926
Views
57
CrossRef citations to date
0
Altmetric
Original Articles

Blood Manganese as an Exposure Biomarker: State of the Evidence

, , , , , & show all

REFERENCES

  • Elder , A. , Gelein , R. Silva , V. 2006 . Translocation of inhaled ultrafine manganese oxide particles to the central nervous system . Environ. Health Perspect. , 114 ( 8 ) : 1172 – 1178 .
  • U.S. Department of Agriculture (USDA) . 2012 . USDA National Nutrient Database for Standard Reference . Release 25
  • Greger , J. L. 1998 . Dietary standards for manganese: Overlap between nutritional and toxicological studies . J. Nutr. , 128 ( 2 Suppl ) : 368S – 371S .
  • Aschner , M. , Erikson , K. M. and Dorman , D. C. 2005 . Manganese dosimetry: Species differences and implications for neurotoxicity . Crit. Rev. Toxicol. , 35 ( 1 ) : 1 – 32 .
  • Roels , H. , Lauwerys , R. Genet , P. 1987 . Relationship between external and internal parameters of exposure to manganese in workers from a manganese oxide and salt producing plant . Am. J. Ind. Med. , 11 ( 3 ) : 297 – 305 .
  • Apostoli , P. , Lucchini , R. and Alessio , L. 2000 . Are current biomarkers suitable for the assessment of manganese exposure in individual workers? . Am. J. Ind. Med. , 37 ( 3 ) : 283 – 290 .
  • Cowan , D. M. , Fan , Q. Zou , Y. 2009 . Manganese exposure among smelting workers: Blood manganese-iron ratio as a novel tool for manganese exposure assessment . Biomarkers , 14 ( 1 ) : 3 – 16 .
  • Smith , D. , Gwiazda , R. Bowler , R. 2007 . Biomarkers of Mn exposure in humans . Am. J. Ind. Med. , 50 ( 11 ) : 801 – 811 .
  • Antonini , J. M. 2003 . Health effects of welding . Crit. Rev. Toxicol. , 33 ( 1 ) : 61 – 103 .
  • Harris , M. K. , Ewing , W. M. Longo , W. 2005 . Manganese exposures during shielded metal arc welding (SMAW) in an enclosed space . J. Occup. Environ. Hyg. , 2 ( 8 ) : 375 – 382 .
  • Meeker , J. D. , Susi , P. and Flynn , M. R. 2007 . Manganese and welding fume exposure and control in construction . J. Occup. Environ. Hyg. , 4 ( 12 ) : 943 – 951 .
  • Aschner , M. and Dorman , D. C. 2006 . Manganese: Pharmacokinetics and molecular mechanisms of brain uptake . Toxicol. Rev. , 25 ( 3 ) : 147 – 154 .
  • Frumkin , H. and Solomon , G. 1997 . Manganese in the U.S. gasoline supply . Am. J. Ind. Med. , 31 ( 1 ) : 107 – 115 .
  • Bowler , R. M. , Roels , H. A. Nakagawa , S. 2007 . Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders . Occup. Environ. Med. , 64 ( 3 ) : 167 – 177 .
  • Mergler , D. 1999 . Neurotoxic effects of low level exposure to manganese in human populations . Environ. Res. , 80 ( 2 Pt 1 ) : 99 – 102 .
  • Myers , J. E. , Thompson , M. L. Ramushu , S. 2003 . The nervous system effects of occupational exposure on workers in a South African manganese smelter . Neurotoxicology , 24 ( 6 ) : 885 – 894 .
  • Racette , B. A. , Criswell , S. R. Lundin , J. I. 2012 . Increased risk of Parkinsonism associated with welding exposure . Neurotoxicology , 33 ( 5 ) : 1356 – 1361 .
  • Choi , D. S. , Kim , E. A. Cheong , H. K. 2007 . Evaluation of MR signal index for the assessment of occupational manganese exposure of welders by measurement of local proton T1 relaxation time . Neurotoxicology , 28 ( 2 ) : 284 – 289 .
  • Ellingsen , D. G. , Dubeikovskaya , L. Dahl , K. 2006 . Air exposure assessment and biological monitoring of manganese and other major welding fume components in welders . J. Environ. Monit. , 8 ( 10 ) : 1078 – 1086 .
  • Kim , Y. , Kim , K. S. Yang , J. S. 1999 . Increase in signal intensities on T1-weighted magnetic resonance images in asymptomatic manganese-exposed workers . Neurotoxicology , 20 ( 6 ) : 901 – 907 .
  • Korczynski , R. E. 2000 . Occupational health concerns in the welding industry . Appl. Occup. Environ. Hyg. , 15 ( 12 ) : 936 – 945 .
  • Li , G. J. , Zhang , L. L. , Lu , L. , Wu , P. and Zheng , W. 2004 . Occupational exposure to welding fume among welders: Alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status . J. Occup. Environ. Med. , 46 ( 3 ) : 241 – 248 .
  • Lu , L. , Zhang , L. L. , Li , G. J. , Guo , W. , Liang , W. and Zheng , W. 2005 . Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders . Neurotoxicology , 26 ( 2 ) : 257 – 265 .
  • Wang , D. , Du , X. and Zheng , W. 2008 . Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders . Toxicol. Lett. , 176 ( 1 ) : 40 – 47 .
  • Hobson , A. , Seixas , N. , Sterling , D. and Racette , B. A. 2011 . Estimation of particulate mass and manganese exposure levels among welders . Ann. Occup. Hyg. , 55 ( 1 ) : 113 – 125 .
  • Antonini , J. M. , Taylor , M. D. , Zimmer , A. T. and Roberts , J. R. 2004 . Pulmonary responses to welding fumes: Role of metal constituents . J. Toxicol. Environ. Health A , 67 ( 3 ) : 233 – 249 .
  • Antonini , J. M. , Santamaria , A. B. , Jenkins , N. T. , Albini , E. and Lucchini , R. 2006 . Fate of manganese associated with the inhalation of welding fumes: Potential neurological effects . Neurotoxicology , 27 ( 3 ) : 304 – 310 .
  • Berlinger , B. , Ellingsen , D. G. , Naray , M. , Zaray , G. and Thomassen , Y. 2008 . A study of the bio-accessibility of welding fumes . J. Environ. Monit. , 10 ( 12 ) : 1448 – 1453 .
  • Chia , S. E. , Foo , S. C. , Gan , S. L. , Jeyaratnam , J. and Tian , C. S. 1993 . Neurobehavioral functions among workers exposed to manganese ore . Scand. J. Work Environ. Health , 19 ( 4 ) : 264 – 270 .
  • Järvisalo , J. , Olkinuora , M. Kiilunen , M. 1992 . Urinary and blood manganese in occupationally nonexposed populations and in manual metal arc welders of mild steel . Int. Arch. Occup. Environ. Health , 63 ( 7 ) : 495 – 501 .
  • Loranger , S. and Zayed , J. 1995 . Environmental and occupational exposure to manganese: A multimedia assessment . Int. Arch. Occup. Environ. Health , 67 ( 2 ) : 101 – 110 .
  • Grass , D. S. , Ross , J. M. Family , F. 2010 . Airborne particulate metals in the New York City subway: A pilot study to assess the potential for health impacts . Environ. Res. , 110 ( 1 ) : 1 – 11 .
  • Criswell , S. R. , Perlmutter , J. S. Huang , J. L. 2012 . Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders . Occup. Environ. Med. , 69 ( 6 ) : 437 – 443 .
  • Jiang , Y. , Zheng , W. Long , L. 2007 . Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure . Neurotoxicology , 28 ( 1 ) : 126 – 135 .
  • Laohaudomchok , W. , Lin , X. Herrick , R. F. 2011 . Toenail, blood, and urine as biomarkers of manganese exposure . J. Occup. Environ. Med. , 53 ( 5 ) : 506 – 510 .
  • Bader , M. , Dietz , M. C. , Ihrig , A. and Triebig , G. 1999 . Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries . Int. Arch. Occup. Environ. Health , 72 ( 8 ) : 521 – 527 .
  • Bowler , R. M. , Harris , M. Gocheva , V. 2012 . Anxiety affecting Parkinsonian outcome and motor efficiency in adults of an Ohio community with environmental airborne manganese exposure . Int. J. Hyg. Environ. Health , 215 ( 3 ) : 393 – 405 .
  • Lander , F. , Kristiansen , J. and Lauritsen , J. M. 1999 . Manganese exposure in foundry furnacemen and scrap recycling workers . Int. Arch. Occup. Environ. Health , 72 ( 8 ) : 546 – 550 .
  • Deschamps , F. J. , Guillaumot , M. and Raux , S. 2001 . Neurological effects in workers exposed to manganese . J. Occup. Environ. Med. , 43 ( 2 ) : 127 – 132 .
  • Wang , X. , Yang , Y. and Xu , S. 2006 . The effect of occupational exposure to metals on the nervous system function in welders . J. Occup. Health , 48 ( 2 ) : 100 – 106 .
  • Lucchini , R. , Selis , L. Folli , D. 1995 . Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure . Scand. J. Work Environ. Health , 21 ( 2 ) : 143 – 149 .
  • Lucchini , R. , Bergamaschi , E. , Smargiassi , A. , Festa , D. and Apostoli , P. 1997 . Motor function, olfactory threshold, and hematological indices in manganese-exposed ferroalloy workers . Environ. Res. , 73 ( 1–2 ) : 175 – 180 .
  • Lucchini , R. , Apostoli , P. Perrone , C. 1999 . Long-term exposure to “low levels” of manganese oxides and neurofunctional changes in ferroalloy workers . Neurotoxicology , 20 ( 2–3 ) : 287 – 297 .
  • Yuan , H. , He , S. , He , M. , Niu , Q. , Wang , L. and Wang , S. 2006 . A comprehensive study on neurobehavior, neurotransmitters and lymphocyte subsets alteration of Chinese manganese welding workers . Life Sci. , 78 ( 12 ) : 1324 – 1328 .
  • Environmental Protection Agency (EPA) . 2011 . Exposure Factors Handbook Washington , D.C.
  • Price , P. S. , Conolly , R. B. Chaisson , C. F. 2003 . Modeling interindividual variation in physiological factors used in PBPK models of humans . Crit. Rev. Toxicol. , 33 ( 5 ) : 469 – 503 .
  • Pesch , B. , Weiss , T. Kendzia , B. 2012 . Levels and predictors of airborne and internal exposure to manganese and iron among welders . J. Expo. Sci. Environ. Epidemiol. , 22 ( 3 ) : 291 – 298 .
  • Applebaum , K. M. , Malloy , E. J. and Eisen , E. A. 2007 . Reducing healthy worker survivor bias by restricting date of hire in a cohort study of Vermont granite workers . Occup. Environ. Med , 64 ( 10 ) : 681 – 687 .
  • Lauwerys , R. , Roels , H. , Genet , P. , Toussaint , G. , Bouckaert , A. and De Cooman , S. 1985 . Fertility of male workers exposed to mercury vapor or to manganese dust: A questionnaire study . Am. J. Ind. Med. , 7 ( 2 ) : 171 – 176 .
  • Roels , H. A. , Ghyselen , P. , Buchet , J. P. , Ceulemans , E. and Lauwerys , R. R. 1992 . Assessment of the permissible exposure level to manganese in workers exposed to manganese dioxide dust . Br. J. Ind. Med. , 49 ( 1 ) : 25 – 34 .
  • Mergler , D. , Huel , G. Bowler , R. 1994 . Nervous system dysfunction among workers with long-term exposure to manganese . Environ. Res. , 64 ( 2 ) : 151 – 180 .
  • Myers , J. E. , teWaterNaude , J. Fourie , M. 2003 . Nervous system effects of occupational manganese exposure on South African manganese mine workers . Neurotoxicology , 24 ( 4–5 ) : 649 – 656 .
  • Ellingsen , D. G. , Haug , E. , Ulvik , R. J. and Thomassen , Y. 2003 . Iron status in manganese alloy production workers . J. Appl. Toxicol. , 23 ( 4 ) : 239 – 247 .
  • Chang , Y. , Woo , S. T. Kim , Y. 2010 . Pallidal index measured with three-dimensional T1-weighted gradient echo sequence is a good predictor of manganese exposure in welders . J. Magn. Reson. Imaging , 31 ( 4 ) : 1020 – 1026 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.