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BASIC REVIEW

Functional Significance of Apoptosis in Chronic Obstructive Pulmonary Disease

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Pages 347-353 | Published online: 02 Jul 2009

REFERENCES

  • Lopez A D, Murray C C. The global burden of disease, 1990−2020. Nature Med 1998; 4: 1241–1243
  • Shapiro S D. The pathogenesis of emphysema: the elastase:antielastase hypothesis 30 years later. Proc Assoc Am Physicians 1995; 107: 346–352
  • Demedts I K, Brusselle G G, Bracke K R, Vermaelen K Y, Pauwels R A. Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol 2005; 5: 257–263
  • Barnes P J, Shapiro S D, Pauwels R A. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 2003; 22: 672–688
  • Pryor W A, Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann NY Acad Sci 1993; 686: 12–27
  • Hodge S, Hodge G, Scicchitano R, Reynolds P N, Holmes M. Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells. Immunol Cell Biol 2003; 81: 289–296
  • Segura-Valdez L, Pardo A, Gaxiola M, Uhal B D, Becerril C, Selman M. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 2000; 117: 684–694
  • Yokohori N, Aoshiba K, Nagai A. Increased levels of cell death and proliferation in alveolar wall cells in patients with pulmonary emphysema. Chest 2004; 125: 626–632
  • Imai K, Mercer B A, Schulman L L, Sonett J R, D'Armiento J M. Correlation of lung surface area to apoptosis and proliferation in human emphysema. Eur Respir J 2005; 25: 250–258
  • Sirianni F E, Chu F SF, Walker D C. Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium. Am J Respir Crit Care Med 2003; 168: 1532–1537
  • Tuder R M, Yoshida T, Arap W, Pasqualini R, Petrache I. State of the art. cellular and molecular mechanisms of alveolar destruction in emphysema. Proc Am Thorac Soc 2006; 3: 503–510
  • Kasahara Y, Tuder R M, Cool C D, Lynch D A, Flores S C, Voelkel N F. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001; 163: 737–744
  • Hodge S, Hodge G, Holmes M, Reynolds P N. Increased airway epithelial and T-cell apoptosis in COPD remains despite smoking cessation. Eur Respir J 2005; 25: 447–454
  • Church D F, Pryor W A. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 1985; 64: 111–126
  • Pryor W A, Stone K. Oxidants in cigarette smoke: radicals, hydrogenperoxides, peroxynitrate, and peroxynitrite. Ann N Y Acad Sci 1993; 686: 12–28
  • Zang L Y, Stone K, Pryor W A. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med 1995; 19: 161–167
  • MacNee W, Rahman I. Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999; 160: S58–S65
  • Carnevali S, Petruzzelli S, Longoni B, Vanacore R, Barale R, Cipollini M, et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2003; 284: L955–L963
  • Sugano N, Ito K. Nicotine switches the form of H2O2 induced cell death from apoptosis to necrosis in U937 cells. Immunol Lett 2000; 70: 163–166
  • Wang J, Wilcken D E, Wang X L. Cigarette smoke activates caspase-3 to induce apoptosis of human umbilical venous endothelial cells. Mol Genet Metab 2001; 72: 82–88
  • Aoshiba K, Tamaoki J, Nagai A. Acute cigarette smoke exposure induces apoptosis of alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1392–L1401
  • Hoshino Y, Mio T, Nagai S, Miki H, Ito I, Izumi T. Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line. Am J Physiol Lung Cell Mol Physiol 2001; 281: L509–L516
  • D'Agostini F, Balansky R M, Izzotti A, Lubet R A, Kelloff G J, De Flora S. Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats. Carcinogenesis 2001; 22: 375–380
  • Kuo W H, Chen J H, Lin H H, Chen B C, Hsu J D, Wang C J. Induction of apoptosis in the lung tissue from rats exposed to cigarette smoke involves p38/JNK MAPK pathway. Chem Biol Interact 2005; 155: 31–42
  • Ishii T, Matsuse T, Igarashi H, Masuda M, Teramoto S, Ouchi Y. Tobacco smoke reduces viability in human lung fibroblasts: protective effect of glutathione S-transferase P1. Am J Physiol Lung Cell Mol Physiol 2001; 280: L1189–L1195
  • Raveendran M, Wang J, Senthil D, Wang J, Utama B, Shen Y, et al. Endogenous nitric oxide activation protects against cigarette smoking induced apoptosis in endothelial cells. FEBS Lett 2005; 579: 733–740
  • Liu X, Conner H, Kobayashi T, Kim H, Wen F, Abe S, et al. Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2005; 33: 121–129
  • Kim H, Liu X, Kobayashi T, Conner H, Kohyama T, Wen F Q, Fang, et al. Reversible cigarette smoke extract–induced DNA damage in human lung fibroblasts. Am J Respir Cell Mol Biol 2004; 31: 483–490
  • Wickenden J A, Clarke M C, Rossi A G, Rahman I, Faux S P, Donaldson K, et al. Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. Am J Respir Cell Mol Biol 2003; 29: 562–570
  • Wu C H, Lin H H, Yan F P, Wu C H, Wang C J. Immunohistochemical detection of apoptotic proteins, p53/Bax and JNK/FasL cascade, in the lung of rats exposed to cigarette smoke. Arch Toxicol 2005; 9: 1–9
  • Hodge S J, Hodge G L, Reynolds P N, Scicchitano R, Holmes M. Increased production of TGF-beta and apoptosis of T lymphocytes isolated from peripheral blood in COPD. Am J Physiol Lung Cell Mol Physiol 2003; 285: L492–L499
  • Banzet N, Francois D, Polla B S. Tobacco smoke induces mitochondrial depolarization along with cell death effects of antioxidants. Redox Rep 1999; 4: 229–236
  • Slebos D J, Ryter S W, van der Toorn M, Liu F, Guo F, Baty C J, et al. Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. Am J Respir Cell Mol Biol 2006, (in press)
  • Ferrara N, Gerber H P, Le Couter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669–676
  • Kasahara Y, Tuder R M, Taraseviciene-Stewart L, Le Cras T D, Abman S H, Hirth P, et al. Inhibition of vascular endothelial growth factor receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000; 106: 1311–1319
  • Tang K, Rossiter H B, Wagner P D, Breen E C. Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice. J Appl Physiol 2004; 97: 1559–1566
  • Taraseviciene-Stewart L, Scerbavicius R, Choe K H, Moore M, Sullivan A, Nicolls M R, et al. An animal model of autoimmune emphysema. Am J Respir Crit Care Med 2005; 171: 734–742
  • Tuder R M, Zhen L, Cho C Y, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003; 29: 88–97
  • Marwick J A, Stevenson C S, Giddings J, MacNee W, Butler K, Rahman I, Kirkham P A. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. Am J Physiol Lung Cell Mol Physiol 2006; 290: L897–L908
  • Schroder K, Hertzog P J, Ravasi T, Hume D A. Interferon-γ: an overview of signals, mechanisms and functions. J Leukocyte Biol 2004; 75: 163–189
  • Wang Z, Zheng T, Zhu Z, Homer R J, Riese R J, Chapman H A, et al. Interferon-γ induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000; 192: 1587–1600
  • Zheng T, Kang M J, Crothers K, Zhu Z, Liu W, Lee C G, et al. Role of Cathepsin S-dependent epithelial cell poptosis in IFN-γ -Induced alveolar remodeling and pulmonary emphysema. J Immunol 2005; 174: 8106–8115
  • deCathelineau A M, Henson P M. The final step in programmed cell death: phagocytes carry apoptotic cells to the grave. Essays Biochem 2003; 39: 105–117
  • Gardai S J, Bratton D L, Ogden C A, Henson P M. Recognition ligands on apoptotic cells: a perspective. J Leukoc Biol 2006; 79: 896–903
  • Golpon H A, Fadok V A, Taraseviciene-Stewart L, Scerbavicius R, Sauer C, Welte T, et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J 2004; 18: 1716–1718
  • Vandivier R W, Fadok V A, Hoffmann P R, Bratton D L, Penvari C, Brown K K, et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest 2002; 109: 661–670
  • Vandivier R W, Ogden C A, Fadok V A, Hoffmann P R, Brown K K, Botto M, et al. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol 2002; 169: 3978–3986
  • Keatings V M, Collins P D, Scott D M, Barnes P J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996; 153: 530–534
  • Lacoste J Y, Bousquet J, Chanez P, Van Vyve T, Simony-Lafontaine J, Lequeu N, et al. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J Allergy Clin Immunol 1993; 92: 537–548
  • Saetta M, Di Stefano A, Turato G, Facchini F M, Corbino L, Mapp C E, et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157: 822–826
  • Liu A N, Mohammed A Z, Rice W R, Fiedeldey D T, Liebermann J S, Whitsett J A, et al. Perforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand. Am J Respir Cell Mol Biol. 1999; 20: 849–858
  • Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H. Metalloproteinase-mediated release of human Fas ligand. J Exp Med 1995; 182: 1777–1783
  • Powell W C, Fingleton B, Wilson C L, Boothby M, Matrisian L M. The metalloproteinase matrilysin (MMP-7) proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol 1999; 9: 1441–1447
  • Petrache I, Natarajan V, Zhen L, Medler T R, Richter A T, Cho C, Hubbard W C, Berdyshev E V, Tuder R M. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med 2005; 11: 491–498
  • Aoshiba K, Rennard S I, Spurzem J R. Cell-matrix and cell-cell interactions modulate apoptosis of bronchial epithelial cells. Am J Physiol 1997; 272: L28–L37
  • Petrache I, Fijalkowska I, Medler T R, Skirball J, Cruz P, Zhen L, Petrache H I, Flotte T R, Tuder R M. α -1 Antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol 2006; 169: 1155–1166
  • MacNee W. Oxidants/antioxidants and chronic obstructive pulmonary disease: pathogenesis to therapy. Novartis Found Symp 2001; 234: 169–185
  • Rahman I, Morrison D, Donaldson K, MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 1996; 154: 1055–1060
  • Rahman I, van Schadewijk A AM, Crowther A JL, Hiemstra P S, Stolk J, MacNee W, De Boer W I. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166: 490–495
  • Ryter S, Kim H P, Hoetzel A, Park J W, Wang X, Choi A M. Mechanisms of cell death in oxidative stress. Antioxidants Redox Signali 2007; 9: 49–89
  • Rangasamy T, Cho C Y, Thimmulappa R K, Zhen L, Srisuma S S, Kensler T W, Yamamoto M, Petrache I, Tuder R M, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004; 114: 1248–1259

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