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Original Articles

A proposed methodology for setting occupational exposure limits for hydrocarbon solvents

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Pages 524-542 | Published online: 04 Mar 2011

References

  • 2005 . TLV®s and BEIs. Threshold Limit Values for Chemical Substances and Physical Agents , Cincinnati , Ohio : ACGIH .
  • 1997 . Occupational Exposure Limits for Hydrocarbon Solvents , Brussels : ECETOC .
  • Bartsch , R. , Forderkunz , S. , Reuter , U. , Sterzl-Eckert , H. and Greim , H. 1998 . Maximum workplace concentration values and carcinogenicity classification for mixtures . Environ. Health Perspect. , 106 : 1291 – 1293 .
  • 1995 . Occupational Exposure Limits 1995 (EH40/95) , London : U.K. Health and Safety Executive .
  • Ogata , M. , Fiserova-Bergerova , V. and Droz , P. 1993 . Biological monitoring VIII: Occupational exposures to mixtures of industrial chemicals . Appl. Occup. Environ. Hyg. , 8 : 609 – 617 .
  • Scheffers , T. , Jongeneelen , F. and Bragt , P. 1985 . Development of effect-specific limit values (ESLVs) for solvent mixtures in painting . Ann. Ind. Hyg. , 2 : 191 – 199 .
  • Lewis , R. J. Sr. 1993 . Hawley's Condensed Chemical Dictionary , New York : Van Nostrand Reinhold .
  • Ridgway , P. , Nixon , T. and Leach , J. -P. 2003 . Occupational exposure to organic solvents and long-term nervous system damage detectable by brain imaging, neurophysiology or histopathology . Food Chem. Toxicol , 41 : 153 – 187 .
  • Tardif , R. , Plaa , G. and Brodeur , J. 1992 . Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats . Can. J. Physiol. Pharmacol. , 70 : 385 – 393 .
  • Travis , C. , Fox , M. , Simmons , M. and Lyon , B. 1992 . Co-exposure to gasoline vapor decreases benzene metabolism in Fischer-344 rats . Toxicol. Lett. , 62 : 231 – 240 .
  • Medinsky , M. , Schlosser , P. and Bond , J. 1994 . Critical issues in benzene toxicity and metabolism: The effect of interactions with other organic chemicals on risk assessment . Environ. Health Perspect. , 102 : 119 – 124 .
  • Bond , J. , Leavens , T. , Seaton , M. and Medinsky , M. 1997 . Predicting the toxicity of chemical mixtures based on knowledge of individual components . CIIT Activities , 17 : 2 – 7 .
  • Bond , J. , Leavens , T. , Seaton , M. and Medinsky , M. 1998 . Predicting the toxicity of chemical mixtures . Chemtech , 28 : 16 – 23 .
  • Kawai , T. , Miyama , Y. and Horiguchi , S. 2000 . Possible metabolic interaction between hexane and other solvents co-exposed at sub-occupational exposure limit levels . Int. Arch. Occup. Environ. Health , 73 : 449 – 456 .
  • Thrall , K. and Poet , T. 2000 . Determination of biokinetic interactions in chemical mixtures using real-time breath analysis and physiologically based pharmacokinetic modeling . J. Toxicol. Environ. Health , 59 : 653 – 670 .
  • Nessel , C. , Owen , D. , Lammers , J. , Muijser , H. and Kulig , B. 2000 . Neurobehavioral assessment of hydrocarbons and its application to the development of occupational exposure limits for hydrocarbon solvents. Abstract 1689 from 39th Annual Meeting of the Society of Toxicology, Philadelphia, Pa., March 19-23, 2000 . The Toxicologist , 54 ( Suppl ) : 360 1
  • Carpenter , C. , Kinkead , E. , Geary , D. , Sullivan , L. and King , J. 1975 . Petroleum hydrocarbon toxicity studies III. Animal and human response to vapors of Stoddard solvent . Toxicol. Appl. Pharmacol. , 32 : 282 – 297 .
  • Dick , R. 1988 . Short duration exposures to organic solvents: The relationship between neurobehavioral test results and other indicators . Neurotoxicol. Teratol. , 10 : 39 – 50 .
  • Anderson , I. , Lundqvist , G. and Molhave , L. 1983 . Human response to controlled levels of toluene in six-hour exposures . Scand. J. Work, Environ. Health , 9 : 405 – 418 .
  • Baelum , J. , Lundqvist , G. , Molhave , L. and Anderson , N. 1990 . Human response to varying concentrations of toluene . Int. Arch. Occup. Environ. Health , 62 : 65 – 71 .
  • Iregren , A. and Gamberale , F. 1990 . Human behavioral toxicology: Central nervous effects of low-dose exposure to neurotoxic substances in the work environment . Scand. J. Work, Environ. Health , 16 : 17 – 25 .
  • Dick , R. , Krieg , E. , Setzer , J. and Taylor , B. 1992 . Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone . Fundam. Appl. Toxicol. , 19 : 453 – 473 .
  • Echeverria , D. , Fine , L. , Langolf , G. , Schork , A. and Sampaio , C. 1989 . Acute neurobehavioral effects of toluene . Br. J. Ind. Med. , 46 : 483 – 495 .
  • Savolainen , K. , Riihimaki , V. , Laine , A. and Kekoni , J. 1981 . Short-term exposure of human subjects to m-xylene and 1,1,1-trichloroethane . Int. Arch. Environ. Health , 49 : 89 – 98 .
  • 1996 . Chronic Neurotoxicity of Solvents , Brussels : ECETOC .
  • Grandjean , P. Neurobehavioural Methods in Occupational and Environmental Health . Reports from the Second International Symposium Copenhagen World Health Organization . Copenhagen . World Health Organization .
  • Cavanagh , J. 1985 . “ Mechanisms of organic solvent toxicity: Morphological changes ” . In Chronic Effects of Organic Solvents on the Central Nervous System and Diagnostic Criteria , 110 – 135 . Copenhagen : World Health Organization .
  • Baker , E. 1994 . A review of recent research on health effects of human occupational exposure to organic solvents . J. Occup. Med. , 10 : 1079 – 1092 .
  • Caldwell , D. , Armstrong , T. , Barone , N. , Suder , J. and Evans , M. 2000 . Hydrocarbon solvent exposure data: Compilation and analysis of the literature . Am. Ind. Hyg. Assoc. J. , 61 : 881 – 894 .
  • Hogstedt , C. 1994 . Has the Scandanavian solvent syndrome controversy been solved? . Scand. J. Work, Environ. Health , 20 : 59 – 64 .
  • Spurgeon , A. , Glass , D. , Calvert , I. , Cunningham-Hill , M. and Harrington , J. 1994 . Investigation of dose related neurobehavioural effects in paintmakers exposed to low levels of solvents . Occup. Environ. Med. , 51 : 626 – 630 .
  • Gamble , J. 2000 . Low-level hydrocarbon solvent exposure and neurobehavioral effects . J. Occup. Med. , 50 : 81 – 102 .
  • Dick , R. , Semple , S. and Osborne , A. 2002 . Organic solvent exposure, genes, and risk of neuropsychological impairment . Q. J. Assoc. Physicians (England) , 95 : 375 – 387 .
  • Hooisma , J. , Hanninen , H. , Emmen , H. and Kulig , B. 1994 . Symptoms indicative of the effects of organic solvent exposure in Dutch painters . Neurotoxicol. Teratol. , 16 : 613 – 622 .
  • White , R. , Proctor , S. , Echeverria , D. , Scheweikert , J. and Feldman , R. 1995 . Neurobehavioral effects of acute and chronic mixed-solvent exposure in the screen printing industry . Am. J. Ind. Med. , 28 : 221 – 231 .
  • Blake , M. and Colquhoun , W. P. 1971 . “ Temperament and time of day ” . In Biological Rhythms and Human Performance , 109 – 148 . London : Academic Press .
  • Bjerre , A. 1989 . Assessing exposure to solvent vapour during the application of paints, etc.—Model calculations versus common sense . Ann. Occup. Hyg. , 33 : 507 – 517 .
  • 1985 . Hazard Communications . Federal Register , 50 : 229
  • 2004 . Review of the Benzene Concentrations in Hydrocarbon Solvents Washington, Brussels, D.C.
  • Fedoruk , M. , Bronstein , R. and Kerger , B. 2003 . Benzene exposure assessment for use of a mineral spirits-based degreaser . Appl. Occup. Environ. Hyg. , 18 : 764 – 771 .
  • Farmer , T. 1996 . Short communication. Occupational exposure limits for hydrocarbon solvents . Ann. Occup. Hyg. , 40 : 237 – 242 .
  • Dalbey , W. , Osmitz , T. , Kommineni , C. , Roy , T. , Feuston , M. and Yang , J. 1991 . Four-week inhalation exposures of rats to aerosols of three lubricant base oils . J. Appl. Toxicol. , 11 : 297 – 302 .
  • Lammers , Pijcken , J. W. , Feron , V. and van Asperen , J. 2002 . Behavioral effects of peak exposures to toluene in the rat . Toxicologist , 66 : 253 – 254 .
  • Kulig , B. , Hissink , A. and Kruse , J. 2000 . PBPK modeling of peak exposures to white spirit . Toxicologist , 54 : 360
  • Dick , R. , Chang , L. and Dyer , R. 1995 . “ Neurobehavioral assessment of occupationally relevant solvents and chemicals in humans ” . In Handbook of Neurotoxicity , 217 – 322 . New York : Marcel Dekker, Inc. .
  • Baker , E. , Letz , R. , Fidler , A. , Shalt , S. , Plantamura , D. and Lyndon , M. 1985 . A computer-based neurobehavioral evaluation system for occupational and environmental epidemiology. Methodology and validation studies . Neurobehav. Toxicol. Teratol. , 7 : 369 – 377 .
  • Emmen , H. , Hoogendijk , E. , Hooisma , J. and Uijtdenhaage , S. 1988 . Adaptation of Two Standardized International Test Batteries for Use in The Netherlands for Detection of Exposure to Neurotoxic Substances , Rijswijk , , Netherlands : Medical Biological Laboratory TNO .
  • Hoosima , J. , Emmen , H. , Kulig , B. , Muijser , H. , Poortvliet , D. , Letz , R. and Johnson , B. L. 1990 . “ Factor analysis of tests from the neurobehavioral evaluation system and the WHO Neurobehavioral Core Test Battery ” . In Advances in Neurobehavioral Toxicology: Applications in Environmental and Occupational Health , Chelsea , Mich : Lewis Publishers .
  • Hissink , A. , Kulig , B. and Lammers , J. 2000 . PBPK modeling of n-decane and 1,2,4-trimethylbenzene alone or as constituents of white spirit . Toxicologist , 54 : 362
  • Lammers , J. , Kulig , B. , McKee , R. , Owen , D. and Nessel , C. 2000 . Acute behavioral effects of n-decane, 1,2,4-trimethylbenzene and white spirit in rats in relation to brain and blood levels . Toxicologist , 54 : 361 – 362 .
  • 2003 . Practical Guidelines for Measuring Solvent Vapour Concentrations Using Chemical Indicator Tubes , Brussels : ESIG .
  • 1999 . The Effects of Short-Term Inhalatory Exposure to n-Pentane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2000 . The Effects of Short-Term Inhalatory Exposure to Isopentane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2000 . The Effects of Short-Term Inhalatory Exposure to Cyclopentane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 1997 . Model Studies for Evaluating the Behavioral Effects of Petroleum Solvents and the Role of Toxicokinetic Factors: The Effects of Cyclohexane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute .
  • 1997 . Model Studies for Evaluating the Behavioral Effects of Solvents and the Role of Toxicokinetic Factors: The Effects of Cyclohexane on Behavior in Human Volunteers , Brussels : TNO Nutrition and Food Research Institute .
  • Hissink , A. , Kruse , J. and Kulig , B. 1999 . “ Model Studies of Hydrocarbon Solvents III ” . In PBPK Modeling of Cyclohexane in Rats and Humans , Oslo : European Society of Toxicology .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to Cypar 7 on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2000 . The Effects of Short-Term Inhalatory Exposure to n-octane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to Iso-octane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • Bowen , S. E. and Balster , R. L. 1998 . The effects of inhaled isoparaffins on locomotor activity and operant performance in mice . Pharmacol. Biochem. Behav. , 61 : 271 – 280 .
  • Balster , R. L. , Bowen , S. E. , Evans , E. B. and Tokarz , M. E. 1997 . Evaluation of the acute behavioral effects and abuse potential of a C8-C9 isoparaffin solvent . Drug Alcohol Depend. , 46 : 125 – 135 .
  • 1991 . Thirteen Week Inhalation Study of Potential Effects of Commercial Hexane on Behavior and Neuromorphology in Rats , Washington, D.C. : API .
  • Daughtrey , W. C. , Neeper-Bradley , T. and Duffy , J. 1994 . Two-generation reproduction study on commercial hexane solvent . J. Appl. Toxicol. , 14 : 387 – 393 .
  • Daughtrey , W. , Newton , P. and Rhoden , R. 1999 . Chronic inhalation carcinogenicity study of commercial hexane solvent in F-344 rats and B6C3F1 mice . Toxicol. Sci. , 48 : 21 – 29 .
  • Christoph , G. R. , Kelly , D. P. and Krivanek , N. 2000 . Acute inhalation exposure to cyclohexane and schedule-controlled operant behavior in rats: Comparison to d-amphetamine and chlorpromazine . Drug Chem. Toxicol. , 23 : 539 – 553 .
  • Kreckmann , K. H. , Roberts , L. G. and Baldwin , J. K. 1998 . Inhalation developmental toxicity studies of cyclohexane in rats and rabbits . Toxicologist , 42 ( 1 ) : 256
  • Malley , L. , Bamberger , J. and Stadler , J. 2000 . Subchronic toxicity of cyclohexane in rats and mice by inhalation exposure . Drug Chem. Toxicol. , 23 : 513 – 537 .
  • McKee , R. , Frank , E. and Heath , J. 1998 . Toxicology of n-pentane (CAS no. 109-66-0) . J. Appl. Toxicol. , 18 : 431 – 442 .
  • 2000 . The Effects of Short-Term Inhalatory Exposure to n-Decane on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to Nappar 10 on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to Isane IP 155 on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • Nilsen , O. G. , Haugen , O. A. and Zahlsen , K. 1988 . Toxicity of n-C9 to n-C13 alkanes in the rat on short-term inhalation . Pharmacol. Toxicol. , 62 : 259 – 266 .
  • Carpenter , C. P. , Geary , D. L. Jr. and Myers , R. C. 1978 . Petroleum hydrocarbon toxicity studies. XVII. Animal response to n-nonane vapor . Toxicol. Appl. Pharmacol. , 44 : 53 – 61 .
  • Dick , R. B. , Setzer , J. V. and Wait , R. 1984 . Effects of acute exposure to toluene and methyl ethyl ketone on psychomotor performance . Int. Arch. Occup. Environ. Health , 54 : 91 – 109 .
  • Campo , P. , Lataye , R. , Cossec , B. and Placidi , V. 1997 . Toluene-induced hearing loss: A mid-frequency location of the cochlear lesions . Neurotoxicol. Teratol. , 19 : 129 – 140 .
  • Morata , T. C. , Fiorini , A. C. and Fishcer , F. M. 1997 . Toluene-induced hearing loss among rotogravure printing workers . Scand. J. Work, Environ. Health , 23 : 289 – 298 .
  • 1990 . Toxicology and Carcinogenesis Studies of Toluene in F344 and B6C3F1 Mice , NTP Technical Report Series No. 371 Research Triangle Park , N.C. : NTP .
  • Savolainen , K. , Riihimaki , V. and Linnoila , M. 1979 . Effects of short-term xylene exposure on psychophysiological functions in man . Int. Arch. Occup. Environ. Health , 44 : 201 – 211 .
  • Carpenter , C. O. , Kinkead , I. R. and Geary , D. L. 1975 . Petroleum hydrocarbon toxicity studies. V. Animal and human response to vapors of mixed xylenes . Toxicol. Appl. Pharmacol. , 33 : 543 – 558 .
  • 1996 . Toxicology and Carcinogenesis Studies of Ethylbenzene (CAS No. 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) , NTP Technical Report Series No. 466 Research Triangle Park , N.C. : NTP .
  • 1999 . The Effects of Short-Term Inhalatory Exposure to 1,2,4-Trimethylbenzene on Behavior in the Rat , Brussels , Belgium : TNO Nutrition and Food Research Institute for CEFIC .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to SHELLSOL A on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .
  • 2001 . The Effects of Short-Term Inhalatory Exposure to Solvarex 10 on Behavior in the Rat , Brussels : TNO Nutrition and Food Research Institute for CEFIC .

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