Transfer of Invitro CD4 + T Cells with Hypomethylation of Perforin Promoter into Rats’ Abdomens Causes Autoimmune Emphysema

References

• Huang X, Zhu Z, Guo X, et al. The roles of microRNAs in the pathogenesis of chronic obstructive pulmonary disease. Int Immunopharmacol. 2019;67:335–347. DOI:10.1016/j.intimp.2018.12.013
   PubMed Web of Science ®Google Scholar
• Lamprecht B, McBurnie MA, Vollmer WM, BOLD Collaborative Research Group, et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest. 2011;139(4):752–763. DOI:10.1378/chest.10-1253
   PubMed Web of Science ®Google Scholar
• Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary Disease (2020 report)[EB/OL]. https://goldcopd.org/wp-content/uploads/2019/12/GOLD-2020-FINAL-ver1.2-03Dec19WMV.pdf
   Google Scholar
• Sze MA, Dimitriu PA, Suzuki M, et al. Host response to the lung microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192(4):438–445. DOI:10.1164/rccm.201502-0223OC
   PubMed Web of Science ®Google Scholar
• Caramori G, Ruggeri P, Di Stefano A, et al. Autoimmunity and COPD: Clinical implications. Chest. 2018;153(6):1424–1431. DOI:10.1016/j.chest.2017.10.033
   PubMed Web of Science ®Google Scholar
• Sileikiene V, Laurinaviciene A, Lesciute-Krilaviciene D, et al. Levels of CD4+ CD25 + T regulatory cells in bronchial mucosa and peripheral blood of chronic obstructive pulmonary disease indicate involvement of autoimmunity mechanisms. Adv Respir Med. 2019;87(3):159–166. DOI:10.5603/ARM.2019.0023
   PubMed Web of Science ®Google Scholar
• Jin Y, Wan Y, Chen G, et al. Treg/IL-17 ratio and treg differentiation in patients with COPD. PLoS One. 2014;9(10):e111044. DOI:10.1371/journal.pone.0111044
   PubMed Web of Science ®Google Scholar
• Taraseviciene-Stewart L, Scerbavicius R, Choe KH, et al. An animal model of autoimmune emphysema. Am J Respir Crit Care Med. 2005;171(7):734–742. DOI:10.1164/rccm.200409-1275OC
   PubMed Web of Science ®Google Scholar
• Laddha AP, Kulkarni YA. VEGF and FGF-2: Promising targets for the treatment of respiratory disorders. Respir Med. 2019;156:33–46. DOI:10.1016/j.rmed.2019.08.003
   PubMed Web of Science ®Google Scholar
• Michalska-Jakubus M, Kowal M, Adamczyk M, et al. Anti-endothelial cell antibodies do not correlate with disease activity in systemic sclerosis. Postepy Dermatol Alergol. 2018;35(2):185–191. DOI:10.5114/ada.2018.75241
   PubMed Web of Science ®Google Scholar
• Lee JH, Hanaoka M, Kitaguchi Y, et al. Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema. Lung. 2012;190(1):69–82. DOI:10.1007/s00408-011-9326-z
   PubMed Web of Science ®Google Scholar
• Zhao YL, Li F, Liu YW, et al. Adiponectin attenuates endoplasmi c reticulum stres s and alveolar epithelial apoptosis in COPD rats. Eur Rev Med Pharmacol Sci. 2017;21(21):4999–5007.
   PubMed Web of Science ®Google Scholar
• Zhang C, Yan MY, Lu P, et al. Hypomethylation of perforin regulatory elements in CD4+ T cells from rat spleens contributes to the development of autoimmune emphysema. Respirology. 2014;19(3):376–381. DOI:10.1111/resp.12240
   PubMed Web of Science ®Google Scholar
• Wilmot B, Fry R, Smeester L, et al. Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2. J Child Psychol Psychiatry. 2016;57(2):152–160. DOI:10.1111/jcpp.12457
   PubMed Web of Science ®Google Scholar
• Gilbert KM, Blossom SJ, Erickson SW, et al. Chronic exposure to trichloroethylene increases DNA methylation of the IFNG promoter in CD4+ T cells. Toxicol Lett. 2016;260:1–7. DOI:10.1016/j.toxlet.2016.08.017
   PubMed Web of Science ®Google Scholar
• Zhang XY, Zhang C, Sun QY, et al. Infliximab protects against pulmonary emphysema in smoking rats. Chin Med J (Engl). 2011;124(16):2502–2506.
   PubMed Web of Science ®Google Scholar
• Karayama M, Inui N, Suda T, et al. Antiendothelial cell antibodies in patients with COPD. Chest. 2010;138(6):1303–1308. DOI:10.1378/chest.10-0863
   PubMed Web of Science ®Google Scholar
• Jia Y, Chang Y, Guo Z, et al. Transcription factor Tbx5 promotes cardiomyogenic differentiation of cardiac fibroblasts treated with 5-azacytidine. J Cell Biochem. 2019;120(10):16503–16515. DOI:10.1002/jcb.28885
   PubMed Web of Science ®Google Scholar
• Li W, Wu D, Niu Z, et al. 5-Azacytidine suppresses EC9706 cell proliferation and metastasis by upregulating the expression of SOX17 and CDH1. Int J Mol Med. 2016;38(4):1047–1054. DOI:10.3892/ijmm.2016.2704
   PubMed Web of Science ®Google Scholar
• Lu Q, Wu A, Ray D, et al. DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol. 2003;170(10):5124–5132. DOI:10.4049/jimmunol.170.10.5124
   PubMed Web of Science ®Google Scholar
• Kiraz Y, Adan A, Kartal Yandim M, et al. Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol. 2016;37(7):8471–8486. DOI:10.1007/s13277-016-5035-9
   PubMed Web of Science ®Google Scholar
• Demedts IK, Demoor T, Bracke KR, et al. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res. 2006;7(1):53. DOI:10.1186/1465-9921-7-53
   PubMedGoogle Scholar
• Gong J, Zhao H, Liu T, et al. Cigarette smoke reduces fatty acid catabolism, leading to apoptosis in lung endothelial cells: Implication for pathogenesis of COPD. Front Pharmacol. 2019;10:941.
   PubMed Web of Science ®Google Scholar
• Wang L, Xu Z, Chen B, et al. The role of vascular endothelial growth factor in small-airway remodelling in a rat model of chronic obstructive pulmonary disease. Sci Rep. 2017;7:41202. DOI:10.1038/srep41202
   PubMed Web of Science ®Google Scholar
• Kranenburg AR, de Boer WI, Alagappan VK, et al. Enhanced bronchial expression of vascular endothelial growth factor and receptors (flk-1 and flt-1) in patients with chronic obstructive pulmonary disease. Thorax. 2005;60(2):106–113. DOI:10.1136/thx.2004.023986
   PubMed Web of Science ®Google Scholar
• Chetta A, Olivieri D. Role of inhaled steroids in vascular airway remodelling in asthma and COPD. Int J Endocrinol. 2012;2012:397693. DOI:10.1155/2012/397693
   PubMed Web of Science ®Google Scholar