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Departments

Case Study

Occupational Exposures to Antineoplastic Drugs in an Oncology-Hematology Department

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Pages D1-D6 | Published online: 05 Feb 2011

REFERENCES

  • World Health Organization, International Agency for Research on Cancer (IARC) . 2004 . IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , Lyons , , France : IARC Press .
  • Ferguson , L. and Pearson , A. 1996 . The clinical use of mutagenic anticancer drugs . Mutat. Res. , 355 ( 1 ) : 1 – 12 .
  • Falck , K. , Gröhn , P. Sorsa , M. 1979 . Mutagenicity in urine of nurses handling cytostatic drugs . Lancet , 1 ( 8128 ) : 1250 – 1251 .
  • Cooke , J. , Williams , J. Morgan , R. 1991 . Use of cytogenetic methods to determine mutagenic changes in the blood of pharmacy personnel and nurses who handle cytotoxic agents . Am. J. Hosp Pharm. , 48 : 1199 – 1205 .
  • Sorsa , M. and Anderson , D. 1996 . Monitoring of occupational exposure to cytostatic anticancer agents . Mutat. Res. , 355 ( 1 ) : 253 – 261 .
  • Connor , T. 2006 . Hazardous anticancer drugs in health care: Environmental exposure assessment . Ann. N.Y. Acad. Sci. , 1076 : 615 – 623 .
  • Hedmer , M. , Tinnerberg , H. Axmon , A. 2008 . Environmental and biological monitoring of antineoplastic drugs in four workplaces in a Swedish hospital . Int. Arch. Occup. Environ. Health , 81 ( 7 ) : 899 – 911 .
  • “Alert: Preventing Occupational Exposure to Antineoplastic and Other Hazardous Drugs in Health Care Settings.” . [Online] Available at http://www.cdc.gov/niosh/docs/2004-165/default.html (Accessed Oct 28, 2010)
  • Valanis , B. , Vollmer , W. Labuhn , K. 1993 . Acute symptoms associated with antineoplastic drug handling among nurses . Cancer Nurs. , 16 ( 4 ) : 288 – 295 .
  • Shortridge , L. , Lemasters , G. Valanis , B. 1995 . Menstrual cycles in nurses handling antineoplastic drugs . Cancer Nurs. , 18 ( 6 ) : 439 – 444 .
  • Valanis , B. , Vollmer , W. Labuhn , K. 1997 . Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists . J. Occup. Environ. Med. , 39 ( 6 ) : 574 – 580 .
  • Valanis , B. , Vollmer , W. and Steele , P. 1999 . Occupational exposure to antineoplastic agents: Self-reported miscarriages and stillbirths among nurses and pharmacists . J. Occup. Environ. Med. , 41 ( 8 ) : 632 – 638 .
  • Occupational Safety and Health Administration (OSHA) . 1995 . Instruction TED 1.15. Directorate of Technical Support. Controlling Occupational Exposure to Hazardous Drugs. Washington, D.C.: U.S . Department of Labor , Sec. V, Chap.3
  • Connor , T. and McDiarmid , M. 2006 . Preventing occupational exposures to antineoplastic drugs in health care settings . CA: Cancer J. Clin. , 56 ( 6 ) : 354 – 365 .
  • Fransman , W. , Peelen , S. Hilhorst , S. 2007 . A pooled analysis to study trends in exposure to antineoplastic drugs among nurses . Ann. Occup. Hyg. , 51 ( 3 ) : 231 – 239 .
  • Eisenberg , S. 2009 . Safe handling and administration of antineoplastic chemotherapy . J. Infus. Nurs. , 32 ( 1 ) : 23 – 32 .
  • Harrison , B. , Peters , B. and Bing , M. 2006 . Comparison of surface contamination with cyclophosphamide and fluorouracil using a closed-system drug transfer device versus standard preparation techniques . Am. J. Health Syst. Pharm. , 63 ( 18 ) : 1736 – 1744 .
  • Connor , T. , Anderson , R. Sessink , P. 1999 . Surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United States . Am. J. Health Syst. Pharm. , 56 ( 14 ) : 1427 – 1432 .
  • American Society of Health-System Pharmacists (ASHP) . 2006 . ASHP guidelines on handling hazardous drugs . Am. J. Health Syst. Pharm. , 63 : 1172 – 1193 .
  • Polovich , M. 2009 . Cancer Chemotherapy Guidelines and Recommendations for Practice (Third Ed.) , Pittsburgh , Pa. : Oncology Nursing Society .
  • Martin , S. and Larson , E. 2003 . Chemotherapy-handling practices of outpatient and office-based oncology nurses . Oncol. Nurs. Forum , 30 ( 4 ) : 575 – 581 .
  • Nieweg , R. , de Boer , M. Dubbleman , R. 1994 . Safe handling of antineoplastic drugs. Results of a survey . Cancer Nurs. , 17 ( 6 ) : 501 – 511 .
  • Mahon , S. , Casperson , D. Yackzan , S. 1994 . Safe handling practices of cytotoxic drugs: The results of a chapter survey . Oncol. Nurs. Forum , 21 ( 7 ) : 1157 – 1165 .
  • Sessink , P. , Boer , K. Scheefhals , A. 1992 . Occupational exposure to antineoplastic agents at several departments in a hospital . Int. Arch. Occup. Environ. Health , 64 ( 2 ) : 105 – 112 .
  • Ziegler , E. , Mason , H. and Baxter , P. 2002 . Occupational exposure to cytotoxic drugs in two UK oncology wards . Occup. Environ Med. , 59 ( 9 ) : 608 – 612 .
  • Touzin , K. , Bussières , J. Langlois , E. 2009 . Evaluation of surface contamination in a hospital hematology -oncology pharmacy . J. Oncol. Pharm Pract. , 15 ( 1 ) : 53 – 61 .
  • Connor , T. , Anderson , R. Sessink , P. 2002 . Effectiveness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamide in an I.V. admixture area . Am. J. Health Syst. Pharm. , 59 ( 1 ) : 68 – 72 .
  • Hedmer , M. , Georgiadi , A. Rämme Bremberg , E. 2005 . Surface contamination of cyclophosphamide packaging and surface contamination with antineoplastic drugs in a hospital pharmacy in Sweden . Ann. Occup. Hyg. , 49 ( 7 ) : 629 – 637 .
  • Nygren , O. , Gustavsson , B. Ström , L. 2002 . Cisplatin contamination observed on the outside of drug vials . Ann. Occup. Hyg. , 46 ( 6 ) : 555 – 557 .
  • Mason , H. , Morton , J. Garfitt , S. 2003 . Cytotoxic drug contamination on the outside of vials delivered to a hospital pharmacy . Ann. Occup. Hyg. , 47 ( 8 ) : 681 – 685 .
  • Kromhout , H. , Hoek , F. Uitterhoeve , R. 2000 . Postulating a dermal pathway for exposure to anti-neoplastic drugs among hospital workers . Ann. Occup. Hyg. , 44 ( 7 ) : 551 – 560 .

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