988;34(2):123–128.
  • Grace PM, Stanford T, Gentgall M, Rolan PE. Utility of saccadic eye movement analysis as an objective biomarker to detect the sedative interaction between opioids and sleep deprivation in opioid-naïve and opioid-tolerant populations. J Psychopharmacol. 2010;24:1631–1640.
  • Grond S, Radbruch L, Meuser T, et al. High-dose tramadol in comparison to low-dose morphine for cancer pain relief. J Pain Symptom Manage. 1999;18(3):174–179.
  • Halbsguth U, Rentsch KM, Eich-Hochli D, Diterich I, Fattinger K. Oral diacetylmorphine (heroin) yields greater morphine bioavailability than oral morphine: bioavailability related to dosage and prior opioid exposure. Br J Clin Pharmacol. 2008;66:781–791.
  • Hand CW, Moore RA, McQuay HJ, Allen MC, Sear JW. Analysis of morphine and its major metabolites by differential radioimmunoassay. Ann Clin Biochem. 1987;24(Pt 2):153–160.
  • Handal M. Effects of Morphine and Morphine–Glucuronides in Relation to the Development of Drug Addiction—Studies in Behavioral Models in Mice. Norway: Faculty of Medicine, University of Oslo; 2009.
  • Hanks GW, O'Neill WM, Simpson P, Wesnes K. The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects. Eur J Clin Pharmacol. 1995;48:455–460.
  • Hasselstrom J, Sawe J. Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Clin Pharmacokinet. 1993;24:344–354.
  • Hill JL, Zacny JP. Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers. Psychopharmacology. 2000;152:31–39.
  • Hoskin PJ, Hanks GW, Aherne GW, et al. The bioavailability and pharmacokinetics of morphine after intravenous, oral and buccal administration in healthy volunteers. Br J Clin Pharmacol. 1989;27:499–505.
  • Jongen S, Vuurman EF, Ramaekers JG, Vermeeren A. The sensitivity of laboratory tests assessing driving related skills to dose-related impairment of alcohol: a literature review. Accid Anal Prev. 2016;89:31–48.
  • Kerr B, Hill H, Coda B, et al. Concentration-related effects of morphine on cognition and motor control in human subjects. Neuropsychopharmacol. 1991;5(3):157–166.
  • Kishner S, Windle ML, Schraga ED. Opioid equivalents and conversions. 2016. Available at: http://emedicine.medscape.com/article/2138678-overview. Accessed March 27, 2017.
  • Kuypers KP, Legrand SA, Ramaekers JG, Verstraete AG. A case–control study estimating accident risk for alcohol, medicines and illegal drugs. PLoS One. 2012;7:e43496.
  • Leveille SG, Buchner DM, Koepsell TD, et al. Psychoactive medications and injurious motor vehicle collisions involving older drivers. Epidemiology. 1994;5:591–598.
  • Marsch LA, Bickel WK, Badger GJ, et al. Effects of infusion rate of intravenously administered morphine on physiological, psychomotor, and self-reported measures in humans. J Pharmacol Exp Ther. 2001;299:1056–1065.
  • Milne RW, Nation RL, Somogyi AA. The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. Drug Metab Rev. 1996;28:345–472.
  • Mura P, Kintz P, Ludes B, et al. Comparison of the prevalence of alcohol, cannabis and other drugs between 900 injured drivers and 900 control subjects: results of a French collaborative study. Forensic Sci Int. 2003;133:79–85.
  • Osborne R, Joel S, Trew D, Slevin M. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther. 1990;47:12–19.
  • Quante M, Scharein E, Zimmermann R, Langer-Brauburger B, Bromm B. Dissociation of morphine analgesia and sedation evaluated by EEG measures in healthy volunteers. Arzneimittelforschung. 2004;54(3):143–151.
  • Ray WA, Thapa PB, Shorr RI. Medications and the older driver. Clin Geriatr Med. 1993;9:413–438.
  • Sawe J, Dahlstrom B, Paalzow L, Rane A. Morphine kinetics in cancer patients. Clin Pharmacol Ther. 1981;30:629–635.
  • Sawe J, Kager L, Svensson Eng JO, Rane A. Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation. Br J Clin Pharmacol. 1985;19:495–501.
  • Schnabel E, Hargutt V, Krüger HP. A meta-analysis of alcohol studies: an attempt to multi-dimensional risk functions. Paper presented at: International Council on Alcohol, Drugs and Traffic Safety; 2007; Seattle, WA.
  • Skarke C, Schmidt H, Geisslinger G, Darimont J, Lotsch J. Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome. Br J Clin Pharmacol. 2003;56:228–231.
  • Stout PR, Farrell LJ. Opioids—effects on human performance and behavior. Forensic Sci Rev. 2003;15:29–59.
  • Strand MC, Fjeld B, Arnestad M, Mørland J. Psychomotor Relevant Performance: 1. After Single Dose Administration of Opioids, Narcoanalgesics and Hallucinogens to Drug Naïve Subjects 2. In Patients Treated Chronically with Morphine or Methadone/Buprenorphine. 2011. Available at: http://www.druid-project.eu/Druid/EN/deliverales-list/downloads/Deliverable_1_1_2_C.pdf?__blob=publicationFile&v=1. Accessed June 28, 2017.
  • Walker DJ, Zacny JP. Subjective, psychomotor, and analgesic effects of oral codeine and morphine in healthy volunteers. Psychopharmacology. 1998;140(2):191–201.
  • Walker DJ, Zacny JP. Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers. J Pharmacol Exp Ther. 1999;289:1454–1464.
  • Walker DJ, Zacny JP, Galva KE, Lichtor JL. Subjective, psychomotor, and physiological effects of cumulative doses of mixed-action opioids in healthy volunteers. Psychopharmacology. 2001;155:362–371.
  • Walsh JM, Verstraete AG, Huestis MA, Morland J. Guidelines for research on drugged driving. Addiction. 2008;103:1258–1268.
  • Westerling D, Frigren L, Hoglund P. Morphine pharmacokinetics and effects on salivation and continuous reaction times in healthy volunteers. Ther Drug Monit. 1993;15:364–374.
  • Zacny JP, Conley K, Galinkin J. Comparing the subjective, psychomotor and physiological effects of intravenous buprenorphine and morphine in healthy volunteers. J Pharmacol Exp Ther. 1997;282:1187–1197.
  • Zacny JP, Conley K, Marks S. Comparing the subjective, psychomotor and physiological effects of intravenous nalbuphine and morphine in healthy volunteers. J Pharmacol Exp Ther. 1997;280:1159–1169.
  • Zacny JP, Hill JL, Black ML, Sadeghi P. Comparing the subjective, psychomotor and physiological effects of intravenous pentazocine and morphine in normal volunteers. J Pharmacol Exp Ther. 1998;286:1197–1207.
  • Zacny JP, James P. A review of the effects of opioids on psychomotor and cognitive functioning in humans. Exp Clin Psychopharmacol. 1995;3:432–466.
  • Zacny JP, Lichtor JL, Flemming D, Coalson DW, Thompson WK. A dose–response analysis of the subjective, psychomotor and physiological effects of intravenous morphine in healthy volunteers. J Pharmacol Exp Ther. 1994;268:1–9.
  • Zacny JP, Lichtor JL, Thapar P, et al. Comparing the subjective, psychomotor and physiological effects of intravenous butorphanol and morphine in healthy volunteers. J Pharmacol Exp Ther. 1994;270:579–588.

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