Physiologic Variables and Functional Status Independently Predict COPD Hospitalizations and Emergency Department Visits in Patients with Severe COPD

REFERENCES

• Burge S, Wedzicha J A. COPD exacerbations: definitions and classifications. Eur Respir J Suppl 2003; 41: 46s–53s
   PubMedGoogle Scholar
• Seemungal T A, Donaldson G C, Paul E A, Bestall J C, Jeffries D J, Wedzicha J A. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 1418–1422, (5 Pt 1)
   PubMed Web of Science ®Google Scholar
• Spencer S, Calverley P M, Burge P S, Jones P W. Impact of preventing exacerbations on deterioration of health status in COPD. Eur Respir J 2004; 23(5)698–702
   PubMed Web of Science ®Google Scholar
• Donaldson G C, Seemungal T A, Bhowmik A, Wedzicha J A. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57(10)847–852
   PubMed Web of Science ®Google Scholar
• Sullivan S D, Ramsey S D, Lee T A. The economic burden of COPD. Chest 2000; 117: 5S–9S, (2 Suppl)
   PubMed Web of Science ®Google Scholar
• Nichol K L, Baken L, Nelson A. Relation between influenza vaccination and outpatient visits, hospitalization, and mortality in elderly persons with chronic lung disease. Ann Intern Med 1999; 130(5)397–403
   PubMed Web of Science ®Google Scholar
• Sin D D, McAlister F A, Man S F, Anthonisen N R. Contemporary management of chronic obstructive pulmonary disease: scientific review. JAMA 2003; 290(17)2301–2312
   PubMed Web of Science ®Google Scholar
• Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomized controlled trial. Lancet 2003; 361(9356)449–456
   PubMed Web of Science ®Google Scholar
• Szafranski W, Cukier A, Ramirez A, Menga G, Sansores R, Nahabedian S, et al. Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J 2003; 21(1)74–81
   PubMed Web of Science ®Google Scholar
• Bourbeau J, Julien M, Maltais F, Rouleau M, Beaupre A, Begin R, et al. Reduction of hospital utilization in patients with chronic obstructive pulmonary disease: a disease-specific self-management intervention. Arch Intern Med 2003; 163(5)585–591
   PubMed Web of Science ®Google Scholar
• Casas A, Troosters T, Garcia-Aymerich J, Roca J, Hernandez C, Alonso A, et al. Integrated care prevents hospitalizations for exacerbations in COPD patients. Eur Respir J 2006
   PubMed Web of Science ®Google Scholar
• Decramer M, Gosselink R, Troosters T, Verschueren M, Evers G. Muscle weakness is related to utilization of health care resources in COPD patients. Eur Respir J 1997; 10(2)417–423
   PubMed Web of Science ®Google Scholar
• Kessler R, Faller M, Fourgaut G, Mennecier B, Weitzenblum E. Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 159(1)158–164
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Guerrero T, Mayordomo C, Sanchez-Agudo L, Nicolau F, Segu J L. Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group. Respiration 2000; 67(5)495–501
   PubMed Web of Science ®Google Scholar
• Garcia-Aymerich J, Farrero E, Felez M A, Izquierdo J, Marrades R M, Anto J M. Risk factors of readmission to hospital for a COPD exacerbation: a prospective study. Thorax 2003; 58(2)100–105
   PubMed Web of Science ®Google Scholar
• Oostenbrink J B, Rutten-van Molken M P. Resource use and risk factors in high-cost exacerbations of COPD. Respir Med 2004; 98(9)883–891
   PubMed Web of Science ®Google Scholar
• Gudmundsson G, Gislason T, Janson C, Lindberg E, Hallin R, Ulrik C S, et al. Risk factors for rehospitalization in COPD: role of health status, anxiety and depression. Eur Respir J 2005; 26(3)414–419
   PubMed Web of Science ®Google Scholar
• Celli B R, Cote C G, Marin J M, Casanova C, Montes de Oca M, Mendez R A, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004; 350(10)1005–1012
   PubMed Web of Science ®Google Scholar
• Ong K C, Earnest A, Lu S J. A multidimensional grading system (BODE index) as predictor of hospitalization for COPD. Chest 2005; 128(6)3810–3806
   PubMed Web of Science ®Google Scholar
• Pepe M S, Janes H, Longton G, Leisenring W, Newcomb P. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J Epidemiol 2004; 159(9)882–890
   PubMed Web of Science ®Google Scholar
• Fishman A, Martinez F, Naunheim K, Piantadosi S, Wise R, Ries A, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003; 348(21)2059–2073
   PubMed Web of Science ®Google Scholar
• Rationale and design of the National Emphysema Treatment Trial (NETT). A prospective randomized trial of lung volume reduction surgery. J Thorac Cardiovasc Surg 1999; 118(3)518–528
   PubMed Web of Science ®Google Scholar
• National Emphysema Treatment Trial Research Group. Patients at high risk of death after lung-volume-reduction surgery. N Engl J Med 2001; 345(15)1075–1083
   PubMed Web of Science ®Google Scholar
• Ramsey S D, Berry K, Etzioni R, Kaplan R M, Sullivan S D, Wood D E. Cost effectiveness of lung-volume-reduction surgery for patients with severe emphysema. N Engl J Med 2003; 348(21)2092–2102
   PubMed Web of Science ®Google Scholar
• Rawson N S, Malcolm E. Validity of the recording of ischaemic heart disease and chronic obstructive pulmonary disease in the Saskatchewan health care datafiles. Stat Med 1995; 14(24)2627–2643
   PubMed Web of Science ®Google Scholar
• Redelmeier D A, Bayoumi A M, Goldstein R S, Guyatt G H. Interpreting small differences in functional status: the Six Minute Walk test in chronic lung disease patients. Am J Respir Crit Care Med 1997; 155(4)1278–1282
   PubMed Web of Science ®Google Scholar
• Sciurba F, Criner G J, Lee S M, Mohsenifar Z, Shade D, Slivka W, et al. Six-minute walk distance in chronic obstructive pulmonary disease: reproducibility and effect of walking course layout and length. Am J Respir Crit Care Med 2003; 167(11)1522–1527
   PubMed Web of Science ®Google Scholar
• Jones P W. A self-complete measure of health status for chronic airflow limitation: The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992; 145: 1321–1327
   PubMed Web of Science ®Google Scholar
• Eakin E G, Resnikoff P M, Prewitt L M, Ries A L, Kaplan R M. Validation of a new dyspnea measure: the UCSD Shortness of Breath Questionnaire. University of California, San Diego. Chest 1998; 113(3)619–624
   PubMed Web of Science ®Google Scholar
• Ries A. Minimally clinically important difference for the UCSD Shortness of Breath Questionnaire, Borg Scale, and Visual Analog Scale. J Chron Obstructive Pulm Dis 2005; 2: 105–110
   Google Scholar
• Jones P W. Interpreting thresholds for a clinically significant change in health status in asthma and COPD. Eur Respir J 2002; 19(3)398–404
   PubMed Web of Science ®Google Scholar
• Deyo R A, Cherkin D C, Ciol M A. Adapting a clinical co-morbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45(6)613–619
   PubMed Web of Science ®Google Scholar
• Charlson M E, Pompei P, Ales K L, MacKenzie C R. A new method of classifying prognostic co-morbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40(5)373–383
   PubMedGoogle Scholar
• Martinez F J, Foster G, Curtis J L, et al. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med 2006; 173: 1326–1334
   PubMed Web of Science ®Google Scholar
• Hosmer D, Lemeshow S. Applied Logistic Regression. Wiley-Interscience, New York 1989
   Google Scholar
• Hosmer D, Lemeshow S. Applied Logistic Regression, 2nd ed. John Wiley & Sons, New York 2000
   Google Scholar
• DeLong E R, DeLong D M, Clarke-Pearson D L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988; 44(3)837–845
   PubMed Web of Science ®Google Scholar
• Harrell F E, Jr., Lee K L, Mark D B. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996; 15(4)361–387
   PubMed Web of Science ®Google Scholar
• Efron B, Tibshirani R J. An Introduction to the Bootstrap. Chapman & Hill, Boca Raton, FL 1998
   Google Scholar
• Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest 2002; 121(5)1434–1440
   PubMed Web of Science ®Google Scholar
• Domingo-Salvany A, Lamarca R, Ferrer M, Garcia-Aymerich J, Alonso J, Felez M, et al. Health-related quality of life and mortality in male patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166(5)680–685
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Murio C, Guerrero T. Factors associated with relapse after ambulatory treatment of acute exacerbations of chronic bronchitis. DAFNE Study Group. Eur Respir J 2001; 17(5)928–933
   PubMed Web of Science ®Google Scholar
• Soler J J, Sanchez L, Roman P, Martinez M A, Perpina M. Risk factors of emergency care and admissions in COPD patients with high consumption of health resources. Respir Med 2004; 98(4)318–329
   PubMed Web of Science ®Google Scholar