Comprehensive Cluster Analysis for COPD Including Systemic and Airway Inflammatory Markers

References

• Rennard SI, Drummond MB. Early chronic obstructive pulmonary disease: definition, assessment, and prevention. Lancet Lond Engl. 2015;385(9979):1778–1788. DOI:10.1016/S0140-6736(15)60647-X
   PubMed Web of Science ®Google Scholar
• Fabbri LM, Luppi F, Beghe B, et al. Complex chronic comorbidities of COPD. Eur Respir J. 2008;31(1):204–212. DOI:10.1183/09031936.00114307
   PubMed Web of Science ®Google Scholar
• Deliu M, Sperrin M, Belgrave D, et al. Identification of asthma subtypes using clustering methodologies. Pulm Ther. 2016;2:19–41. DOI:10.1007/s41030-016-0017-z
   PubMedGoogle Scholar
• Johnson RA, Wichern DW. Applied multivariate statistical analysis: international edition. 6th ed. Pearson; ISBN-13 : 978-0135143506 Publisher: Pearson (4 May 2007)
   Google Scholar
• Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008;178(3):218–224. DOI:10.1164/rccm.200711-1754OC
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, National Heart, Lung, and Blood Institute's Severe Asthma Research Program, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med. 2010;181(4):315–323. DOI:10.1164/rccm.200906-0896OC
   PubMed Web of Science ®Google Scholar
• Castaldi PJ, Benet M, Petersen H, et al. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax. 2017;72(11):998–1006. DOI:10.1136/thoraxjnl-2016-209846
   PubMed Web of Science ®Google Scholar
• Vanfleteren LEGW, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187(7):728–735. DOI:10.1164/rccm.201209-1665OC
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Roche N, Paillasseur J-L, INITIATIVES BPCO Scientific Committee, et al. Clinical COPD phenotypes identified by cluster analysis: validation with mortality. Eur Respir J. 2012;40(2):495–496. DOI:10.1183/09031936.00228511
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Paillasseur J-L, Caillaud D, Initiatives BPCO Scientific Committee, et al. Clinical COPD phenotypes: a novel approach using principal component and cluster analyses. Eur Respir J. 2010;36(3):531–539. DOI:10.1183/09031936.00175109
   PubMed Web of Science ®Google Scholar
• Garcia-Aymerich J, Gomez FP, Benet M, on behalf of the PAC-COPD Study Group, et al. Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax. 2011;66(5):430–437. DOI:10.1136/thx.2010.154484
   PubMed Web of Science ®Google Scholar
• Fens N, van Rossum AGJ, Zanen P, et al. Subphenotypes of mild-to-moderate COPD by factor and cluster analysis of pulmonary function, CT imaging and breathomics in a population-based survey. COPD J Chronic Obstr Pulm Dis. 2013;10(3):277–285. DOI:10.3109/15412555.2012.744388
   Web of Science ®Google Scholar
• Basagaña X, Barrera-Gómez J, Benet M, et al. A framework for multiple imputation in cluster analysis. Am J Epidemiol. 2013;177(7):718–725. DOI:10.1093/aje/kws289
   PubMed Web of Science ®Google Scholar
• Pistolesi M, Camiciottoli G, Paoletti M, et al. Identification of a predominant COPD phenotype in clinical practice. Respir Med. 2008;102(3):367–376. DOI:10.1016/j.rmed.2007.10.019
   PubMed Web of Science ®Google Scholar
• Paoletti M, Camiciottoli G, Meoni E, et al. Explorative data analysis techniques and unsupervised clustering methods to support clinical assessment of Chronic Obstructive Pulmonary Disease (COPD) phenotypes. J Biomed Inform. 2009;42(6):1013–1021. DOI:10.1016/j.jbi.2009.05.008
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Nesme-Meyer P, Chanez P, et al. Cough and sputum production are associated with frequent exacerbations and hospitalizations in COPD subjects. Chest. 2009;135(4):975–982. DOI:10.1378/chest.08-2062
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Paillasseur J-L, Peene B, et al. Two distinct chronic obstructive pulmonary disease (COPD) phenotypes are associated with high risk of mortality. Sethi. S, ed. PLoS ONE. 2012;7(12):e51048. DOI:10.1371/journal.pone.0051048
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Paillasseur J-L, Janssens W, et al. A simple algorithm for the identification of clinical COPD phenotypes. Eur Respir J. 2017;50(5):1701034. DOI:10.1183/13993003.01034-2017
   PubMed Web of Science ®Google Scholar
• Burgel P-R, Paillasseur J-L, Roche N. Identification of clinical phenotypes using cluster analyses in COPD patients with multiple comorbidities. BioMed Res Int. 2014;2014:420134–420139. DOI:10.1155/2014/420134
   PubMed Web of Science ®Google Scholar
• Cataldo D, Corhay J-L, Derom E, et al. A Belgian survey on the diagnosis of asthma-COPD overlap syndrome. COPD. 2017;Volume 12:601–613. DOI:10.2147/COPD.S124459
   Google Scholar
• Molenberghs G, Kenward M. Missing data in clinical studies. John Wiley & Sons; ISBN:9780470849811 Publisher is: John Wiley & Sons: Chichester, 2007.
   Google Scholar
• Buuren S. v. Flexible imputation of missing data. CRC Press; ISBN-13: 978-1439868249 Publisher: Chapman and Hall/CRC; 1st Edition (March 29, 2012).
   Google Scholar
• Rubin DB. Multiple imputation for nonresponse in surveys. John Wiley & Sons; ISBN:0470317361, 9780470317365 Publisher: John Wiley & Sons, Inc. 2009.
   Google Scholar
• Agusti A, Pavord ID. Do we really need a new classification of airway diseases? Lancet Respir Med. 2018;6(12):891–893. DOI:10.1016/S2213-2600(18)30386-2
   PubMed Web of Science ®Google Scholar
• Moermans C, Heinen V, Nguyen M, et al. Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease. Cytokine. 2011;56(2):298–304. DOI:10.1016/j.cyto.2011.07.010
   PubMed Web of Science ®Google Scholar
• Celli BR, Locantore N, Yates J, for the ECLIPSE Investigators, et al. Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;185(10):1065–1072. DOI:10.1164/rccm.201110-1792OC
   PubMed Web of Science ®Google Scholar
• Demarche S, Schleich F, Henket M, et al. Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory? BMC Pulm Med. 2016;16(1):46. DOI:10.1186/s12890-016-0208-2
   PubMedGoogle Scholar
• Schleich FN, Chevremont A, Paulus V, et al. Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. Eur Respir J. 2014;44(1):97–108. DOI:10.1183/09031936.00201813
   PubMed Web of Science ®Google Scholar
• O'Connor GT, Sparrow D, Weiss ST. The role of allergy and nonspecific airway hyperresponsiveness in the pathogenesis of chronic obstructive pulmonary disease. Am Rev Respir Dis. 1989;140(1):225–252. DOI:10.1164/ajrccm/140.1.225
   PubMedGoogle Scholar
• Amaral AFS, Newson RB, Abramson MJ, et al. Changes in IgE sensitization and total IgE levels over 20 years of follow-up. J Allergy Clin Immunol. 2016;137(6):1788–1795.e9. DOI:10.1016/j.jaci.2015.09.037
   PubMed Web of Science ®Google Scholar
• Manise M, Bakayoko B, Schleich F, et al. IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity. Int J Clin Pract. 2016;70(7):596–605. DOI:10.1111/ijcp.12837
   PubMed Web of Science ®Google Scholar
• Lapperre TS, Snoeck-Stroband JB, Gosman MME, Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease Study Group, et al. Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170(5):499–504. DOI:10.1164/rccm.200401-112OC
   PubMed Web of Science ®Google Scholar
• Pavord ID, Lettis S, Locantore N, et al. Blood eosinophils and inhaled corticosteroid/long-acting β-2 agonist efficacy in COPD. Thorax. 2016;71(2):118–125. DOI:10.1136/thoraxjnl-2015-207021
   PubMed Web of Science ®Google Scholar