275
Views
5
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Roflumilast Increases Clara Cell Secretory Protein in Cigarette Smoke-Exposed Mice

, , , , &
Pages 185-191 | Published online: 18 Jul 2009

REFERENCES

  • Rabe K F, Bateman E D, O'Donnell D, Witte S, Bredenbroker D, Bethke T D. Roflumilast- an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomized controlled trial. Lancet 2005; 366: 563–571
  • Grootendorst D C, Gauw S A, Verhoosel R M, Sterk P J, Hospers J J, Bredenbröker D, Bethke T D, Hiemstra P S, Rabe K F. The PDE4 inhibitor roflumilast reduces sputum neutrophil and eosinophil numbers in patients with COPD. Thorax 2007; 62: 1081–1087
  • Martorana P A, Beume R, Lucattelli M, Wollin L, Lungarella G. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005; 172: 848–853
  • Hayashida S, Harrod K S, Whitsett J A. Regulation and function of CCSP during pulmonary Pseudomonas aeruginosa infection in vivo. Am J Physiol Lung Cell Mol Physiol 2000; 279: L452–L459
  • Harrod K S, Mounday A D, Stripp B R, Whitsett J A. Clara cell secretory protein decreases lung inflammation after acute virus infection. Am J Physiol 1998; 275: L924–L930
  • Shijubo N, Honda Y, Itoh Y, Yamaguchi T, Kuroki Y, Akino T, Kawai T, Abe S. BAL surfactant protein A and Clara cell 10-kDa protein levels in healthy subjects. Lung 1998; 176: 257–265
  • Shijubo N, Itoh Y, Yamaguchi T, Shibuya Y, Morita Y, Hirasawa M, Okutani R, Kawai T, Abe S. Serum and BAL Clara cell 10 kDa protein (CC10) levels and CC10-positive bronchiolar cells are decreased in smokers. Eur Respir J 1997; 10: 1108–1114
  • Pilette C, Godding V, Kiss R, Delos M, Verbeken E, Decaestecker C, De Paepe K, Vaerman J P, Decramer M, Sibille Y. Reduced epithelial expression of secretory component in small airways correlates with airflow obstruction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163: 185–194
  • Al-Wadei H A, Takahashi T, Schuller H M. Caffeine stimulates the proliferation of human lung adenocarcinoma cells and small airway epithelial cells via activation of PKA, CREB and ERK1/2. Oncol Rep 2006; 15: 431–435
  • Hussein A, Al-Wadei N, Takahashi T, Schuller H M. Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia. Int J Oncol 2005; 27: 155–160
  • Ramsay P L, Luo Z, Major A, Park M S, Finegold M, Welty S E, Kwak I, Darlington G, Demayo F J. Multiple mechanisms for oxygen-induced regulation of the Clara cell secretory protein gene. FASEB J 2003; 17: 2142–2144
  • Luppi F, Aarbiou J, van Wetering S, Rahman I, de Boer W I, Rabe K F, Hiemstra P S. Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res 2005; 6: 140
  • Zhong C Y, Zhou Y M, Douglas G C, Witschi H, Pinkerton K E. MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of rats. Carcinogenesis 2005; 26: 2187–2195
  • Mata M, Sarria B, Buenestado A, Cortijo J, Cerda M, Morcillo E J. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 2005; 60: 144–152
  • Chu H W, Rino J G, Wexler R B, Campbell K, Harbeck R J, Martin R J. Mycoplasma pneumoniae infection increases airway collagen deposition in a murine model of allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol 2005; 289: L125–L133
  • Sawaya P L, Stripp B R, Whitsett J A, Luse D S. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol Cell Biol 1993; 13: 3860–3871
  • Stevens B. Cross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation. Novartis Found Symp 2006; 276: 162–175
  • Hu A, Nino G, Grunstein J S, Fatma S, Grunstein M M. Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction. Am J Physiol Lung Cell Mol Physiol 2008, Epub
  • Al-Wadei H A, Schuller H M. Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells. Cancer Detect Prev 2006; 30: 403–411
  • Huang Z, Mancini J A. Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD. Curr Med Chem 2006; 13: 3253–3262
  • AI-Wadei H A, Schuller H M. Cyclic adenosine monophosphate-dependent cell type-specific modulation of mitogenic signaling by retinoids in normal and neoplastic lung cells. Cancer Detect Prev 2006; 30: 403–411
  • Al-Wadei H A, Takahashi T, Schuller H M. Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer 2006; 118: 1370–1380
  • Al-Wadei H A, Takahasi T, Schuller H M. PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. Eur J Cancer 2005; 41: 2745–2753
  • Hodge S, Hodge G, Ahern J, Jersmann H, Holmes M, Reynolds P N. Smoking alters alveolar macrophage recognition and phagocytic ability: implications in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2007; 37: 748–755
  • Mango G W, Johnston C J, Reynolds S D, Finkelstein J N, Plopper C G, Stripp B R. Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. Am J Physiol 1998; 275: L348–L356
  • Johnston C J, Mango G W, Finkelstein J N, Stripp B R. Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am J Respir Cell Mol Biol 1997; 17: 147–155
  • Hung C H, Chen L C, Zhang Z, Chowdhury B, Lee W L, Plunkett B, Chen C H, Myers A C, Huang S K. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol 2004; 114: 664–670
  • Facchiano A, Cordella-Miele E, Miele L, Mukherjee A B. Inhibition of pancreatic phospholipase A2 activity by uteroglobin and antiflammin peptides: possible mechanism of action. Life Sci 1991; 48: 453–464
  • Lesur O, Bernard A, Arsalane K, Lauwerys R, Bégin R, Cantin A, Lane D. Clara cell protein (CC-16) induces a phospholipase A2-mediated inhibition of fibroblast migration in vitro. Am J Respir Crit Care Med 1995; 152: 290–297
  • Okutani R, Itoh Y, Yamada T, Yamaguchi T, Singh G, Yagisawa H, Kawai T. Preparation and characterization of human recombinant protein 1/Clara cell M(r) 10,000 protein. Eur J Clin Chem Clin Biochem 1996; 34: 691–696
  • Martin R J, Wexler R B, Day B J, Harbeck R J, Pinkerton K E, Chu H W. Interaction between cigarette smoke and mycoplasma infection: a murine model. COPD 2006; 3: 3–8

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.