Variants of the ADRB2 Gene in COPD: Systematic Review and Meta-Analyses of Disease Risk and Treatment Response

References

• World Health Organisation. The 10 leading causes of death in the world 2012, factsheet No 310. WHO (Internet). 2014 (cited 2016 Jan 5). Available from: http://www.who.int/mediacentre/factsheets/fs310/en/. 2014 May.
   Google Scholar
• Thomsen M, Nordestgaard BG, Vestbo J, Lange P. Characteristics and outcomes of chronic obstructive pulmonary disease in never smokers in Denmark: a prospective population study. Lancet Respir Med 2013; 1(7):543–550.
   PubMed Web of Science ®Google Scholar
• Zoeller B, Li X, Sundquist J, Sundquist K. Familial transmission of chronic obstructive pulmonary disease in adoptees: a Swedish nationwide family study. BMJ Open 2015; 5:e007310.
   PubMed Web of Science ®Google Scholar
• Vacca G, Schwabe K, Dück R, Hlawa H-P, Westphal A, Pabst S, et al. Polymorphisms of the beta2 adrenoreceptor gene in chronic obstructive pulmonary disease. Ther Adv Respir Dis 2009; 3(1):3–10.
   PubMedGoogle Scholar
• Papatheodorou A, Makrythanasis P, Kaliakatsos M, Dimakou A, Orfanidou D, Roussos C, et al. Development of novel microarray methodology for the study of mutations in the SERPINA1 and ADRB2 genes–their association with Obstructive Pulmonary Disease and Disseminated Bronchiectasis in Greek patients. Clin Biochem 2010; 43(1–2):43–50.
   PubMed Web of Science ®Google Scholar
• Ho LI, Harn HJ, Chen CJ, Tsai NM. Polymorphism of the beta(2)-adrenoceptor in COPD in Chinese subjects. Chest 2001; 120(5):1493–1489.
   PubMed Web of Science ®Google Scholar
• Brøgger J, Steen VM, Eiken HG, Gulsvik A, Bakke P. Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1. Eur Respir J 2006; 27(4):682–688.
   PubMed Web of Science ®Google Scholar
• Poller W, Meisen C, Olek K. DNA polymorphisms of the alpha 1-antitrypsin gene region in patients with chronic obstructive pulmonary disease. Eur J Clin Invest 1990; 20(1):1–7.
   PubMed Web of Science ®Google Scholar
• Ahles A, Engelhardt S. Polymorphic variants of adrenoceptors: Pharmacology, physiology, and role in disease. Pharmacol Rev 2014; 66:598–637.
   PubMed Web of Science ®Google Scholar
• Johnson M. Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. J Allergy Clin Immunol 2006; 117:18–24: quiz 25.
   PubMed Web of Science ®Google Scholar
• Small KM, McGraw DW, Liggett SB. Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol 2003; 43:381–411.
   PubMed Web of Science ®Google Scholar
• Grech G, Grossman I. Preventive and Predictive Genetics: Towards Personalised Medicine. Vol. 2015. Springer; 378 p.
   Google Scholar
• Thomsen M, Nordestgaard BG, Sethi AA, Tybjærg-Hansen A, Dahl M. β2-adrenergic receptor polymorphisms, asthma and COPD: Two large population-based studies. Eur Respir J 2012; 39(3):558–566.
   PubMed Web of Science ®Google Scholar
• Al-Balushi K, Zadjali F, Al-Sinani S, Al-Zadjali A-M, Bayoumi R. Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis. Sultan Qaboos Univ Med J 2015; 15(4):e486–e490.
   PubMedGoogle Scholar
• Nielsen AO, Quaum S, Bouchelouche PN, Laursen LC, Dahl R, Dahl M. Risk of asthma in heterozygous carriers for cystic fibrosis: A meta-analysis. J Cyst Fibrosis 2016; 15:563–567.
   PubMed Web of Science ®Google Scholar
• Attia J, Thakkinstian A, D'Este C. Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol 2003; 56(4):297–303.
   PubMed Web of Science ®Google Scholar
• Hegab AE, Sakamoto T, Saitoh W, Massoud HH, Massoud HM, Hassanein KM, et al. Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. Chest 2004; 126(6):1832–1839.
   PubMed Web of Science ®Google Scholar
• Ferdinands JM, Mannino DM, Gwinn ML, Bray MS. ADRB2 Arg16Gly polymorphism, lung function, and mortality: results from the Atherosclerosis Risk in Communities study. PloS One 2007; 2(3):e289.
   PubMed Web of Science ®Google Scholar
• Hussein MH, Sobhy KE, Sabry IM, El Serafi AT, Toraih EA. Beta2-adrenergic receptor gene haplotypes and bronchodilator response in Egyptian patients with chronic obstructive pulmonary disease. Adv Med Sci 2017(62):193–201.
   Google Scholar
• Ganbold C, Jamyansuren J, Puntsag O, Batjargal O, Dashtseren I, Jav S. ADRB2 and ACE gene polymorphisms in COPD susceptibility. Cent Asian J Med Sci 2016; 2016(2):127–133.
   Google Scholar
• Bleecker ER, Meyers DA, Bailey WC, Sims A-M, Bujac SR, Goldman M, et al. ADRB2 polymorphisms and budesonide/formoterol responses in COPD. Chest 2012; 142(2):320–328.
   PubMed Web of Science ®Google Scholar
• Matheson MC, Ellis JA, Raven J, Johns DP, Walters EH, Abramson MJ. Beta2-adrenergic receptor polymorphisms are associated with asthma and COPD in adults. J Hum Genet 2006; 51(11):943–951.
   PubMed Web of Science ®Google Scholar
• Hizawa N, Makita H, Nasuhara Y, Betsuyaku T, Itoh Y, Nagai K, et al. Beta2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD. Chest 2007; 132(5):1485–1492.
   PubMed Web of Science ®Google Scholar
• Kim WJ, Oh Y-M, Sung J, Kim T-H, Huh JW, Jung H, et al. Lung function response to 12-week treatment with combined inhalation of long-acting beta2 agonist and glucocorticoid according to ADRB2 polymorphism in patients with chronic obstructive pulmonary disease. Lung 2008; 186(6):381–386.
   PubMed Web of Science ®Google Scholar
• Konno S, Makita H, Hasegawa M, Nasuhara Y, Nagai K, Betsuyaku T, et al. Beta2-adrenergic receptor polymorphisms as a determinant of preferential bronchodilator responses to β2-agonist and anticholinergic agents in Japanese patients with chronic obstructive pulmonary disease. Pharmacogenet Genomics 2011; 21(11):687–693.
   PubMed Web of Science ®Google Scholar
• Rabe KF, Fabbri LM, Israel E, Kögler H, Riemann K, Schmidt H, et al. Effect of ADRB2 polymorphisms on the efficacy of salmeterol and tiotropium in preventing COPD exacerbations: a prespecified substudy of the POET-COPD trial. Lancet Respir Med 2014; 2(1):44–53.
   PubMed Web of Science ®Google Scholar
• Yelensky R, Li Y, Lewitzky S, Leroy E, Hurwitz C, Rodman D, et al. A pharmacogenetic study of ADRB2 polymorphisms and indacaterol response in COPD patients. Pharmacogenomics J 2012; 12(6):484–488.
   PubMed Web of Science ®Google Scholar
• Wang W, Li P, Chen Y, Yang J. Association between β2-adrenergic receptor-16Arg/Gly gene polymorphism and chronic obstructive pulmonary disease risk: Systematic review and meta-analysis. Iran J Public Health 2014; 43(7):877–888.
   PubMed Web of Science ®Google Scholar
• Niu L-M, Liang Y, Xu M, Zhang Y-Y, Zhang Y, He B. Effect of polymorphisms in the β2-adrenergic receptor on the susceptibility and pulmonary function of patients with chronic obstructive pulmonary disease: A meta analysis. Chin Med J (Engl) 2012; 125(12):2213–2218.
   PubMed Web of Science ®Google Scholar
• Bossé Y. Updates on the COPD gene list. Int J COPD 2012; 7:607–631.
   Web of Science ®Google Scholar
• Palmer CNA, Lipworth BJ, Lee S, Ismail T, Macgregor DF, Mukhopadhyay S. Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol. Thorax 2006; 61(11):940–944.
   PubMed Web of Science ®Google Scholar
• Hall IP, Blakey JD, Al Balushi KA, Wheatley A, Sayers I, Pembrey ME, et al. Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study. Lancet Lond Engl 2006; 368(9537):771–779.
   Google Scholar
• Migita O, Noguchi E, Jian Z, Shibasaki M, Migita T, Ichikawa K, et al. ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis. Int Arch Allergy Immunol 2004; 134(2):150–157.
   PubMed Web of Science ®Google Scholar
• Shah NJ, Vinod Kumar S, Gurusamy U, Annan Sudarsan AK, Shewade DG. Effect of ADRB2 (adrenergic receptor β2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma. J Asthma Off J Assoc Care Asthma 2015; 52(8):755–762.
   PubMed Web of Science ®Google Scholar
• Danielewicz H. What the genetic background of individuals with asthma and obesity can reveal: Is β2-adrenergic receptor gene polymorphism important? Pediatr Allergy Immunol Pulmonol 2014; 27(3):104–110.
   PubMed Web of Science ®Google Scholar
• Petrovic-Stanojevic N, Topic A, Nikolic A, Stankovic M, Dopudja-Pantic V, Milenkovic B, et al. Polymorphisms of beta2-adrenergic receptor gene in serbian asthmatic adults: effects on response to Beta-agonists. Mol Diagn Ther 2014; 18(6):639–646.
   PubMed Web of Science ®Google Scholar
• de Paiva ACZ, Marson FA, de L, Ribeiro JD, Bertuzzo CS. Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors. Allergy Asthma Clin Immunol Off J Can Soc Allergy Clin Immunol 2014; 10(1):8.
   PubMed Web of Science ®Google Scholar
• Manolopoulos KN, Karpe F. ADRB2 Arg16Gly polymorphism in the LARGE trial. Lancet Lond Engl 2010; 375(9716):724–725; author reply 725.
   PubMed Web of Science ®Google Scholar
• Hardin M, Cho M, McDonald M-L, et al. A Genome-wide analysis of the response to inhaled beta2-agonists in chronic obstructive pulmonary disease. J Pharmacogenomics 2016; 16(4):326–335.
   Google Scholar
• Hersh C. Pharmacogenetics of chronic obstructive pulmonary disease: challenges and oppportunities. Pharmacogenetics 2010; 11:237–247.
   Google Scholar
• Dekkers BGJ, Pehlić A, Mariani R, Bos IST, Meurs H, Zaagsma J. Glucocorticosteroids and β2-adrenoceptor agonists synergize to inhibit airway smooth muscle remodeling. J Pharmacol Exp Ther 2012; 342(3):780–787.
   PubMed Web of Science ®Google Scholar
• Mirza ZN, Kato M, Kimura H, Tachibana A, Fujiu T, Suzuki M, et al. Fenoterol inhibits superoxide anion generation by human polymorphonuclear leukocytes via beta-adrenoceptor-dependent and -independent mechanisms. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol 2002; 88(5):494–500.
   PubMed Web of Science ®Google Scholar
• Dowling RB, Johnson M, Cole PJ, Wilson R. Effect of fluticasone propionate and salmeterol on Pseudomonas aeruginosa infection of the respiratory mucosa in vitro. Eur Respir J 1999; 14(2):363–369.
   PubMed Web of Science ®Google Scholar
• Wegner CD. Novel mechanistic targets for the treatment of sub-acute and chronic bronchitis. Curr Pharm Des 2001; 7(3):199–212.
   PubMed Web of Science ®Google Scholar